Journal of Perinatal Medicine最新文献

{"title":"Evaluation of safety and performance of CentaFlow™ in the assessment of fetal growth restriction - a randomized trial and prospective cohort study.","authors":"Cathrine Vedel, Ane Rom, Dave Wright, Richard Farlie, Lise Hald Nielsen, Anne Hammer Lauridsen, Simone Hansen, Hanne Hegaard, Frederikke Huitfeldt Sander, Mie de Wolff, Olav Bjørn Petersen","doi":"10.1515/jpm-2025-0153","DOIUrl":"https://doi.org/10.1515/jpm-2025-0153","url":null,"abstract":"<p><strong>Objectives: </strong>The aim was to evaluate the sensitivity and specificity of centaflow (CF) in a prospective multicenter study, and secondary to evaluate the safety of the CF device in a randomized multicenter study.</p><p><strong>Methods: </strong>A sponsor-initiated multicenter randomized controlled clinical trial with termination of the randomization after enough women had been included to evaluate safety. The study proceeded as a prospective multicenter study including high-risk women (estimated fetal weight <-15 %, FGR). The first part randomized women to either standard care (SC) or SC+CF. Participants underwent CF evaluation with subsequent analysis for sensitivity and specificity for FGR at birth. Secondarily, adverse events were evaluated. Clinical assessments of fetal size conducted by midwives served as a reference. The performance of CF and SC was compared by McNemar's Test. The performance analysis of CF was done per-protocol sample.</p><p><strong>Results: </strong>A total of 1,601 pregnant women were enrolled, with 886 undergoing CF evaluation. A total of 123 were FGR (<3rd percentile) at birth, of which 88 were evaluated by CF, and 117 had a clinical assessment of the estimated fetal weight. CF demonstrated no evidence of benefit for detecting FGR with a sensitivity of 50 % and specificity of 43 %. Adverse events associated with CF use were limited to minor skin irritation. McNemar's test showed SC was superior to CF regarding specificity as a screening tool (p=0.014).</p><p><strong>Conclusions: </strong>While CF was safe to use, we found no evidence that CF can be used as a predictor of FGR. Further refinement of signal analysis is necessary to enhance CFs diagnostic utility.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine disrupting chemicals: translating mechanisms into perinatal risk assessment.","authors":"Wiku Andonotopo, Muhammad Adrianes Bachnas, Julian Dewantiningrum, Mochammad Besari Adi Pramono, Muhammad Ilham Aldika Akbar, Ernawati Darmawan, I Nyoman Hariyasa Sanjaya, Dudy Aldiansyah, Sri Sulistyowati, Milan Stanojevic, Asim Kurjak","doi":"10.1515/jpm-2025-0259","DOIUrl":"https://doi.org/10.1515/jpm-2025-0259","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the evidence linking prenatal exposure to environmental endocrine-disrupting chemicals (EDCs) - including bisphenol A (BPA), phthalates, and per- and polyfluoroalkyl substances (PFAS) - with adverse pregnancy and fetal developmental outcomes, and to assess the potential translation of this evidence into clinical perinatal risk assessment.</p><p><strong>Methods: </strong>A systematic literature search was conducted in PubMed, Scopus, and Web of Science for studies published between January 2000 and May 2025. Eligible studies included epidemiological and experimental research addressing prenatal EDC exposure and fetal-placental outcomes. After duplicate removal and screening, 52 studies met inclusion criteria and were categorized by study type (epidemiological, mechanistic, translational). Data extraction included exposure metrics, critical developmental windows, and reported effect sizes (odds ratios, risk ratios, hazard ratios).</p><p><strong>Results: </strong>Evidence suggests that EDC exposure during early pregnancy is associated with placental dysfunction, altered fetal growth trajectories, endocrine and epigenetic modifications, and increased risk of selected neonatal outcomes. Effect sizes were variable, often modest (many<2.0), but consistently indicated biological plausibility supported by mechanistic data. Biomonitoring studies demonstrate widespread EDC exposure across populations, including higher body burdens in lower-income and racially diverse groups. Despite robust basic science evidence, clinical screening for EDC exposure remains limited, and routine risk assessment frameworks rarely incorporate environmental chemical exposures.