Journal of Perinatal Medicine最新文献_第10页

McDonald vs. Shirodkar cerclage for the prevention of preterm birth in patients with obesity. McDonald与Shirodkar环扎术预防肥胖患者早产的比较。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-20 Print Date: 2026-02-24 DOI: 10.1515/jpm-2025-0137

Sarah H Abelman, Frank I Jackson, Nathan A Keller, Julie Chen, Luis A Bracero, Matthew J Blitz

{"title":"McDonald vs. Shirodkar cerclage for the prevention of preterm birth in patients with obesity.","authors":"Sarah H Abelman, Frank I Jackson, Nathan A Keller, Julie Chen, Luis A Bracero, Matthew J Blitz","doi":"10.1515/jpm-2025-0137","DOIUrl":"10.1515/jpm-2025-0137","url":null,"abstract":"Objectives: Transvaginal cervical cerclage is a common intervention to prevent preterm birth in high-risk patients. This study aimed to compare McDonald and Shirodkar cerclage techniques in preventing preterm birth among patients with obesity, a group at increased risk for adverse pregnancy outcomes.Methods: This was a retrospective study of singleton pregnancies complicated by pre-pregnancy obesity (BMI≥30 kg/m2) and transvaginal cerclage placement between 2018 and 2023 within a large health system in New York. The primary exposure was type of cerclage, McDonald or Shirodkar. Primary outcomes were preterm birth <37 weeks and <34 weeks. Secondary outcomes were spontaneous preterm birth <37 and <34 weeks, and gestational age at delivery. Subgroup analyses were performed by cerclage indication (history-, ultrasound-, or exam-indicated). Multivariate logistic regression and linear mixed model analyses were utilized to evaluate these outcomes while controlling for potential confounders.Results: Of 495 patients included, 375 (76 %) underwent McDonald and 120 (24 %) underwent Shirodkar cerclage. In adjusted and unadjusted analyses, there was no significant difference in preterm birth at <37 or <34 weeks (p=0.98 and p=0.30 respectively) or spontaneous preterm birth at <37 or <34 weeks (p=0.75 and p=0.36) between the groups. There was no significant difference in mean gestational age at delivery (36.4 ± 4.3 vs. 35.9 ± 4.7 weeks, p=0.50). Subgroup analyses confirmed similar findings across cerclage indications, though with a benefit for the McDonald technique for ultrasound-indicated cerclages (36.6 ± 4.2 vs. 35.0 ± 5.1 weeks, p=0.02).Conclusions: McDonald and Shirodkar cerclages are equally effective in prolonging pregnancy in patients with obesity.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"302-308"},"PeriodicalIF":1.4,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes in early term neonates requiring extracorporeal membrane oxygenation. 需要体外膜氧合的早期足月新生儿的预后。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-20 Print Date: 2026-02-24 DOI: 10.1515/jpm-2025-0235

Sourabh Verma, Bryn H S Seltzer, Jason C Fisher, Erin Cicalese

{"title":"Outcomes in early term neonates requiring extracorporeal membrane oxygenation.","authors":"Sourabh Verma, Bryn H S Seltzer, Jason C Fisher, Erin Cicalese","doi":"10.1515/jpm-2025-0235","DOIUrl":"10.1515/jpm-2025-0235","url":null,"abstract":"Objectives: To evaluate ECMO-related morbidity and mortality between early-term (ET) and Full-term (FT) infants.Methods: We performed a retrospective review of 3,831 neonatal ECMO runs for meconium aspiration syndrome (MAS) and/or persistent pulmonary hypertension of the newborn (PPHN) in the Extracorporeal Life Support Organization (ELSO) Registry from 2007 to 2017. Neonates born at 370/7-386/7 weeks were classified as ET and those born at 390/7-406/7 weeks were classified as FT. Primary outcomes were ECMO survival and survival to discharge. Secondary outcomes were complications while on ECMO. Data were analyzed using Mann-Whitney U and Fisher's Exact testing. Logistic regression was performed to assess odds of ECMO survival for factors noted to be significantly different between groups.Results: Of 2,551 infants who met inclusion criteria based on gestational age, we identified 805 (32 %) ET and 1,746 (68 %) FT infants. ET infants had significantly lower ECMO survival (90 vs. 94 %, p<0.01) and survival to discharge (80 vs. 88 %, p<0.01), more neurologic complications on ECMO (15 vs. 12 %, p=0.024), and increased need for hemofiltration (33 vs. 29 %, p=0.033). There were no statistically significant differences between groups in mechanical, hemorrhagic, infectious, metabolic, renal, pulmonary, limb, or cardiovascular complications while on ECMO. Multiple logistic regression showed that ET gestational age, development of neurologic complications on ECMO, and need for hemofiltration are independent negative predictors of ECMO survival.Conclusions: ET gestational age is an independent risk factor for worse ECMO outcomes and survival in comparison to FT infants, highlighting the vulnerability of this population.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"424-430"},"PeriodicalIF":1.4,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA biomarkers in hypertensive disorders of pregnancy: systematic review. 妊娠期高血压疾病的RNA生物标志物：系统综述。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-17 Print Date: 2026-03-26 DOI: 10.1515/jpm-2025-0143

