Journal of Perinatal Medicine最新文献

筛选
英文 中文
Faculty retention in academic OB/GYN: comprehensive strategies and future directions. 学术妇产科的师资保留:综合策略和未来方向。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 DOI: 10.1515/jpm-2024-0513
Ivica Zalud
{"title":"Faculty retention in academic OB/GYN: comprehensive strategies and future directions.","authors":"Ivica Zalud","doi":"10.1515/jpm-2024-0513","DOIUrl":"10.1515/jpm-2024-0513","url":null,"abstract":"<p><p>The retention of academic faculty, particularly in the field of Obstetrics and Gynecology (OB/GYN), has become a growing challenge in the post-COVID era. The healthcare landscape has been dramatically altered, leading to a \"Great Exit\" where a large number of faculty members are resigning or retiring early. This phenomenon is not just a financial burden as recruitment costs have skyrocketed, but also poses a threat to the stability and reputation of academic institutions. In this review article, we explore the underlying causes of faculty attrition, the predictors of resignation, and propose comprehensive strategies to retain talented faculty members. We highlight the importance of mentorship, career development opportunities, and fostering a supportive work environment that aligns with both institutional and individual values. The goal is to create a sustainable framework for faculty engagement that strengthens the academic mission and improves clinical outcomes.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sonographic visualization and measurement of the fetal optic chiasm and optic tract and association with the cavum septum pellucidum. 胎儿视交叉、视束及其与透明隔腔的关系的超声显示和测量。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 Print Date: 2025-02-25 DOI: 10.1515/jpm-2024-0393
Sevim Tuncer Can, Hakan Golbasi, Burak Bayraktar, Ceren Saglam, Ibrahim Omeroglu, Raziye Torun, Ilker Ucar, Ilknur Gumus Toka, Atalay Ekin
{"title":"Sonographic visualization and measurement of the fetal optic chiasm and optic tract and association with the cavum septum pellucidum.","authors":"Sevim Tuncer Can, Hakan Golbasi, Burak Bayraktar, Ceren Saglam, Ibrahim Omeroglu, Raziye Torun, Ilker Ucar, Ilknur Gumus Toka, Atalay Ekin","doi":"10.1515/jpm-2024-0393","DOIUrl":"10.1515/jpm-2024-0393","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the sonographic visualization of the fetal optic chiasm (OC) and optic tracts (OTs), establish mid-trimester reference values, and assess the relationship between OC and OT dimensions and cavum septum pellucidum (CSP) measurements.</p><p><strong>Methods: </strong>This prospective cross-sectional study included 154 morphologically normal fetuses between 19 and 23 weeks of gestation. The diameters of the fetal OC and OTs were measured using two-dimensional transabdominal ultrasound in a transventricular axial section angled approximately 20-40° caudally. CSP length as well as anterior, middle, and posterior widths were measured by placing the cursor on the inner surfaces in the transventricular section. The average CSP width was included in the analysis.</p><p><strong>Results: </strong>The OC and OTs were successfully visualized in 109 fetuses and included in the analysis. Visualization success in transabdominal axial sections at 19-23 weeks was 70.8 %, with high intraobserver and interobserver reproducibility. Additionally, visualization rates were higher in advanced gestational weeks and in fetuses with breech presentation (p=0.007 and p=0.017, respectively). OC and OT dimensions were positively correlated with CSP length and width, biparietal diameter (BPD), head circumference (HC), and gestational age (p<0.05, for all).</p><p><strong>Conclusions: </strong>The OC and OTs were successfully visualized transabdominally in axial sections with high intraobserver and interobserver reproducibility. Additionally, OC and OT dimensions were positively correlated with gestational age, as well as with BPD, HC, and CSP measurements.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"213-221"},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The predictive role of serial transperineal sonography during the first stage of labor for cesarean section.
