Journal of Parenteral and Enteral Nutrition最新文献

{"title":"Nutrition-impacting symptoms in survivors of critical illness: A descriptive cohort study.","authors":"Breanna J Teleki, Elizabeth Viner Smith, Rosalie Yandell, Matthew J Summers, Lee-Anne S Chapple","doi":"10.1002/jpen.2753","DOIUrl":"https://doi.org/10.1002/jpen.2753","url":null,"abstract":"<p><strong>Background: </strong>Oral intake is the most common route of nutrition following intensive care unit (ICU) discharge; yet is associated with inadequate intake, and barriers are largely unknown. This study aimed to determine the prevalence and severity of symptoms that may impact oral intake (termed nutrition-impacting symptoms) in ICU survivors.</p><p><strong>Methods: </strong>A single-center descriptive cohort study quantified prevalence and severity of nutrition-impacting symptoms in ICU survivors at ICU (T1) and hospital (T2) discharge and at 1 month posthospital discharge (T3) via patient-reported questionnaires. Secondary outcomes were nutrition status (via Subjective Global Assessment) and energy and protein intakes (via 24-h recall). Data are median (IQR) or (percent).</p><p><strong>Results: </strong>Forty-nine ICU survivors (64 [51-71] years; 31% female) were included. The most prevalent nutrition-impacting symptoms were T1: tiredness (96%), loss of appetite (82%), and early satiety (82%); T2: tiredness (93%), early satiety (88%), and dry mouth (78%); and T3: tiredness (95%), early satiety (81%), and low mood (66%). Nutrition-impacting symptoms with the greatest severity (out of 10, higher equates to worse) at each time point were T1: tiredness, constipation, diarrhea, nausea (all 8 [5-10]); T2: tiredness and constipation (both 7 [5-8]); and T3: tiredness (6 [3-8]) and diarrhea (6 [2-7]). Malnutrition rates were 34% at T1. Energy and protein intakes were T1: 1046 [548-1481] kcal, 45.2 [23.9-61.0] g; T2: 1370 [958-1962] kcal, 70.9 [39.0-92.2] g; T3: 1580 [1168-2042] kcal, 45.2 [54.6-100.4] g.</p><p><strong>Conclusions: </strong>ICU survivors experience multiple nutrition-impacting symptoms of varying prevalence and severity, which improve across the post-ICU continuum.</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenteral nutrition and bioelectrical impedance analysis estimated fat-free mass in adult patients with chronic intestinal failure: A descriptive cohort study.","authors":"Trevor Tabone","doi":"10.1002/jpen.2752","DOIUrl":"https://doi.org/10.1002/jpen.2752","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between a 6-h feeding protocol and postprocedure hospital length of stay following percutaneous endoscopic gastrostomy in hospitalized adults: A before-and-after cohort study","authors":"Trevor Tabone MD","doi":"10.1002/jpen.2751","DOIUrl":"10.1002/jpen.2751","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 4","pages":"402-403"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition and Metabolism Research Oral Paper Session Abstracts","authors":"","doi":"10.1002/jpen.2733","DOIUrl":"10.1002/jpen.2733","url":null,"abstract":"&lt;p&gt;&lt;b&gt;Sunday, March 23, 2025&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU30 Parenteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU31 Enteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU32 Malnutrition and Nutrition Assessment&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU33 Critical Care and Critical Health Issues&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU34 GI, Obesity, Metabolic, and Other Nutrition Related Concepts&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU35 Pediatric, Neonatal, Pregnancy, and Lactation&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Parenteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Abstract of Distinction&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Shaurya Mehta, BS&lt;sup&gt;1&lt;/sup&gt;; Chandrashekhara Manithody, PhD&lt;sup&gt;1&lt;/sup&gt;; Arun Verma, MD&lt;sup&gt;1&lt;/sup&gt;; Christine Denton&lt;sup&gt;1&lt;/sup&gt;; Kento Kurashima, MD, PhD&lt;sup&gt;1&lt;/sup&gt;; Jordyn Wray&lt;sup&gt;1&lt;/sup&gt;; Ashlesha Bagwe, MD&lt;sup&gt;1&lt;/sup&gt;; Sree