Prevalence of anti-HLA antibodies in highly sensitized kidney transplant candidates

IF 0.2 Q4 UROLOGY & NEPHROLOGY
Farahnooh Farnood, A. Mardomi, S. Zununi Vahed, M. Ardalan
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引用次数: 0

Abstract

Introduction: Kidney transplantation is the standard gold therapy for the treatment of the majority of end-stage renal diseases (ESRDs). Despite the general success rate of allogeneic transplantation due to immunosuppressive therapy, it is difficult to find an appropriate donor for some sensitized patients. Objectives: This study aimed to estimate the prevalence and titers of anti-HLA-class I and anti-HLA-class II antibodies in sensitized patients in a kidney transplantation center. The history of the risk factors of sensitization was studied. Patients and Methods: Twenty highly sensitized ESRD patients with a calculated panel-reactive antibody (CPRA) ≥50% were selected, and anti-HLA-I and anti-HLA-II antibodies were assessed in their sera using a single antigen bead (SAB) Luminex assay. Results: The previous history of kidney transplantation was the most critical sensitization risk factor. The results indicated that HLA A*24:02 and DQA1*02:01/DQB1*06:02 were the most frequent antibodies in class I and class II, respectively. Moreover, the mean fluorescence intensity (MFI) levels of anti-HLA class II antibodies were significantly higher than the MFI levels of anti-HLA class I antibodies. Conclusion: According to the findings of this study, matching HLA alleles, particularly class II molecules, can reduce sensitization in the first kidney transplant. A better understanding of the sensitization status of transplant candidates could be gained by examining CPRA values.
hla抗体在高敏感肾移植候选者中的流行
引言:肾移植是治疗大多数终末期肾病(ESRD)的标准黄金疗法。尽管由于免疫抑制治疗,同种异体移植的成功率一般,但很难为一些致敏患者找到合适的供体。目的:本研究旨在评估肾移植中心致敏患者中抗HLA I类和抗HLA II类抗体的流行率和滴度。研究了致敏危险因素的历史。患者和方法:选择20名计算群体反应性抗体(CPRA)≥50%的高度致敏ESRD患者,并使用单抗原珠(SAB)Luminex测定法在其血清中评估抗HLA-I和抗HLA-II抗体。结果:既往肾移植史是最重要的致敏危险因素。结果表明,HLA A*24:02和DQA1*02:01/DQB1*06:02分别是I类和II类中最常见的抗体。此外,抗HLA II类抗体的平均荧光强度(MFI)水平显著高于抗HLA I类抗体的MFI水平。结论:根据本研究的结果,匹配HLA等位基因,特别是II类分子,可以降低首次肾移植的致敏性。通过检查CPRA值,可以更好地了解移植候选者的致敏状态。
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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