Journal of Perinatal Medicine最新文献

The use of laser therapy in fetal medicine: a narrative review. 激光治疗在胎儿医学中的应用：综述。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-13 DOI: 10.1515/jpm-2025-0191

Janina Semmler, Wolfgang Henrich, Christian Bamberg

{"title":"The use of laser therapy in fetal medicine: a narrative review.","authors":"Janina Semmler, Wolfgang Henrich, Christian Bamberg","doi":"10.1515/jpm-2025-0191","DOIUrl":"https://doi.org/10.1515/jpm-2025-0191","url":null,"abstract":"Introduction: Fetal therapy has evolved into an established clinical specialty in fetal medicine, offering life-saving interventions for conditions with high intrauterine morbidity and mortality. Among various approaches, laser therapy has played a significant role in advancing fetal procedures.Content: The most established application of laser is fetoscopic laser coagulation for twin-twin transfusion syndrome, which significantly reduces perinatal mortality and neurological complications. Other indications include twin anemia-polycythemia sequence and, as an intrafetal application, twin reversed arterial perfusion sequence. As an experimental approach, intrafetal laser therapy can be used to close the feeding blood vessel of unwanted tissue, thus preventing further tissue growth. Despite the advantages of fetal laser therapy, it presents challenges such as preterm premature rupture of membranes, preterm birth, technical difficulties, and the need for specialized expertise.Summary: Laser therapy has become a cornerstone of fetal medicine, demonstrating significant clinical benefits. While laser therapy for TTTS is supported by high-level evidence, other applications rely on observational or experimental data.Outlook: Future advancements, including improved imaging technologies, artificial intelligence, and robotic-assisted techniques, are expected to further enhance the precision, safety, and accessibility of fetal laser therapy. Large-scale studies through international collaborations will be essential to standardize protocols and improve outcomes.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a universal low-dose aspirin protocol for the prevention of preeclampsia in a federally qualified health center. 在联邦合格的医疗中心实施普遍低剂量阿司匹林预防先兆子痫方案。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-13 DOI: 10.1515/jpm-2025-0215

Jaclyn Del Pozzo, Insaf Kouba, Frank Jackson, Jamie Green, Kristen Demertzis, Quratulain Zeeshan, Matthew J Blitz

{"title":"Implementation of a universal low-dose aspirin protocol for the prevention of preeclampsia in a federally qualified health center.","authors":"Jaclyn Del Pozzo, Insaf Kouba, Frank Jackson, Jamie Green, Kristen Demertzis, Quratulain Zeeshan, Matthew J Blitz","doi":"10.1515/jpm-2025-0215","DOIUrl":"https://doi.org/10.1515/jpm-2025-0215","url":null,"abstract":"Objectives: Low-dose aspirin (LDA) prophylaxis is an evidence-based intervention that reduces preeclampsia risk, yet adherence remains suboptimal in underserved populations due to inconsistent risk assessment and communication gaps. This study evaluated the impact of a universal LDA protocol at a Federally Qualified Health Center (FQHC) serving a socially vulnerable population.Methods: Patients initiating prenatal care between 12 and 28 weeks of gestation were included. A retrospective cohort from 2021 (pre-intervention) was compared to a prospective cohort from 2022 (post-intervention). The intervention prescribed daily LDA to all eligible patients. Adherence was defined as provider-documented patient use during at least one follow-up visit and at delivery, an indirect measure relying on patient report and provider documentation. The primary outcome was LDA adherence. Secondary outcomes included preeclampsia with and without severe features and postpartum hemorrhage requiring blood transfusion. Multivariable logistic regression adjusted for maternal age, pregestational diabetes, and chronic hypertension.Results: Among 775 patients, LDA adherence increased from 8.7 % pre-intervention to 75.0 % post-intervention (p<0.001). The incidence of preeclampsia with severe features decreased significantly (OR 0.14, 95 % CI 0.04-0.37). In high-risk patients, adherence rose from 8.9 to 70.9 % (p<0.001) with a similar reduction in severe preeclampsia (OR 0.16, 95 % CI 0.05-0.44). No significant changes were observed in preeclampsia without severe features or postpartum hemorrhage requiring transfusion.Conclusions: Implementation of a universal LDA protocol in a high-risk, underserved population markedly improved adherence and reduced severe preeclampsia without increasing hemorrhage risk, offering a practical, low-cost strategy to improve maternal outcomes.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complications in monochorionic twin pregnancies. 单绒毛膜双胎妊娠的并发症。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-13 DOI: 10.1515/jpm-2025-0384

