Journal of pediatric rehabilitation medicine最新文献_第7页

REhabilitation Approaches in CHildren with cerebellar mutism syndrome (REACH): An international cross-disciplinary survey study. 小脑缄默症儿童康复方法（REACH）：一项国际跨学科调查研究。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-230006

Sharyl Samargia-Grivette, Helen Hartley, Karin Walsh, Jurgen Lemiere, Allison D Payne, Emma Litke, Ashley Knight

{"title":"REhabilitation Approaches in CHildren with cerebellar mutism syndrome (REACH): An international cross-disciplinary survey study.","authors":"Sharyl Samargia-Grivette, Helen Hartley, Karin Walsh, Jurgen Lemiere, Allison D Payne, Emma Litke, Ashley Knight","doi":"10.3233/PRM-230006","DOIUrl":"10.3233/PRM-230006","url":null,"abstract":"Objective: Pediatric cerebellar mutism syndrome (pCMS) can occur following resection of a posterior fossa tumor and, although some symptoms are transient, many result in long-lasting neurological deficits. A multi-disciplinary rehabilitation approach is often used in cases of pCMS; however, there have been no clinical trials to determine gold standards in rehabilitation practice in this population, which remains a research priority. The purpose of this study was to identify and compare intervention practices used in pCMS throughout the disciplines of occupational and physical therapy, speech-language pathology, and neuropsychology across geographic regions.Methods: A 55-question e-survey was created by an international multidisciplinary research group made up of members of the Posterior Fossa Society and sent to rehabilitation professionals in pediatric neuro-oncology centers in the US, Canada, and Europe.Results: Although some differences in the type of intervention used in pCMS were identified within each discipline, many of the targeted interventions including dose, frequency, and intensity were similar within disciplines across geographic regions. In addition, there were common themes identified across disciplines regarding challenges in the rehabilitation of this population.Conclusion: These results provide a foundation of current practices on which to build future intervention-based clinical trials.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"185-197"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid prescription patterns among commercially insured children with and without cerebral palsy. 患有和未患有脑瘫的商业保险儿童的阿片类药物处方模式。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-230009

Lubna Ayoubi, Jessica Pruente, Alecia K Daunter, Steven R Erickson, Daniel Whibley, Daniel G Whitney

{"title":"Opioid prescription patterns among commercially insured children with and without cerebral palsy.","authors":"Lubna Ayoubi, Jessica Pruente, Alecia K Daunter, Steven R Erickson, Daniel Whibley, Daniel G Whitney","doi":"10.3233/PRM-230009","DOIUrl":"10.3233/PRM-230009","url":null,"abstract":"Purpose: This study aimed to describe opioid prescription patterns for children with vs. without cerebral palsy (CP).Methods: This cohort study used commercial claims from 01/01/2015-12/31/2016 and included children aged 2-18 years old with and without CP. Opioid prescription patterns (proportion exposed, number of days supplied) were described. A zero-inflated generalized linear model compared the proportion exposed to opioids in the follow-up year (2016) and, among those exposed, the number of days supplied opioids between cohorts before and after adjusting for age, gender, race, U.S. region of residence, and the number of co-occurring neurological/neurodevelopmental disabilities (NDDs).Results: A higher proportion of children with (n = 1,966) vs. without (n = 1,219,399) CP were exposed to opioids (12.1% vs. 5.3%), even among the youngest age group (2-4 years: 9.6% vs. 1.8%), and had a greater number of days supplied (median [interquartile range], 8 [5-13] vs. 6 [4-9] days; P < 0.05). Comparing children with opioid exposure with vs. without CP, a greater number of days supplied was identified for older age, Asian race/ethnicity, and without co-occurring NDDs, and a lower number of days supplied was observed for Black race/ethnicity and with ≥1 co-occurring NDDs.Conclusion: Children with CP are more likely to be exposed to opioids and have a higher number of days supplied.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"47-56"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of a model for pediatric physical therapy and clinical education via telehealth. 通过远程医疗进行儿科物理治疗和临床教育的模式分析。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-220112

Courtney McKenzie, Melanie Titzer, Alyssa Hutchinson, Camaran Dodge, Andrea Fergus

