Journal of Renal Injury Prevention最新文献

{"title":"The effect of single dose prophylactic vancomycin before semi-permanent catheterization to prevent catheter related infection; a randomized controlled trial, phase II","authors":"A. Aref, Zohreh Zandbaf, A. Ghorbani, Shahla Ahmadi Halili","doi":"10.34172/jrip.2022.32071","DOIUrl":"https://doi.org/10.34172/jrip.2022.32071","url":null,"abstract":"Introduction: Catheter-related infections are a common complication and a major cause of morbidity and mortality in hemodialysis patients with tunneled central venous catheters. The optimal strategy for the management and prevention of catheter-related infections is unclear. Objectives: This study is aimed to evaluate the single-dose prophylactic vancomycin efficacy before semi-permanent catheterization to prevent catheter-related infection. Patients and Methods: This randomized double-blind controlled clinical trial was conducted on patients with chronic renal failure requiring hemodialysis and insertion of a double-lumen central venous catheter admitted to Ahvaz Golestan Hospital. The intervention group (n=30) received 1 g of vancomycin intravenously one hour before catheter insertion and the control group (n=30) received an equal amount of normal saline. The incidence of catheter-related infections and other complications for 6 months was evaluated. Results: During the 6-month follow-up, hospitalization due to catheter-related infection and the need for antibiotic administration was observed in 9 patients (30.0%) who received vancomycin and 14 patients (46.7%) in the control group (P=0.184). Catheter extraction due to infection was observed in 4 patients of the vancomycin group (13.3%) and 6 patients of the control group (20.7%) (P=0.451). Complications other than infection were observed in four patients (13.3%) in each group (P=1.000). The mean time to onset of infection was 2.43 ±0.38 months in the control group and 3.85 ± 0.42 months in the vancomycin group (P=0.002). Conclusion: Although a single dose of intravenous vancomycin one hour before insertion of a bi-luminal hemodialysis catheter did not show a significant effect on preventing catheter-related infections over 6 months, it significantly delayed the onset of infection. Trial Registration: The trial protocol was approved by Iranian Registry of Clinical Trial (Ethical code: IR.AJUMS.HGOLESTAN.REC.1399.106 and IRCT code: IRCT20201206049617N1; https://www.irct.ir/trial/52832).","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46813818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal outcomes in myeloma associated acute kidney injury; a single centre experience","authors":"Shivendra Singh, H. Sreenidhi","doi":"10.34172/jrip.2022.32020","DOIUrl":"https://doi.org/10.34172/jrip.2022.32020","url":null,"abstract":"Introduction: At initial diagnosis of multiple myeloma (MM) 30% to 40% of patients has renal impairment and acute kidney injury (AKI) being most common renal presentation. Poor renal outcome is associated with poor overall survival of patients. Objectives: The present study was conducted to determine renal outcome in patients with newly diagnosed MM presenting with AKI. Patients and Methods: A prospective observational study was carried out from March 2016 to March 2021. We included newly diagnosed myeloma patients presenting with AKI. Diagnosis and staging of AKI was conducted by kidney disease improving global outcomes (KDIGO) guidelines. Diagnosis of MM was performed by International Myeloma Working Group (IMWG) criteria. Complete renal response was defined as estimated glomerular filtration rate (eGFR) of ≥60 mL/min. Statistical analysis was done using SPSS Statistics software version 28. Results: Total number of patients were 48 male, female was 32.16, median age was 69 years. With a median follow-up of 9 weeks 30 patients (62.5%) had complete renal response, 10 patients (20.8%) expired and 8 patients (16.6%) were dialysis dependent. On comparing patients with and without complete renal response, significant variables were serum creatinine (P<0.001), serum calcium (P<0.001), oliguria at presentation (P<0.001), RRT requirement (P<0.001), AKI stage Ⅲ (P<0.001) and light chain myeloma(P<0.001). On Kaplan Meier analysis oliguria at presentation (P<0.001), renal replacement therapy (RRT) requirement (P<0.001), AKI stage Ⅲ (P<0.001) and light chain myeloma (P<0.001) were significantly associated with poor renal outcomes. Conclusion: In patients with newly diagnosed MM presenting with AKI renal recovery is 62.5%. Factors associated with poor renal recovery are higher serum creatinine, oliguria, RRT requirement, AKI stage Ⅲ and light chain myeloma.