Damilya Salimbayeva, Gulfairuz Urazbayeva, Almagul Kurmanova, Makhambet Smailov, Altynay Nurmakova

{"title":"RNA biomarkers in hypertensive disorders of pregnancy: systematic review.","authors":"Damilya Salimbayeva, Gulfairuz Urazbayeva, Almagul Kurmanova, Makhambet Smailov, Altynay Nurmakova","doi":"10.1515/jpm-2025-0143","DOIUrl":"10.1515/jpm-2025-0143","url":null,"abstract":"Objectives: The purpose of the study is to explore the potential of novel genetic markers in predicting and diagnosing hypertensive conditions during pregnancy, focusing on their role in key pathological processes. The relevance of this study is determined by the necessity to improve methods for the early detection and effective management of pregnancy complications, particularly those associated with elevated blood pressure, which pose a threat to the health of both mother and foetus.Methods: The research methodology involves a systematic analysis of scientific literature from the past five years, specifically from 2019 to 2024, emphasising the integration of data from various populations and research approaches within the field of molecular medicine.Results: The main findings demonstrate that certain molecular markers reflecting gene activity exhibit high accuracy in predicting the risks of complications associated with hypertension of pregnancy. It is established that these markers can detect disturbances in the regulation of vascular tone, angiogenesis processes, and inflammatory responses long before the onset of clinical symptoms. This opens up opportunities for timely medical intervention and a personalised approach to pregnancy management.Conclusions: The results of the study confirm the potential of utilising genetic markers in clinical practice to improve pregnancy outcomes and reduce risks for both mother and child. The practical value lies in the possibility of developing new screening programmes and therapeutic strategies based on the individual characteristics of patients, contributing to more effective management of hypertensive disorders during pregnancy.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"467-480"},"PeriodicalIF":1.4,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early unfavorable outcomes of second-trimester selective feticide for complicated monochorionic twins: single-operator experiences. 复杂单绒毛膜双胞胎妊娠中期选择性堕胎的早期不良后果：单个操作人员的经验。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-14 Print Date: 2026-03-26 DOI: 10.1515/jpm-2025-0487

Tuangsit Wataganara, Katika Nawapun, Kanokwaroon Watananirun, Sommai Viboonchart, Suparat Jaingam, Nisarat Phithakwatchara