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 Print Date: 2025-02-25 DOI: 10.1515/jpm-2024-0450
Esra Kartal Gölcük, Burcu Dincgez, Gulten Ozgen, Emın Ustunyurt
{"title":"The predictive role of serial transperineal sonography during the first stage of labor for cesarean section.","authors":"Esra Kartal Gölcük, Burcu Dincgez, Gulten Ozgen, Emın Ustunyurt","doi":"10.1515/jpm-2024-0450","DOIUrl":"https://doi.org/10.1515/jpm-2024-0450","url":null,"abstract":"<p><strong>Objectives: </strong>Head to perineum distance (HPD) and angle of progression (AOP) are sonographic markers which have been investigated for the evaluation of labor progress. Here, we aimed to evaluate the predictive role of serially measured AOP and HPD during the first stage of labor in labor progress both in nulliparous and multiparous patients. Also, we firstly compared this role for labor progress.</p><p><strong>Methods: </strong>This was a prospective longitudinal study including 299 patients. Patients were grouped as vaginal delivery (n=247) and cesarean section (n=52). Demographic and obstetric characteristics, HPD and AOP values, and vaginal examination findings were recorded and compared between groups.</p><p><strong>Results: </strong>Slower changes in HPD and AOP values were detected in cesarean group. A HPD >38 mm predicted cesarean section with 86.9 % sensitivity and 59.2 % specificity (AUC=0.782, p<0.001) whereas AOP ≤117° predicted cesarean section with 93.5 % sensitivity and 65.1 % specificity in all patients (AUC=0.877, p<0.001). A HPD >37 mm predicted cesarean section with 84.2 % sensitivity and 55.2 % specificity (AUC=0.763, p<0.001) while AOP ≤110° predicted it with 82.7 % sensitivity and 73.3 % specificity in nulliparous patients (AUC=0.862, p<0.001). In multiparous patients, HPD>39 mm predicted cesarean section with 95.5 % sensitivity and 62.5 % specificity (AUC=0.824, p<0.001) and AOP ≤109° predicted cesarean section with 87.9 % sensitivity and 78.2 % specificity (AUC=0.909, p<0.001). AOP had superior predictive role than HPD in both nulliparous and multiparous groups (p<0.001 for both).</p><p><strong>Conclusions: </strong>We suggest that differences in labor progress could be determined by using serial intrapartum sonography. However, more research is needed for the implementation of sonopartogram to the clinical obstetric practice.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":"53 2","pages":"132-139"},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cicero's universal law: a timeless guide to reproductive justice. 西塞罗的普遍法则:生殖正义的永恒指南。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 DOI: 10.1515/jpm-2024-0403
Frank A Chervenak, Susan L Pollet, Renee McLeod-Sordjan, Amos Grünebaum
{"title":"Cicero's universal law: a timeless guide to reproductive justice.","authors":"Frank A Chervenak, Susan L Pollet, Renee McLeod-Sordjan, Amos Grünebaum","doi":"10.1515/jpm-2024-0403","DOIUrl":"10.1515/jpm-2024-0403","url":null,"abstract":"<p><p>Marcus Tullius Cicero's concept of \"ius gentium,\" or universal law, provides a timeless framework for understanding and defending fundamental human rights, particularly in the context of reproductive freedom. Cicero distinguished between \"ius gentium\" and \"ius civile,\" emphasizing that while civil law governs specific communities, universal law, rooted in natural reason, applies to all humanity. This philosophical foundation resonates with modern discussions on reproductive rights, where universal principles of justice and bodily autonomy are at stake. Enlightened by Immanuel Kant's notion of innate freedom, Cicero's philosophy challenges present day's US states' restrictive reproductive laws, which often contradict the universal principles of justice. Applying these concepts to contemporary issues, such as abortion rights, underscores the need to align civil laws with universal ethics, ensuring that individual freedoms are upheld against arbitrary state interventions. By advocating for policies that promote equitable access to reproductive healthcare, Cicero's vision of universal law remains a powerful tool for advancing human dignity and autonomy in modern society.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and awareness of dysphoric milk ejection reflex (DMER). 烦躁性泌乳反射(DMER)的发生率和意识。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 Print Date: 2025-02-25 DOI: 10.1515/jpm-2024-0299
