Journal of psychoactive drugs最新文献

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Delta-8- and Delta-9-THC Use Frequency, Use Motives, and Mental Health Outcomes. δ-8-和δ-9-四氢大麻酚的使用频率、使用动机和心理健康结果。
IF 2.8 4区 医学
Journal of psychoactive drugs Pub Date : 2024-04-01 Epub Date: 2023-04-09 DOI: 10.1080/02791072.2023.2200211
Michael J Pellicane, Madison E Quinn, Christian A L Bean, Madeline E Bartek, Luke F Heggeness, Jeffrey A Ciesla
{"title":"Delta-8- and Delta-9-THC Use Frequency, Use Motives, and Mental Health Outcomes.","authors":"Michael J Pellicane, Madison E Quinn, Christian A L Bean, Madeline E Bartek, Luke F Heggeness, Jeffrey A Ciesla","doi":"10.1080/02791072.2023.2200211","DOIUrl":"10.1080/02791072.2023.2200211","url":null,"abstract":"<p><p>Use of delta-8-THC (\"delta-8\") has proliferated after the passage of the 2018 Farm Bill. Yet, research on the mental health effects of this increasingly popular cannabinoid is scant. The current study sought to examine mental health correlates of delta-8 use frequency and motives, investigate whether delta-8 use motives predict use frequency, and compare use motives and problems between delta-8 and traditional cannabis. Participants consisted of 363 self-reported delta-8 users who completed measures of delta-8 use frequency, motives, and problems that were adapted from comparable measures for cannabis, as well as measures of mental health outcomes. Delta-8 use frequency was unrelated to use problems and other mental health outcomes. Delta-8 use frequency was positively associated with social and coping motives, but negatively associated with enhancement and conformity motives. Coping and conformity motives were associated with greater depression, anxiety, insomnia, and delta-8 use problems. Participants were more likely to report coping and enhancement motives for delta-8 use compared to cannabis use, but less likely to report conformity motives. Further longitudinal research is needed to assess causality for associations between delta-8 use frequency, use motives, and mental health outcomes.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9261712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Policy and Practice Changes Associated with a Tobacco-Free Initiative in Residential Substance Use Disorder Treatment. 与药物使用障碍住院治疗中的无烟倡议相关的政策和实践变化。
IF 2.8 4区 医学
Journal of psychoactive drugs Pub Date : 2024-02-16 DOI: 10.1080/02791072.2024.2316278
Barbara K Campbell, Thao Le, Caravella McCuistian, Catherine Bonniot, Kevin Delucchi, Joseph Guydish
{"title":"Policy and Practice Changes Associated with a Tobacco-Free Initiative in Residential Substance Use Disorder Treatment.","authors":"Barbara K Campbell, Thao Le, Caravella McCuistian, Catherine Bonniot, Kevin Delucchi, Joseph Guydish","doi":"10.1080/02791072.2024.2316278","DOIUrl":"https://doi.org/10.1080/02791072.2024.2316278","url":null,"abstract":"<p><p>A California-sponsored, 18-month, tobacco-free intervention in residential substance use disorder (SUD) programs was associated with increases in tobacco-free grounds and tobacco-related client services. The current study examined whether positive results would be replicated in 11 programs participating subsequently. Program directors (<i>N</i> = 11) completed surveys of tobacco-related policies pre- and post-intervention. Pre- (<i>n</i> = 163) and post-intervention (<i>n</i> = 128) cross-sectional staff surveys examined tobacco-related training, beliefs, practices, smoking policy, and smoking status. Directors reported increases in tobacco-free grounds (from 3 to 8 programs), tobacco-related staff training (1 to 10 programs), tobacco cessation staff services (1 to 9 programs) and nicotine replacement therapy (NRT) provision (6 to 10 programs). At post-intervention, staff were more likely to report smoke-free workplaces (<i>p</i> = 0.008), positive beliefs about treating tobacco use (<i>p</i> = 0.017) and less likely to report current smoking (<i>p</i> = 0.003). Clinical staff were more likely to report tobacco-related training receipt (<i>p</i> = 0.001), program-level NRT provision (<i>p</i> = 0.009) and conducting tobacco-related client services (<i>p</i> < 0.0001) post-intervention. Findings of increases in tobacco-free grounds and tobacco cessation client services corroborated prior results. These and the additional finding of decreases in staff smoking strengthen evidence that initiatives supporting tobacco-free policies can be successfully implemented in SUD treatment.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139741301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Qualitative Inquiry into the Challenges in Overcoming Heroin Addiction Among Chinese Individuals Who Experience Voluntary Rehabilitation. 对自愿戒毒的中国人在克服海洛因毒瘾过程中所面临挑战的定性调查。