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42280470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The change of disease stage and clinical outcome of retardation of renal degeneration among patients living with the third and fourth stages of chronic kidney disease in the kidney degeneration clinic of secondary health services","authors":"Pairat Puaksawat, Praditporn Pongtriang","doi":"10.34172/jrip.2022.32034","DOIUrl":"https://doi.org/10.34172/jrip.2022.32034","url":null,"abstract":"Introduction: The mortality rate from chronic kidney disease (CKD) at all ages has increased worldwide. It is possible to eliminate the progression of CKD, as it can be treated with early diagnosis and treatment. Objectives: This research aims to study the changes in the stages of the disease and clinical outcomes in patients with the third and fourth stages of CKD. Patients and Methods: This research is a retrospective analytic study in patients diagnosed with third- and fourth-stage of CKD at the Tha Chang Hospital, Thailand. The research sample consisted of 169 medical records of a small population with a confidence level of 0.95. Research data were collected between October 2019 and March 2021. Data analysis utilized frequency, percentage, paired t test, and Wilcoxon signed-rank test. Results: The results revealed that after one year of attending the clinic, the average systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), hemoglobin A1c (HbA1c), uric acid, high-density lipoprotein (HDL), estimated glomerular filtration rate (eGFR), and urine microalbumin had no differences. However, the average body mass index (BMI), total cholesterol (TC), low-density lipoprotein (LDL), and serum creatinine (sCr) showed statistically significant differences at P<0.05. Most patients with CKD were in stable health conditions and disease stage (87.57%). Conclusion: The third and fourth-stage CKD care model could be achieved by the multidisciplinary care team and requires a strategy that is sustainable in addition to continuous care by involving a family member and caregiver in the community.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45917095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of olive leaf use on blood pressure; A systematic review and meta-analysis","authors":"A. Fatahian, S. Yousefi, M. Azadbakht, M. Moosazadeh, M. Fakhri","doi":"10.34172/jrip.2022.31933","DOIUrl":"https://doi.org/10.34172/jrip.2022.31933","url":null,"abstract":"Context: Hypertension has been identified as the world’s third leading cause of death. Due to their cost-effectiveness and lack of adverse effects compared to antihypertensive medications, medicinal plants have gained popularity in most countries. The olive leaf is one of these plants. As a result, the purpose of the current systematic review and meta-analysis was to determine the effect of olive leaf consumption on systolic and diastolic blood pressure. Evidence acquisition: The following domestic and international databases were searched in order to retrieve relevant studies: PubMed, Scopus, Web of Science, Embase, Cochrane, ProQuest, and Google Scholar search engine, the ClinicalTrials.gov Protocol Registration and Results System (PRS), the ISRCTN registry administered by BioMed Central, and the World Health Organization’s (WHO) International Clinical Trials Registry Platform. The data collected were analyzed using STATA software (version14) at a significance level of P<0.05. Results: Olive leaf consumption had a significant effect on systolic blood pressure [-0.87 (95% CI: -1.09, -0.64)] and diastolic blood pressure [-0.39 (95% CI: -0.57, -0.21)] in five studies with a sample size of 145 people (mean age range of 33.30 ± 5.25 years). Consumption of olive leaves also decreased cholesterol levels [-0.52 (95% CI: -0.81, -0.22)], low-density lipoprotein (LDL-c) levels [-0.35 (95% CI: -0.58, -0.12)], and triglycerides levels [-0.67 (95% CI: -1.19, -0.16)]. Nonetheless, the olive leaf had no statistically significant effect on reducing highdensity lipoprotein levels. Conclusion: We observed that olive leaf consumption significantly reduced the levels of systolic and diastolic blood pressure, cholesterol, triglycerides, and LDL-c. Registration: The current protocol was also registered on PROSPERO (ID: 221277, Date: 16.04.2022).","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48183310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly