Journal of psychoactive drugs最新文献_第8页

Attitudes of Mental Healthcare Professionals Towards the Use of Psychedelics in the Treatment of Substance Use Disorders: A Systematic Review. 精神卫生保健专业人员对使用致幻剂治疗物质使用障碍的态度：一项系统综述。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-06-17 DOI: 10.1080/02791072.2026.2685514

F van Dalen, S C Tap, S D Venema, A F A Schellekens, R A Schoevers, S K Spoelstra

{"title":"Attitudes of Mental Healthcare Professionals Towards the Use of Psychedelics in the Treatment of Substance Use Disorders: A Systematic Review.","authors":"F van Dalen, S C Tap, S D Venema, A F A Schellekens, R A Schoevers, S K Spoelstra","doi":"10.1080/02791072.2026.2685514","DOIUrl":"https://doi.org/10.1080/02791072.2026.2685514","url":null,"abstract":"Psychedelic-assisted therapy (PAT) is increasingly recognized as a potential novel treatment for substance use disorder (SUD). As evidence continues to grow, the successful implementation of this modality into clinical practice will depend significantly on the perceptions and attitudes of mental healthcare professionals. Accordingly, a systematic review was conducted to provide a comprehensive overview of the scientific literature on how professionals view the use of psychedelics for the treatment of SUD. A systematic search was performed across six databases, including PubMed, MEDLINE, PsycINFO, Academic Search Premier, CINAHL, and SocIndex. A total of six studies were identified with a total of 966 participants. Findings revealed that the majority of mental healthcare professionals hold a cautiously optimistic attitude toward PAT. Moreover, a minority expressed hesitancy and critical perspectives, citing concerns about safety, efficacy, and the practical challenges of integrating PAT into existing clinical frameworks. Finally, the results indicate that knowledge and familiarity with PAT were key predictors of a more positive outlook. Given the current limited level of knowledge among professionals, these findings underscore a significant need for targeted education and training. Addressing these barriers is essential to facilitate the effective and responsible integration of PAT into standard clinical care for SUD.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barbiturates for the Management of Gamma-Hydroxybutyrate (GHB) Withdrawal: A Systematic Review. 巴比妥类药物治疗γ -羟基丁酸盐（GHB）戒断：一项系统综述。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-06-17 DOI: 10.1080/02791072.2026.2686369

Gayane Archer, Alyssa Bernanke, Cecilia N Hollenhorst, Miranda Yu, Brent Schnipke, Scott Gershan

{"title":"Barbiturates for the Management of Gamma-Hydroxybutyrate (GHB) Withdrawal: A Systematic Review.","authors":"Gayane Archer, Alyssa Bernanke, Cecilia N Hollenhorst, Miranda Yu, Brent Schnipke, Scott Gershan","doi":"10.1080/02791072.2026.2686369","DOIUrl":"https://doi.org/10.1080/02791072.2026.2686369","url":null,"abstract":"Gamma-hydroxybutyrate (GHB) withdrawal is an uncommon but potentially severe syndrome which may not respond to benzodiazepines, with no clear guidelines for treatment escalation. This systematic review examines the evidence of barbiturates as alternative or adjunct therapies in managing GHB withdrawal. PubMed was searched for articles published from 1964-2025 using terms related to GHB, its precursors, withdrawal, and barbiturates. Two independent reviewers screened articles, with a third resolving discrepancies. English-language primary reports involving barbiturate use for GHB withdrawal in humans were included; reviews were excluded. Of 1,398 articles identified, 16 were included, describing 30 cases. Data were analyzed using descriptive statistics and narrative synthesis. Phenobarbital was commonly used (n = 26), with daily doses from 30-1200 mg and cumulative doses from 60-8500 mg. Barbiturates were generally initiated after inadequate response to benzodiazepines, although no consistent thresholds for escalation were identified. Barbiturate use was not associated with complications and in several cases provided rapid symptom resolution. Comparisons and conclusions were limited by incomplete and inconsistent reporting of patient characteristics, interventions, and outcomes; co-administered treatments; and non-standardized dosing across small, heterogenous, retrospective studies (primarily case reports) describing patients with severe withdrawal. Controlled studies are needed to establish evidence-based protocols, including dosing, timing, and safety considerations.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-25"},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substance Use or Alcohol Consumption and HIV-Related Sexual Behaviors Among Sexual Minority Men (SMM) in San Francisco, CA. 加州旧金山性少数男性（SMM）的物质使用或酒精消费与hiv相关的性行为