IF 2.8 4区 医学
Journal of psychoactive drugs Pub Date : 2024-02-13 DOI: 10.1080/02791072.2024.2315316
Liu Liu, Zhenni Tang, Xuemeng Li, Wing Hong Chui
{"title":"A Qualitative Inquiry into the Challenges in Overcoming Heroin Addiction Among Chinese Individuals Who Experience Voluntary Rehabilitation.","authors":"Liu Liu, Zhenni Tang, Xuemeng Li, Wing Hong Chui","doi":"10.1080/02791072.2024.2315316","DOIUrl":"https://doi.org/10.1080/02791072.2024.2315316","url":null,"abstract":"<p><p>This study explores the intentions and experiences of individuals seeking abstinence from heroin use through voluntary rehabilitation, as well as challenges to achieving a positive outcome. This study used semi-structured interviews with 37 individuals (22 female) who used heroin and utilized rational choice theory to guide data analysis. This study found that participants tried both medical and non-medical treatment methods but faced structural and personal barriers that hindered their efforts. While ceasing heroin use would presumably benefit their health and family relationships, individuals perceived the physical, psychological, and social costs of abstinence as outweighing the potential benefits and ultimately resumed heroin use. More targeted voluntary rehabilitation programs addressing specific structural and personal barriers are therefore recommended to benefit Chinese people seeking abstinence from drug use.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Predicts Beneficial Outcomes in Psychedelic Use? A Quantitative Content Analysis of Psychedelic Health Outcomes. 什么能预测使用迷幻剂的有益结果?对迷幻剂健康结果的定量内容分析。
IF 2.8 4区 医学
Journal of psychoactive drugs Pub Date : 2024-02-10 DOI: 10.1080/02791072.2024.2314729
Elias C Acevedo, Scott Uhler, Kaitlyn P White, Laith Al-Shawaf
{"title":"What Predicts Beneficial Outcomes in Psychedelic Use? A Quantitative Content Analysis of Psychedelic Health Outcomes.","authors":"Elias C Acevedo, Scott Uhler, Kaitlyn P White, Laith Al-Shawaf","doi":"10.1080/02791072.2024.2314729","DOIUrl":"https://doi.org/10.1080/02791072.2024.2314729","url":null,"abstract":"<p><p>Interest in psychedelics and their possible therapeutic potential has been growing. <i>Metaphysical belief theory</i> asserts that these benefits stem from the adoption of comforting supernatural beliefs following a mystical experience. By contrast, <i>predictive self-binding theory</i> suggests that the beneficial outcomes of psychedelics are primarily driven by psychological insights. The present study tests these competing models of psychedelic benefits. We conducted a quantitative content analysis on unsolicited self-reports of psychedelic users available on Erowid.org, to examine the potential relations between psychological insight, ego dissolution, therapeutic intent, altered metaphysical belief, and enduring health outcomes. We randomly selected, coded, and analyzed two hundred forty psychedelic experience reports from the website. Path analysis using structural equation modeling showed that psychological insight, not metaphysical beliefs, uniquely predicted beneficial outcomes. Moreover, beneficial outcomes' positive relation to ego dissolution and therapeutic intent was fully mediated by psychological insight. These findings support the predictive self-binding model over the metaphysical belief model.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychedelic Microdosing among Young Adults from Southern California. 南加州青少年中的迷幻药吸食情况。
IF 2.1 4区 医学
Journal of psychoactive drugs Pub Date : 2024-02-10 DOI: 10.1080/02791072.2024.2313684
Alyssa F Harlow, Peter S Hendricks, Adam M Leventhal, Jessica L Barrington-Trimis
