Furosemide stress test predicts acute kidney injury progression in intensive care unit

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2022-03-09 DOI:10.34172/jrip.2022.31995

Srivatsava Jayakrishna Murthy, L. Venugopal, V. Jayaprakash, Raghavan Padmanabhan, Sailapathy Sreedhar

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Abstract

Introduction: Clinical tools to predict acute kidney injury (AKI) in intensive care unit (ICU) are lacking. Objectives: This prospective study was conducted to assess the utility of furosemide stress test (FST) to predict AKI and its progression to severe stages and requirement of hemodialysis (HD). Patients and methods: Patients in AKI stage I or II were given a standardized dose of frusemide as per protocol. The study cohort included 62 patients. Response to FST was assessed by urine output (UOP) at 2 hours. Study patients were subsequently divided into two groups, those with UOP >200 mL (group A) and those with UOP <200 mL (group B). Results: Group A constituted 71% (n=44) of cases. Of them, 2 (4.54%) patients progressed to AKI Network (AKIN) stage III. Group B constituted 29% of cases (n=18). Of them, 12 (66%) cases progressed to AKIN stage III. In group A, 4.5% (n=2) of cases required HD. In comparison, 55% (n=10) of group B patients required HD during the hospital stay. Mortality rate was 6.8% (n=3) in group A and 33.3% (n=6) in group B. The duration of stay was more in the patients with UOP <200 mL group compared to UOP >200 mL group. Conclusion: FST may be a reliable predictor of AKI progression to severe stages and requirement of dialysis in ICUs.

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速尿压力试验预测重症监护病房急性肾损伤进展

临床工具预测急性肾损伤(AKI)在重症监护病房(ICU)是缺乏的。目的:本前瞻性研究旨在评估呋塞米应激试验(FST)在预测AKI及其进展到严重阶段和血液透析(HD)需求方面的应用。患者和方法:AKI I期或II期患者按照方案给予标准剂量的氟塞胺。研究队列包括62名患者。通过2小时的尿量(UOP)来评估FST的疗效。研究患者随后被分为两组，UOP bb0 200 mL组(A组)和UOP 200 mL组。结论:FST可能是icu患者AKI进展到严重阶段和需要透析的可靠预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.