Journal of Pharmacy Research最新文献_第7页

Synthesis of novel indole based scaffolds holding pyrazole ring as anti-inflammatory and antioxidant agents 新型吡唑环吲哚基抗炎抗氧化支架的合成

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-07-20 DOI: 10.1016/j.jopr.2013.07.002

Vishwanath Sharath , Honnaiah Vijay Kumar , Nagaraja Naik

{"title":"Synthesis of novel indole based scaffolds holding pyrazole ring as anti-inflammatory and antioxidant agents","authors":"Vishwanath Sharath , Honnaiah Vijay Kumar , Nagaraja Naik","doi":"10.1016/j.jopr.2013.07.002","DOIUrl":"10.1016/j.jopr.2013.07.002","url":null,"abstract":"<div><h3>Aim</h3><p>To synthesize substituted indole based scaffolds having pyrazole ring and evaluate for their anti-inflammatory activity and antioxidant.</p></div><div><h3>Method</h3><p>The structures of newly synthesized compounds were elucidated by spectroscopic methods such as IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass, <sup>1</sup>H NMR spectra and elemental analysis. Antioxidant assays like 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2-azino <em>bis</em> (3-ethylbenzothiazoline-6-sulfonic acid) (<span><math><mrow><msup><mrow><mtext>ABTS</mtext></mrow><mrow><mtext><mglyph></mglyph></mtext><mo>+</mo></mrow></msup></mrow></math></span>) radical ion decolorization assay and lipid peroxidation activity (LPO) were performed. Anti-inflammatory activity was studied using linoleic acid as substrate and lipoxidase enzyme.</p></div><div><h3>Results</h3><p>Among the synthesized analogues compound <strong>7d</strong> revealed broad-spectrum of antioxidant activity and on the other hand compound <strong>7c</strong> exhibits a promising anti-inflammatory activity.</p></div><div><h3>Conclusion</h3><p>The achieved results prove that the distinctive compounds could serve as promising lead candidates and also for acclimatization and investigation to construct more active analogues.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 7","pages":"Pages 785-790"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77493974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Identification and characterization of foodborne pathogen Listeria monocytogenes strain Pyde1 and Pyde2 using 16S rRNA gene sequencing 食源性致病菌单核增生李斯特菌Pyde1和Pyde2的16S rRNA基因测序及鉴定

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-07-27 DOI: 10.1016/j.jopr.2013.07.009

Acharya Nagarjun Pyde , P. Nagaraja Rao , Aditya Jain , Divya Soni , Shailesh Saket , Sheaza Ahmed , Sugunakar Vuree , Anuraj Nayarisseri

{"title":"Identification and characterization of foodborne pathogen Listeria monocytogenes strain Pyde1 and Pyde2 using 16S rRNA gene sequencing","authors":"Acharya Nagarjun Pyde , P. Nagaraja Rao , Aditya Jain , Divya Soni , Shailesh Saket , Sheaza Ahmed , Sugunakar Vuree , Anuraj Nayarisseri","doi":"10.1016/j.jopr.2013.07.009","DOIUrl":"10.1016/j.jopr.2013.07.009","url":null,"abstract":"<div><h3>Aim</h3><p><em>Listeria monocytogenes</em> acts as a pathogen for humans and animals, mainly causing, neonatal sepsis, abortions in pregnant females and severe infections such as septicemia and meningoencephalitis in susceptible hosts. Current study was aimed to identify novel strains of <em>L. monocytogenes</em> from retail chicken, beef meat and seafood samples.</p></div><div><h3>Methods</h3><p>In order to identify the strain, extraction and amplification of genomic DNA, 16S rRNA sequence analysis was carried out. Phylogenetic trees were constructed using dnapars and dnaml available in Phylip. The secondary structures of 16S rRNA gene sequence were predicted using UNAFOLD, a Linux based software.</p></div><div><h3>Results</h3><p>The results obtained were found to be a novel foodborne pathogens, which was further named <em>L. monocytogenes</em> strain <em>Pyde1</em> and <em>L. monocytogenes</em> strain <em>Pyde2</em>, after characterization the sequence of isolate was deposited in GenBank with accession numbers ‘KC852899’ and ‘KC852900’ respectively. The Gibb's free energy of the secondary structures of <em>L. monocytogenes</em> strain <em>Pyde1</em> and <em>Pyde2</em> were −275.60 and −282.20 kcal/mol seems to be more stable in the present investigation.</p></div><div><h3>Conclusion</h3><p>The described results of phylogenetic distinctiveness and phenotypic disparities indicate that strain 2b represents a novel strain of foodborne pathogens within <em>L. monocytogenes</em> species, for which the name <em>L. monocytogenes</em> strain <em>Pyde1</em> and <em>L. monocytogenes</em> strain <em>Pyde2</em> is proposed.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 7","pages":"Pages 736-741"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88070963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Reverse vaccinology: An approach to search vaccine leads of Shigella sonnei 反向疫苗学:寻找索内志贺氏菌疫苗线索的一种方法

