Journal of Perinatal Medicine最新文献

{"title":"Fetal mental programming: maternal psychological homeostasis as a placenta-mediated determinant of cognitive and emotional development - an integrative perspective.","authors":"Wiku Andonotopo, Muhammad Adrianes Bachnas, Mochammad Besari Adi Pramono, Julian Dewantiningrum, Efendi Lukas, I Nyoman Hariyasa Sanjaya, Anak Agung Gede Putra Wiradnyana, Anak Agung Ngurah Jaya Kusuma, Khanisyah Erza Gumilar, Ernawati Darmawan, Muhammad Ilham Aldika Akbar, Dovy Djanas, Dudy Aldiansyah, Aloysius Suryawan, Ridwan Abdullah Putra, Theresia Monica Rahardjo, Rizna Tyrani Rumanti, Roland Frederik Lengkey, Julia Windi Gunadi, Anita Deborah Anwar, Cut Meurah Yeni, Aryani Aziz, Nuswil Bernolian, Donel Suhaimi, Agus Rusdhy Hamid, Laksmana Adi Krista Nugraha, Waskita Ekamaheswara Kasumba Andanaputra, Wibisana Andika Krista Dharma, Sri Sulistyowati, Milan Stanojevic, Asim Kurjak","doi":"10.1515/jpm-2026-0068","DOIUrl":"https://doi.org/10.1515/jpm-2026-0068","url":null,"abstract":"<p><strong>Background: </strong>Fetal programming has traditionally been interpreted through metabolic and endocrine paradigms, while maternal psychological regulation remains underdeveloped as a biological determinant of neurodevelopment. Emerging evidence from placental biology, epigenetics, and fetal neuroimaging suggests that maternal psychological states may act not only as contextual exposures but also as dynamic physiological signals during pregnancy.</p><p><strong>Content: </strong>This article proposes an integrative perspective in which maternal psychological homeostasis is conceptualized as a multidimensional regulatory state encompassing endocrine, immune, autonomic, and circadian processes. We hypothesize that the placenta functions as an active signal-processing interface, translating maternal physiological signals into developmental cues. Potential mechanisms include glucocorticoid signaling, inflammatory pathways, and epigenetic regulation, which may influence fetal neural connectivity, stress-response systems, and early neurobehavioral organization. Although converging findings support biological plausibility, the evidence remains heterogeneous, with uncertainties regarding causality and timing.</p><p><strong>Summary: </strong>Within this framework, fetal mental programming may arise, in part, from maternal psychological regulation as it is integrated within placental biology, involving interacting and temporally sensitive regulatory layers rather than a single pathway.</p><p><strong>Outlook: </strong>Future research should prioritize longitudinal human studies, validation of placental biomarkers, and identification of sensitive developmental windows. Improved understanding may support integration of mental health into perinatal care and inform early preventive strategies.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: The fetus as a patient in the 21st century: science, ethics, technology and global responsibility.","authors":"Ivica Zalud, Milan Stanojevic, Amos Grunebaum, Frank A Chervenak","doi":"10.1515/jpm-2026-0279","DOIUrl":"https://doi.org/10.1515/jpm-2026-0279","url":null,"abstract":"","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148055082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A lifetime of innovation, visionary leadership, and global mentorship in Doppler ultrasound: honoring professor Asim Kurjak.","authors":"Ivica Zalud","doi":"10.1515/jpm-2026-0088","DOIUrl":"10.1515/jpm-2026-0088","url":null,"abstract":"<p><p>Professor Asim Kurjak is internationally recognized as one of the most influential pioneers in medical ultrasound and perinatal medicine. His lifelong contributions to Doppler ultrasound fundamentally reshaped obstetric and gynecologic practice worldwide, with measurable impact on maternal and perinatal morbidity and mortality. From seminal work in uteroplacental and fetal circulation to pioneering applications of transvaginal color and three-dimensional Doppler imaging, Professor Kurjak's visionary leadership and mentorship established a global school of thought that transcended geographic, political, and economic boundaries. His achievements are particularly remarkable given that much of this transformative work originated in a small country, Croatia, yet profoundly influenced clinical practice across the world.