Kolli&lt;sup&gt;1&lt;/sup&gt;; Marzena Swiderska-Syn&lt;sup&gt;1&lt;/sup&gt;; Miguel Guzman, MD&lt;sup&gt;1&lt;/sup&gt;; Sherri Besmer, MD&lt;sup&gt;1&lt;/sup&gt;; Sonali Jain, MD&lt;sup&gt;1&lt;/sup&gt;; Matthew Mchale, MD&lt;sup&gt;1&lt;/sup&gt;; John Long, DVM&lt;sup&gt;1&lt;/sup&gt;; Chelsea Hutchinson, MD&lt;sup&gt;1&lt;/sup&gt;; Aaron Ericsson, DVM, PhD&lt;sup&gt;2&lt;/sup&gt;; Ajay Jain, MD, DNB, MHA&lt;sup&gt;1&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Saint Louis University, St. Louis, MO; &lt;sup&gt;2&lt;/sup&gt;University of Missouri, Columbia, MO&lt;/p&gt;&lt;p&gt;&lt;b&gt;Financial Support:&lt;/b&gt; None Reported.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Total parenteral nutrition (TPN) provides lifesaving nutritional support intravenously, however, is associated with significant side effects. Given gut microbial alterations noted with TPN, we hypothesized transferring intestinal microbiota from healthy controls to those on TPN would restore gut-systemic signaling and mitigate injury.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; Using our novel ambulatory model (US Provisional Patent: US 63/136,165), 31 piglets were randomly allocated to enteral nutrition (EN), TPN only, TPN + antibiotics (TPN-A) or TPN + post pyloric intestinal microbiota transplant (TPN-IMT) for 14 days. Gut, liver, and serum samples were assessed though histology, biochemistry, and qPCR. Stool samples underwent 16s rRNA sequencing. PERMANOVA, Jaccard and Bray-Curtis metrics were performed.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Significant bilirubin elevation in TPN and TPN-A vs EN (p &lt; 0.0001) was prevented with IMT. Serum cytokine profiles revealed significantly higher IFN-G, TNF-alpha, IL-beta, IL-8, in TPN (p = 0.009/0.001/0.043/0.011), with preservation upon IMT. Significant gut-atrophy by villous/crypt ratio in TPN (p &lt; 0.0001) and TPN-A (p = 0.0001) vs EN was prevented by IMT (p = 0.426 vs EN). Microbiota profiles using Principal Coordinate Analysis (PCA) demonstrated significant overlap between IMT and EN, with the largest separation in TPN-A followed by TPN, driven primarily by firmicutes and fusobacteria. TPN altered gut barrier (Claudin-3 and Occludin) was preserved upon IMT. Gene expression showed upregulation of CYP7A1 and BSEP in TPN and TPN-A, with downregulation of FGFR4, EGF, FXR and TGR5 vs EN and prevention with IMT. In a subgroup analysis on TPN and EN, regional gut integrity differences were analyzed through the varying presence of E-cadherin and Occludin in the segment","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 S1","pages":"S5-S80"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024–2025 ASPEN Abstract Review Committee","authors":"","doi":"10.1002/jpen.2736","DOIUrl":"https://doi.org/10.1002/jpen.2736","url":null,"abstract":"&lt;p&gt;The American Society for Parenteral and Enteral Nutrition (ASPEN) Abstract Review Committee reviews, ranks and selects scientific and clinical practice abstracts submitted for presentation at the annual ASPEN Nutrition Science &amp; Practice Conference. Members of this committee are experts in the field and have the necessary skills to review and evaluate submitted research abstracts, many of which are eligible for several prestigious abstract awards. Committee members may also serve as moderators in the oral paper sessions at the ASPEN Nutrition Science &amp; Practice Conference. In compliance with accreditation standards, committee members complete conflicts of interest statements prior to participation and industry representatives and employees are not appointed to this committee.