sensitive C-reactive protein, pentraxin-3 and mannose-binding lectin in patients with hemodialysis and their association with cardiovascular complications and mortality","authors":"A. Firouzjahi, Reyhaneh Ramezanzade, S. Mouodi, Hossein Ghorbani, K. Hajian-Tilaki, B. Heidari, M. Saravi, R. Akbari","doi":"10.34172/jrip.2022.32031","DOIUrl":"https://doi.org/10.34172/jrip.2022.32031","url":null,"abstract":"Introduction: Cardiovascular disorder(CVD) is one of the most important comorbidities in patients with hemodialysis(HD). Several markers for kidney disease and kidney transplantation have been investigated. Objectives: This study aimed to evaluate the association between three inflammatory biomarkers including C-reactive protein (CRP), pentraxin 3 (PTX-3) and mannose-binding lectin (MBL) with CVD events and mortality in HD patients. Patients and Methods: This study was carried on patients with immunosuppressive therapy aged between 18-80 years with chronic renal failure undergoing HD. Patients were visited at baseline and every six month for 12 months. The levels of biomarkers and complications were recorded before, one week later and 2 months after transplantation. Echocardiography and calculation of ejection fraction(EF) were performed to determine the occurrence of CVD events. Results: Ninety patients with the mean age of 54.0±3.24 years were included. All biomarkers had significant area under the curve for accurate diagnosis between the patients with low EF (with a decreasing measure) and normal EF patients (p<0.05); however, none of them had a significant accurate diagnosis between patients with low EF (with a constant measure) and normal EF patients (P>0.05). PTX-3 and MBL showed a significant correlation to detect CVD events (r=0.987; p<0.0001). Also, PTX-3 and MBL had significant correlations with hs-CRP (P<0.05). None of these markers had significant accuracy for prediction of mortality. Conclusion: Serum level of PTX-3 and MBL not only increase reactive protein, but also may be considered as diagnostic biomarkers for early detection of CVD events in patients with end stage renal disorders.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46628455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of sleeve gastrectomy on renal function in diabetic and non-diabetic morbidly obese patients","authors":"Z. Davoudi, N. Zahed, Sahab-sadat Tabatabaei, Y. Farsi, Mohsen Soori, S. Mirhashemi","doi":"10.34172/jrip.2022.32028","DOIUrl":"https://doi.org/10.34172/jrip.2022.32028","url":null,"abstract":"Introduction: Obesity is associated with albuminuria and impaired renal function. Bariatric surgery has been shown to improve and resolve diabetes and improve renal function in patients with morbid obesity. This study investigates the potential effects of sleeve gastrectomy on the improvement of renal function and albuminuria in diabetic and non-diabetic morbidly obese patients and discusses probable mechanisms. Material and methods: This prospective study included, 137 morbidly obese patients (44 diabetics and 93 non-diabetic) who underwent laparoscopic sleeve gastrectomy who were evaluated clinically (anthropometric measurements) and biochemically before surgery and at 1 year from surgery. Results: Sleeve gastrectomy significantly decreases weight and body mass index, improves glycemic parameters, hyperfiltration, and urinary albumin excretion in diabetic and non-diabetic patients; (P < 0.001). Alterations in C- reactive protein (CRP) levels are strongly associated with ACR decline in diabetic patients. Conclusion: Our findings revealed significant decreases in weight, body mass index, and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic patients, accompanied by the resolve of hyperfiltration, urinary albumin excretion, and improvement of renal function via reduction of the systemic inflammation.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47489293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIALYSIS PRACTICES DURING THE COVID -19 PANDEMIC: A SURVEY FROM INDIA","authors":"Pallavi Prasad, Ramprasad Elumalai, J. Matcha","doi":"10.34172/jrip.2022.32027","DOIUrl":"https://doi.org/10.34172/jrip.2022.32027","url":null,"abstract":"INTRODUCTION: We aimed to study the practices being followed in dialysis units across the country during the COVID-19 pandemic. METHODS: A questionnaire assessing treatment and preventive practices being followed in dialysis units during the COVID-19 pandemic was emailed to nephrologists and nephrology trainees practising in India. Responses were recorded electronically. RESULTS: We received 173 valid responses. 