{"title":"Early unfavorable outcomes of second-trimester selective feticide for complicated monochorionic twins: single-operator experiences.","authors":"Tuangsit Wataganara, Katika Nawapun, Kanokwaroon Watananirun, Sommai Viboonchart, Suparat Jaingam, Nisarat Phithakwatchara","doi":"10.1515/jpm-2025-0487","DOIUrl":"10.1515/jpm-2025-0487","url":null,"abstract":"Objectives: This study reviews early unfavorable outcomes following selective in-utero cord occlusion in monochorionic twin pregnancies at risk of hemodynamic accidents by a single operator.Methods: The study analyzed laser ablation (LA), laser transection (LT), radiofrequency ablation (RFA), and bipolar diathermy (BD) procedures performed between 14 and 22 weeks of gestation from 2006 to 2022. Outcomes included: (1) technical failure (abandonment before cessation of Doppler flow), (2) intraoperative events (hemodynamic instability in the woman or co-twin), and (3) complications (e.g., fluid leakage, infection, abruption, co-twin demise, or miscarriage) within 1 week post-procedure.Results: Ten LAs were performed at 14-15 weeks for discordant anomalies, all without complications. Two LTs were conducted at 20 weeks for umbilical cord knotting; with one procedure experienced technical failure. All twin reversed arterial perfusion sequence (TRAPS) (n=55) received RFA, with one procedure experienced technical failure. All twin-to-twin transfusion syndrome (TTTS) (n=25) received BD, with one procedure experienced technical failure. Selective intrauterine growth restriction (sIUGR) (n=30) received RFA (n=5) and BD (n=25), with 1 RFA (25 %) and 1 BD (4 %) experienced technical failure. (p<0.01) All four technical failure cases had extensive anterior placenta. There were no intraoperative events. McDonald cervical cerclage was performed in 8/25 TTTS cases with pre-operative cervical length of ≤25 mm and/or funneling of the internal cervical os. Early procedure-related complications were experienced in two sIUGR cases receiving BD, both of which had extensive anterior placenta.Conclusions: Early unfavorable outcomes were associated with sIUGR as an indication.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"543-549"},"PeriodicalIF":1.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual fetal holography for parental counseling and education: applications, limitations, and future directions. 虚拟胎儿全息技术用于父母咨询和教育：应用、限制和未来方向。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-14 Print Date: 2026-03-26 DOI: 10.1515/jpm-2025-0127

Wiku Andonotopo, Muhammad Adrianes Bachnas, Efendi Lukas, Julian Dewantiningrum, Mochammad Besari Adi Pramono, Sri Sulistyowati, Milan Stanojevic, Asim Kurjak

{"title":"Virtual fetal holography for parental counseling and education: applications, limitations, and future directions.","authors":"Wiku Andonotopo, Muhammad Adrianes Bachnas, Efendi Lukas, Julian Dewantiningrum, Mochammad Besari Adi Pramono, Sri Sulistyowati, Milan Stanojevic, Asim Kurjak","doi":"10.1515/jpm-2025-0127","DOIUrl":"10.1515/jpm-2025-0127","url":null,"abstract":"Introduction: Effective prenatal counseling relies on clear communication of fetal development and potential complications. Conventional 2D and 3D ultrasound images often fail to intuitively convey complex anatomy to expectant parents, limiting engagement and informed decision-making.Content: Virtual fetal holography combines advanced image processing and 3D/4D ultrasound data to generate interactive, life-like fetal models. This review synthesizes current literature on its technological basis, clinical applications, and patient-centered outcomes. Evidence from cardiology, surgical planning, and anatomy education demonstrates how holography improves spatial understanding, supports multidisciplinary counseling, and enhances patient experience compared to standard imaging. Applications in anomaly counseling, maternal-fetal bonding, and clinical training are highlighted, alongside workflow models integrating mixed reality headsets and AI algorithms.Summary: Virtual fetal holography shows potential for improving prenatal education and emotional engagement. Current evidence is largely descriptive and feasibility-based, with limited empirical validation of its impact on clinical decision-making or patient outcomes.Outlook: Future research should address cost, technical complexity, ethical considerations, and standardized clinical protocols. Large-scale trials and cost-effectiveness analyses are needed to define its role in routine prenatal care.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"455-466"},"PeriodicalIF":1.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of laser therapy in fetal medicine: a narrative review. 激光治疗在胎儿医学中的应用：综述。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-13 Print Date: 2026-02-24 DOI: 10.1515/jpm-2025-0191

Janina Semmler, Wolfgang Henrich, Christian Bamberg

{"title":"The use of laser therapy in fetal medicine: a narrative review.","authors":"Janina Semmler, Wolfgang Henrich, Christian Bamberg","doi":"10.1515/jpm-2025-0191","DOIUrl":"10.1515/jpm-2025-0191","url":null,"abstract":"Introduction: Fetal therapy has evolved into an established clinical specialty in fetal medicine, offering life-saving interventions for conditions with high intrauterine morbidity and mortality. Among various approaches, laser therapy has played a significant role in advancing fetal procedures.Content: The most established application of laser is fetoscopic laser coagulation for twin-twin transfusion syndrome, which significantly reduces perinatal mortality and neurological complications. Other indications include twin anemia-polycythemia sequence and, as an intrafetal application, twin reversed arterial perfusion sequence. As an experimental approach, intrafetal laser therapy can be used to close the feeding blood vessel of unwanted tissue, thus preventing further tissue growth. Despite the advantages of fetal laser therapy, it presents challenges such as preterm premature rupture of membranes, preterm birth, technical difficulties, and the need for specialized expertise.Summary: Laser therapy has become a cornerstone of fetal medicine, demonstrating significant clinical benefits. While laser therapy for TTTS is supported by high-level evidence, other applications rely on observational or experimental data.Outlook: Future advancements, including improved imaging technologies, artificial intelligence, and robotic-assisted techniques, are expected to further enhance the precision, safety, and accessibility of fetal laser therapy. Large-scale studies through international collaborations will be essential to standardize protocols and improve outcomes.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"231-243"},"PeriodicalIF":1.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of discordance in birth weights of dichorionic twins with the incidence of preeclampsia in pregnant women. 双绒毛膜双胞胎出生体重不一致与孕妇先兆子痫发生率的关系。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-13 Print Date: 2026-01-23 DOI: 10.1515/jpm-2025-0362