Philipp Klaritsch

引用次数: 0

Urinary immune biomarkers for late-onset sepsis in preterm very low birth weight neonates - a diagnostic accuracy study. 尿免疫生物标志物对早产极低出生体重新生儿迟发性败血症的诊断准确性研究

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-07 DOI: 10.1515/jpm-2025-0342

Gayatri Morajker, Ashwini Ankush Patil, Prashanth Ranya Raghavendra, Anuja Datar, Sruthi Nair, Prajakta Dandekar Jain, Haribalakrishna Balasubramanian, Anitha Haribalakrishna, Medha Goyal, Nandkishor S Kabra

{"title":"Urinary immune biomarkers for late-onset sepsis in preterm very low birth weight neonates - a diagnostic accuracy study.","authors":"Gayatri Morajker, Ashwini Ankush Patil, Prashanth Ranya Raghavendra, Anuja Datar, Sruthi Nair, Prajakta Dandekar Jain, Haribalakrishna Balasubramanian, Anitha Haribalakrishna, Medha Goyal, Nandkishor S Kabra","doi":"10.1515/jpm-2025-0342","DOIUrl":"https://doi.org/10.1515/jpm-2025-0342","url":null,"abstract":"Objectives: To evaluate diagnostic accuracy of urinary immune biomarkers (IBM) for late-onset sepsis (LOS) in very preterm infants.Methods: This multicenter, prospective diagnostic accuracy study, included preterm infants <32 weeks of gestation and birth weight <1,500 g, needing evaluation for suspected LOS. Urine samples obtained concurrent to blood culture and sepsis screen were evaluated for interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) levels using enzyme immunoassay. Positive blood and/or CSF culture served as reference standards. Receiver operating characteristic curves were used to evaluate performance of urinary IBM for detection of LOS.Results: During September 2021-September 2023, we evaluated 136 preterm, very low birth weight infants (mean gestational age: 28.2 weeks, mean birth weight: 933 g) for sepsis after 72 h of postnatal age and prior to 37 weeks postmenstrual age. Twenty four infants had culture-positive sepsis. Median IL-8 and MCP-1 levels in neonates with LOS were 86.5 pg/mL and 230.2 pg/mL and those in non-infected neonates were 66.5 pg/mL and 212.1 pg/mL. Urinary IL-8 had sensitivity and specificity of 42 and 51 % [AUC: 0.46 (0.35-0.57)] and urinary MCP-1 had sensitivity and specificity of 46 and 53 % [AUC: 0.49 (0.38-0.60)] for detection of LOS.Conclusions: Urinary IL-8 and MCP-1 had low sensitivity and specificity for diagnosis of LOS in very preterm infants. These findings underscore the need to establish reference ranges for urinary IBM in preterm neonates.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac output-guided maternal positioning may protect the fetal oxygen supply and thereby reduce pregnancy complications. 心输出量引导的产妇体位可以保护胎儿供氧，从而减少妊娠并发症。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-01 DOI: 10.1515/jpm-2025-0333

Thomas L Archer

引用次数: 0

Preeclampsia is associated with increased NT-proBNP and altered lipid profiles in umbilical cord blood: a propensity score-matched analysis. 子痫前期与脐带血NT-proBNP升高和脂质谱改变有关：倾向评分匹配分析。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-09-26 DOI: 10.1515/jpm-2025-0223