&lt;/p&gt;&lt;p&gt;&lt;b&gt;The 2024–2025 ASPEN Abstract Review Committee&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;Co-Chairs&lt;/i&gt;: April Church and Paul McCarthy&lt;/p&gt;&lt;p&gt;&lt;i&gt;Parenteral Nutrition Therapy Group Leader:&lt;/i&gt; Mireille Hamdan&lt;/p&gt;&lt;p&gt;&lt;i&gt;Enteral Nutrition Therapy Group Leader:&lt;/i&gt; Joy Douglas&lt;/p&gt;&lt;p&gt;&lt;i&gt;Malnutrition and Nutrition Assessment Group Leader:&lt;/i&gt; Jana Ponce&lt;/p&gt;&lt;p&gt;&lt;i&gt;Critical Care and Critical Health Issues Group Leader:&lt;/i&gt; Caran Graves&lt;/p&gt;&lt;p&gt;&lt;i&gt;GI, Obesity, Metabolic, and Other Nutrition Related Concepts Group Leader:&lt;/i&gt; Lindsey Russell&lt;/p&gt;&lt;p&gt;&lt;i&gt;Pediatric, Neonatal, Pregnancy, and Lactation Group Leader:&lt;/i&gt; Laura Gearman&lt;/p&gt;&lt;p&gt;&lt;i&gt;ASPEN Board liaison to the committee: Anne Tucker&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;At-Large Committee Members:&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Andrew Adorno&lt;/p&gt;&lt;p&gt;Monica Agarwal&lt;/p&gt;&lt;p&gt;Christine Allen&lt;/p&gt;&lt;p&gt;Mohammad Alsharhan&lt;/p&gt;&lt;p&gt;Leah Anderson&lt;/p&gt;&lt;p&gt;Stephanie Bachi De Castro Oliveira&lt;/p&gt;&lt;p&gt;Sarita Bajpai&lt;/p&gt;&lt;p&gt;Janice Baker&lt;/p&gt;&lt;p&gt;Lauren Beckman&lt;/p&gt;&lt;p&gt;Jonathan Berken&lt;/p&gt;&lt;p&gt;Miss Zainab Bibi&lt;/p&gt;&lt;p&gt;Barbara Bielawska&lt;/p&gt;&lt;p&gt;Ellen Bowser&lt;/p&gt;&lt;p&gt;Rebecca Brody&lt;/p&gt;&lt;p&gt;Cassandra Brown&lt;/p&gt;&lt;p&gt;Christopher Buckley&lt;/p&gt;&lt;p&gt;Lingtak-Neander Chan&lt;/p&gt;&lt;p&gt;Lee-anne Chapple&lt;/p&gt;&lt;p&gt;Anisha Chhibber&lt;/p&gt;&lt;p&gt;Adeeti Chiplunker&lt;/p&gt;&lt;p&gt;Vikram Christian&lt;/p&gt;&lt;p&gt;Laura Cutten&lt;/p&gt;&lt;p&gt;Valentina Da Prat&lt;/p&gt;&lt;p&gt;Emily Diemer&lt;/p&gt;&lt;p&gt;Felecia Dispense&lt;/p&gt;&lt;p&gt;Angela DiTucci&lt;/p&gt;&lt;p&gt;Jithinraj Edakkanambeth Varayil&lt;/p&gt;&lt;p&gt;Arlene Escuro&lt;/p&gt;&lt;p&gt;Gustave Falciglia&lt;/p&gt;&lt;p&gt;Kristy Feeney&lt;/p&gt;&lt;p&gt;Megan Follett&lt;/p&gt;&lt;p&gt;Amanda Gilhool&lt;/p&gt;&lt;p&gt;Allison Gomes&lt;/p&gt;&lt;p&gt;Shanna Hager&lt;/p&gt;&lt;p&gt;Benjamin Hall&lt;/p&gt;&lt;p&gt;Maria Hetherton&lt;/p&gt;&lt;p&gt;Jessie Hulst&lt;/p&gt;&lt;p&gt;Carol Ireton-Jones&lt;/p&gt;&lt;p&gt;Muna Islami&lt;/p&gt;&lt;p&gt;Syed-Mohammed Jafri&lt;/p&gt;&lt;p&gt;Renuka Jayatissa&lt;/p&gt;&lt;p&gt;Lisa Kinder&lt;/p&gt;&lt;p&gt;Merin Kinikini&lt;/p&gt;&lt;p&gt;Mark Klang&lt;/p&gt;&lt;p&gt;Samuel Kocoshis&lt;/p&gt;&lt;p&gt;Gabriela Lemos&lt;/p&gt;&lt;p&gt;Ada Lin&lt;/p&gt;&lt;p&gt;Rachel Ludke&lt;/p&gt;&lt;p&gt;Kristen MacEachern&lt;/p&gt;&lt;p&gt;Diana Mager&lt;/p&gt;&lt;p&gt;Abigail Martin&lt;/p&gt;&lt;p&gt;Christine Meissner&lt;/p&gt;&lt;p&gt;Yolanda Del Carmen Mendez&lt;/p&gt;&lt;p&gt;Lauri Metzger&lt;/p&gt;&lt;p&gt;Osman Mohamed Elfadil&lt;/p&gt;&lt;p&gt;Dawna Mughal&lt;/p&gt;&lt;p&gt;Samantha Mumford&lt;/p&gt;&lt;p&gt;Kristin Munroe&lt;/p&gt;&lt;p&gt;Michele Nicolo&lt;/p&gt;&lt;p&gt;Aimuan Oreavbiere&lt;/p&gt;&lt;p&gt;Hannah Piper&lt;/p&gt;&lt;p&gt;Jessica Pollard&lt;/p&gt;&lt;p&gt;Emily Ryder&lt;/p&gt;&lt;p&gt;William San Pablo&lt;/p&gt;&lt;p&gt;Senthilkumar Sankararaman&lt;/p&gt;&lt;p&gt;Christine Scarcello&lt;/p&gt;&lt;p&gt;Parul Sharma&lt;/p&gt;&lt;p","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 S1","pages":"S309"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Abstracts","authors":"","doi":"10.1002/jpen.2735","DOIUrl":"10.1002/jpen.2735","url":null,"abstract":"&lt;p&gt;&lt;b&gt;P1–P34 Parenteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P35–P52 Enteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P53–P83 Malnutrition and Nutrition Assessment&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P84–P103 Critical Care and Critical Health Issues&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P104–P131 GI, Obesity, Metabolic, and Other Nutrition Related Concepts&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P132–P165 Pediatric, Neonatal, Pregnancy, and Lactation&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Parenteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Sarah Williams, MD, CNSC&lt;sup&gt;1&lt;/sup&gt;; Angela Zimmerman, RD, CNSC&lt;sup&gt;2&lt;/sup&gt;; Denise Jezerski, RD, CNSC&lt;sup&gt;2&lt;/sup&gt;; Ashley Bestgen, RD, CNSC&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Cleveland Clinic Foundation, Parma, OH; &lt;sup&gt;2&lt;/sup&gt;Cleveland Clinic Foundation, Cleveland, OH&lt;/p&gt;&lt;p&gt;&lt;b&gt;Financial Support:&lt;/b&gt; Morrison Healthcare.