Rachel L Solmonovich, Insaf Kouba, Christine Bailey, Wendi Andria, Kristen Demertzis, Matthew J Blitz, Jolene Muscat
{"title":"Incidence and awareness of dysphoric milk ejection reflex (DMER).","authors":"Rachel L Solmonovich, Insaf Kouba, Christine Bailey, Wendi Andria, Kristen Demertzis, Matthew J Blitz, Jolene Muscat","doi":"10.1515/jpm-2024-0299","DOIUrl":"10.1515/jpm-2024-0299","url":null,"abstract":"<p><strong>Objectives: </strong>To determine Dysphoric Milk Ejection Reflex (DMER) incidence. Secondary objectives were to describe the symptom profiles and patient characteristics of DMER and assess DMER familiarity.</p><p><strong>Methods: </strong>A prospective observational study of people who initiated breastfeeding after delivery between December 2022 and May 2023 at two hospitals in New York. Participants filled out an Initial Survey, assessing prior DMER familiarity, and recurring DMER Symptoms Surveys, assessing symptom presence, severity, and transiency. Medical records were reviewed for patient demographics and clinical history. Descriptive and basic inferential statistics were performed. A p<0.05 was considered statistically significant.</p><p><strong>Results: </strong>Based on the DMER definition utilized, incidence was 26.9 % (n=21), and symptom severity was mostly very mild to moderate. Those with DMER had similar baseline characteristics to those without, apart from a significantly higher rate of having delivered via cesarean section (71.4.0 vs. 33.3 %, p<0.01). Among the 55 patients who completed the initial survey, 61.8 % were unfamiliar with the condition.</p><p><strong>Conclusions: </strong>DMER is described as brief, abrupt, negative emotions experienced by breastfeeding individuals prior to milk letdown. We found that more than 1 in 4 participants screened positive. Future research could better define, quantify, qualify, and publicize this condition to inform clinical practices and facilitate successful breastfeeding relationships.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"258-261"},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viability of Extremely Premature neonates: clinical approaches and outcomes. 极度早产儿的生存能力:临床方法和结果。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 DOI: 10.1515/jpm-2024-0432
Esin Koc, Sezin Unal
{"title":"Viability of Extremely Premature neonates: clinical approaches and outcomes.","authors":"Esin Koc, Sezin Unal","doi":"10.1515/jpm-2024-0432","DOIUrl":"10.1515/jpm-2024-0432","url":null,"abstract":"<p><p>Viability refers to an infant's ability to survive outside the womb, which is influenced by both developmental maturity and the quality of medical care received. The concept of periviability, which has evolved alongside medical advancements, describes the stage between viability and nonviability, typically spanning from 20<sup>0/7</sup> to 25 <sup>6/7</sup> weeks of gestation. While the chances of survival are extremely low at the earlier end of this range, the possibility of surviving without significant long-term complications improves towards the later end. The effectiveness of various antenatal and postnatal care practices, particularly those considered to be part of an active approach, plays a crucial role in influencing survival rates and mitigating morbidities. However, the decision to provide such active care is heavily influenced by national guidelines as well as international standards. The variability in guideline recommendations from one country to another, coupled with differences based on gestational age or accompanying risk factors, prevents the establishment of a standardized global approach. This variability results in differing practices depending on the country or institution where the birth occurs. Consequently, healthcare providers must navigate these discrepancies, which often leads to complex ethical dilemmas regarding the balance between potential survival and the associated risks. This review article explores the evolution of the definition of viability, the vulnerabilities faced by periviable infants, and the advancements in medical care that have improved survival rates. Additionally, it examines the viability and periviability definitions, the care and outcomes of periviable infants and recommendations in guidelines.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shifts in peak month of births and socio-economic factors: a study of divided and reunified Germany 1950-2022. 出生高峰月份的变化和社会经济因素:1950-2022年德国分裂和统一的研究。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 Print Date: 2025-02-25 DOI: 10.1515/jpm-2024-0526