Ji Eun Park, Juseok Yang, Hyen Chul Jo, Jong Chul Baek, Jeong Kyu Shin

{"title":"Preeclampsia is associated with increased NT-proBNP and altered lipid profiles in umbilical cord blood: a propensity score-matched analysis.","authors":"Ji Eun Park, Juseok Yang, Hyen Chul Jo, Jong Chul Baek, Jeong Kyu Shin","doi":"10.1515/jpm-2025-0223","DOIUrl":"https://doi.org/10.1515/jpm-2025-0223","url":null,"abstract":"Objectives: Preeclampsia (PE) is a hypertensive disorder of pregnancy related to adverse maternal and neonatal outcomes. While its effects on maternal health are well established, its impact on neonatal cardiovascular health remains incompletely understood. The aim of this study was to analyze metabolic and cardiovascular biomarkers in umbilical cord blood from pregnancies affected by PE.Methods: A single-center retrospective observational study was conducted at Gyeongsang National University Changwon Hospital from September 2023 to December 2024. Umbilical cord blood samples from neonates of mothers with PE (n=72) and normotensive pregnancies (n=456) were analyzed to identify the lipid profiles and measure the levels of cardiovascular biomarkers. Propensity score matching (PSM) was applied to control for confounding variables such as maternal BMI and gestational age.Results: After PSM, neonates born to mothers with PE had significantly higher total umbilical cord blood cholesterol levels (80.12 ± 32.45 vs. 67.27 ± 20.00 mg/dL, p<0.001), lower HDL cholesterol levels (29.12 ± 7.36 vs. 31.24 ± 6.75 mg/dL, p=0.042), and elevated NT-proBNP levels (3,805.43 ± 8,412.21 vs. 1,516.50 ± 2,439.78 pg/mL, p=0.004). Troponin-T levels were not significantly different between the groups after matching (p=0.320).Conclusions: PE significantly alters umbilical cord blood lipid profiles and cardiovascular biomarkers, suggesting negative implications for the cardiovascular health of the fetus and early metabolic programming. Elevated NT-proBNP levels may serve as an early marker of neonatal cardiac stress, whereas abnormal lipid profiles may necessitate long-term cardiovascular monitoring.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FetalDenseNet: multi-scale deep learning for enhanced early detection of fetal anatomical planes in prenatal ultrasound. FetalDenseNet：多尺度深度学习增强产前超声胎儿解剖平面的早期检测。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-09-24 DOI: 10.1515/jpm-2025-0249

Samrat Kumar Dey, Arpita Howlader, Md Shabukta Haider, Tonmoy Saha, Deblina Mazumder Setu, Tania Islam, Umme Raihan Siddiqi, Md Mahbubur Rahman

{"title":"FetalDenseNet: multi-scale deep learning for enhanced early detection of fetal anatomical planes in prenatal ultrasound.","authors":"Samrat Kumar Dey, Arpita Howlader, Md Shabukta Haider, Tonmoy Saha, Deblina Mazumder Setu, Tania Islam, Umme Raihan Siddiqi, Md Mahbubur Rahman","doi":"10.1515/jpm-2025-0249","DOIUrl":"https://doi.org/10.1515/jpm-2025-0249","url":null,"abstract":"Objectives: The study aims to improve the classification of fetal anatomical planes using Deep Learning (DL) methods to enhance the accuracy of fetal ultrasound interpretation.Methods: Five Convolutional Neural Network (CNN) architectures, such as VGG16, ResNet50, InceptionV3, DenseNet169, and MobileNetV2, are evaluated on a large-scale, clinically validated dataset of 12,400 ultrasound images from 1,792 patients. Preprocessing methods, including scaling, normalization, label encoding, and augmentation, are applied to the dataset, and the dataset is split into 80 % for training and 20 % for testing. Each model was fine-tuned and evaluated based on its classification accuracy for comparison.Results: DenseNet169 achieved the highest classification accuracy of 92 % among all the tested models.Conclusions: The study shows that CNN-based models, particularly DenseNet169, significantly improve diagnostic accuracy in fetal ultrasound interpretation. This advancement reduces error rates and provides support for clinical decision-making in prenatal care.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-based antioxidant strategies with potential for preeclampsia prevention: clinical and mechanistic insights. 基于植物的抗氧化策略与潜在的子痫前期预防：临床和机制的见解。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-09-24 DOI: 10.1515/jpm-2025-0229

Wiku Andonotopo, Muhammad Adrianes Bachnas, Julian Dewantiningrum, Mochammad Besari Adi Pramono, Theresia Monica Rahardjo, Aloysius Suryawan, Bambang Rahardjo, I Nyoman Hariyasa Sanjaya, Sri Sulistyowati, Milan Stanojevic, Asim Kurjak

{"title":"Plant-based antioxidant strategies with potential for preeclampsia prevention: clinical and mechanistic insights.","authors":"Wiku Andonotopo, Muhammad Adrianes Bachnas, Julian Dewantiningrum, Mochammad Besari Adi Pramono, Theresia Monica Rahardjo, Aloysius Suryawan, Bambang Rahardjo, I Nyoman Hariyasa Sanjaya, Sri Sulistyowati, Milan Stanojevic, Asim Kurjak","doi":"10.1515/jpm-2025-0229","DOIUrl":"https://doi.org/10.1515/jpm-2025-0229","url":null,"abstract":"Background: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality, driven by oxidative stress, endothelial dysfunction, and systemic inflammation. Current preventive strategies, such as low-dose aspirin, offer modest benefit, highlighting the need for alternative approaches. Medicinal plants with antioxidant and anti-inflammatory properties, long used in maternal health traditions, may provide biological pathways relevant to preeclampsia prevention.Summary: This review synthesizes human clinical and mechanistic evidence on four medicinal plants with documented antioxidant activity - Curcuma longa, Moringa oleifera, Orthosiphon aristatus, and Centella asiatica. These botanicals demonstrate potential mechanisms of action including redox modulation, preservation of endothelial function, and suppression of pro-inflammatory pathways, all of which are implicated in preeclampsia pathophysiology.Content: A PRISMA-guided systematic search of PubMed, Scopus, Web of Science, and the Cochrane Library (2000-2025) identified human studies evaluating these plants' effects on oxidative stress and vascular health. Evidence was synthesized narratively due to heterogeneous study designs and outcomes. Most studies were small, often not pregnancy-specific, and used non-standardized botanical formulations.Outlook: These medicinal plants offer biologically plausible pathways to reduce preeclampsia risk. However, pregnancy-focused randomized trials, dose optimization, pharmacokinetic profiling, and safety evaluations are essential before clinical integration into maternal care.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The FAIR framework: ethical hybrid peer review. 公平框架：伦理混合同行评议。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-09-23 DOI: 10.1515/jpm-2025-0285