{"title":"Analysis of a model for pediatric physical therapy and clinical education via telehealth.","authors":"Courtney McKenzie, Melanie Titzer, Alyssa Hutchinson, Camaran Dodge, Andrea Fergus","doi":"10.3233/PRM-220112","DOIUrl":"10.3233/PRM-220112","url":null,"abstract":"A novel entry-level collaborative clinical learning experience (CLE) in pediatric physical therapy (PT) delivered via telehealth was implemented involving 12 families, 54 DPT students, and 12 clinical instructors (CIs). Children of various ages, a wide range of home environments, and diagnoses received individualized PT via telehealth during a four-week CLE. Retrospective quantitative and qualitative analyses of student documentation, video recordings of sessions, and CI, student, and caregiver survey responses were performed. All children demonstrated qualitative improvements and 73% demonstrated quantitative improvements. CIs, students, and caregivers believed the children benefited from the experience and 98% believed the children were able to work toward their goals. Most students (95%) and CIs (100%) felt that it was a valuable and effective learning experience. Most (>71%) CIs and students believed students were able to learn in all relevant domains of the clinical performance instrument. This model provides a unique CLE for students in both pediatric PT and telehealth.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"271-288"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The critical need to accelerate cerebral palsy research with consumer engagement, global networks, and adaptive designs. 迫切需要通过消费者参与、全球网络和适应性设计来加快脑瘫研究。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-240014

Sruthi P Thomas, Iona Novak, Anina Ritterband-Rosenbaum, Karin Lind, Annabel Webb, Paul Gross, Maria McNamara

{"title":"The critical need to accelerate cerebral palsy research with consumer engagement, global networks, and adaptive designs.","authors":"Sruthi P Thomas, Iona Novak, Anina Ritterband-Rosenbaum, Karin Lind, Annabel Webb, Paul Gross, Maria McNamara","doi":"10.3233/PRM-240014","DOIUrl":"10.3233/PRM-240014","url":null,"abstract":"The prevalence of cerebral palsy (CP) varies globally, with higher rates and burden of disease in low- and middle-income countries. CP is a lifelong condition with no cure, presenting diverse challenges such as motor impairment, epilepsy, and mental health disorders. Research progress has been made but more is needed, especially given consumer demands for faster advancements and improvements in the scientific evidence base for interventions. This paper explores three strategies to accelerate CP research: consumer engagement, global clinical trial networks, and adaptive designs. Consumer engagement involving individuals with lived experience enhances research outcomes. Global clinical trial networks provide efficiency through larger and more diverse participant pools. Adaptive designs, unlike traditional randomized controlled trials, allow real-time modifications based on interim analyses, potentially answering complex questions more efficiently. The establishment of a CP Global Clinical Trials Network, integrating consumer engagement, global collaboration, and adaptive designs, marks a paradigm shift. The Network aims to address consumer-set research priorities. While challenges like ethical considerations and capacity building exist, the potential benefits for consumers, clinicians, researchers, and funding bodies are substantial. This paper underscores the urgency of transforming CP research methodologies for quicker translation of novel treatments into clinical practice to improve quality of life for those with CP.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":"17 1","pages":"9-17"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140326721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oculomotor screening and neuro-visual rehabilitation following pediatric brain tumor resection. 儿童脑肿瘤切除术后的眼动筛查和神经视觉康复。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-220127

Per Ertzgaard, Per Nyman, Maria Jakobsson, Jan Johansson

{"title":"Oculomotor screening and neuro-visual rehabilitation following pediatric brain tumor resection.","authors":"Per Ertzgaard, Per Nyman, Maria Jakobsson, Jan Johansson","doi":"10.3233/PRM-220127","DOIUrl":"10.3233/PRM-220127","url":null,"abstract":"Visual difficulties are common after brain tumors, despite a lack of visual complaints at diagnosis. These include difficulties with eye movements, visual coordination, vergence, accommodation, and photophobia, in addition to more obvious problems such as visual field defects. This case report presents the results of a thorough neuro-visual evaluation in a boy with sequelae after a brain tumor including intermittent double vision that was not explained by routine visual examination. Subjective complaints included poor reading perseverance, intermittent blurred and double vision, headache around the eyes when performing near activities, less efficient eye movement behavior in reading tasks, and increased sensitivity to visual motion. The patient participated in a multidisciplinary visual rehabilitation program that included reading glasses with prism compensation and tinted glasses, as well as training with the aim of improving eye teaming, near vision functions, and perseverance in eye movements. The patient responded quickly to the vision therapy program, with positive changes after just four weeks. Repeated neuro-visual evaluations over eight months showed remarkable improvements that were stable over time. This encouraging case report supports the notion that neuro-visual evaluation and rehabilitation should be included in the follow-up of patients after brain tumors.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"253-260"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ankle proprioception in children with cerebral palsy. 脑瘫患儿的踝关节本体感觉。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-220140