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"645-647"},"PeriodicalIF":1.3,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy and delivery outcomes in fetal macrosomia (birth weight exceeding 5,000 g).","authors":"Manfred Voigt, Hans-Peter Hagenah, Ralf L Schild, Jasper Ehlermann, Niels Rochow, Josefine Königbauer, Joachim W Dudenhausen","doi":"10.1515/jpm-2025-0276","DOIUrl":"10.1515/jpm-2025-0276","url":null,"abstract":"<p><strong>Objectives: </strong>This study examines the association between fetal macrosomia (>5,000 g) and pregnancy and birth outcomes.</p><p><strong>Methods: </strong>This was a retrospective cohort study using data from the perinatal survey of Lower Saxony, Germany (2001-2009).</p><p><strong>Results: </strong>Pregnancies complicated by advanced maternal age (>35 years), elevated BMI (>25.0), and excessive gestational weight gain were significantly more likely to result in macrosomic births. Additionally, pregnancies involving macrosomic fetuses were characterized by prolonged gestation and an increased likelihood of cesarean delivery. Neonates with macrosomia exhibited significantly lower Apgar scores at 1, 5, and 10 min (<7) compared to the control group (<5,000 g), though umbilical artery pH values did not differ significantly between groups.</p><p><strong>Conclusions: </strong>These findings highlight the need for targeted prenatal monitoring and risk assessment in pregnancies predisposed to fetal macrosomia.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"752-760"},"PeriodicalIF":1.3,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral adjuvants supplemented to phototherapy as a therapeutic strategy for neonatal hyperbilirubinemia: a systematic review.","authors":"Luana Cardosos Tavares, Edson Gabriel Santos Nascimento, Leonardo Gouvêa de Oliveira, Luiz Arthur de Oliveira Nantes, Luana Nóbrega Dos Santos, Giovana Pereira Lobato Brito, Rita de Cássia Silva de Oliveira","doi":"10.1515/jpm-2025-0394","DOIUrl":"10.1515/jpm-2025-0394","url":null,"abstract":"<p><strong>Introduction: </strong>Neonatal jaundice is a common condition characterized by elevated serum bilirubin levels. Although usually benign, inadequate management may result in severe complications such as bilirubin encephalopathy and kernicterus. Phototherapy is the standard treatment; however, concerns regarding potential short- and long-term adverse effects have motivated the investigation of oral adjuvants as complementary therapies to accelerate bilirubin clearance and reduce phototherapy exposure.</p><p><strong>Content: </strong>This systematic review followed PRISMA guidelines and was registered in PROSPERO (CRD420251071886). Randomized controlled trials published between 2010 and 2025 were included, evaluating full-term neonates (35-42 weeks, 2-4 kg) without Rh incompatibility. Searches were conducted in PubMed, Cochrane Central, Embase, and Web of Science. Of 193 identified records, 18 RCTs met eligibility criteria. The oral adjuvants assessed included probiotics, phenobarbital, ursodeoxycholic acid (UDCA), oral calcium, zinc sulfate, fenofibrate, and clofibrate. Lactobacillus reuteri demonstrated greater 24-hour reductions in total serum bilirubin (TSB) compared to controls, whereas Bifidobacterium strains primarily reduced phototherapy duration. Phenobarbital did not outperform phototherapy alone and was associated with longer hospitalization. UDCA showed substantial bilirubin reductions, although findings were heterogeneous. Zinc supplementation did not demonstrate consistent significant benefit. Fenofibrate produced statistically significant decreases in TSB across trials and showed the most consistent efficacy. Clofibrate also reduced bilirubin levels but with methodological variability and limited comparative data.</p><p><strong>Summary: </strong>Oral adjuvants combined with phototherapy may enhance bilirubin reduction in term neonates, particularly fenofibrate.</p><p><strong>Outlook: </strong>However, heterogeneity and potential bias limit definitive conclusions, emphasizing the need for large, multicenter randomized trials.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"648-657"},"PeriodicalIF":1.