</p><p><strong>Conclusions: </strong>Prenatal EDC exposure is biologically linked to disrupted fetal-placental development, yet translation into clinical practice remains incomplete. Integrating environmental exposure assessment and preventive counseling into perinatal care may improve maternal-fetal health and reduce disparities.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum maternal complications: a retrospective single-center study.","authors":"Nuša Stopar, Andreja Trojner Bregar","doi":"10.1515/jpm-2025-0332","DOIUrl":"https://doi.org/10.1515/jpm-2025-0332","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the incidence and underlying causes of postpartum complications, with a focus on infections, among women who delivered at a tertiary maternity hospital over a 17-year period.</p><p><strong>Methods: </strong>This retrospective observational study was conducted at the University Medical Center Ljubljana, the largest maternity hospital in Slovenia. The study included all women who delivered vaginally or via cesarean section between 2008 and 2024 and subsequently required medical assessment or hospitalization within six weeks postpartum. We analyzed the frequency and types of complications, paying special attention to infection rates by delivery method and microbiological findings from wound swabs.</p><p><strong>Results: </strong>Postpartum complications were observed in 7.6 % of women following vaginal birth and 10.6 % after cesarean delivery. Infections and breastfeeding-related problems were the most common causes for medical reevaluation. After vaginal delivery, breast complications such as mastitis or milk stasis represented 36.4 % of all cases, followed by minor perineal issues. Following cesarean section, surgical site complications were most frequent (42.1 %), with a wound infection rate of 7.7 %. Between 2020 and 2024, readmissions to intensive care occurred in 0.92 % of vaginal deliveries and 2.76 % of cesarean deliveries. Endometritis was the most common infection after vaginal birth, while wound infections predominated post-cesarean. Wound swab cultures often revealed polymicrobial flora.</p><p><strong>Conclusions: </strong>Postpartum infections remain a leading complication, particularly after cesarean delivery. Strengthening preventive measures including antibiotic prophylaxis, timely postpartum follow-up, and continuous microbial surveillance is critical to reducing maternal morbidity and supporting more effective, targeted interventions.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and mortality trends in congenital diaphragmatic hernia in the United States.","authors":"Nihaal D Shah, Fredrick Dapaah-Siakwan","doi":"10.1515/jpm-2025-0195","DOIUrl":"https://doi.org/10.1515/jpm-2025-0195","url":null,"abstract":"<p><strong>Objectives: </strong>The average incidence of congenital diaphragmatic hernia (CDH) in the United States (US) is 2.6 per 10,000 live births but it varies based on the population studied, the database used, and the study period. Further, previous studies suggest that pre-discharge mortality in CDH is declining but this may not capture the 'hidden mortality' and post-discharge mortality. We examined a population-based database to evaluate the trends in the incidence (2016-2023) and CDH-related infant mortality rate (CDH-IMR) [2007-2022] in the US.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional analysis of the CDC WONDER database. First, we queried the 2016-2023 natality dataset derived from birth certificates for live births with CDH (ICD-10 code Q79.0). We expressed CDH incidence as per 10,000 live births. Next, we queried the linked birth/infant death dataset from 2007 to 2022 for CDH-IMR through 1 year of age. CDH-IMR was expressed per 100,000 live births. Trends were evaluated with Joinpoint regression and reported using average annual percentage change (AAPC) with 95 % confidence intervals (CI).</p><p><strong>Results: </strong>Among 29, 880, 509 live births between 2016 and 2023, 3,797 had CDH (1.3 per 10,000). Of these, 33.4 % were transferred within 24 h after birth. There was no significant change in the CDH incidence during the study period (AAPC 0.93 %; CI: -0.1, 2.0). The overall CDH-IMR (per 100,000) was 5.7, and it declined significantly from 6.3 in 2007 to 4.7 in 2022 (AAPC: -1.5 %; CI: -2.2, -0.8).