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Essential fatty acid deficiency (EFAD) is a rare disorder among the general population but can be a concern in patients reliant on home parenteral nutrition (HPN), particularly those who are not receiving intravenous lipid emulsions (ILE). In the US, the only ILE available until 2016 was soybean oil based (SO-ILE), which contains more than adequate amounts of essential fatty acids, including alpha-linolenic acid (ALA, an omega-3 fatty acid) and linoleic acid (LA, an omega-6 fatty acid). In 2016, a mixed ILE containing soybean oil, medium chain triglycerides, olive oil and fish oil, became available (SO, MCT, OO, FO-ILE). However, it contains a lower concentration of essential fatty acids compared to SO-ILE, raising theoretical concerns for development of EFAD if not administered in adequate amounts. Liver dysfunction is a common complication in HPN patients that can occur with soybean based ILE use due to their pro-inflammatory properties. Short-term studies and case reports in patients receiving SO, MCT, OO, FO-ILE have shown improvements in liver dysfunction for some patients. Our study evaluates the long-term impact of SO, MCT, OO, FO-ILE in our HPN patient population.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; This single-center, retrospective cohort study was conducted at the Cleveland Clinic Center for Human Nutrition using data from 2017 to 2020. It involved adult patients who received HPN with SO, MCT, OO, FO-ILE for a minimum of one year. The study assessed changes in essential fatty acid profiles, including triene-tetraene ratios (TTRs) and liver function tests (LFTs) over the year. Data was described as mean and standard deviation for normal distributed continuous variables, medians and interquartile range for non-normally distributed continuous variables and frequency for categorical variables. The Wilcoxon signed rank test was used to compare the baseline and follow-up TTR values (mixed time points). The Wilcoxon signed rank test with pairwise comparisons was used to compare the LFTs at different time points and to determine which time groups were different. P-values were adjusted using Bonferroni corrections. Ordinal logistic regression was used to assess the association between lipid dosing and follow-up T","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 S1","pages":"S90-S308"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harry M. Vars Award Candidate Abstracts","authors":"","doi":"10.1002/jpen.2734","DOIUrl":"10.1002/jpen.2734","url":null,"abstract":"&lt;p&gt;Monday, March 24, 2025&lt;/p&gt;&lt;p&gt;Premier Paper Session and Vars Award Competition&lt;/p&gt;&lt;p&gt;&lt;b&gt;Harry M. Vars Award Candidate&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Lizl Veldsman, RD, M Nutr, BSc Dietetics&lt;sup&gt;1&lt;/sup&gt;; Guy Richards, MD, PhD&lt;sup&gt;2&lt;/sup&gt;; Daniel Nel, PhD&lt;sup&gt;3&lt;/sup&gt;; Renée Blaauw, PhD, RD&lt;sup&gt;1&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Human Nutrition, Department of Global Health, Faculty of Medicine &amp; Health Sciences, Stellenbosch University, Cape Town, Western Cape; &lt;sup&gt;2&lt;/sup&gt;Department of Surgery, Division of Critical Care, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng; &lt;sup&gt;3&lt;/sup&gt;Centre for Statistical Consultation, Department of Statistics and Actuarial Science, Stellenbosch University, Stellenbosch, Western Cape&lt;/p&gt;&lt;p&gt;&lt;b&gt;Financial Support:&lt;/b&gt; This research study was funded by the Fresenius Kabi Jumpstart Research grant.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Critical illness is associated with severe muscle wasting. A combination of protein supplementation and mobilization may attenuate muscle loss. We determined the effect of a combination of intravenous (IV) bolus amino acid (AA) supplementation and in-bed cycling, versus standard care only, on skeletal muscle mass during the first ICU week.