Amos Grünebaum, Joachim Dudenhausen, Frank A Chervenak

{"title":"The FAIR framework: ethical hybrid peer review.","authors":"Amos Grünebaum, Joachim Dudenhausen, Frank A Chervenak","doi":"10.1515/jpm-2025-0285","DOIUrl":"https://doi.org/10.1515/jpm-2025-0285","url":null,"abstract":"Objectives: Traditional peer review faces critical challenges including systematic bias, prolonged delays, reviewer fatigue, and lack of transparency. These failures violate ethical obligations of beneficence, justice, and autonomy while hindering scientific progress and costing billions annually in academic labor. To propose an ethically-guided hybrid peer review system that integrates generative artificial intelligence with human expertise while addressing fundamental shortcomings of current review processes.Methods: We developed the FAIR Framework (Fairness, Accountability, Integrity, and Responsibility) through systematic analysis of peer review failures and integration of AI capabilities. The framework employs standardized prompt engineering to guide AI evaluation of manuscripts while maintaining human oversight throughout all stages.Results: FAIR addresses bias through algorithmic detection and standardized evaluation protocols, ensures accountability via transparent audit trails and documented decisions, maintains integrity through secure local AI processing and confidentiality safeguards, and upholds responsibility through ethical oversight and constructive feedback mechanisms. The hybrid model automates repetitive tasks including initial screening, methodological verification, and plagiarism detection while preserving human judgment for novelty assessment, ethical evaluation, and final decisions.Conclusions: The FAIR Framework offers a principled solution to peer review inefficiencies by combining AI-enabled consistency and speed with essential human expertise. This hybrid approach reduces review delays, eliminates systematic bias, and enhances transparency while maintaining confidentiality and editorial control. Implementation could significantly reduce the estimated 100 million hours of global reviewer time annually while improving review quality and equity across diverse research communities.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating generative AI in perinatology: applications for literature review. 集成生成式人工智能在围产期：应用的文献综述。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-09-23 DOI: 10.1515/jpm-2025-0392

Rodrigo Ayala-Yáñez, Amos Grünebaum, Frank A Chervenak

{"title":"Integrating generative AI in perinatology: applications for literature review.","authors":"Rodrigo Ayala-Yáñez, Amos Grünebaum, Frank A Chervenak","doi":"10.1515/jpm-2025-0392","DOIUrl":"https://doi.org/10.1515/jpm-2025-0392","url":null,"abstract":"Perinatology relies on continuous engagement with an expanding body of clinical literature, yet the volume and velocity of publications increasingly exceed the capacity of clinicians to keep pace. Generative artificial intelligence (GAI) tools - such as ChatGPT4, Claude AI, Gemini, and Perplexity AI - offer a novel approach to assist with literature retrieval, comparison of clinical guidelines, and manuscript drafting. This study evaluates the strengths and limitations of these tools in maternal-fetal medicine, using structured clinical prompts to simulate real-world applications. Perplexity AI demonstrated the best citation accuracy, while ChatGPT4 and Claude excelled in content summarization but required manual verification of citations. In simulated trials, GAI tools reduced the time to generate clinically relevant summaries by up to 70 % compared to traditional PubMed searches. However, risks such as hallucinated references and overreliance on machine-generated text persist. Use cases include summarizing aspirin use guidelines for preeclampsia and comparing ACOG vs. NICE protocols. GAI should be viewed as a supportive assistant, not a substitute, for expert review. To ensure responsible integration, clinicians must develop AI literacy, apply rigorous oversight, and adhere to ethical standards. When used judiciously, GAI can enhance efficiency, insight, and evidence-based decision-making in perinatal care.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0