</p><p><strong>Conclusions: </strong>The CDH incidence, which was lower than previously reported and did not change from 2016 to 2023, requires validation. The downward trend in mortality needs ongoing surveillance to monitor the impact of new management strategies on mortality rates.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver fibrosis markers as predictors of adverse outcomes in pregnancy-related hypertensive disorders.","authors":"Murad Gezer, Ümit Taşdemir, Mucize Eriç Özdemir, Sevdenur Yiğit, Büşra Cambaztepe, Oya Demirci","doi":"10.1515/jpm-2025-0190","DOIUrl":"https://doi.org/10.1515/jpm-2025-0190","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare noninvasive liver fibrosis markers, including the Aspartate Aminotransferase Platelet Ratio Index (APRI) and FIB-4, between patients with hypertensive disorders of pregnancy (HDP) and healthy controls and to investigate the association between these markers and adverse maternal and perinatal outcomes.</p><p><strong>Methods: </strong>In this retrospective case-control study, 205 patients with HDP and 192 normotensive controls were included for evaluation. Demographic data, laboratory findings, and maternal and perinatal outcomes were compared. FIB-4 and APRI scores were calculated using second-trimester AST, ALT, and platelet levels. ROC curve analysis was used to assess the predictive accuracy of these indices for HELLP syndrome and other complications. Linear regression analysis was applied to evaluate the parameters associated with the FIB-4 score.</p><p><strong>Results: </strong>FIB-4 and APRI scores were significantly higher in patients with HDP compared to controls (p<0.05). Among patients with severe preeclampsia and HELLP syndrome, fibrosis scores were markedly elevated. FIB-4 and APRI showed excellent diagnostic performance for HELLP syndrome (AUC: 0.976 and 0.992, respectively), with optimal cutoffs of 1.52 and 0.7. However, their predictive role for general adverse maternal and perinatal outcomes was limited. In multivariate regression, systolic blood pressure, maternal age, and adverse maternal outcomes were independent predictors of increased FIB-4 scores (p<0.05).</p><p><strong>Conclusions: </strong>FIB-4 and APRI may be considered simple, noninvasive indices that could contribute to early risk stratification for HELLP syndrome among patients with HDP. Although their predictive capacity remains to be validated in larger prospective studies, they may offer preliminary insights into hepatic dysfunction during pregnancy.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal maternal stress and long-term neurodevelopmental outcomes: a narrative review.","authors":"Dimitris Baroutis, Ioanna Myrto Sotiropoulou, Rafail Mantzioros, Marianna Theodora, George Daskalakis, Panagiotis Antsaklis","doi":"10.1515/jpm-2025-0297","DOIUrl":"https://doi.org/10.1515/jpm-2025-0297","url":null,"abstract":"<p><strong>Introduction: </strong>Maternal stress during pregnancy has been increasingly recognized as a significant factor influencing fetal development, with potential long-term effects on neurodevelopmental outcomes in offspring. Understanding the mechanisms and implications of prenatal stress exposure is crucial for informing preventative and interventional strategies in perinatal care.</p><p><strong>Content: </strong>This narrative review synthesizes findings from epidemiological, neurobiological, and clinical research on the long-term consequences of prenatal maternal stress. It explores a broad spectrum of stressors - including psychological distress, depression, anxiety, and acute traumatic events such as natural disasters - and their associations with cognitive, behavioral, and emotional outcomes in offspring from infancy through adolescence. Key biological mechanisms are discussed, including alterations in the maternal-placental-fetal axis, HPA axis dysregulation, placental gene expression changes, epigenetic modifications, and neuroinflammatory responses. Neuroimaging and biomarker studies are highlighted to provide evidence for stress-related changes in brain structure and function.</p><p><strong>Summary: </strong>Current literature supports a robust association between maternal stress during pregnancy and a heightened risk of neurodevelopmental challenges in children. These include deficits in executive function, increased anxiety and depressive symptoms, emotional dysregulation, and susceptibility to psychiatric disorders. The effects appear to be moderated by timing of exposure, genetic predispositions, and the postnatal environment.