Journal of Parenteral and Enteral Nutrition最新文献

{"title":"Managing pregnancy with long-term parenteral nutrition: A case report and review of the literature.","authors":"Muhammad Shahzil, Ammad Javaid Chaudhary, Abdullah Sohail, Kamran Haq, Muhammad Zarrar Khan, Yakir Muszkat, Syed-Mohammed Jafri","doi":"10.1002/jpen.2758","DOIUrl":"https://doi.org/10.1002/jpen.2758","url":null,"abstract":"<p><p>Parenteral nutrition (PN) is essential for patients with chronic intestinal failure but poses significant challenges during pregnancy because of increased nutrition needs and associated risks such as central line-associated bloodstream infections. We report a case of a 29-year-old primigravid woman with Crohn's disease who required chronic PN. Despite these complexities, her pregnancy was managed successfully with tailored PN adjustments. She developed intrahepatic cholestasis of pregnancy at 38 weeks and delivered a healthy, full-term newborn. Meticulous planning and individualized nutrition management are crucial in navigating the complexities of PN during pregnancy, demonstrating the potential for successful outcomes with strategic and personalized interventions.</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JPEN Journal Club 92. Adjusting randomized trials.","authors":"Ronald L Koretz","doi":"10.1002/jpen.2750","DOIUrl":"https://doi.org/10.1002/jpen.2750","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition.","authors":"C W Compher, R Fukushima, M I T D Correia, M C Gonzalez, L McKeever, K Nakamura, Z Y Lee, J J Patel, P Singer, C Stoppe, J C Ayala, R Barazzoni, M M Berger, T Cederholm, K Chittawatanarat, A Cotoia, J C Lopez-Delgado, C P Earthman, G Elke, W Hartl, M S Hasan, N Higashibeppu, G L Jensen, K J Lambell, C C H Lew, J I Mechanick, M Mourtzakis, G C C Nogales, T Oshima, S J Peterson, T W Rice, R Rosenfeld, P Sheean, F M Silva, P C Tah, M Uyar","doi":"10.1002/jpen.2748","DOIUrl":"https://doi.org/10.1002/jpen.2748","url":null,"abstract":"<p><strong>Background: </strong>Patients with critical illness may present with disease-related malnutrition upon intensive care unit (ICU) admission. They are at risk of development and progression of malnutrition over the disease trajectory because of inflammation, dysregulated metabolism, and challenges with feeding.</p><p><strong>Methods: </strong>The Global Leadership Initiative on Malnutrition (GLIM) convened a panel of 36 clinical nutrition experts to develop consensus-based guidance statements addressing the diagnosis of malnutrition during critical illness using a modified Delphi approach with a requirement of ≥75% agreement.</p><p><strong>Results: </strong>(1) To identify pre-existing malnutrition, we suggest evaluation within 48 h of ICU admission when feasible (100% agreement) or within 4 days (94% agreement). (2) To identify the development and progression of malnutrition, we suggest re-evaluation of all patients every 7-10 days (97% agreement). (3) To identify progressive loss of muscle mass, we suggest evaluation of muscle mass as soon as feasible (92% agreement) and again after 7-10 days (89% agreement). (4) To identify the development and progression of malnutrition before and after ICU discharge, we suggest re-evaluating nutrition status before ICU discharge and during clinical visits that follow (100% agreement).</p><p><strong>Conclusion: </strong>Research using consistent etiologic and phenotypic variables offers great potential to assess the efficacy of nutrition interventions for critically ill patients with malnutrition. Assessment of these variables during and beyond the ICU stay will clarify the trajectory of malnutrition and enable exploration of impactful treatment modalities at each juncture. GLIM offers a diagnostic approach that can be used to identify malnutrition in critically ill patients.