Bertram Häussler, Joachim W Dudenhausen
{"title":"Shifts in peak month of births and socio-economic factors: a study of divided and reunified Germany 1950-2022.","authors":"Bertram Häussler, Joachim W Dudenhausen","doi":"10.1515/jpm-2024-0526","DOIUrl":"10.1515/jpm-2024-0526","url":null,"abstract":"<p><strong>Objectives: </strong>The seasonality of conception and birth has intrigued scientists for over 200 years. Since the 1970s, peak birth months in the northern hemisphere have shifted from early spring to late summer, influenced by oral contraceptives and socio-economic factors. The division of Germany from the end of World War II until reunification in 1990 offers a unique opportunity to analyze these influences while both regions had equal access to contraception. This study aims to identify differences in fertility trends and peak birth months between West and East Germany before and after reunification, considering political, socio-economic factors, and contraceptive availability.</p><p><strong>Methods: </strong>A population-based study analyzed overall fertility rates, monthly birth data, peak birth months, and average maternal ages from 1950 to 2022.</p><p><strong>Results: </strong>Fertility patterns were similar in both regions until 1970, showing a sharp increase post-1955 followed by a decline around 1965, likely due to contraception. From 1970 to 1990, East German fertility increased while West Germany's remained lower. After reunification, East German fertility fell sharply but later rose to West German levels. The peak birth month shifted from March to August in West Germany by the mid-1980s, while East Germany experienced this change 20 years later, post-reunification.</p><p><strong>Conclusions: </strong>The 20-year delay in East Germany's shift suggests that oral contraception's impact was influenced by other factors, particularly the age of women at childbirth. Increased control over fertility in the West allowed for more choice in conception timing, a trend adopted in the East after gaining similar autonomy.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"126-131"},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemolytic disease of the fetus and newborn: pregnant person's and fetal immune systems interaction. 胎儿和新生儿溶血性疾病:孕妇和胎儿免疫系统的相互作用。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 DOI: 10.1515/jpm-2024-0438
Liliana Voto, Carlos Alberto Gonzalez, Silvana Gonzalez
{"title":"Hemolytic disease of the fetus and newborn: pregnant person's and fetal immune systems interaction.","authors":"Liliana Voto, Carlos Alberto Gonzalez, Silvana Gonzalez","doi":"10.1515/jpm-2024-0438","DOIUrl":"10.1515/jpm-2024-0438","url":null,"abstract":"<p><p>There exists a need to research new diagnostic and therapeutic approaches that consider hemolytic disease of fetus and newborn (HDFN)'s physiopathology and focus not only on the pregnant person's immune system but also on the fetal immune system. This implies, in the final sense, to view the fetus as our patient. In spite of having found a safe and efficient method of prevention of HDFN more than 50 years ago, HDFN continues to be a relevant cause of perinatal morbidity and mortality, due to lack of access to immunoprophylaxis. In light of the above, we should strive to prevent sensitization and HDFN by ensuring certain health policies across the globe, especially in countries and regions of high morbidity and mortality.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gestational weight gain and obstetric outcomes in women with obesity in an inner-city population. 市中心人口中肥胖妇女的妊娠期体重增加和产科结局。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-12-02 Print Date: 2025-02-25 DOI: 10.1515/jpm-2024-0193
Deepali Mathur, Megan Haugland, Megan Leubner, Sara Hovstadius, Dorothy Wakefield, Reinaldo Figueroa