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-08-22 DOI: 10.1016/j.jopr.2013.07.030

Yatharth Anand , Sunil Pande , Dilip Gore

引用次数: 4

Pharmacogenomics of drug resistance in Breast Cancer Resistance Protein (BCRP) and its mutated variants 乳腺癌耐药蛋白(BCRP)及其突变体耐药的药物基因组学研究

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-07-29 DOI: 10.1016/j.jopr.2013.06.020

Sugunakar Vuree , Nageswara Rao Dunna , Imran Ali Khan , Khalid K. Alharbi , Satti Vishnupriya , Divya Soni , Pratik Shah , Harshpreet Chandok , Mukesh Yadav , Anuraj Nayarisseri

{"title":"Pharmacogenomics of drug resistance in Breast Cancer Resistance Protein (BCRP) and its mutated variants","authors":"Sugunakar Vuree , Nageswara Rao Dunna , Imran Ali Khan , Khalid K. Alharbi , Satti Vishnupriya , Divya Soni , Pratik Shah , Harshpreet Chandok , Mukesh Yadav , Anuraj Nayarisseri","doi":"10.1016/j.jopr.2013.06.020","DOIUrl":"10.1016/j.jopr.2013.06.020","url":null,"abstract":"<div><h3>Aim</h3><p>Drugs in breast cancer treatment suffer resistance and drug efflux from ATP-binding cassette (ABC) efflux transporter protein. Drugs inhibiting BCRP suffer activity alteration due to sequence variants. It is imperative to investigate role of mutant variants using structure based aspects of drug binding.</p></div><div><h3>Method</h3><p>In present work, we included single nucleotide polymorphisms like F208S, S248P and F431L in BCRP structure and evaluated their role in alteration of drug binding affinities using computational approaches. Comparative modeling of BCRP 3D structure was achieved using various tools available followed by structure validation. Mutagenesis and its impact by SNPs was attained in 3D structure of BCRP. A set of selected and established BCRP inhibitors were further docked into binding site to record the drug resistance in mutant variants.</p></div><div><h3>Results</h3><p>Nucleotide binding (NB) domain (258 AA) and transmembrane (TM) domain (291 AA) of BCRP were modeled separately and assembled together to generate a single structure. Ramachandran Plot confirmed quality of modeled structures along with main chain and side chain parameters. Mutagenesis included three main variants (F208S, S248P and F431L) using Triton program. Molecular docking results showed inhibitor CID_25223199 binding effectively to wild and F431L mutant structure of BCRP while inhibitors CID_25223002 to F208S and CID_119373 to S248P.</p></div><div><h3>Conclusion</h3><p>Distortion in spatial arrangement of amino acids in BCRP protein due to mutations led to low efficacy in drug response with respect to wild isoform. Results of present work demand to probe pharmacogenomic aspects in drug development efforts for breast cancer.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 7","pages":"Pages 791-798"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.06.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76188395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Synthesis and pharmacological evaluation of some new dibenzo [b, f] [1, 4]thiazepines 几种新型二苯并[b, f][1,4]噻唑类药物的合成及药理评价

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-07-27 DOI: 10.1016/j.jopr.2013.07.011

Sarita Pawar , Akhilesh Roy , Sanjay Wagh

{"title":"Synthesis and pharmacological evaluation of some new dibenzo [b, f] [1, 4]thiazepines","authors":"Sarita Pawar , Akhilesh Roy , Sanjay Wagh","doi":"10.1016/j.jopr.2013.07.011","DOIUrl":"10.1016/j.jopr.2013.07.011","url":null,"abstract":"<div><h3>Aim</h3><p>In the present study ten dibenzothiazepines with a methylene bridge between tricyclic nucleus and the substituent at C-11 were synthesized in order to investigate their antipsychotic activity. Some of the derivatives showed significant activity.</p></div><div><h3>Methods</h3><p>The title compounds were synthesized by condensation of 11-piperazinyl-dibenzothiazepine with the substituted benzyl halides in presence of triethylamine and 1,4-dioxane. The structures of the derivatives were elucidated by spectral analysis. The antipsychotic activity of the synthesized derivatives was evaluated using haloperidol induced catalepsy and lithium induced head twitches.</p></div><div><h3>Results</h3><p>In SSP-9 treated group, maximum catalepsy was noted 30 min after haloperidol. Lithium induced 40.2 ± 1.655 head twitches in 1 h. Clozapine (5 mg per kg) and SSP-9 (5 mg per kg) reduced the number of head twitches to 10 ± 0.7071 and 14.8 ± 0.8602, respectively.</p></div><div><h3>Conclusion</h3><p>The results demonstrated that the derivative SSP-9 possesses significant in vitro antipsychotic activity when compared with standard clozapine. Therefore, compound SSP-9 prototype could be considered as novel antipsychotic agent for further developing new atypical antipsychotics.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 7","pages":"Pages 756-760"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87720282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cytotoxic and antioxidant activities of marine sponge diversity at Pecaron Bay Pasir Putih Situbondo East Java, Indonesia 东爪哇Pecaron湾Pasir Putih sitbondo海域海绵多样性的细胞毒性和抗氧化活性