{"title":"Psychedelic Microdosing among Young Adults from Southern California.","authors":"Alyssa F Harlow, Peter S Hendricks, Adam M Leventhal, Jessica L Barrington-Trimis","doi":"10.1080/02791072.2024.2313684","DOIUrl":"10.1080/02791072.2024.2313684","url":null,"abstract":"<p><p>Despite common depictions in the media, there is little scientific evidence on microdosing psychedelic drugs. We assessed awareness, prevalence, and dosing practices of microdosing psychedelic drugs among young adults 18-22 years old from Southern California (2018-2019). We examined whether sociodemographic factors, personality traits, mental health, or other substance use behaviors were correlated with having ever microdosed. Among 2,396 participants, 293 (12%) had heard of microdosing and 74 (3%) ever microdosed. Among those who had heard of microdosing, 79% correctly defined microdosing as taking an amount of a psychedelic much lower than a standard dose, whereas 15% misperceived microdosing as a standard psychedelic dose. Psilocybin was the most common drug ever microdosed (70%), followed by lysergic acid diethylamide (LSD, 57%). Among those who ever microdosed, ~18% reported using psychoactive doses far higher than would be generally considered a microdose. White race, male/masculine gender identity, bisexual identity, past 6-month other drug use, greater attention deficit/hyperactivity disorder symptoms, mindfulness, and sensation-seeking were positively associated with having ever microdosed in multivariable models. Young adult microdosing merits further attention from scientific and public health professionals to help prevent misperceptions and potential adverse consequences as well as explore its potential therapeutic applications.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct-To-Definitive Urine and Oral Fluid Test Results for Unscreened and Rarely Screened Drugs in Individuals Applying for Methadone Treatment in 7 U.S. States. 美国 7 个州申请美沙酮治疗者尿液和口腔液中未筛查和罕见筛查药物的直接定量检测结果。
IF 2.1 4区 医学
Journal of psychoactive drugs Pub Date : 2024-02-08 DOI: 10.1080/02791072.2024.2314220
Miranda J Lee-Easton, Stephen Magura, Ruqayyah Abu-Obaid, Pete Reed, Brandi Allgaier, Emily Fish, Abigail Maletta, Piyadarsha Amaratunga, Bridget Lorenz-Lemberg, Matthew Levitas, EricD Achtyes
{"title":"Direct-To-Definitive Urine and Oral Fluid Test Results for Unscreened and Rarely Screened Drugs in Individuals Applying for Methadone Treatment in 7 U.S. States.","authors":"Miranda J Lee-Easton, Stephen Magura, Ruqayyah Abu-Obaid, Pete Reed, Brandi Allgaier, Emily Fish, Abigail Maletta, Piyadarsha Amaratunga, Bridget Lorenz-Lemberg, Matthew Levitas, EricD Achtyes","doi":"10.1080/02791072.2024.2314220","DOIUrl":"10.1080/02791072.2024.2314220","url":null,"abstract":"<p><p>The standard protocol in addiction treatment/pain management is to conduct immunoassay screens for major drugs subject to misuse, followed by confirmatory testing of positive results. However, this may miss unscreened or rarely screened drugs that could pose risks, especially to polydrug users. We sought to determine the prevalences of unscreened/rarely screened drugs in a sample of individuals misusing drugs in 7 U.S. states, and to compare the results of urine vs. oral testing for these drugs by direct-to-definitive liquid chromatography/tandem mass spectrometry (LC-MS-MS). The five drugs with the highest prevalences were: gabapentin (16.8%), quetiapine (6.2%), chlorpheniramine (5.3%), hydroxyzine (4.9%), and ephedrine (3.5%). All have clinical significance as indicated by severity of possible side effects, interactions with other drugs, and/or misuse potential. Drugs were generally detected more frequently in oral fluid than urine, but gabapentin was more frequently detected in urine. The prevalences of the included drugs seem high enough, and their clinical significance important enough, to warrant consideration of expanding clinical drug test panels, either by direct-to-definitive testing or the addition of selected immunoassay screens when available. Oral fluid was usually more suitable than urine as the test matrix, given the higher rates of detection in oral fluid for most substances included in this study.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Ayahuasca on Gratitude and Relationships with Nature: A Prospective, Naturalistic Study. 死藤水对感恩以及与自然关系的影响:前瞻性自然研究
IF 2.8 4区 医学
Journal of psychoactive drugs Pub Date : 2024-02-04 DOI: 10.1080/02791072.2024.2312980