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-06-16 DOI: 10.1080/02791072.2026.2673839

Ahmad Danesh, Thye Peng Ngo, Glenn-Milo Santos

{"title":"Substance Use or Alcohol Consumption and HIV-Related Sexual Behaviors Among Sexual Minority Men (SMM) in San Francisco, CA.","authors":"Ahmad Danesh, Thye Peng Ngo, Glenn-Milo Santos","doi":"10.1080/02791072.2026.2673839","DOIUrl":"https://doi.org/10.1080/02791072.2026.2673839","url":null,"abstract":"Substance and alcohol use are often used in sexual contexts among sexual minority men (SMM) and may be associated with condomless anal sex (CAS), a proximal exposure relevant to HIV risk. This study examined the association between alcohol and substance use during sex and the frequency of insertive (ICAS) and receptive (RCAS) condomless anal sex. A secondary analysis of cross-sectional data from a respondent-driven sample (RDS) of 252 SMM in San Francisco in 2020 was conducted, and 135 participants who reported at least one CAS event with their last three sexual partners in the past six months were included in the analysis. A zero-truncated negative binomial regression model was used to estimate the rate ratio (ERR) of ICAS and RCAS. Results indicated that being drunk before or during sex was associated with a 2.6-fold increase in the number of ICAS events and a 7.2-fold increase in the number of RCAS events. Methamphetamine showed inverse associations with ICAS (ERR = 0.5) and RCAS (ERR = 0.3), while poppers were positively associated with ICAS (ERR = 2.5) and RCAS (ERR = 3). Overall, alcohol intoxication and popper use in sexual contexts were associated with higher CAS counts among SMM, supporting stigma-free harm-reduction screening and PrEP/STI prevention, while inverse associations with methamphetamine warrant cautious interpretation and event-level study in future work.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-7"},"PeriodicalIF":2.4,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketamine-Assisted Psychotherapy for Depression: A Survey of Current Practices, Rationales, and Future Directions. 氯胺酮辅助抑郁症心理治疗：当前实践、基本原理和未来方向的调查。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-06-10 DOI: 10.1080/02791072.2026.2685515

Jack H Buchanan, Brandon Reynante, Michael T Dinh, Joseph Zamaria

{"title":"Ketamine-Assisted Psychotherapy for Depression: A Survey of Current Practices, Rationales, and Future Directions.","authors":"Jack H Buchanan, Brandon Reynante, Michael T Dinh, Joseph Zamaria","doi":"10.1080/02791072.2026.2685515","DOIUrl":"10.1080/02791072.2026.2685515","url":null,"abstract":"Ketamine-assisted psychotherapy (KAP) is an emerging treatment approach that may enhance ketamine's antidepressant effects through neuroplastic synergism or transformative psychological experience. Despite growing clinical use, real-world KAP practices remain understudied. This cross-sectional survey examined the practices of fifty licensed KAP providers treating depression, recruited from a U.S.-based online provider network. Participants represented a professionally diverse sample, including physicians, clinical psychologists, social workers, and other practitioners. Ketamine was most commonly administered intramuscularly (42%) or sublingually (40%), often at psychedelic-dose ranges. Most practitioners (74%) conducted psychotherapy before, during, and after ketamine administration. The most frequently used psychotherapy modalities were Internal Family Systems (74%), humanistic/existential (62%), and supportive (58%), with most practitioners employing an eclectic approach blending three to four different modalities on average. The most commonly endorsed overall treatment goals were fostering inner healing intelligence, leveraging neuroplastic effects of ketamine, and facilitating a transformative experience. No significant association was found between psychotherapy modalities and treatment goals, revealing unclear logic for how therapeutic approaches are matched to desired outcomes. Findings reveal broad variability in real-world KAP practices, underscoring the need for comparative clinical trials to establish evidence-based standards. These insights may inform the development of protocols for emerging psychedelic-assisted psychotherapies more broadly.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.4,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shifting Patterns in Ecstasy Use: Increasing Detection of MDA in Forensic Seizures and Toxicological Cases in Southern Brazil. 摇头丸使用的转变模式：在巴西南部法医缉获和毒理学案例中增加丙二醛的检测。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-06-10 DOI: 10.1080/02791072.2026.2686365