Elizabeth Boyer, Qiyin Huang, Stacy Ngwesse, Jennifer Nelson, Jinseok Oh, Jürgen Konczak

{"title":"Ankle proprioception in children with cerebral palsy.","authors":"Elizabeth Boyer, Qiyin Huang, Stacy Ngwesse, Jennifer Nelson, Jinseok Oh, Jürgen Konczak","doi":"10.3233/PRM-220140","DOIUrl":"10.3233/PRM-220140","url":null,"abstract":"Purpose: There is no established clinical standard to evaluate ankle proprioception in children with cerebral palsy (CP). This study compared ankle position sense of children with CP to age-matched children who are typically developing (TD).Methods: Children aged 6-17 years participated (15 CP, 58 TD). Using a custom-built device, the ankle was passively rotated to two positions for 25 trials. Using a psychophysical forced-choice paradigm, participants indicated which position was more plantarflexed. A psychometric function was fitted to the response data to determine the just noticeable difference (JND) threshold and the associated uncertainty (random error) for ankle position sense.Results: Median JND thresholds for the CP group were elevated (CP: 4.3°, TD: 3.0°). Three children with CP exceeded the 95th percentile of TD. No differences in random error were found.Conclusion: This method assessed ankle proprioception relative to norm data and identified position sense impairments in children with CP. Using this method can provide data on proprioceptive status in CP, augmenting the assessment of motor impairment.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"75-83"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rehabilitation and functional outcomes for thoraco-omphalo-ischiopagus conjoined twins five years after separation: A case report. 胸脑异畸形连体婴儿分离五年后的康复和功能疗效：病例报告。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-220121

Dana L Sheng, Shawna Arsenault, Michael Wadekamper, Eric Smith

{"title":"Rehabilitation and functional outcomes for thoraco-omphalo-ischiopagus conjoined twins five years after separation: A case report.","authors":"Dana L Sheng, Shawna Arsenault, Michael Wadekamper, Eric Smith","doi":"10.3233/PRM-220121","DOIUrl":"10.3233/PRM-220121","url":null,"abstract":"Conjoined twins are identical twins joined in utero and are a rare phenomenon. This report discusses a case of female thoraco-omphalo-ischiopagus tripus conjoined twins. The twins were separated at age two, and once medically stable, spent one month in inpatient rehabilitation to improve their sitting balance and gross motor skills. This was followed by outpatient physical therapy. The twins initially had customized ZipZac seats, which they were able to wheel independently. After six months of therapy, the girls began walking with posterior walkers and prostheses. The hemipelvectomy prosthesis included a customized thoracolumbosacral orthosis component and was directly attached to a non-articulated pylon. A manual-locking hip joint was added to accommodate sitting. An articulated ankle-foot orthosis was used for the intact leg. Care of formerly conjoined twins requires comprehensive care from a multidisciplinary team involving, but not limited to, a physiatrist, orthopaedic surgeon, physical therapist, and orthotist/prosthetist. Complex congenital limb deficiencies are often a major undertaking for the rehabilitation team as continuous treatment and management are needed throughout the patient's lifetime due to growth, development, and evolving physical demands. Anatomic variations must be examined on a case-by-case basis but often include limb deficiencies, orthopedic abnormalities, and organ comorbidities.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"261-269"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of serial casting protocols in idiopathic toe-walking. 连续铸造方案对特发性足趾行走症的疗效。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-230041

Tyler Shirel, Tonye Sylvanus, Kelly Cho, Amy Authement, Linda E Krach

{"title":"Efficacy of serial casting protocols in idiopathic toe-walking.","authors":"Tyler Shirel, Tonye Sylvanus, Kelly Cho, Amy Authement, Linda E Krach","doi":"10.3233/PRM-230041","DOIUrl":"10.3233/PRM-230041","url":null,"abstract":"Objective: Idiopathic toe-walking (ITW) is a diagnosis of exclusion. A relationship between ITW and decreased range of motion (ROM) is postulated. Treatments focus on increasing ankle dorsiflexion including serial casting. There is no consensus for duration of serial casting. This study aimed to determine ROM changes with cast change intervals of one vs. two weeks, and the rate of ITW recurrence.Methods: This was a retrospective study of 86 patients, ages 0-9 years with ITW undergoing weekly casting (N = 29) and two-week casting (N = 57) at a children's hospital from 2014-2020. ROM at baseline, two weeks, four weeks, and final cast removal were collected. Statistical analyses included chi-squared tests, two-sample t-tests, and linear mixed regression. Outcome distributions were assessed for normality. P-values < 0.05 were considered statistically significant.Results: After adjusting for baseline ROM, the mean change in ROM from baseline to two weeks was 10.6∘ vs 7.5∘ in the one-week vs. two-week casting interval, respectively (p < 0.001). The baseline to final measurement was 13.4∘ vs 9.8∘ in the one-week vs. two-week casting interval, respectively (p < 0.001). The rate of recurrence of ITW was similar between the two groups.Conclusion: This study suggests greater improvement in ROM in the one-week vs. two-week casting interval group.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"179-184"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidisciplinary physical rehabilitation program of individuals with spinal muscular atrophy in an inclusive school setting. 脊髓性肌萎缩症患者在包容性学校环境中的多学科物理康复计划。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-230008

