Urinary neutrophil gelatinase-associated lipocalin might be an associated marker for anticipating scar formation in children with vesicoureteral reflux

IF 0.2 Q4 UROLOGY & NEPHROLOGY
Rahimpour Amiri, R. Raeisi, J. Amiri, Fateme Sheida, Ziba Mohammad Alizadeh, G. Solgi, H. Bazmamoun, J. Faradmal, A. Hasanpour Dehkordi
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Abstract

Introduction: Vesicoureteral reflux (VUR) is considered as the most common urogenital abnormality occurring in children. There is no reliable and routine clinical test that is non-invasive and rapid for recognizing the renal scars from VUR. Objectives: Urine neutrophil gelatinase-associated lipocalin (uNGAL) can be the best indicator for early diagnosis of scar formation in children with VUR. Patients and Methods: Children with primary VUR admitted to Hamadan’s Besat hospital from March to December 2020 were included in this cross-sectional study. A dimercaptosuccinic acid (DMSA) scan was employed to assess all subjects in order to diagnose scar formation at least 180 days after the last episode of urinary tract infection (UTI). Additionally, uNGAL and its ratio to urine creatinine (uCr) levels were measured. Results: During the study, all 63 cases (male/female, 13.50) with VUR were included for further evaluation. The mean age of the patients was 59.1 ± 34.7 months (range 2 to 132 months). Twelve subjects suffered from unilateral VUR, while bilateral VUR inflicted 51. According to the disease severity, nine patients had mild, 35 had moderate, and 19 had a severe form of VUR. No significant difference was observed between patients with (n = 31) and without (n = 32) renal scars regarding mean levels of the uNGAL and uNGAL/uCR ratios (P>0.05). Conclusion: We found no significant difference between the groups with and without the renal scar in terms of biomarker levels.
尿中性粒细胞明胶酶相关脂钙素可能是预测膀胱输尿管反流儿童瘢痕形成的相关标志物
膀胱输尿管反流(VUR)被认为是儿童最常见的泌尿生殖系统异常。目前尚无可靠的、常规的、无创的、快速的临床检测方法来识别VUR所致的肾瘢痕。目的:尿中性粒细胞明胶酶相关脂钙素(uNGAL)可作为早期诊断VUR患儿瘢痕形成的最佳指标。患者和方法:本横断面研究纳入了2020年3月至12月在哈马丹Besat医院住院的原发性VUR儿童。采用二巯基琥珀酸(DMSA)扫描对所有受试者进行评估,以便在最后一次尿路感染(UTI)发作后至少180天内诊断瘢痕形成。此外,测定uNGAL及其与尿肌酐(uCr)水平的比值。结果:在研究期间,所有63例(男/女,13.50例)VUR被纳入进一步评估。患者平均年龄59.1±34.7个月(2 ~ 132个月)。单侧VUR 12例,双侧VUR 51例。根据疾病严重程度,9例为轻度,35例为中度,19例为重度VUR。肾瘢痕患者(n = 31)和非肾瘢痕患者(n = 32) uNGAL平均水平和uNGAL/uCR比值无显著性差异(P < 0.05)。结论:我们发现有无肾瘢痕组在生物标志物水平上无显著差异。
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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