Bruno Pereira Dos Santos, Vítor Camargo Pôrto, Letícia Birk, Sabrina Nunes do Nascimento, Viviane Cristina Sebben, Sarah Eller, Tiago Franco de Oliveira

{"title":"Shifting Patterns in Ecstasy Use: Increasing Detection of MDA in Forensic Seizures and Toxicological Cases in Southern Brazil.","authors":"Bruno Pereira Dos Santos, Vítor Camargo Pôrto, Letícia Birk, Sabrina Nunes do Nascimento, Viviane Cristina Sebben, Sarah Eller, Tiago Franco de Oliveira","doi":"10.1080/02791072.2026.2686365","DOIUrl":"https://doi.org/10.1080/02791072.2026.2686365","url":null,"abstract":"Ecstasy-type drugs are the most frequently seized synthetic drugs in Brazil, usually containing a mixture of MDMA and its analog MDA. In recent years, an increasing number of samples have been found to contain only MDA, possibly reflecting shifts in the synthetic routes of ecstasy-type substances during the COVID-19 pandemic. However, the exclusive use of MDA remains poorly characterized, and its toxicological profile is still not fully understood. Data from chemical analyses of drug seizures in Rio Grande do Sul, Southern Brazil, were reviewed. In addition, blood and urine samples collected from clinical and forensic cases involving ecstasy use were analyzed by LC-MS/MS. MDA was detected in 31.1% of seized drug samples, surpassing MDMA, which accounted for 25.6%. A marked rise in MDA detections was observed after 2020, peaking at 52.6% of seizures in 2023. In addition, sixteen clinical and four postmortem cases involving MDMA and/or MDA were documented, with MDA predominating from 2021 onwards. The study identified a higher prevalence of MDA compared to MDMA, indicating a shift in ecstasy use patterns in Brazil. This finding underscores the need for robust analytical approaches and sustained toxicological monitoring to support drug surveillance and public health policies.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-7"},"PeriodicalIF":2.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graded Associations of Tranquilizer Use and Misuse with Suicidal Thoughts and Behaviors in a National Sample of U.S. Veterans. 在美国退伍军人的全国样本中，镇定剂的使用和滥用与自杀想法和行为的分级关联。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-06-07 DOI: 10.1080/02791072.2026.2685519

Colin J Jarratt, Victoria E Carlin, Grant H Ripley, Joon Kyung Nam, Kenneth J Marfilius, Joseph W Ditre

{"title":"Graded Associations of Tranquilizer Use and Misuse with Suicidal Thoughts and Behaviors in a National Sample of U.S. Veterans.","authors":"Colin J Jarratt, Victoria E Carlin, Grant H Ripley, Joon Kyung Nam, Kenneth J Marfilius, Joseph W Ditre","doi":"10.1080/02791072.2026.2685519","DOIUrl":"https://doi.org/10.1080/02791072.2026.2685519","url":null,"abstract":"U.S. military veterans face an elevated suicide risk compared to the general population. Both the use and misuse of tranquilizers (i.e. several classes of medications that treat anxiety and muscle spasms via central nervous system action, including benzodiazepines) have been associated with suicidal thoughts and behaviors among veterans. However, it remains unclear whether risk varies across different patterns of tranquilizer use. Participants included 12,584 U.S. military veterans (13.0% female; 78.1% non-Hispanic White; 49.3% age 65 and older), from the 2015-2019 National Survey on Drug Use and Health (NSDUH). Tranquilizer use without misuse was associated with greater odds of suicidal ideation and planning, relative to nonuse (p's < 0.01). Tranquilizer misuse was associated with greater odds of suicide ideation, planning, and attempts compared to nonuse (p's < 0.01). Relative to use without misuse, tranquilizer misuse was associated with greater odds of suicide ideation, planning, and attempts (p's < 0.01). These results support a graded association between tranquilizer use/misuse and suicidal thoughts and behaviors, suggesting that risk for suicide-related outcomes may increase from no use, to use without misuse, to misuse. Future research should explore the clinical utility of addressing tranquilizer use/misuse as part of targeted suicide prevention strategies among veterans.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intention-Setting Among Recreational Psychedelic Users: Associated Acute Effects and Changes in Well-Being. 娱乐性致幻剂使用者的意图设定：相关的急性效应和幸福感的变化。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-05-22 DOI: 10.1080/02791072.2026.2673844