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-07-23 DOI: 10.1016/j.jopr.2013.07.001

Syamsudin Abdillah , Awik Puji Dyah Nurhayati , Sri Nurhatika , Edwin Setiawan , Wan Lelly Heffen

{"title":"Cytotoxic and antioxidant activities of marine sponge diversity at Pecaron Bay Pasir Putih Situbondo East Java, Indonesia","authors":"Syamsudin Abdillah , Awik Puji Dyah Nurhayati , Sri Nurhatika , Edwin Setiawan , Wan Lelly Heffen","doi":"10.1016/j.jopr.2013.07.001","DOIUrl":"10.1016/j.jopr.2013.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>A study on the cytotoxic and antioxidant activities of Sponges collected from Pecaron Bay Pasir Putih Situbondo was conducted. This study aimed at screening the hydro-ethanolic extracts of 7 sponge species: <em>Callyspongia</em> sp, <em>Acanthella</em> sp and <em>Xestospongia</em> sp colleted at the Pecaron Situbondo, East Java, Indonesia for antiproliferative and antioxidant activities.</p></div><div><h3>Methods</h3><p>After collection, the species were immediately immersed in ethanol and stored at low temperatures (−20 °C) until use. Cytotoxic assay was conducted using MTT methods for some cancerous cells, including T47D, Casky and HT-29 meanwhile antioxidant assay was conducted using DPPH method.</p></div><div><h3>Results</h3><p>the extracts from species <em>A. suberitoides</em> has the highest toxicity compare to another species which valued level on tumor cell lines (HT-29, T47D and Casky). Antioxidant assay using DPPH method found that only <em>Aaptos suberitoides</em> that had been identified to show strong activity due to IC<sub>50</sub> value of <30 μg/mL; meanwhile <em>Fascaplysinopsis reticulata</em>, <em>Acanthella</em> sp, <em>Petrosia contignata</em> and <em>Xestospongia exigua</em> showed moderate antioxidant activity with a IC<sub>50</sub> < 100 μg/mL. <em>Xestospongia</em> sp<em>, Callyspongia</em> sp showed a value of IC<sub>50</sub> > 100 μg/mL.</p></div><div><h3>Conclusion</h3><p>The study showed that <em>Xestospongia</em> sp<em>, Fascaplysinopsis reticulata, Callyspongia</em> sp, <em>Petrosia contignata</em>, <em>Aaptos suberitoides</em> were highly potential to develop for isolation of bioactive compounds as anticancer and antioxidant agents.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 7","pages":"Pages 685-689"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74629095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Acute oral toxicity studies of the standardized methanolic extract of Phyllanthus amarus Schum & Thonn 毛茛标准化甲醇提取物的急性口服毒性研究

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-07-29 DOI: 10.1016/j.jopr.2013.04.020

S.K. Kushwaha , A. Dashora , N. Dashora , J.R. Patel , M.L. Kori

{"title":"Acute oral toxicity studies of the standardized methanolic extract of Phyllanthus amarus Schum & Thonn","authors":"S.K. Kushwaha , A. Dashora , N. Dashora , J.R. Patel , M.L. Kori","doi":"10.1016/j.jopr.2013.04.020","DOIUrl":"10.1016/j.jopr.2013.04.020","url":null,"abstract":"<div><h3>Objectives</h3><p>To determine the acute toxicity of standardized methanolic extract of <em>Phyllanthus amarus in vivo</em> in female albino rats.</p></div><div><h3>Methods</h3><p>Treated group of animals were administrated 300, 600, 2000 and 5000 mg/kg body weight of extract orally and the control group received standard laboratory diet and water <em>ad libitum</em> following OECD guideline 423 with some modifications. All animals were sacrificed after 14 days of treatment.</p></div><div><h3>Results</h3><p>The extract was standardized by HPLC to contain phyllanthin and hypophyllanthin. No mortality was noted and the study exhibited no significant changes in general behavior, body weight, gross appearance of internal organs, hematological and biochemical parameters and the histological profile of liver also indicated the nontoxic nature of this drug. Biochemical studies showed no significant change in the levels of ALT, AST, albumin, triglycerides, cholesterol and albumin. There were no evidence found about congestion of sinusoids, hemorrhage, hepatocytes, fatty changes, centrilobular necrosis and the changes in number of Kupffer cells in the liver. There was no increase of blood pressure and does not induce any nephrotoxicity and acute severe hepatotoxicity.</p></div><div><h3>Conclusion</h3><p>The present study provides pivotal evidences for ascertaining the safety of the standardized MEPA (LD<sub>50</sub> > 5000 mg/kg) that could be used as tonic or food supplement in folklore medicine.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 7","pages":"Pages 720-724"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.04.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86615106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Antinociceptive activity of the ethanolic extract of Persicaria acuminata Sach. 荆芥醇提物的抗伤活性研究。