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; This randomized controlled trial (ClinicalTrials.gov NCT04099108) was undertaken in a predominantly trauma adult surgical ICU. Participants were randomly assigned into two groups, both of which received standard care nutrition (SCN) and mobilization. The intervention group received an additional IV AA bolus, starting on ICU day 3 on-average, along with a 45-minute in-bed cycling session for a mean of 6 days. Histological change in vastus lateralis (VL) myofiber cross-sectional area (CSA) and ultrasound rectus femoris (RF) muscle CSA was measured from pre-intervention (average ICU day 2) to post-intervention (average ICU day 8) and analyzed using mixed model ANOVA and post hoc least significant difference (LSD) testing. Secondarily, we assessed the change in the protein-to-DNA ratio over time. We further compared responses between participants with and without baseline organ dysfunction (defined as SOFA≥2, due to infection or trauma-related inflammation).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Fifty critically ill patients (90% male, mean age 37±12 years, APACHE II score 13.5±6.6, SOFA score 4.5±3.2, BMI 24.8±4.0 kg/m&lt;sup&gt;2&lt;/sup&gt;, modified NUTRIC 2.2±1.8) were included. The control (n = 25) and intervention (n = 25) groups received, on average, 87.62±32.18 and 85.53±29.29 grams of protein per day (1.26±0.41 and 1.29±0.40g/kg/day, respectively) from SCN, and the intervention group an additional 30.43±5.62 grams of AA (0.37±0.06g/kg protein equivalents) from the supplement. There was significant loss of muscle mass over time in all participants (VL myofiber CSA 11.76%, p = 0.011; RF muscle CSA 13.01% p &lt; 0.001). No significant difference was found between groups, but a more compatible trend for greater muscle loss in the control group versus","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 S1","pages":"S81-S89"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to Conference Abstracts","authors":"","doi":"10.1002/jpen.2731","DOIUrl":"10.1002/jpen.2731","url":null,"abstract":"<p>The American Society for Parenteral and Enteral Nutrition (ASPEN) is dedicated to improving patient care by advancing the science and practice of clinical nutrition and metabolism. Founded in 1975, ASPEN is an interprofessional organization whose members are involved in the provision of clinical nutrition therapies, including parenteral and enteral nutrition. With more than 6000 members from around the world, ASPEN is a community of dietitians, nurses, pharmacists, physicians, scientists, students, and other health professionals from every facet of nutrition support clinical practice, research, and education.</p><p>ASPEN hosts an annual forum for clinical nutrition research and education, the ASPEN Nutrition Science &amp; Practice Conference. The ASPEN Abstract Review Committee reviewed all abstracts submitted for the conference and selected those published herein for presentation. Selected abstracts feature data relevant to nutrition therapy and metabolic support, many of which were eligible for several of ASPEN's prestigious abstract awards.</p><p>The abstracts in this supplement have not been copyedited. Any errors contained within the abstracts are the sole responsibility of the authors. ASPEN does not assume liability for any errors herein. This content does not constitute medical or other professional advice. Please visit ASPEN's conference webpage for more information: https://www.nutritioncare.org/conference/</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 S1","pages":"S4"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal failure–associated liver disease in adult patients with chronic intestinal failure receiving home parenteral nutrition: A descriptive cohort study","authors":"Sarah Frezet MD,&nbsp;Paul Hermabessière MD,&nbsp;Laurianne Kerlogot RD,&nbsp;Eva Wilsius RN,&nbsp;Coraline Balde RN,&nbsp;Gauthier Pellet MD,&nbsp;Constance Chevrier PharmD,&nbsp;Jean Castinel MD,&nbsp;Victor de Ledinghen MD, PhD,&nbsp;Florian Poullenot MD","doi":"10.1002/jpen.2746","DOIUrl":"10.1002/jpen.2746","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Intestinal failure–associated liver disease (IFALD) is a major complication of chronic intestinal failure. Few