Fiona Low, Mitch Earleywine

{"title":"Intention-Setting Among Recreational Psychedelic Users: Associated Acute Effects and Changes in Well-Being.","authors":"Fiona Low, Mitch Earleywine","doi":"10.1080/02791072.2026.2673844","DOIUrl":"https://doi.org/10.1080/02791072.2026.2673844","url":null,"abstract":"Limited research suggests that distinct intentions covary with acute experiences and subsequent outcomes. Nevertheless, data on the types of intentions set by users remain scarce, and their effects lack clarity. This study uses a retrospective, mixed-methods, cross-sectional approach to investigate intention-setting among psychedelic users. We establish a taxonomy of intentions in naturalistic use and examine how domain-specific intentions correlate with acute effects and changes in well-being. Additionally, we test qualities for effective intention-setting. The most common intentions focus on self-discovery and personal growth, as well as healing and mental health. Participants reported that intention-setting provided direction and cognitive focus, as well as positive emotional anchoring. Intentions related to mental health, self-expansion, and physical health were associated with greater subjective effects, including mystical experiences, emotional breakthroughs, and challenging experiences, as well as improved well-being and reductions in dysfunctional attitudes. In contrast, recreational intentions were unrelated to reductions in dysfunctional attitudes and correlated negatively with changes in well-being. Finally, intentions that were specific, relevant, and integrated after the psychedelic experience correlated with improvements in well-being. Unexpectedly, flexible intentions covaried with worse outcomes. These data suggest that specific, relevant, integrated intentions focused on self-discovery and mental health might offer the most benefits.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Use of Ibogaine in Opioid Recovery: Insights from Lived Experience. 探索伊博格因在阿片类药物康复中的使用：来自生活经验的见解。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-05-22 DOI: 10.1080/02791072.2026.2673843

Jamie Walker, Daryle Deering, Bruno Hamish Unger

{"title":"Exploring the Use of Ibogaine in Opioid Recovery: Insights from Lived Experience.","authors":"Jamie Walker, Daryle Deering, Bruno Hamish Unger","doi":"10.1080/02791072.2026.2673843","DOIUrl":"https://doi.org/10.1080/02791072.2026.2673843","url":null,"abstract":"Opioid dependence is a public health concern in New Zealand, with limited treatment options beyond opioid substitution therapy (OST). Ibogaine, a psychoactive alkaloid with reported anti-withdrawal and anti-craving effects for opioid dependence, is legally available by prescription in New Zealand, offering a context for exploring user experiences. A qualitative collective case study design was used to examine the experiences and motivations of 10 opioid-dependent individuals who used ibogaine for opioid detoxification. Participants were recruited through ibogaine networks, OST services, and snowball sampling. Semi-structured interviews were conducted and analyzed using an inductive thematic analysis approach, informed by an interpretive, experiential framework. Analysis focused on how participants understood their motivations, treatment processes, safety practices, and post-treatment outcomes. Seven themes were identified: \"Desperation to be opioid free,\" \"motivations for using ibogaine,\" \"safety conscious and support seeking,\" \"improving ibogaine practices,\" \"effects of treatment on depression and anxiety,\" \"effects of treatment on dependence,\" and \"the spiritual effect.\" Participants associated ibogaine treatment with rapid detoxification, improved mood, reduced anxiety, and periods of sustained abstinence, though relapse occurred in some cases. Preparation, medical screening, and post-treatment psychosocial support were critical to positive outcomes. This study adds to the literature by documenting experiences of ibogaine use, with implications for clinical practice, policy, and future research.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of the Psychedelic Experience Among Brazilians: A Survey Study. 巴西人迷幻体验的整合：一项调查研究。

IF 2.2 4区医学

Journal of psychoactive drugs Pub Date : 2026-05-19 DOI: 10.1080/02791072.2026.2673842