Jacob S Aday, Emily K Bloesch, Alan K Davis, Sarah E Domoff, Kyle Scherr, Josh D Woolley, Christopher C Davoli
{"title":"Effects of Ayahuasca on Gratitude and Relationships with Nature: A Prospective, Naturalistic Study.","authors":"Jacob S Aday, Emily K Bloesch, Alan K Davis, Sarah E Domoff, Kyle Scherr, Josh D Woolley, Christopher C Davoli","doi":"10.1080/02791072.2024.2312980","DOIUrl":"https://doi.org/10.1080/02791072.2024.2312980","url":null,"abstract":"<p><p>Qualitative studies and anecdotal reports suggest that experiences with ayahuasca, a psychedelic brew found in Central and South America, may be followed by individuals enduringly feeling more grateful and connected to nature. Yet, to date, these changes have been understudied. Here, participants (<i>N</i> = 54) completed validated surveys related to gratitude, nature relatedness, and nature appreciation one-week before, one-week after, and one-month after attending an ayahuasca retreat center. Compared to baseline, there was a significant increase in gratitude, nature relatedness, and nature appreciation at the one-week and one-month follow-ups. Ratings of mystical-type experiences and awe, but not ego dissolution, during participants' ayahuasca sessions were weakly-to-moderately correlated with these increases. The number of ayahuasca ceremonies attended at the retreat was not related to change in outcomes, underscoring the importance of the quality rather than the quantity of the experiences in post-acute change. Lastly, participant age was negatively related to the occurrence of mystical-type experiences and awe, supporting literature indicating blunted psychedelic effects with increased age. In the context of study limitations, the results suggest that mystical-type experiences and awe occasioned by ayahuasca may be linked to prosocial changes in gratitude and relationships with nature that may be beneficial to mental health.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sweating for Sobriety: Exploring the Relationship Between Exercise Engagement and Substance Use Disorders. 为清醒而流汗:探索参与运动与药物使用障碍之间的关系。
IF 2.8 4区 医学
Journal of psychoactive drugs Pub Date : 2024-02-01 DOI: 10.1080/02791072.2024.2311143
Baldur Jón Gústafsson, Cheneal Puljević, Emma L Davies, Monica J Barratt, Jason Ferris, Adam Winstock, Timothy Piatkowski
{"title":"Sweating for Sobriety: Exploring the Relationship Between Exercise Engagement and Substance Use Disorders.","authors":"Baldur Jón Gústafsson, Cheneal Puljević, Emma L Davies, Monica J Barratt, Jason Ferris, Adam Winstock, Timothy Piatkowski","doi":"10.1080/02791072.2024.2311143","DOIUrl":"https://doi.org/10.1080/02791072.2024.2311143","url":null,"abstract":"<p><p>Despite various interventions available for substance use disorders, relapse rates remain substantial and, therefore, alternative strategies for attenuating dependence are needed. This study examined the associations between exercise frequency, illicit substance use, and dependence severity among a large sample of people who use drugs. The study utilized data from the Global Drug Survey 2018 (<i>N</i> = 57,110) to investigate the relationship between exercise frequency, illicit substance use, and substance dependence severity. Binomial regressions were employed to examine the relationship between exercise and SDS scores for 9 drugs. Greater exercise frequency correlated with reduced severity of substance dependence for specific drugs: cannabis (χ2 = 14.75, <i>p</i> < .001), MDMA (χ2 = 4.73, <i>p</i> = .029), cocaine (χ2 = 8.37, <i>p</i> = .015), amphetamine powder (χ2 = 6.39, <i>p</i> = .041), and methamphetamine (χ2 = 15.17, <i>p</i> < .001). These findings suggest a potential link between exercise and reduced substance use dependency. Further research is needed to understand the complex dynamics between exercise and substance use, considering potential bidirectional relationships and concurrent factors.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep-Related Cannabis Expectancy Questionnaire (SR-CEQ): Factor Analysis Replication, Internal Reliability, and Construct Validity. 与睡眠有关的大麻预期问卷(SR-CEQ):因子分析复制、内部信度和结构效度。
IF 2.8 4区 医学
Journal of psychoactive drugs Pub Date : 2024-01-30 DOI: 10.1080/02791072.2024.2308803
Patricia A Goodhines, Krutika Rathod, Aubriana A Schwarz, Lisa R LaRowe, Amelia V Wedel