data exist about hepatic monitoring of IFALD using the liver stiffness measurement. The aim of this study was to provide a descriptive analysis of IFALD and its prevalence in a tertiary center and to determine the IFALD risk factors and high liver stiffness measurement values using FibroScan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adult patients with chronic intestinal failure treated with home parenteral nutrition and followed in a tertiary center with no underlying liver disease and at least one liver stiffness measurement record were included between January 1, 2007, and June 6, 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighty-nine patients were included from this cohort of 145 patients. The prevalence of IFALD was 34%. A total of 14% had a liver stiffness measurement &gt;10 kPa, and 49% had a liver stiffness measurement &lt;5 kPa. In multivariate analysis, IFALD was positively associated with the use of a customized admixture (odds ratio [OR] = 7.04; 95% CI, 1.44–43.64; <i>P</i> = 0.017) and negatively associated with the colon in continuity (OR = 0.25; 95% CI, 0.07–0.87; <i>P</i> = 0.029). No significant association was observed between liver stiffness measurement values and IFALD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The prevalence of IFALD was low in our study. Absence of the colon and the use of a customized admixture were risk factors for IFALD. Liver stiffness measurement was abnormal in 51% of cases. A long-term follow-up of this cohort will help to assess the prognostic relevance of IFALD and liver stiffness measurement in these patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 4","pages":"507-516"},"PeriodicalIF":3.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measured resting energy expenditure and predicted resting energy expenditure based on ASPEN critical care guidelines for nutrition support: An agreement study","authors":"Kiara Gaspari MND,&nbsp;Jessica Flechner-Klein MND,&nbsp;Tamara R. Cohen PhD, RD,&nbsp;Courtney Wedemire DCN, RD","doi":"10.1002/jpen.2744","DOIUrl":"10.1002/jpen.2744","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Predictive equations often inaccurately estimate energy needs in critically ill patients. This study evaluated the level of agreement between resting energy expenditure using 12 and 25 kcal/kg as recommended by the 2021 American Society for Parenteral and Enteral Nutrition critical care guidelines for nutrition support and energy expenditure measured by indirect calorimetry in patients in the intensive care unit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An agreement study was conducted on mechanically ventilated adults who had a documented measured energy expenditure within 10 days of intensive care unit admission. Agreement was assessed using Bland-Altman plots and Wilcoxon signed rank tests. A subgroup analysis was performed for patients with a body mass index of ≥30 kg/m² using actual body weight, adjusted body weight, and ideal body weight. Correlations between measured energy expenditure and patient characteristics were also explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-eight patients were included and were a median age of 64 years, 63.8% male, and a median body mass index of 28.0 kg/m². The 12 kcal/kg and 25 kcal/kg differed significantly from measured energy expenditure (<i>P</i> &lt; 0.001). Bland-Altman plots showed mean biases of −644.6 kcal/day for 12 kcal/kg and 406.5 kcal/day for 25 kcal/kg. In the body mass index ≥30 kg/m² subgroup (<i>n</i> = 22), 12 kcal/kg underestimated measured energy expenditure across all weights, and 25 kcal/kg was more accurate when using ideal or adjusted body weights.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Predicted energy expenditure using 12 kcal/kg and 25 kcal/kg based on the 2021 American Society for Parenteral and Enteral Nutrition critical care guidelines for nutrition support had poor agreement with measured energy expenditure in mechanically ventilated patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 4","pages":"468-475"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}