</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between a 6-h feeding protocol and postprocedure hospital length of stay following percutaneous endoscopic gastrostomy in hospitalized adults: A before-and-after cohort study.","authors":"Jeffrey L Roberson","doi":"10.1002/jpen.2754","DOIUrl":"https://doi.org/10.1002/jpen.2754","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition-impacting symptoms in survivors of critical illness: A descriptive cohort study.","authors":"Breanna J Teleki, Elizabeth Viner Smith, Rosalie Yandell, Matthew J Summers, Lee-Anne S Chapple","doi":"10.1002/jpen.2753","DOIUrl":"https://doi.org/10.1002/jpen.2753","url":null,"abstract":"<p><strong>Background: </strong>Oral intake is the most common route of nutrition following intensive care unit (ICU) discharge; yet is associated with inadequate intake, and barriers are largely unknown. This study aimed to determine the prevalence and severity of symptoms that may impact oral intake (termed nutrition-impacting symptoms) in ICU survivors.</p><p><strong>Methods: </strong>A single-center descriptive cohort study quantified prevalence and severity of nutrition-impacting symptoms in ICU survivors at ICU (T1) and hospital (T2) discharge and at 1 month posthospital discharge (T3) via patient-reported questionnaires. Secondary outcomes were nutrition status (via Subjective Global Assessment) and energy and protein intakes (via 24-h recall). Data are median (IQR) or (percent).</p><p><strong>Results: </strong>Forty-nine ICU survivors (64 [51-71] years; 31% female) were included. The most prevalent nutrition-impacting symptoms were T1: tiredness (96%), loss of appetite (82%), and early satiety (82%); T2: tiredness (93%), early satiety (88%), and dry mouth (78%); and T3: tiredness (95%), early satiety (81%), and low mood (66%). Nutrition-impacting symptoms with the greatest severity (out of 10, higher equates to worse) at each time point were T1: tiredness, constipation, diarrhea, nausea (all 8 [5-10]); T2: tiredness and constipation (both 7 [5-8]); and T3: tiredness (6 [3-8]) and diarrhea (6 [2-7]). Malnutrition rates were 34% at T1. Energy and protein intakes were T1: 1046 [548-1481] kcal, 45.2 [23.9-61.0] g; T2: 1370 [958-1962] kcal, 70.9 [39.0-92.2] g; T3: 1580 [1168-2042] kcal, 45.2 [54.6-100.4] g.</p><p><strong>Conclusions: </strong>ICU survivors experience multiple nutrition-impacting symptoms of varying prevalence and severity, which improve across the post-ICU continuum.</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenteral nutrition and bioelectrical impedance analysis estimated fat-free mass in adult patients with chronic intestinal failure: A descriptive cohort study.","authors":"Trevor Tabone","doi":"10.1002/jpen.2752","DOIUrl":"https://doi.org/10.1002/jpen.2752","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between a 6-h feeding protocol and postprocedure hospital length of stay following percutaneous endoscopic gastrostomy in hospitalized adults: A before-and-after cohort study.","authors":"Trevor Tabone","doi":"10.1002/jpen.2751","DOIUrl":"https://doi.org/10.1002/jpen.2751","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition and Metabolism Research Oral Paper Session Abstracts","authors":"","doi":"10.1002/jpen.2733","DOIUrl":"10.1002/jpen.2733","url":null,"abstract":"&lt;p&gt;&lt;b&gt;Sunday, March 23, 2025&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU30 Parenteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU31 Enteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU32 Malnutrition and Nutrition Assessment&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU33 Critical Care and Critical Health Issues&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU34 