83.2% nephrologists were providing dialysis for COVID-19. Hemodialysis/Slow low efficient dialysis was the most common modality (65.2%) of renal replacement therapy (RRT) in COVID-19 acute kidney injury. In dialysis patients with suspicious symptoms, most common test to rule out COVID-19 was RTPCR(reverse transcriptase polymerase chain reaction) +chest imaging ( 42.2%)followed by RT-PCR alone (34.1%). 80.9% nephrologists sought a negative RT-PCR in patients who had recovered from COVID-19 before discontinuation of isolation measures. Adherence to COVID-19 preventive measures varied between 15.2% (portable reverse osmosis disinfection) to 97.1% (mask wearing). Healthcare worker (HCW) training programme was present in 88.4% cases, paid leaves for COVID-19 in 89% and daily HCW symptom screen in 65.3%. The most frequently identified barrier to chronic kidney disease care was a delay in transplantation (66.5%).20.8% reported a temporary closure of dialysis unit due to COVID-19 outbreak. 63% nephrologists counseled patients to choose peritoneal dialysis above hemodialysis as permanent RRT. CONCLUSION: Hemodialysis/SLED is the preferred modality of RRT in COVID 19-AKI.Many nephrologists are counseling for peritoneal dialysis as superior to hemodialysis during COVID-19 for maintenance RRT. Preventive measure adherence is variable across centres. Healthcare worker safety has been addressed in most centres.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44792084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procalcitonin for diagnosis of asymptomatic bacteriuria in kidney transplant recipients","authors":"tahere zarouk ahimahalle, E. Razeghi, M. Lessan-pezeshki, F. Ahmadi","doi":"10.34172/jrip.2022.32026","DOIUrl":"https://doi.org/10.34172/jrip.2022.32026","url":null,"abstract":"Background and aim. Asymptomatic bacteriuria (ASB) is a frequent finding in allograft kidney transplant recipients and may be associated with a higher incidence of urinary tract infections in this population. We aimed to investigate the potential utility of serum procalcitonin (PCT) concentrations, an early marker of infection, for ASB diagnosis. We also compared its diagnostic performance with white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and highly sensitive C-reactive protein (hsCRP). Methods. In a single-center, cross-sectional study, 37 kidney transplant recipients with no clinical signs or symptoms of urinary tract infections were included. ASB was assessed by means of urine culture. Serum PCT concentrations were determined by the electrochemiluminescence immunoassay technique. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic performance of PCT and other classifiers. Results. Seventeen patients (46%) had ASB. Serum PCT concentrations were significantly higher in ASB+ patients (0.14 vs. 0.08 ng/ml, p=0.009). PCT concentrations significantly correlated with serum creatinine (r=0.408, p=0.012) and ESR (r=0.466, p=0.004). Of the four tested classifiers (PCT, WBC count, ESR, and hsCRP), only PCT was able to significantly distinguish between ASB+ and ASB- patients [area under the curve: 0.74, (95% CI: 057-0.91) p=0.012]. Adjustment of the ROC model for serum creatinine showed that the ability of PCT in classifying patients by ASB status is not affected by creatinine concentrations (crude vs. adjusted area under the curve: 0.74 vs. 0.72, test of AUC difference: p=0.891). A cut-point of 0.10 ng/ml of PCT correctly classified ASB+ patients with a sensitivity and specificity of 64.7% and 80.0%, respectively. Conclusion. PCT might be a useful surrogate marker for ASB diagnosis among kidney transplant recipients. Diagnostic performance of PCT is superior to that of WBC count, ESR, and hsCRP. Further, diagnostic ability of PCT appears to be independent of renal function.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47307815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vitamin D treatment on magnesium levels in chronic hemodialysis patient; a double blind controlled clinical trial","authors":"Shahla Ahmadi Halili, A. Ghorbani, Ebrahim Hamreh, Leila Sabetnia, F. Hayati, Khojasteh Hoseinynejad","doi":"10.34172/jrip.2022.31984","DOIUrl":"https://doi.org/10.34172/jrip.2022.31984","url":null,"abstract":"Introduction: The homeostasis of magnesium (Mg) is impaired in chronic kidney disease (CKD) and it has been suggested that intestinal absorption of Mg may be affected by vitamin D status. 