</p><p><strong>Outlook: </strong>While the evidence base is growing, methodological limitations such as variability in stress assessment and inconsistent follow-up durations persist. Future research should emphasize longitudinal, biomarker-informed designs and evaluate interventions aimed at reducing prenatal stress. Integrating maternal mental health support into routine prenatal care may offer a promising pathway to improving both maternal and child outcomes.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutriepigenomics in perinatal medicine: maternal nutrition as a modulator of fetal gene expression and long-term health.","authors":"Wiku Andonotopo, Muhammad Adrianes Bachnas, Julian Dewantiningrum, Mochammad Besari Adi Pramono, Sri Sulistyowati, I Nyoman Hariyasa Sanjaya, Milan Stanojevic, Asim Kurjak","doi":"10.1515/jpm-2025-0289","DOIUrl":"https://doi.org/10.1515/jpm-2025-0289","url":null,"abstract":"<p><strong>Introduction: </strong>Maternal nutrition during pregnancy can influence fetal development through epigenetic modifications, affecting gene expression without altering DNA sequence. Nutriepigenomics - the study of nutrient-driven epigenetic regulation - provides critical insights into how prenatal nutritional exposures can shape immediate and lifelong health outcomes.</p><p><strong>Content: </strong>This narrative review synthesizes evidence from human cohort studies and experimental animal models on how macro- and micronutrients, including folate, vitamin B12, choline, vitamin D, omega-3 fatty acids, and bioactive compounds such as polyphenols and resveratrol, modify key epigenetic processes. These include DNA methylation, histone modifications, and non-coding RNA regulation, particularly within the placenta and developing fetal tissues.</p><p><strong>Summary: </strong>Maternal diet-induced epigenetic changes influence fetal metabolic programming, neurodevelopment, immune maturation, and organogenesis, with impacts detectable at birth and persisting into adulthood. Evidence indicates associations with altered birthweight trajectories, increased risk of childhood obesity and immune dysregulation, and potential elevation in lifelong cardiometabolic and neuropsychiatric disease risk.</p><p><strong>Outlook: </strong>Integrating nutriepigenomic insights into perinatal care offers opportunities for early preventive strategies and personalized nutrition interventions. Translational application of epigenetic biomarkers, coupled with population-level nutritional policies, could reduce disease risk across generations and improve long-term population health outcomes.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference ranges for fetal tricuspid and mitral annular plane systolic excursions.","authors":"Jakkapop Kanjak, Ratana Komwilaisak, Piyamas Saksiriwuttho, Kiattisak Kongwattanakul, Sukanya Chaiyarach, Chatuporn Duangkum, Termtem Waidee","doi":"10.1515/jpm-2025-0189","DOIUrl":"https://doi.org/10.1515/jpm-2025-0189","url":null,"abstract":"<p><strong>Objectives: </strong>Echocardiography is the standard tool for assessing fetal cardiac function. Tricuspid annular plane systolic excursion (TAPSE) and mitral annular plane systolic excursion (MAPSE) are simple, reliable indicators of systolic function. Many studies have established reference ranges in adult and pediatric populations; however, data remain limited in fetuses, especially in Southeast Asia. The aim of the study was to establish normal reference ranges for TAPSE and MAPSE in fetuses born between 18 + 0 and 37 + 6 weeks' gestation in a Southeast Asian population.</p><p><strong>Methods: </strong>This prospective, cross-sectional study was conducted between January 2024 and February 2025. Data from 280 singleton pregnancies with normal fetal growth and no maternal comorbidities were included in the study. TAPSE and MAPSE were measured using M-mode imaging in a four-chamber view. Percentile reference values were determined using quantile regression models, with gestational age (GA) and estimated fetal weight (EFW) as predictors. The intraclass correlation coefficient (ICC) was used to assess intra- and interobserver reliability.