Faruq Ahmed, Asma Islam, Suria Akter, Md Abdullah Al Zubayer, Md Nasim Mahmud, Hosneara Yeasmin, Zannatul Mawa

{"title":"Multidisciplinary physical rehabilitation program of individuals with spinal muscular atrophy in an inclusive school setting.","authors":"Faruq Ahmed, Asma Islam, Suria Akter, Md Abdullah Al Zubayer, Md Nasim Mahmud, Hosneara Yeasmin, Zannatul Mawa","doi":"10.3233/PRM-230008","DOIUrl":"10.3233/PRM-230008","url":null,"abstract":"Spinal muscular atrophy (SMA) is a neuromuscular ailment that leads to the deprivation of motor neurons in the spinal cord, producing denervation and muscle weakness. This case report explains how a patient with type 2 SMA used a therapeutic exercise rehabilitation program in a school environment. Motor functions were assessed by Gross Motor Function Measure-88 (GMFM-88), Manual Muscle Testing (MMT), and Hammersmith Functional Motor Scale (HFMS), which is validated and reliable. This study employed a repeated pre-test post-test measures design. During a year of treatment sessions, the child underwent twice weekly 45-minute physical therapy sessions for 48 weeks. The research was carried out between March 2022 and February 2023. The purpose of the intervention, which comprised a variety of therapeutic workouts, was to enhance physical function and gross motor abilities in an age-appropriate manner. The intervention utilized in this study led to improvements in GMFM-88, HFMS, and MMT total scores. The results of this case study showed that a child with type 2 SMA aged nine had successfully improved their gross motor skills and muscle strength.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"247-252"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of botulinum toxin injections in children less than one year old: A retrospective chart review. 一岁以下儿童注射肉毒杆菌毒素的安全性：回顾性病历审查。

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Journal of pediatric rehabilitation medicine Pub Date : 2024-01-01 DOI: 10.3233/PRM-220003

Nikhil Deshpande, Mark E Gormley, Supreet Deshpande

{"title":"Safety of botulinum toxin injections in children less than one year old: A retrospective chart review.","authors":"Nikhil Deshpande, Mark E Gormley, Supreet Deshpande","doi":"10.3233/PRM-220003","DOIUrl":"10.3233/PRM-220003","url":null,"abstract":"Purpose: Infants can have muscle hypertonia due to cerebral palsy, muscle strength imbalances due to brachial plexus palsy, refractory clubfoot, and torticollis. These muscle problems can cause significant development impairments. A child with severe sialorrhea and dysphagia from leukodystrophy can aspirate, causing respiratory problems. Botulinum toxin (BoNT) injections can improve these conditions but may lead to adverse effects from the toxin spreading to non-targeted muscles, potentially impacting breathing, swallowing, and overall strength. This is particularly concerning in infants. This study assessed the safety of BoNT injections in children less than one year of age.Methods: This was a retrospective cohort study.Results: Forty-seven patients (22 male, 25 female) received BoNT injections before one year of age (three to 12 months). Thirty-seven received one round of injections and 10 were injected on multiple occasions. Forty-five received onabotulinumtoxinA (15-100 units [U], 1.9-15.2 U/kg), one received abobotulinumtoxinA (70 U, 9.0 U/kg), and one received incobotulinumtoxinA (25 U, 3.5 U/kg). Lower extremities were treated in 15 patients, upper extremities in 38, the sternocleidomastoid in two, and the salivary glands in one. Forty-five patients had no reported complications. One experienced transient fever, vomiting, and diarrhea. The parent of another reported subjective weakness in one muscle.Conclusion: BoNT injections in children less than one year of age appear to be safe.","PeriodicalId":16692,"journal":{"name":"Journal of pediatric rehabilitation medicine","volume":" ","pages":"67-73"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10977367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10343624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0