应用尿中性粒细胞明胶酶依赖性脂质运载蛋白预测重症监护患者急性肾损伤的可能性评估

IF 0.2 Q4 UROLOGY & NEPHROLOGY
S. Hajian, Nafiseh Rastgoo, Sanaz Jamshidi
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引用次数: 0

摘要

引言:由于急性肾损伤(AKI)的发生率增加,特别是在重症监护室(ICU)的患者中,已经使用尿液中性粒细胞明胶酶依赖性脂质运载蛋白(uNGAL)等生物标志物研究了其发生率。然而,其临床应用尚未得到批准。目的:本研究旨在探讨使用uNGAL作为ICU患者AKI预测指标的可能性。患者和方法:这项前瞻性研究对32名入住ICU的患者进行,这些患者在入住ICU时肌酐水平正常,但不符合RIFLE(风险、损伤、衰竭、肾功能丧失和终末期肾病)标准。最初,记录肌酸酐水平和连续器官衰竭评估(SOFA)评分。在住院的前24小时,从患者身上采集尿液样本以评估uNGAL水平。在接下来的几天里,记录肌酐水平及其上升的日期。根据RIFLE标准评估AKI的发病率,并评估入院时AKI发病率与uNGAL水平之间的关系。结果:患者的平均年龄(SD)为63±17岁,18例(56%)为男性。21名患者(66%)的住院原因是心脏手术后。患者入院时SOFA评分中位数为2.5。根据RIFLE标准,47%的患者在不同阶段有肾脏问题。住院时间中位数为13天,4名患者(13%)死亡。所有患者入院时uNGAL水平的范围和平均值(SD)分别为46.1至172.5 ng/mL和89.94±30.9 ng/mL,这在两性之间以及在世和已故患者之间没有显著差异。尽管与正常患者相比,处于RIFLE标准的风险和损伤阶段的患者的uNGAL平均值增加,但两者之间的差异并不显著。uNGAL的增加与SOFA评分的增加直接相关(Spearman’s rho=0.360,P=0.043),而其变化与年龄或肌酸酐升高率无关。结论:我们的研究结果表明,在ICU入院患者中,根据RIFLE标准,第一天的uNGAL水平对预测AKI没有帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the possibility of using urinary neutrophil gelatinase-dependent lipocalin as a predictor of acute kidney injury in intensive care unit patients
Introduction: Due to the increase in the incidence of acute kidney injury (AKI), especially in patients admitted to the intensive care unit (ICU), its occurrence has been studied using biomarkers such as urinary neutrophil gelatinase-dependent lipocalin (uNGAL). However, its clinical utility has not yet been approved. Objectives: This study aimed to investigate the possibility of using uNGAL as a predictor of AKI in patients admitted to the ICU. Patients and Methods: This prospective study was conducted on 32 patients admitted to the ICU who had normal creatinine level at the ICU admission and did not fulfill the RIFLE (risk, injury, failure, loss of kidney function, and end-stage kidney disease) criteria. Initially, creatinine level and the sequential organ failure assessment (SOFA) score were recorded. In the first 24 hours of hospitalization, urine samples were taken from patients to assess uNGAL levels. In the following days, creatinine levels and the day of its rise were recorded. The incidence of AKI was assessed based on the RIFLE criteria, and the relationship between the AKI incidence and the uNGAL level at admission was assessed. Results: The mean (SD) of patients’ age was 63 ± 17 years, and 18 patients (56%) were male. The cause of hospitalization was post-cardiac surgery in 21 patients (66%). The median SOFA score of patients was 2.5 at admission. According to the RIFLE criteria, 47% of patients had kidney problems at different stages. The median length of hospital stay was 13 days, while four patients (13%) died. Range and mean (SD) of uNGAL level at admission in all patients was 46.1 to 172.5 ng/mL and 89.94 ± 30.9 ng/mL, respectively, which was not significantly different between the two sexes and between living and deceased patients. Although the mean of uNGAL increased in patients in the risk and injury stage of the RIFLE criteria compared to normal patients, the difference between them was not significant. The increase in uNGAL was directly related to the increase in SOFA score (Spearman’s rho = 0.360, P = 0.043), while its changes was not significantly related to age or creatinine elevation ratio. Conclusion: The findings of our study showed that, in ICU admitted patients, first-day uNGAL level was not helpful in predicting AKI based on the RIFLE criteria.
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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