血液透析患者血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值与炎症因子的关系

IF 0.2 Q4 UROLOGY & NEPHROLOGY
M. Ghorbani, Maryam Kia, Maedeh Razzaghi
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引用次数: 0

摘要

引言:与健康人相比,慢性炎症是血液透析患者动脉粥样硬化发病机制的主要因素。慢性炎症是晚期肾功能衰竭的营养不良、动脉粥样硬化和炎症综合征的一部分。目的:探讨血小板与淋巴细胞比值(PLR)和中性粒细胞与淋巴细胞比值与炎症因子的关系。患者和方法:这项横断面研究对108名透析时间超过三个月的血液透析患者进行了研究。对于患者,在透析前评估血清尿素、肌酸酐(Cr)、钠、钾、钙、磷酸盐、甲状旁腺激素、总胆固醇、甘油三酯、铁蛋白、25-羟基维生素D、白蛋白、血沉(ESR)、C反应蛋白(CRP)和全血细胞计数的水平,因为透析后也会再次检查血清尿素。结果:男58例,女50例,平均年龄63.43±14.65岁。NLR和PLR的中位数分别为2.25和114.7。血沉在NLR>2.25的血液透析患者中显著升高(46.7±29.7对36±22.7),在PLR>14.7的患者中显著提高(47.09±27.8对35.6±24.8)。PLR>11.7的患者血浆血红蛋白和血清25-羟基维生素D水平较低(10.37±1.6对11.7±1.8和33.1±2.5对37.9±15.2)。二元相关分析表明,PLR和NLR与ESR呈正相关,而PLR与血液25-羟基维生素D血红蛋白和Cr值呈显著负相关。PLR可能比NLR更好地预测炎症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The association between platelet to lymphocyte ratio and neutrophil to lymphocyte ratio with inflammatory factors in hemodialysis patients
Introduction: Chronic inflammation is a major factor in the pathogenesis of atherosclerosis in hemodialysis patients compared to healthy individuals. Chronic inflammation is part of the malnutrition, atherosclerosis, and inflammation syndrome in advanced renal failure. Objectives: In this study, the relationships of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) with the inflammatory factors were investigated. Patients and Methods: This cross-sectional study was conducted on 108 hemodialysis patients who were on dialysis for more than three months. For patients, serum levels of urea, creatinine (Cr), sodium, potassium, calcium, phosphate, parathyroid hormone, total cholesterol, triglyceride, ferritin, 25-hydroxy vitamin D, albumin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and complete blood cell count were assessed before dialysis since serum urea was examined again after dialysis too. Results: The mean age of the patients (58 male and 50 female) was 63.43±14.65 years. The median values for NLR and PLR were 2.25 and 114.7, respectively. ESR was significantly higher in hemodialysis patients with NLR >2.25 (46.7±29.7 versus 36±22.7) and in those with PLR >114.7 (47.09±27.8 versus 35.6±24.8). Plasma hemoglobin and serum 25-hydroxy vitamin D levels were observed to be lower (10.37±1.6 versus 11.7±1.8 and 33.1±2.5 versus 37.9±15.2) in patients with PLR >114.7. Bivariate correlation showed that PLR and NLR had positive significant correlation with ESR while PLR had a significant negative correlation with values of blood 25-hydroxy vitamin D hemoglobin and Cr. Conclusion: Due to availability and affordability of PLR and NLR, they could be used for early assessment of inflammation in end-stage renal disease (ESRD) patients. PLR may be better predictor than NLR (to detect inflammation.
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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