反向疫苗学:寻找索内志贺氏菌疫苗线索的一种方法

Journal of Pharmacy Research Pub Date : 2013-07-01 DOI:10.1016/j.jopr.2013.07.030

Yatharth Anand , Sunil Pande , Dilip Gore

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引用次数: 4

摘要

目的利用反向疫苗学方法开发sonnei志贺氏菌疫苗先导物。材料与方法本研究从NCBI网站收集sonnei沙门氏菌作为疫苗靶点的编码蛋白进行筛选，并使用SignalP 4.1、TMHMM、LipoP 1.0、PsortB和BLASTP等程序筛选为细胞表面蛋白。观察与结果近年来，由于基因组测序技术的快速发展，疫苗开发计划取得了明确的特异性和成功。在我们的研究中，共搜索到63种作为疫苗引线的细胞表面蛋白，这些蛋白在志贺氏菌属中高度保守。结论本研究成功地应用了反向疫苗学方法寻找sonnei链球菌的疫苗线索。

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Reverse vaccinology: An approach to search vaccine leads of Shigella sonnei

Aim

To develop vaccine leads by reverse vaccinology approach for Shigella sonnei.

Materials and methods

Study screened the coding proteins of S. sonnei as vaccine targets collected from NCBI website and filtered as cell surface proteins using programs such as SignalP 4.1, TMHMM, LipoP 1.0, PsortB and BLASTP.

Observation and results

In recent years due to rapid development in genome sequencing technology vaccine development program has achieved defined specificity and success. In our study, in total 63 cell surface proteins as vaccine leads were searched which are highly conserved among genus Shigella.

Conclusion

Study successfully used reverse vaccinology in search of vaccine leads in S. sonnei.

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来源期刊

Journal of Pharmacy Research

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