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence rate of and risk factors for anorectal diseases in primiparae in the first 6 weeks following delivery.","authors":"Hao Sun, Bailing Zou, Chenglin Li","doi":"10.1515/jpm-2025-0480","DOIUrl":"10.1515/jpm-2025-0480","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to explore the incidence rate of and risk factors for anorectal diseases in primiparae in the first 6 weeks following delivery, and to establish a risk evaluation model for the early identification of high-risk groups and precise intervention.</p><p><strong>Methods: </strong>Subjects (350 in total) in this prospective observational cohort study were recruited from eligible primiparae who delivered between January 2023 and January 2025. The pregnancy data, intrapartum data and postpartum follow-up (completed at 1 week, 3 weeks and 6 weeks following delivery) data were acquired. Relevant variables were identified using univariate analysis plus Least Absolute Shrinkage and Selection Operator regression, and a machine learning Logistic regression prediction model was constructed.</p><p><strong>Results: </strong>Finally, 326 of the enrolled 350 primiparae finished the follow-up, with a completion rate of 93.14 %. The incidence rate of anorectal diseases in the first 6 weeks after delivery was 29.14 %. Prolonged second stage of labor, elevated fetal birth weights, increased pre-pregnancy body mass index (BMI), a history of gestational constipation, and epidural anesthesia served as independent risk factors (p<0.001). The area under the curve (AUC) of the prediction model was 0.928, which was well calibrated, and the mean AUC by 5-fold cross-validation was 0.865, implying good discrimination and generalization ability. The constructed nomogram realized individualized risk assessment.</p><p><strong>Conclusions: </strong>Prolonged second stage of labor, large fetal weights, high pre-pregnancy BMI, gestational constipation, and epidural anesthesia are considered independent risk factors. The model supports screening high-risk groups and improving postpartum anorectal health management.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"714-723"},"PeriodicalIF":1.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Gestational diabetes mellitus: the role of IGF-1 and leptin in cord blood.","authors":"Alexandra Krause, Karl Otfried Schwab, Julia Trost, Martine Thill, Mirjam Kunze, Jochen Seufert, Roland Hentschel","doi":"10.1515/jpm-2026-0080","DOIUrl":"https://doi.org/10.1515/jpm-2026-0080","url":null,"abstract":"","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":"54 3","pages":"641-644"},"PeriodicalIF":1.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of stillbirth: a retrospective study in China.","authors":"Xiaoyan Yang, Li Wu","doi":"10.1515/jpm-2025-0529","DOIUrl":"10.1515/jpm-2025-0529","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to analyze the incidence and causes of stillbirth, identify associated risk factors, and explore effective interventions.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 324 stillbirth cases admitted to the Obstetrics Department of Chongqing Health Center for Women and Children from January 2017 to December 2023. A comparison was made with live births in the same period. The study investigated the origins of stillbirth, identified key risk factors, and proposed strategies for the prevention and management of stillbirth.</p><p><strong>Results: </strong>The stillbirth rate was 3.2 ‰, with no significant variation over the 7 years (p>0.05). A \"U-shaped\" relationship was observed between maternal age and stillbirth. The incidence of stillbirth among multiparous women was significantly higher than among primiparous women. The top three maternal factors associated with stillbirth were genital malformations, severe preeclampsia, and infections, with stillbirth rates of 20 , 13, and 13 ‰, respectively. The top three umbilical cord and placental factors associated with stillbirth were identified as umbilical cord shortness, umbilical cord true knot, and placental abruption, with incidence rates of 19 , 17, and 11 ‰, respectively. Twin pregnancies had a stillbirth rate of 17 ‰. Advanced maternal age, multiparity, and twin pregnancies were identified as high-risk groups for stillbirth.</p><p><strong>Conclusions: </strong>To reduce stillbirth incidence, essential measures include strengthening pre-conception healthcare and counseling, proactively addressing pregnancy-related complications, improving monitoring methods throughout gestation and delivery, and refining midwifery skills.