GI, Obesity, Metabolic, and Other Nutrition Related Concepts&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;SU35 Pediatric, Neonatal, Pregnancy, and Lactation&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Parenteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Abstract of Distinction&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Shaurya Mehta, BS&lt;sup&gt;1&lt;/sup&gt;; Chandrashekhara Manithody, PhD&lt;sup&gt;1&lt;/sup&gt;; Arun Verma, MD&lt;sup&gt;1&lt;/sup&gt;; Christine Denton&lt;sup&gt;1&lt;/sup&gt;; Kento Kurashima, MD, PhD&lt;sup&gt;1&lt;/sup&gt;; Jordyn Wray&lt;sup&gt;1&lt;/sup&gt;; Ashlesha Bagwe, MD&lt;sup&gt;1&lt;/sup&gt;; Sree Kolli&lt;sup&gt;1&lt;/sup&gt;; Marzena Swiderska-Syn&lt;sup&gt;1&lt;/sup&gt;; Miguel Guzman, MD&lt;sup&gt;1&lt;/sup&gt;; Sherri Besmer, MD&lt;sup&gt;1&lt;/sup&gt;; Sonali Jain, MD&lt;sup&gt;1&lt;/sup&gt;; Matthew Mchale, MD&lt;sup&gt;1&lt;/sup&gt;; John Long, DVM&lt;sup&gt;1&lt;/sup&gt;; Chelsea Hutchinson, MD&lt;sup&gt;1&lt;/sup&gt;; Aaron Ericsson, DVM, PhD&lt;sup&gt;2&lt;/sup&gt;; Ajay Jain, MD, DNB, MHA&lt;sup&gt;1&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Saint Louis University, St. Louis, MO; &lt;sup&gt;2&lt;/sup&gt;University of Missouri, Columbia, MO&lt;/p&gt;&lt;p&gt;&lt;b&gt;Financial Support:&lt;/b&gt; None Reported.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Total parenteral nutrition (TPN) provides lifesaving nutritional support intravenously, however, is associated with significant side effects. Given gut microbial alterations noted with TPN, we hypothesized transferring intestinal microbiota from healthy controls to those on TPN would restore gut-systemic signaling and mitigate injury.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; Using our novel ambulatory model (US Provisional Patent: US 63/136,165), 31 piglets were randomly allocated to enteral nutrition (EN), TPN only, TPN + antibiotics (TPN-A) or TPN + post pyloric intestinal microbiota transplant (TPN-IMT) for 14 days. Gut, liver, and serum samples were assessed though histology, biochemistry, and qPCR. Stool samples underwent 16s rRNA sequencing. PERMANOVA, Jaccard and Bray-Curtis metrics were performed.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Significant bilirubin elevation in TPN and TPN-A vs EN (p &lt; 0.0001) was prevented with IMT. Serum cytokine profiles revealed significantly higher IFN-G, TNF-alpha, IL-beta, IL-8, in TPN (p = 0.009/0.001/0.043/0.011), with preservation upon IMT. Significant gut-atrophy by villous/crypt ratio in TPN (p &lt; 0.0001) and TPN-A (p = 0.0001) vs EN was prevented by IMT (p = 0.426 vs EN). Microbiota profiles using Principal Coordinate Analysis (PCA) demonstrated significant overlap between IMT and EN, with the largest separation in TPN-A followed by TPN, driven primarily by firmicutes and fusobacteria. TPN altered gut barrier (Claudin-3 and Occludin) was preserved upon IMT. Gene expression showed upregulation of CYP7A1 and BSEP in TPN and TPN-A, with downregulation of FGFR4, EGF, FXR and TGR5 vs EN and prevention with IMT. In a subgroup analysis on TPN and EN, regional gut integrity differences were analyzed through the varying presence of E-cadherin and Occludin in the segment","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 S1","pages":"S5-S80"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024–2025 ASPEN Abstract Review Committee","authors":"","doi":"10.1002/jpen.2736","DOIUrl":"https://doi.org/10.1002/jpen.2736","url":null,"abstract":"&lt;p&gt;The American Society for Parenteral and Enteral Nutrition (ASPEN) Abstract Review Committee reviews, ranks and selects scientific and clinical practice abstracts submitted for presentation at the annual ASPEN Nutrition Science &amp; Practice Conference. Members of this committee are experts in the field and have the necessary skills to review and evaluate submitted research abstracts, many of which are eligible for several prestigious abstract awards. Committee members may also serve as moderators in the oral paper sessions at the ASPEN Nutrition Science &amp; Practice Conference. In compliance with accreditation standards, committee members complete conflicts of interest statements prior to participation and industry representatives and employees are not appointed to this committee.