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-07-25 DOI: 10.1016/j.jopr.2013.07.005

Md. Saifuzzaman , Md. Sarowar Jahan Shamim , Kamanashis Mahaldar , Eunus Sheemul Ali , Md. Amirul Islam

引用次数: 2

Molecular modelling studies of Histone Deacetylase inhibitors as anticancer agents 组蛋白去乙酰化酶抑制剂抗癌作用的分子模拟研究

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-08-19 DOI: 10.1016/j.jopr.2013.07.017

Sibi Narayanan , D. Velmurugan

{"title":"Molecular modelling studies of Histone Deacetylase inhibitors as anticancer agents","authors":"Sibi Narayanan , D. Velmurugan","doi":"10.1016/j.jopr.2013.07.017","DOIUrl":"10.1016/j.jopr.2013.07.017","url":null,"abstract":"<div><h3>Background</h3><p>Cancer causes death to over 7.6 million people every year. The disease can be classified as cells' uncontrolled division. This uncontrolled division of cells or uncontrolled growth is caused by DNA damage. This eventually results in genes mutations, which encodes cell division controlling proteins. Histone deacetylase (HDAC) is one among the principal targets for the anticancer drugs.</p></div><div><h3>Methods</h3><p>Molecular docking studies of nearly 60 Trichostatin A, SuberoylAnilide Hydroxamic Acid and Sulfonamide anilides which show good inhibitory activity against HDAC were carried out using GLIDE program of Schrödinger Suite 2009. Comparison of docking scores of the compounds with their respective QSAR IC<sub>50</sub> have also been made.</p></div><div><h3>Results</h3><p>From Trichostatin A and SuberoylAnilide Hydroxamic Acid analogues binding results, it was found that HDAC conformational changes are based on the ligand binding. C/N/O atoms present in the aliphatic chains of the analogues interacted well with the Zn<sup>2+</sup> metal ion and active site amino acid residues to disrupt the enzymatic activity of target protein HDAC.</p></div><div><h3>Conclusion</h3><p>Analogue inhibition taken into study with the target protein HDAC assures to be an advantageous therapeutic approach in cancer treatment.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"7 7","pages":"Pages 611-620"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85186120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpretation of consumer's perception on readability of Consumer Medical Information Leaflets on obesity and lipid lowering drugs with standard methods 用标准方法解读消费者对减肥药降脂药《消费者医疗信息手册》可读性的认知

Journal of Pharmacy Research Pub Date : 2013-07-01 Epub Date: 2013-08-19 DOI: 10.1016/j.jopr.2013.07.024

Elizabeth M. Mathew , Kingston Rajiah , Krishana Kumar Sharma

{"title":"Interpretation of consumer's perception on readability of Consumer Medical Information Leaflets on obesity and lipid lowering drugs with standard methods","authors":"Elizabeth M. Mathew , Kingston Rajiah , Krishana Kumar Sharma","doi":"10.1016/j.jopr.2013.07.024","DOIUrl":"10.1016/j.jopr.2013.07.024","url":null,"abstract":"<div><h3>Aim</h3><p>Printed education materials are often used to augment healthcare professional's verbal information to consumers so it serves as an important component of symptom management. They also enhance the teaching process and can be used by consumers as a home reference. This study was aimed to interpret consumers' perception on Consumer Medical Information Leaflets (CMILs) on obesity and lipid lowering drugs, according to the standard formulae such as Flesch Reading Ease (FRE), Flesch–Kincaid Grade Level (FK-GL).</p></div><div><h3>Method</h3><p>The study was conducted over a period of 3 years in community pharmacy settings in Tamil Nadu, India. CMILs were interpreted by using the formulae such as Flesch Reading Ease (FRE) and Flesch–Kincaid Grade Level (FK-GL). Among the 1800 consumers, 300 consumers were excluded from the study due to lack of interest.</p></div><div><h3>Results</h3><p>Data revealed the consumer's perception on readability of Consumer Medical Information Leaflets on obesity and lipid lowering drugs based consumers rating.</p></div><div><h3>Conclusions</h3><p>Pharmaceutical companies (leaflets providers) are not taking the reading level of consumers into consideration which may not achieve the intended purpose. There is a need for developing CMILs having good readability score according to Indian set up.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"7 7","pages":"Pages 606-610"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85153942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4