{"title":"Reverse vaccinology: An approach to search vaccine leads of Shigella sonnei","authors":"Yatharth Anand , Sunil Pande , Dilip Gore","doi":"10.1016/j.jopr.2013.07.030","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>To develop vaccine leads by reverse vaccinology approach for <em>Shigella sonnei</em>.</p></div><div><h3>Materials and methods</h3><p>Study screened the coding proteins of <em>S. sonnei</em> as vaccine targets collected from NCBI website and filtered as cell surface proteins using programs such as SignalP 4.1, TMHMM, LipoP 1.0, PsortB and BLASTP.</p></div><div><h3>Observation and results</h3><p>In recent years due to rapid development in genome sequencing technology vaccine development program has achieved defined specificity and success. In our study, in total 63 cell surface proteins as vaccine leads were searched which are highly conserved among genus Shigella.</p></div><div><h3>Conclusion</h3><p>Study successfully used reverse vaccinology in search of vaccine leads in <em>S. sonnei</em>.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"7 7","pages":"Pages 576-581"},"PeriodicalIF":0.0000,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.030","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacy Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0974694313003137","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Aim
To develop vaccine leads by reverse vaccinology approach for Shigella sonnei.
Materials and methods
Study screened the coding proteins of S. sonnei as vaccine targets collected from NCBI website and filtered as cell surface proteins using programs such as SignalP 4.1, TMHMM, LipoP 1.0, PsortB and BLASTP.
Observation and results
In recent years due to rapid development in genome sequencing technology vaccine development program has achieved defined specificity and success. In our study, in total 63 cell surface proteins as vaccine leads were searched which are highly conserved among genus Shigella.
Conclusion
Study successfully used reverse vaccinology in search of vaccine leads in S. sonnei.
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