&lt;/p&gt;&lt;p&gt;&lt;b&gt;The 2024–2025 ASPEN Abstract Review Committee&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;Co-Chairs&lt;/i&gt;: April Church and Paul McCarthy&lt;/p&gt;&lt;p&gt;&lt;i&gt;Parenteral Nutrition Therapy Group Leader:&lt;/i&gt; Mireille Hamdan&lt;/p&gt;&lt;p&gt;&lt;i&gt;Enteral Nutrition Therapy Group Leader:&lt;/i&gt; Joy Douglas&lt;/p&gt;&lt;p&gt;&lt;i&gt;Malnutrition and Nutrition Assessment Group Leader:&lt;/i&gt; Jana Ponce&lt;/p&gt;&lt;p&gt;&lt;i&gt;Critical Care and Critical Health Issues Group Leader:&lt;/i&gt; Caran Graves&lt;/p&gt;&lt;p&gt;&lt;i&gt;GI, Obesity, Metabolic, and Other Nutrition Related Concepts Group Leader:&lt;/i&gt; Lindsey Russell&lt;/p&gt;&lt;p&gt;&lt;i&gt;Pediatric, Neonatal, Pregnancy, and Lactation Group Leader:&lt;/i&gt; Laura Gearman&lt;/p&gt;&lt;p&gt;&lt;i&gt;ASPEN Board liaison to the committee: Anne Tucker&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;At-Large Committee Members:&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Andrew Adorno&lt;/p&gt;&lt;p&gt;Monica Agarwal&lt;/p&gt;&lt;p&gt;Christine Allen&lt;/p&gt;&lt;p&gt;Mohammad Alsharhan&lt;/p&gt;&lt;p&gt;Leah Anderson&lt;/p&gt;&lt;p&gt;Stephanie Bachi De Castro Oliveira&lt;/p&gt;&lt;p&gt;Sarita Bajpai&lt;/p&gt;&lt;p&gt;Janice Baker&lt;/p&gt;&lt;p&gt;Lauren Beckman&lt;/p&gt;&lt;p&gt;Jonathan Berken&lt;/p&gt;&lt;p&gt;Miss Zainab Bibi&lt;/p&gt;&lt;p&gt;Barbara Bielawska&lt;/p&gt;&lt;p&gt;Ellen Bowser&lt;/p&gt;&lt;p&gt;Rebecca Brody&lt;/p&gt;&lt;p&gt;Cassandra Brown&lt;/p&gt;&lt;p&gt;Christopher Buckley&lt;/p&gt;&lt;p&gt;Lingtak-Neander Chan&lt;/p&gt;&lt;p&gt;Lee-anne Chapple&lt;/p&gt;&lt;p&gt;Anisha Chhibber&lt;/p&gt;&lt;p&gt;Adeeti Chiplunker&lt;/p&gt;&lt;p&gt;Vikram Christian&lt;/p&gt;&lt;p&gt;Laura Cutten&lt;/p&gt;&lt;p&gt;Valentina Da Prat&lt;/p&gt;&lt;p&gt;Emily Diemer&lt;/p&gt;&lt;p&gt;Felecia Dispense&lt;/p&gt;&lt;p&gt;Angela DiTucci&lt;/p&gt;&lt;p&gt;Jithinraj Edakkanambeth Varayil&lt;/p&gt;&lt;p&gt;Arlene Escuro&lt;/p&gt;&lt;p&gt;Gustave Falciglia&lt;/p&gt;&lt;p&gt;Kristy Feeney&lt;/p&gt;&lt;p&gt;Megan Follett&lt;/p&gt;&lt;p&gt;Amanda Gilhool&lt;/p&gt;&lt;p&gt;Allison Gomes&lt;/p&gt;&lt;p&gt;Shanna Hager&lt;/p&gt;&lt;p&gt;Benjamin Hall&lt;/p&gt;&lt;p&gt;Maria Hetherton&lt;/p&gt;&lt;p&gt;Jessie Hulst&lt;/p&gt;&lt;p&gt;Carol Ireton-Jones&lt;/p&gt;&lt;p&gt;Muna Islami&lt;/p&gt;&lt;p&gt;Syed-Mohammed Jafri&lt;/p&gt;&lt;p&gt;Renuka Jayatissa&lt;/p&gt;&lt;p&gt;Lisa Kinder&lt;/p&gt;&lt;p&gt;Merin Kinikini&lt;/p&gt;&lt;p&gt;Mark Klang&lt;/p&gt;&lt;p&gt;Samuel Kocoshis&lt;/p&gt;&lt;p&gt;Gabriela Lemos&lt;/p&gt;&lt;p&gt;Ada Lin&lt;/p&gt;&lt;p&gt;Rachel Ludke&lt;/p&gt;&lt;p&gt;Kristen MacEachern&lt;/p&gt;&lt;p&gt;Diana Mager&lt;/p&gt;&lt;p&gt;Abigail Martin&lt;/p&gt;&lt;p&gt;Christine Meissner&lt;/p&gt;&lt;p&gt;Yolanda Del Carmen Mendez&lt;/p&gt;&lt;p&gt;Lauri Metzger&lt;/p&gt;&lt;p&gt;Osman Mohamed Elfadil&lt;/p&gt;&lt;p&gt;Dawna Mughal&lt;/p&gt;&lt;p&gt;Samantha Mumford&lt;/p&gt;&lt;p&gt;Kristin Munroe&lt;/p&gt;&lt;p&gt;Michele Nicolo&lt;/p&gt;&lt;p&gt;Aimuan Oreavbiere&lt;/p&gt;&lt;p&gt;Hannah Piper&lt;/p&gt;&lt;p&gt;Jessica Pollard&lt;/p&gt;&lt;p&gt;Emily Ryder&lt;/p&gt;&lt;p&gt;William San Pablo&lt;/p&gt;&lt;p&gt;Senthilkumar Sankararaman&lt;/p&gt;&lt;p&gt;Christine Scarcello&lt;/p&gt;&lt;p&gt;Parul