Sara Čebron, Anja Rupar, Ivan Verdenik, Tanja Premru-Sršen

{"title":"Association of discordance in birth weights of dichorionic twins with the incidence of preeclampsia in pregnant women.","authors":"Sara Čebron, Anja Rupar, Ivan Verdenik, Tanja Premru-Sršen","doi":"10.1515/jpm-2025-0362","DOIUrl":"10.1515/jpm-2025-0362","url":null,"abstract":"Objectives: Preeclampsia (PE) is more common in multiple pregnancies, especially dichorionic twins, which often show birthweight discordance. The threshold of birthweight discordance linked to increased risk remains unclear, based largely on the Delphi consensus method. This study examines whether discordance independently predicts PE and identifies the most predictive threshold to guide prenatal care.Methods: We conducted a retrospective population-based cohort study of 2,546 women with dichorionic twins who delivered in Slovenia between 2013 and 2022, using data from the National Perinatal Information System. The association between twin birthweight discordance, the main independent variable, and PE, the main outcome variable, was determined using multivariate logistic regression. We calculated the crude odds ratio (OR) and adjusted odds ratio (aOR) with a 95 % confidence interval. ROC analysis determined the area under the curve (AUC), the sensitivity, and the false positive rate for predicting PE. Two-sided p-values <0.05 were considered statistically significant.Results: In our cohort PE occurred in 5.38 %. Compared with a birthweight discordance of <10 %, a discordance >25 % was identified as a statistically significant independent risk factor for PE development (aOR=1.66; 95 % CI 1.10-2.52; p=0.016). Birthweight discordance between 10 and 25 % was not significantly associated with PE. The AUC for predicting PE with birthweight discordance was significant at 55.2 % (51.6-58.8 %). However, at a birthweight discordance threshold of >25 %, only 10.2 % of pregnant women with PE could be identified with 5.8 % false-positive results.Conclusions: This study revealed that a birthweight discordance >25 % in dichorionic twins significantly increases PE risk.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"84-92"},"PeriodicalIF":1.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a universal low-dose aspirin protocol for the prevention of preeclampsia in a federally qualified health center. 在联邦合格的医疗中心实施普遍低剂量阿司匹林预防先兆子痫方案。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-13 Print Date: 2026-02-24 DOI: 10.1515/jpm-2025-0215

Jaclyn Del Pozzo, Insaf Kouba, Frank Jackson, Jamie Green, Kristen Demertzis, Quratulain Zeeshan, Matthew J Blitz