</p><p><strong>Results: </strong>TAPSE and MAPSE were significantly and positively correlated with GA and EFW. Mean TAPSE ranged from 3.76 to 9.08 mm (GA) and 3.42 to 9.30 mm (EFW), while MAPSE ranged from 3.10 to 6.34 mm (GA) and 2.71 to 6.60 mm (EFW). The TAPSE values consistently exceeded the MAPSE values across all GAs. The inter- and intra-observer ICCs were high (TAPSE, 0.94/0.91; MAPSE, 0.91/0.88).</p><p><strong>Conclusions: </strong>This study established the first normal TAPSE and MAPSE reference ranges for a Southeast Asian population and provided reliable tools for fetal cardiac assessment.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational diabetes and fetal macrosomia: a dissenting opinion.","authors":"Renata Košir Pogačnik, Maja Krajec, Marija Batkoska, Andreja Trojner Bregar","doi":"10.1515/jpm-2025-0247","DOIUrl":"https://doi.org/10.1515/jpm-2025-0247","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the effect of interaction between parity, overweight/obesity, gestational weight gain, and gestational diabetes mellitus (GDM) on the incidence of fetal macrosomia.</p><p><strong>Methods: </strong>We used a population-based dataset to establish the incidence of macrosomia (birth weight >4000 g) in singleton births at ≥38 weeks' gestation. The cohort included women who were (1) overweight/obese or had normal body mass index (BMI) before pregnancy, (2) nulliparous or multiparous, (3) with appropriate or excessive weight gain, and (4) without GDM, with GDM controlled by nonpharmacological treatment (GDM0), or with GDM requiring insulin treatment (GDM1).</p><p><strong>Results: </strong>We examined 129 686 births at ≥38 weeks. The mean gestational age at birth for all subgroup was similar. When compared with a reference incidence for nulliparas with normal pregravid BMI, appropriate weight gain, and without GDM, all variables, except GDM, independently and significantly increased the incidence of neonates weighing >4000 g. The logistic regression analysis found that excessive weight gain, pregravid BMI >25, and parity were the only independent factors associate with birth weight >4000 g.</p><p><strong>Conclusions: </strong>Well-managed GDM is not significantly associated with macrosomia, whereas pre-pregnancy obesity, excessive gestational weight gain, and parity appear to be significant risk factors. These results emphasize the need for effective weight management before and during pregnancy to reduce the risk of fetal overgrowth.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antepartum cerebroplacental ratio in low risk pregnancy and its relationship with adverse perinatal outcome: a prospective cohort study.","authors":"Neha Rathore, Manu Goyal, Pratibha Singh, Taruna Yadav, Shashank Shekhar","doi":"10.1515/jpm-2025-0114","DOIUrl":"https://doi.org/10.1515/jpm-2025-0114","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the relationship of cerebroplacental ratio (CPR) with non-reassuring/abnormal cardiotocography (CTG) tracing and perinatal outcomes like operative delivery, birth weight, NICU admission, meconium-stained liquor, and APGAR score in low-risk pregnancy.</p><p><strong>Methods: </strong>This was a prospective cohort study at tertiary center in western India which included low risk singleton pregnancies between 35 and 37+6 weeks with cephalic presentation. Ultrasound was done between 35 and 37+6 weeks gestation including fetal biometry and Doppler for CPR calculation. Patients were divided into two groups, with normal CPR (>10th centile) and abnormal CPR (≤10th centile), and maternal and neonatal outcomes were compared.</p><p><strong>Results: </strong>Out of 172 cases enrolled, CPR was abnormal in 55 (31.97 %) patients and normal in 117 (68.02 %) patients. In abnormal CPR group, CTG tracing was reassuring in 61.81 %, non-reassuring in 18.18 %, and abnormal in 20 %. While in normal CPR group, CTG tracing was reassuring in 81.19 %, non-reassuring in 11.11 %, and abnormal in 7.69 %. This was significant difference between the two groups (p=0.027). Cesarean and operative vaginal delivery rates were comparable in both groups, (p value=0.63, 0.33). Lower birth weight was observed in 45.45 % of women in the abnormal CPR group, while 21.36 % of women had low birth weight in the normal CPR group (p value=0.006). No significant difference was found in APGAR score and NICU admissions between the two groups (p-value-0.94, 0.87).</p><p><strong>Conclusions: </strong>We conclude that CPR measurement has good negative predictive value for fetal outcome in low risk pregnancy.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}