Placental growth factor as a predictive marker of preeclampsia in twin pregnancy.

IF 1.7 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Perinatal Medicine Pub Date : 2024-12-23 Print Date: 2025-02-25 DOI:10.1515/jpm-2024-0184

Guijie Qi, Ling Yao, Zhiming Liu, Wanru Guo, Heng Liu, Jinghua Zhang, Yulian He, Tiancong Jiang

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引用次数: 0

Abstract

Objectives: Placental growth factor (PlGF) has been reported as a good biomaker for the prediction of preeclampsia occurring in the short term in singleton pregnancies, in women presenting with clinical suspicion of preeclampsia. This study aims to evaluate the predictive value of the PlGF in twin pregnancies.

Methods: Twin pregnancies with clinically suspected preeclampsia (24 weeks 0 days-36 weeks 6 days of gestation) were enrolled in this study. The threshold of PlGF for predicting preeclampsia was determined on the basis of a receiver-operating characteristic curve to predict preeclampsia and the short-term occurrence of preeclampsia.

Results: Within 1 week, 2 weeks, and 4 weeks of testing respectively, a cutoff value of 215 pg/mL for PlGF to predict preeclamsia in twin pregnancies suspected to have preeclampsia has a specificity of 100 %[51.7 %, 100 %], 100 %[62.9 %, 100 %], 93.8 %[667.6 %, 99.7 %], and a negative predictive value of 100 %[94.8 %, 100 %], 100 %[95.0 %, 100 %], and 98.9 %[93.0 %, 99.9 %].

Conclusions: A cutoff value of 215 pg/mL for PlGF is a useful tool to exclude the development of preeclampsia within 4 weeks of measurement.

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胎盘生长因子作为双胎妊娠子痫前期的预测指标。

目的：据报道，胎盘生长因子（PlGF）是预测单胎妊娠、临床怀疑有子痫前期的妇女短期发生子痫前期的良好生物标志物。本研究旨在评估PlGF在双胎妊娠中的预测价值。方法：临床怀疑为子痫前期的双胎妊娠（妊娠24周0天~ 36周6天）纳入本研究。PlGF预测子痫前期的阈值是根据预测子痫前期和子痫前期短期发生的受体-工作特征曲线确定的。结果:在1周,2周,4周的测试分别215 pg / mL的截断值PlGF预测双胎妊娠preeclamsia怀疑患有子痫前期的特异性为100 %[51.7 %、100 %],100 %(62.9 %、100 %),93.8 %(667.6 %,99.7 %),和一个消极的预测价值100 %[94.8 %、100 %],100 %(95.0 %、100 %)和98.9 %(93.0 %,99.9 %)。结论：PlGF的临界值为215 pg/mL是排除4周内发生子痫前期的有效工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatal Medicine 医学-妇产科学

CiteScore

4.40

自引率

8.30%

发文量

183

审稿时长

4-8 weeks

期刊介绍： The Journal of Perinatal Medicine (JPM) is a truly international forum covering the entire field of perinatal medicine. It is an essential news source for all those obstetricians, neonatologists, perinatologists and allied health professionals who wish to keep abreast of progress in perinatal and related research. Ahead-of-print publishing ensures fastest possible knowledge transfer. The Journal provides statements on themes of topical interest as well as information and different views on controversial topics. It also informs about the academic, organisational and political aims and objectives of the World Association of Perinatal Medicine.