25-Hydroxy vitamin D or 25(OH)D deficiency is common in patients undergoing chronic hemodialysis; however the efficacy of nutritional vitamin D supplementation on Mg level in this population remains uncertain. Objectives: The aim of this study was to evaluate the effect of vitamin D treatment on Mg levels in chronic hemodialysis patients. Patients and Methods: This randomized clinical trial study was conducted on 69 chronic hemodialysis patients (mean age of 56.93 ±12.26 years) with serum 25-hydroxy vitamin D levels <30 ng/mL. The patients were randomly assigned to one of treatment groups of oral vitamin D3- 50 000 units per week (n=35; experimental group) or 500 mg calcium D3 tablets, every 12 hours (n=34; control group) for three months. At the beginning and end of the treatment period, the levels of serum 25-hydroxy vitamin D and the levels of Mg, calcium, phosphorus and intact parathyroid hormone (iPTH) were measured in two groups. Results: In both groups, serum vitamin D levels increased significantly after treatment (P<0.0001 for both groups), however after three months of treatment, in the experimental group the levels of vitamin D were significantly higher than the patients in the control group (57 ng/mL versus 28 ng/mL; P<0.0001) and the median increase of vitamin D after treatment in the experimental group was significantly higher than the control group (40 ng/mL versus 10.5; P<0.0001). Serum Mg levels before and after treatment were not significantly different between two groups (P=0.880 and P=0.434). In this study, we found no significant correlation between serum vitamin D level with serum Mg, calcium, phosphate, and parathyroid Hormone levels (P>0.05). Conclusion: Our study shows that oral vitamin D therapy can increase 25(OH)D levels in maintenance hemodialysis patients without significant alterations in serum calcium, phosphate, magnesium and parathyroid hormone during a 12-week period. Trial Registration: Registration of trial protocol has been approved by the Iranian registry of clinical trial (#IRCT20210314050698N1; https://en.irct.ir/trial/55159, local ethical code# IR.SKUMS.REC.1397.181).","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45747670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of B12 supplementation on renal anemia among hemodialysis patients at El-Najar hospital, Gaza strip","authors":"Abdul Rahman Mahmoud F. Nahas, Raghdaa Hamdan Al Zarzour, Asmaa Salama M. Abu Laila, Ahmed Mahmoud Tabash, A. A. Abu Mustafa, F. Allyan, A. M. Elregeb, Eyad Elabed Muadi Abou Teior, A. Al-Shami, M. Elnaem","doi":"10.34172/jrip.2022.32009","DOIUrl":"https://doi.org/10.34172/jrip.2022.32009","url":null,"abstract":"Introduction: Patients with end-stage renal disease (ESRD) are predisposed to nutritional deficiencies, resulting in vitamin B12 deficiency with negative hematologic consequences. Objective: This study aimed to investigate the impact of intramuscular B12 on renal anemia among ESRD patients receiving hemodialysis (HD) at El-Najar hospital, Gaza Strip. Patients and Methods: A case-control study conducted, which included 110 healthy controls and 110 HD patients who received B12 on a daily, weekly, and monthly basis over two months. Sociodemographics and current diseases were reported. Serum levels of serum B12, white blood cell (WBC), red blood cell (RBC), hemoglobin (Hb), mean corpuscular volume (MCV), and platelet (PLT) were recorded before and after treatment. Data analysis was conducted using SPSS. Results: Baseline serum B12 level was significantly lower in HD patients compared to controls (362.62 ± 166.40 versus 483.36 ± 115.07 ρg/mL, P<0.001), which significantly improved after vitamin B12 treatment (639.08 ± 362.99 ρg/mL, P<0.001). Additionally, mean WBCs, RBCs, Hb, and PLT levels were significantly increased after treatment (P<0.001). Serum B12 level was positively and significantly (P<0.001) correlated with levels of WBC (r = 0.45), RBC (r = 0.43), Hb (r = 0.39) and PLT (r = 0.51), and negatively correlated with MCV (r = -0.46, P<0.001). Conclusion: Administration of vitamin B12 improves serum B12 levels in HD patients, which was associated with increased WBCs, RBCs, Hb, and PLT levels and decreased MCV levels. Treatment by vitamin B12 can improve HD patients’ renal anemia. Future studies with larger sample sizes and prolonged follow-up are advocated.","PeriodicalId":16950,"journal":{"name":"Journal of Renal Injury Prevention","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41397683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}