Sharma&lt;/p&gt;&lt;p","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 S1","pages":"S309"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Abstracts","authors":"","doi":"10.1002/jpen.2735","DOIUrl":"10.1002/jpen.2735","url":null,"abstract":"&lt;p&gt;&lt;b&gt;P1–P34 Parenteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P35–P52 Enteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P53–P83 Malnutrition and Nutrition Assessment&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P84–P103 Critical Care and Critical Health Issues&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P104–P131 GI, Obesity, Metabolic, and Other Nutrition Related Concepts&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;P132–P165 Pediatric, Neonatal, Pregnancy, and Lactation&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Parenteral Nutrition Therapy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Sarah Williams, MD, CNSC&lt;sup&gt;1&lt;/sup&gt;; Angela Zimmerman, RD, CNSC&lt;sup&gt;2&lt;/sup&gt;; Denise Jezerski, RD, CNSC&lt;sup&gt;2&lt;/sup&gt;; Ashley Bestgen, RD, CNSC&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Cleveland Clinic Foundation, Parma, OH; &lt;sup&gt;2&lt;/sup&gt;Cleveland Clinic Foundation, Cleveland, OH&lt;/p&gt;&lt;p&gt;&lt;b&gt;Financial Support:&lt;/b&gt; Morrison Healthcare.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Essential fatty acid deficiency (EFAD) is a rare disorder among the general population but can be a concern in patients reliant on home parenteral nutrition (HPN), particularly those who are not receiving intravenous lipid emulsions (ILE). In the US, the only ILE available until 2016 was soybean oil based (SO-ILE), which contains more than adequate amounts of essential fatty acids, including alpha-linolenic acid (ALA, an omega-3 fatty acid) and linoleic acid (LA, an omega-6 fatty acid). In 2016, a mixed ILE containing soybean oil, medium chain triglycerides, olive oil and fish oil, became available (SO, MCT, OO, FO-ILE). However, it contains a lower concentration of essential fatty acids compared to SO-ILE, raising theoretical concerns for development of EFAD if not administered in adequate amounts. Liver dysfunction is a common complication in HPN patients that can occur with soybean based ILE use due to their pro-inflammatory properties. Short-term studies and case reports in patients receiving SO, MCT, OO, FO-ILE have shown improvements in liver dysfunction for some patients. Our study evaluates the long-term impact of SO, MCT, OO, FO-ILE in our HPN patient population.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; This single-center, retrospective cohort study was conducted at the Cleveland Clinic Center for Human Nutrition using data from 2017 to 2020. It involved adult patients who received HPN with SO, MCT, OO, FO-ILE for a minimum of one year. The study assessed changes in essential fatty acid profiles, including triene-tetraene ratios (TTRs) and liver function tests (LFTs) over the year. Data was described as mean and standard deviation for normal distributed continuous variables, medians and interquartile range for non-normally distributed continuous variables and frequency for categorical variables. The Wilcoxon signed rank test was used to compare the baseline and follow-up TTR values (mixed time points). The Wilcoxon signed rank test with pairwise comparisons was used to compare the LFTs at different time points and to determine which time groups were different. P-values were adjusted using Bonferroni corrections. Ordinal logistic regression was used to assess the association between lipid dosing and follow-up T","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 S1","pages":"S90-S308"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}