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"694-702"},"PeriodicalIF":1.3,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripartum haemorrhage and associated red blood cell transfusion.","authors":"Luisa Diecke, Elena Langer, Holger Stepan, Reinhard Henschler","doi":"10.1515/jpm-2025-0382","DOIUrl":"10.1515/jpm-2025-0382","url":null,"abstract":"<p><strong>Objectives: </strong>The safety and efficacy of peripartum transfusion support depends on a comprehensive risk analysis, the provision of substantiated criteria for ordering blood products, and surveillance of outcomes over time. We aimed to determine bleeding frequencies and volumes of blood loss, associated patient risk factors, and the effectiveness of our transfusion support scheme.</p><p><strong>Methods: </strong>Birth records of 12,255 pregnant women who gave birth at our hospital were screened for haemorrhage volumes, mode of delivery, bleeding aetiology, accompanying risk factors as well as outcome. Transfusion related data was extracted from the electronic blood product database.</p><p><strong>Results: </strong>A total of 204 (1.6 %) women who gave birth within the 5-year study period received at least one RBC transfusion within 48 h after delivery. Differences in haemorrhage volumes in all women compared to those receiving RBC transfusion confirmed an increased probability of RBC transfusion with larger haemorrhage volumes. Uterus atony bleeding (UAB) was the most common cause associated with transfusions. Six risk factors for RBC transfusion among transfused patients were identified that showed a probability of >10 %: Adherent placenta (31.4 %), preterm rupture of membranes (PROM) (25.5 %), age over 35 (25.0 %), a previous caesarean section (19.6 %), gestational diabetes mellitus (15.2 %), and a twin pregnancy (11.8 %). An overall crossmatch-to-transfusion (C/T) ratio of 2.75:1 was reached and no patient with major haemorrhage-related morbidity or mortality was recorded.</p><p><strong>Conclusions: </strong>Evaluation of peripartum haemorrhage and associated RBC transfusion using the described methodology revealed RBC transfusions in 1.6 % of all women who gave birth within the study period. The described blood ordering scheme demonstrates a safe and efficient utilisation of blood products.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"734-743"},"PeriodicalIF":1.3,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early kangaroo care in preterm ≤32 weeks and very low birth weight infants: a systematic review and meta-analysis.","authors":"Joana Arêde Martins, Renato Ferreira-da-Silva, André Assunção, Fátima Clemente, Inês Azevedo, Sandra Costa","doi":"10.1515/jpm-2025-0202","DOIUrl":"10.1515/jpm-2025-0202","url":null,"abstract":"<p><strong>Objectives: </strong>Kangaroo care (KC), involving skin-to-skin contact, early breastfeeding and early discharge, demonstrated benefits in improving outcomes for preterm and low birth weight infants. This systematic review and meta-analysis aimed to evaluate the effectiveness of early KC (initiated within the first 24 h) vs. conventional neonatal care in very preterm infants (≤32 weeks) and/or very low birth weight (VLBW) infants (<1,500 g).</p><p><strong>Methods: </strong>A comprehensive search of MEDLINE, SCOPUS, Web of Science, and CENTRAL databases was conducted. Randomized controlled trials (RCTs) comparing early KC to conventional care in very preterm and/or VLBW infants were included. Risk of bias was assessed using the <i>Cochrane Risk of Bias tool</i>. Meta-analysis was conducted using R, with relative risks (RR) and 95 % confidence intervals (CI) calculated.</p><p><strong>Results: </strong>Four RCTs, encompassing 1,679 newborns, were included. Meta-analysis revealed a significant reduction in mortality risk (RR=0.81, 95 % CI: 0.67-0.98) with early KC. The pooled RR for infection risk was 0.89 (95 % CI: 0.77-1.02). The impact on hypothermia was mixed, with moderate heterogeneity observed.</p><p><strong>Conclusions: </strong>Early KC may reduce mortality and morbidity in very preterm and VLBW infants although its effects on hypothermia vary by severity. Further studies are required to assess its effects on infants weighing <1,000 g or born before 28 weeks of gestation.</p>","PeriodicalId":16704,"journal":{"name":"Journal of Perinatal Medicine","volume":" ","pages":"799-810"},"PeriodicalIF":1.3,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}