{"title":"Gestational weight gain and obstetric outcomes in women with obesity in an inner-city population.","authors":"Deepali Mathur, Megan Haugland, Megan Leubner, Sara Hovstadius, Dorothy Wakefield, Reinaldo Figueroa","doi":"10.1515/jpm-2024-0193","DOIUrl":"10.1515/jpm-2024-0193","url":null,"abstract":"<p><strong>Objectives: </strong>To describe maternal and perinatal outcomes in patients with BMI ≥30 kg/m<sup>2</sup> by BMI class and gestational weight gain.</p><p><strong>Methods: </strong>Retrospective review of singleton pregnancies with pre-pregnancy BMI ≥30 kg/m<sup>2</sup> who received care at our institution between January 1, 2016 and December 31, 2021. Patients were divided into three categories based on BMI (kg/m<sup>2</sup>): Class I (BMI 30.0-34.9), Class II (BMI 35-39.9), and Class III (BMI≥40) obesity. For gestational weight gain analysis, pregnancies were stratified into three groups: <11 pounds, 11-20 pounds, and >20 pounds. Maternal demographics and outcomes were compared using chi-square analysis, analysis of variance, nonparametric tests, and multivariable regression analysis.</p><p><strong>Results: </strong>Of 641 patients included, 299 (46.6 %) were in Class I, 209 (32.6 %) in Class II, and 133 (20.7 %) in Class III. Readmission within 6 weeks postpartum, the only outcome found to have a significant difference between BMI categories, was higher in the Class III group (p=0.01). One hundred sixty-two (25.3 %) patients gained <11 pounds, 164 (25.6 %) gained 11-20 pounds, and 313 (48.8 %) gained ≥20 pounds. Greater gestational weight gain was associated with increased rates of cesarean delivery (p<0.001), higher quantitative blood loss (p=0.006), longer length of hospitalization (p=0.03), and higher birthweights (p<0.001).</p><p><strong>Conclusions: </strong>This represents a unique and actionable opportunity for clinicians to counsel and support their patients in adhering to optimal weight gain targets throughout their pregnancy. Future studies are needed to determine the optimal gestational weight gain recommendations for obese patients.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"140-148"},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental fetal vascular malperfusion in maternal diabetes mellitus. 母体糖尿病导致胎儿胎盘血管灌注不良。
IF 1.7 4区 医学
Journal of Perinatal Medicine Pub Date : 2024-11-27 Print Date: 2025-02-25 DOI: 10.1515/jpm-2024-0370
Jerzy Stanek
{"title":"Placental fetal vascular malperfusion in maternal diabetes mellitus.","authors":"Jerzy Stanek","doi":"10.1515/jpm-2024-0370","DOIUrl":"10.1515/jpm-2024-0370","url":null,"abstract":"<p><strong>Objectives: </strong>To study the clinical and placental correlations in diabetic pregnancies in which placental histopathology included routine double E cadherin/CD34 immunostaining.</p><p><strong>Methods: </strong>Retrospective study of 229 cases of diabetic pregnancies, mostly with gestational diabetes mellitus. The cases were individually matched for gestational age at delivery with non-diabetic pregnancies to yield a comparative group of 229 cases. 23 independent clinical and 50 placental phenotypes (variables) were statistically compared by analysis of variance or chi-square with application of the Bonferroni correction for multiple comparisons.</p><p><strong>Results: </strong>The study group showed statistically significantly more common gestational hypertension, chronic hypertension, polyhydramnios, umbilical cord compromise, cesarean sections, macerated stillbirths, neonatal deaths, and fetal malformations. About a third of cases in each group showed lesions of maternal and fetal vascular malperfusion (FVM), the latter more common than reported in literature. The CD34 component of the double immunostaining increased the sensitivity of placental examination by highlighting clustered endothelial fragmentation of recent fetal vascular malperfusion or increasing the grade of fetal vascular malperfusion (on-going distal villous fetal vascular malperfusion with temporal heterogeneity).</p><p><strong>Conclusions: </strong>With the double immunostaining, FVM is as common as maternal vascular malperfusion pattern of placental injury in diabetic pregnancies with high prevalence of fetal congenital malformations. This is likely due to umbilical cord compression evoked by mass-forming fetal anomalies. Recognizing placental FVM may sensitize to the increased risk of neonatal systemic thrombotic pathology. However, several hypoxic lesions and patterns as well as those of shallow placental implantation were also seen with increased frequencies in diabetic pregnancies.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"179-187"},"PeriodicalIF":1.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信