{"title":"Sleep-Related Cannabis Expectancy Questionnaire (SR-CEQ): Factor Analysis Replication, Internal Reliability, and Construct Validity.","authors":"Patricia A Goodhines, Krutika Rathod, Aubriana A Schwarz, Lisa R LaRowe, Amelia V Wedel","doi":"10.1080/02791072.2024.2308803","DOIUrl":"https://doi.org/10.1080/02791072.2024.2308803","url":null,"abstract":"<p><p>Expectancies regarding the sleep-promoting effects of cannabis may exacerbate the propensity to self-medicate sleep problems with cannabis. Given the potential clinical importance of expectancies for the sedative effects of cannabis, Goodhines et al (2020) developed the Sleep-Related Cannabis Expectancies Questionnaire (SR-CEQ). However, concurrent validity of this instrument has not been evaluated. This study aimed to replicate the two-factor structure and internal reliability and explore incremental construct validity of the SR-CEQ. Cross-sectional online survey data were collected from 287 college students (<i>M</i><sub>age</sub> = 19.07 ± 1.44 years, range 18-25; 47% male; 84% non-Hispanic White; 61% lifetime cannabis use). Confirmatory factor analysis replicated an adequate fit of the two-factor model (SRMR = 0.08) with excellent internal consistency within positive (α = .94) and negative (α = .91) subscales. Novel correlates were observed for positive (greater mood, sleep, cannabis risk; <i>r</i>s = .16-.48, <i>p</i>s = .001-.03) and negative (lesser cannabis risk; <i>r</i>s = -.18-.61, <i>p</i>s = .001-.03) subscales. Positive expectancies were greater among students with insomnia (<i>t</i>[285] = 2.70, <i>p</i> < .01; <i>d</i> = .33) and hazardous cannabis use (<i>t</i>[284] = 6.63, <i>p</i> < .001; <i>d</i> = 0.91). No group differences were observed by sex or for negative sleep-related cannabis expectances. This study extends psychometric validation of the SR-CEQ and highlights positive expectancies as a potential risk factor for insomnia and hazardous cannabis use.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurocognitive Dysfunctions in People with Concurrent Cannabis Use and Opioid Dependence: A Cross-Sectional, Controlled Study. 同时吸食大麻和阿片类药物依赖者的神经认知功能障碍:一项横断面对照研究。
IF 2.8 4区 医学
Journal of psychoactive drugs Pub Date : 2024-01-22 DOI: 10.1080/02791072.2024.2308213
Abhishek Ghosh, Alka Shaktan, Abhishek Verma, Debasish Basu, Devender K Rana, Ritu Nehra, Chirag K Ahuja, Manish Modi, Paramjit Singh
{"title":"Neurocognitive Dysfunctions in People with Concurrent Cannabis Use and Opioid Dependence: A Cross-Sectional, Controlled Study.","authors":"Abhishek Ghosh, Alka Shaktan, Abhishek Verma, Debasish Basu, Devender K Rana, Ritu Nehra, Chirag K Ahuja, Manish Modi, Paramjit Singh","doi":"10.1080/02791072.2024.2308213","DOIUrl":"https://doi.org/10.1080/02791072.2024.2308213","url":null,"abstract":"<p><p>Cannabis and opioid co-dependence is independently associated with cognitive impairments. We examined neurocognitive dysfunctions in people with concurrent opioid dependence with cannabis dependence (OD+CD) or cannabis use (OD+CU) compared to those with only opioid dependence (OD) and healthy controls (HC). We selected adult participants, any sex, who met the diagnosis of OD (<i>N</i> = 268), OD+CU (<i>N</i> = 58), and OD + CD (<i>N</i> = 115). We recruited 68 education-matched HC. We administeredStandard progressive matrices (SPM), Wisconsin card sorting test (WCST), Iowa gambling task (IGT), Trail making tests A and B (TMT), and verbal and visual working memory 1-, 2-backtests. 496 (97.5%) were men, and 13 (2.5%) were women. In WCST, OD and OD+CD had significantly higher non-perseverative errors than HC. OD+CD group completed significantly lesser categories than HC. In verbal working memory 2-back, HC scored significantly fewer errors than OD and OD +CD. All patient groups, OD, OD+CU, and OD+CD, scored higher commission errors than HC in visual working memory 1-back. OD and OD+CD scored higher commission and total errors than the controls. OD+CU showed lesser error score than HC in TMT B. Cannabis and opioid co-dependence contribute to cognitive impairments, especially in working memory and executive functions.</p>","PeriodicalId":16902,"journal":{"name":"Journal of psychoactive drugs","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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