Protective effects of pretreatment or concomitant treatment with Hypericum extract on renal function and renal toxicity in cisplatin-induced nephrotoxicity

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2022-03-09 DOI:10.34172/jrip.2022.31958

Hori Ghaneialvar, M. Kaffashian, Amir Hussein Salimi, Neda Moulaei, N. Afsordeh, Shams Parvari, Naser Abasi, A. Kenarkoohi, M. Maleki

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引用次数: 0

Abstract

Introduction: Cisplatin is a strong anticancer medicine, but its use is limited due to the potential nephrotoxicity induction. Objectives: The present study seeks to determine the impact of Hypericum hydroalcoholic extract on cisplatin-induced nephrotoxicity. Materials and Methods: Thirty-two male rats were assigned to groups 1 to 4. Group 1, control (Cont); treated by saline (IP). Group 2, Cis; cisplatin [intraperitoneal (IP), 7.5 mg/kg]. Group 3, CisH; cisplatin + Hypericum (70 mg/kg, IP, for one week). Group 4, HCis; first treated with Hypericum for a week, followed by cisplatin. Renal tissue and blood samples were obtained a week after cisplatin injection for tissue assay and biochemical analysis. Kidney tissue damage score (KTDS), plasma creatinine (Cr), blood urea nitrogen (BUN), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were measured. Results: Kidney weight showed significant differences between the treated groups and the Cont group (P<0.001). Serum BUN, Cr, SGOT, and SGPT increased significantly in Cont (P<0.01). BUN decreased in CisH and HCis groups compared to Cis group, although there was no significant difference. Serum Cr, SGOT, and SGPT decreased significantly in CisH and HCis groups compared to the Cis group (P<0.05). MDA and KTDS increased in the Cis group and decreased significantly in the CisH and HCis groups compared to the Cis group (P<0.05). Serum SOD and CAT decreased significantly in Cis compared to Cont (P<0.05) and increased in CisH and HCis groups compared to Cis. There was no significant difference between the CisH and HCis groups in any of the measured parameters. Conclusion: This study reveals that pretreatment with Hypericum extract or its concomitant administration with cisplatin can moderate the side-effects of cisplatin, improve renal function and decrease lipid peroxidation, renal toxicity and the KTDS.

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金丝桃提取物预处理或联合治疗对顺铂肾毒性中肾功能和肾毒性的保护作用

简介：顺铂是一种强效抗癌药物，但由于潜在的肾毒性，其使用受到限制。目的：本研究旨在确定金丝桃水醇提取物对顺铂诱导的肾毒性的影响。材料和方法：32只雄性大鼠被分为第1组至第4组。第1组，对照组（续）；用生理盐水（IP）处理。第2组，Cis；顺铂[腹膜内（IP），7.5mg/kg]。第3组，CisH；顺铂+金丝桃（70 mg/kg，IP，持续一周）。第4组，HCis；首先用金丝桃治疗一周，然后用顺铂治疗。在顺铂注射后一周获得肾组织和血液样本，用于组织测定和生化分析。测定肾组织损伤评分（KTDS）、血肌酐（Cr）、血尿素氮（BUN）、血清谷草转氨酶（SGOT）、血清谷丙转氨酶（SGPT）、丙二醛（MDA）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）。结果：治疗组和Cont组的肾脏重量有显著差异（P＜0.001）。Cont组血清BUN、Cr、SGOT和SGPT显著升高（P＜0.01）。与Cis组相比，CisH组和HCis组的BUN降低，但没有显著差异。与Cis组相比，Cis组和HCis组的血清Cr、SGOT和SGPT显著降低（P＜0.05）。MDA和KTDS在Cis组增加，在Cis和HCCis组显著下降（P＜0.01）。血清SOD和CAT在Cis中显著降低（P＜0.05），在Ciss组和HCCis中增加。CisH组和HCis组在任何测量参数方面均无显著差异。结论：金丝桃提取物预处理或与顺铂联合给药可减轻顺铂的副作用，改善肾功能，降低脂质过氧化、肾毒性和KTDS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.