{"title":"Implementation of a universal low-dose aspirin protocol for the prevention of preeclampsia in a federally qualified health center.","authors":"Jaclyn Del Pozzo, Insaf Kouba, Frank Jackson, Jamie Green, Kristen Demertzis, Quratulain Zeeshan, Matthew J Blitz","doi":"10.1515/jpm-2025-0215","DOIUrl":"10.1515/jpm-2025-0215","url":null,"abstract":"Objectives: Low-dose aspirin (LDA) prophylaxis is an evidence-based intervention that reduces preeclampsia risk, yet adherence remains suboptimal in underserved populations due to inconsistent risk assessment and communication gaps. This study evaluated the impact of a universal LDA protocol at a Federally Qualified Health Center (FQHC) serving a socially vulnerable population.Methods: Patients initiating prenatal care between 12 and 28 weeks of gestation were included. A retrospective cohort from 2021 (pre-intervention) was compared to a prospective cohort from 2022 (post-intervention). The intervention prescribed daily LDA to all eligible patients. Adherence was defined as provider-documented patient use during at least one follow-up visit and at delivery, an indirect measure relying on patient report and provider documentation. The primary outcome was LDA adherence. Secondary outcomes included preeclampsia with and without severe features and postpartum hemorrhage requiring blood transfusion. Multivariable logistic regression adjusted for maternal age, pregestational diabetes, and chronic hypertension.Results: Among 775 patients, LDA adherence increased from 8.7 % pre-intervention to 75.0 % post-intervention (p<0.001). The incidence of preeclampsia with severe features decreased significantly (OR 0.14, 95 % CI 0.04-0.37). In high-risk patients, adherence rose from 8.9 to 70.9 % (p<0.001) with a similar reduction in severe preeclampsia (OR 0.16, 95 % CI 0.05-0.44). No significant changes were observed in preeclampsia without severe features or postpartum hemorrhage requiring transfusion.Conclusions: Implementation of a universal LDA protocol in a high-risk, underserved population markedly improved adherence and reduced severe preeclampsia without increasing hemorrhage risk, offering a practical, low-cost strategy to improve maternal outcomes.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"282-287"},"PeriodicalIF":1.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complications in monochorionic twin pregnancies. 单绒毛膜双胎妊娠的并发症。

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-13 Print Date: 2026-01-23 DOI: 10.1515/jpm-2025-0384

Philipp Klaritsch

引用次数: 0

Urinary immune biomarkers for late-onset sepsis in preterm very low birth weight neonates - a diagnostic accuracy study. 尿免疫生物标志物对早产极低出生体重新生儿迟发性败血症的诊断准确性研究

IF 1.4 4区医学

Journal of Perinatal Medicine Pub Date : 2025-10-07 Print Date: 2026-03-26 DOI: 10.1515/jpm-2025-0342

Gayatri Morajker, Ashwini Ankush Patil, Prashanth Ranya Raghavendra, Anuja Datar, Sruthi Nair, Prajakta Dandekar Jain, Haribalakrishna Balasubramanian, Anitha Haribalakrishna, Medha Goyal, Nandkishor S Kabra

{"title":"Urinary immune biomarkers for late-onset sepsis in preterm very low birth weight neonates - a diagnostic accuracy study.","authors":"Gayatri Morajker, Ashwini Ankush Patil, Prashanth Ranya Raghavendra, Anuja Datar, Sruthi Nair, Prajakta Dandekar Jain, Haribalakrishna Balasubramanian, Anitha Haribalakrishna, Medha Goyal, Nandkishor S Kabra","doi":"10.1515/jpm-2025-0342","DOIUrl":"10.1515/jpm-2025-0342","url":null,"abstract":"Objectives: To evaluate diagnostic accuracy of urinary immune biomarkers (IBM) for late-onset sepsis (LOS) in very preterm infants.Methods: This multicenter, prospective diagnostic accuracy study, included preterm infants <32 weeks of gestation and birth weight <1,500 g, needing evaluation for suspected LOS. Urine samples obtained concurrent to blood culture and sepsis screen were evaluated for interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) levels using enzyme immunoassay. Positive blood and/or CSF culture served as reference standards. Receiver operating characteristic curves were used to evaluate performance of urinary IBM for detection of LOS.Results: During September 2021-September 2023, we evaluated 136 preterm, very low birth weight infants (mean gestational age: 28.2 weeks, mean birth weight: 933 g) for sepsis after 72 h of postnatal age and prior to 37 weeks postmenstrual age. Twenty four infants had culture-positive sepsis. Median IL-8 and MCP-1 levels in neonates with LOS were 86.5 pg/mL and 230.2 pg/mL and those in non-infected neonates were 66.5 pg/mL and 212.1 pg/mL. Urinary IL-8 had sensitivity and specificity of 42 and 51 % [AUC: 0.46 (0.35-0.57)] and urinary MCP-1 had sensitivity and specificity of 46 and 53 % [AUC: 0.49 (0.38-0.60)] for detection of LOS.Conclusions: Urinary IL-8 and MCP-1 had low sensitivity and specificity for diagnosis of LOS in very preterm infants. These findings underscore the need to establish reference ranges for urinary IBM in preterm neonates.","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"630-636"},"PeriodicalIF":1.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0