Ana Cláudia Mesquita Garcia, Lucas Oliveira Maia, Everson Meireles, Jaime Andrés Vinasco Barco, Luís Fernando Tófoli

{"title":"Integration of the Psychedelic Experience Among Brazilians: A Survey Study.","authors":"Ana Cláudia Mesquita Garcia, Lucas Oliveira Maia, Everson Meireles, Jaime Andrés Vinasco Barco, Luís Fernando Tófoli","doi":"10.1080/02791072.2026.2673842","DOIUrl":"https://doi.org/10.1080/02791072.2026.2673842","url":null,"abstract":"This study examines psychedelic integration among Brazilian users by validating a Brazilian Portuguese version of the Psychedelic Integration Scales (PIS), developed through translation and cultural adaptation to ensure relevance and applicability within the Brazilian sociocultural context. A cross-sectional survey was conducted with 1379 participants recruited online. Confirmatory Factor Analysis supported a unidimensional structure for the Brazilian version of the scale (PIS-BR), with satisfactory internal consistency (α = 0.95) and strong evidence of validity based on the relationship with external variables with mystical experience (r = 0.636, p < .01) and positivity (r = 0.352, p < .01). Qualitative analysis of open-ended responses, supported by AI-assisted methods and reviewed by researchers, identified diverse integration strategies, including personal reflection and self-analysis, psychotherapy and professional support, spiritual and meditative practices, connection with nature, social sharing and support networks, personal and relational transformation, and difficulties in integration. This study contributes to understanding psychedelic integration processes in a culturally distinct context. Despite limitations related to sampling and cross-sectional design, the findings provide valuable insights for future research on the conceptualization, measurement, and cultural variability of psychedelic integration beyond the acute effects of these experiences.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Lifetime Hallucinogen Use and Valvular Heart Disease: Findings from the All of Us Research Program. 终身使用致幻剂与瓣膜性心脏病之间的关系：来自我们所有人研究项目的发现。

IF 2.4 4区医学

Journal of psychoactive drugs Pub Date : 2026-05-18 DOI: 10.1080/02791072.2026.2673845

Kevin H Yang, Miranda Rasmussen, Kush Bhatt, Nora Satybaldiyeva, Wayne Kepner, Alison A Moore, Jaclyn Bergstrom

{"title":"Association Between Lifetime Hallucinogen Use and Valvular Heart Disease: Findings from the All of Us Research Program.","authors":"Kevin H Yang, Miranda Rasmussen, Kush Bhatt, Nora Satybaldiyeva, Wayne Kepner, Alison A Moore, Jaclyn Bergstrom","doi":"10.1080/02791072.2026.2673845","DOIUrl":"10.1080/02791072.2026.2673845","url":null,"abstract":"Recent literature suggests potential associations between hallucinogen use and valvular heart disease (VHD) due to prolonged activation of serotonin 5-HT2B receptors, which may lead to valvular fibrosis - a condition also linked to drugs including fenfluramine and pergolide. Despite these concerns, epidemiological studies exploring this association are lacking. This exploratory analysis investigated associations between lifetime hallucinogen use and VHD using cross-sectional data from US adults with linked electronic health record data in the NIH All of Us Research Program who completed the Lifestyle survey. This survey included questions about lifetime hallucinogen use (lysergic acid diethylamide [LSD], mushrooms/psilocybin, 3,4-Methylenedioxymethamphetamine [MDMA]/ecstasy, ketamine, phencyclidine [PCP]). Multivariable logistic regression models examined the association between hallucinogen use and VHD, adjusting for sociodemographic factors and other confounding health conditions. Our sample comprised 286,842 adults (mean age 50.8 [SD 16.7], 61.4% female, 60.6% White). Among them, 13.2% reported lifetime hallucinogen use. Individuals with lifetime hallucinogen use had lower unadjusted VHD prevalence compared to those without lifetime hallucinogen use (3.6% vs. 4.7%, p < .001). However, after adjusting for confounders, models revealed modestly increased VHD odds (aOR = 1.08, 95% CI: 1.01-1.55, p = .017). This exploratory study found that hallucinogen use was associated with modestly increased VHD odds after adjustment, requiring confirmation through longitudinal research.","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0