Journal of Parenteral and Enteral Nutrition最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 3","pages":"352-354"},"PeriodicalIF":4.1,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148069121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 4","pages":"507-514"},"PeriodicalIF":4.1,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148070254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 S1","pages":"S71-S332"},"PeriodicalIF":4.1,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148063507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicutaneo-caval catheter occlusion in neonates without heparin infusion during parenteral nutrition: A descriptive cohort study","authors":"Vito D'Andrea MD,&nbsp;Giorgia Prontera MD,&nbsp;Cecilia Monachini MD,&nbsp;Micaela Cerreti MD,&nbsp;Francesca Baldo MD,&nbsp;Giovanni Barone MD,&nbsp;Giovanni Vento","doi":"10.1002/jpen.70037","DOIUrl":"10.1002/jpen.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Heparin is frequently infused in neonatal central venous catheters to prevent occlusion during parenteral nutrition despite limited evidence of its effectiveness and potential safety concerns in preterm infants. This study evaluated the incidence of catheter occlusion in epicutaneo-caval catheters managed without heparin in a large neonatal cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a descriptive cohort study including all neonates admitted to the neonatal intensive care unit who required epicutaneo-caval catheters placement for parenteral nutrition. No heparin was added to infusions. Data were collected on catheter characteristics, insertion parameters, and reasons for removal. The primary outcome was the incidence of catheter occlusion per 1000 catheter-days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 357 neonates with 357 epicutaneo-caval catheters were analyzed, representing 4007 catheter-days. Mean ± SD gestational age was 29 ± 4.1 weeks, and mean ± SD birthweight was 1050 ± 797 g. The mean ± SD catheter dwell time was 11.2 ± 7.7 days. Most catheter insertions occurred in the upper extremities (92.7%), with prematurity being the most common indication (53.7%). Catheter removal was elective in 67.5% of cases. Only three occlusions were reported, corresponding to 0.7% of catheters and 0.76 occlusions per 1000 catheter-days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrates a low rate of epicutaneo-caval catheters occlusion in neonates receiving parenteral nutrition without heparin infusion. These findings support the safety and feasibility of a heparin-free approach in neonatal central catheter management when standardized care protocols are followed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"247-251"},"PeriodicalIF":4.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of electronic health records with automated compounding for parenteral nutrition: A narrative review","authors":"Nora Albanyan PharmD, PhP,&nbsp;Ahmed Ali Alrashed MSc,&nbsp;Jude Howaidi PharmD,&nbsp;Aljawharah Binrokan PharmD,&nbsp;Yahya Mohzari PharmD, PhP,&nbsp;Ahmed AlRassan MSc,&nbsp;Khalid Almagwasi MSc,&nbsp;Dena Alahaideb MSc,&nbsp;Razan Orfali PhD","doi":"10.1002/jpen.70045","DOIUrl":"10.1002/jpen.70045","url":null,"abstract":"<p>The integration of electronic health record systems has transformed healthcare by enhancing workflow efficiency, improving data accessibility, and enhancing patient safety. King Fahad Medical City transitioned from a fragmented, paper-based parenteral nutrition management system to a fully integrated Epic electronic health record system, replacing the standalone Baxter ABACUS software. This review outlines a structured approach to integrating automated compounding devices with Epic, incorporating standardized data exchange protocols, interoperability frameworks, development of parenteral nutrition order sets, barcode-enabled verification, and staff training. The clinical decision support system within Epic optimized parenteral nutrition prescription accuracy through real-time alerts, dose limits, and automated calculations. A dedicated parenteral nutrition navigator tool further simplified access to patient data, supporting informed clinical decision-making. This manuscript focuses on the implementation process rather than outcome evaluation. A qualitative approach, using process mapping, training assessments, and end-user feedback, was employed to guide and monitor the integration progress. System refinement and multidisciplinary collaboration resolved challenges, including barcode recognition failures and coding mismatches. This experience underscores the importance of interoperability, decision support tools, and continuous quality improvement in optimizing parenteral nutrition therapy within electronic health record systems, offering a scalable model for healthcare institutions seeking digital transformation.</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"161-169"},"PeriodicalIF":4.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenteral nutrition after major elective upper gastrointestinal surgery: A descriptive cohort study","authors":"Georgia Stringer BNut&Diet,&nbsp;Oana A. Tatucu Babet PhD,&nbsp;Graeme Duke MD,&nbsp;Jo Englezos BNut&Diet,&nbsp;Emma J. Ridley PhD","doi":"10.1002/jpen.70040","DOIUrl":"10.1002/jpen.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients undergoing major upper gastrointestinal surgery are at high nutrition risk, with central or peripheral parenteral nutrition an option when oral or enteral nutrition are not possible. We aimed to determine the number of patients who were indicated but did not receive parenteral nutrition according to an international consensus guideline following major upper gastrointestinal surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective audit of patients undergoing major upper gastrointestinal surgery was conducted at a single center between August 13, 2021, and December 29, 2023. Included patients were considered at nutrition risk. Data were extracted on baseline characteristics, nutrition therapy and adequacy of nutrition intake. Data were analyzed using descriptive statistics and were presented as median or mean. The primary outcome was the number of patients who were indicated but did not receive parenteral nutrition according to an international consensus guideline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 100 patients were included (55 [55%] male; age 68 [59–78] years, and body mass index 25.0 [22.5–29.0] kg/m²). Out of 100 patients, parenteral nutrition was indicated in 42 (42%). Among those who met criteria, 3 of 42 (7%) received parenteral nutrition, whereas 39 of 42 (93%) did not. The percentage of energy and protein adequacy at day 7 was 53 [41–68] % and 58 [39–74] %, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Most patients who were indicated to did not receive parenteral nutrition within 7 days postsurgery in a single center in Australia. The potential indicators for use of parenteral nutrition via central or peripheral delivery should be further explored.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"219-227"},"PeriodicalIF":4.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial","authors":"Lizl Veldsman PhD, RD,&nbsp;Guy A. Richards MD, PhD,&nbsp;Daniel Nel PhD,&nbsp;Tertius A. Kohn PhD,&nbsp;Renée Blaauw PhD, RD","doi":"10.1002/jpen.70041","DOIUrl":"10.1002/jpen.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Muscle wasting is a hallmark of critical illness. We evaluated the effect of amino acid supplementation and mobilization on early muscle loss in critically ill patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a randomized parallel-group trial involving adult patients admitted to the surgical intensive care unit of a tertiary hospital. Participants were randomly assigned to two groups, both receiving standard care nutrition and mobilization. The intervention group also received a daily intravenous amino acid bolus with 45 min of cycle ergometry, starting on days 3–4 for a mean of 6 days. The primary co-outcomes were changes in vastus lateralis myofiber cross-sectional area (from biopsies) and ultrasound-derived rectus femoris cross-sectional area, measured between the preintervention (day 2) and postintervention (day 8) time points. Analyses were conducted using mixed-model analysis of variance and least significant difference testing. Secondary outcomes included the protein-to-DNA ratio, muscle echogenicity, whole-body phase angle, muscle strength (Medical Research Council sum score) and physical capability (6-min walk test).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty patients (90% male, age 37 ± 12 years) were included. Standard of care participants received 1.23 ± 0.18 g/kg/day protein; intervention participants 1.57 ± 0.27 g/kg/day, including 0.37 ± 0.05 g/kg/day from the supplement. Muscle loss occurred significantly over time (biopsy <i>P</i> = 0.01; ultrasound <i>P</i> &lt; 0.001), with no significant differences between groups. Similarly, no significant differences were observed in protein-to-DNA ratio, muscle echogenicity, phase angle, muscle strength, or physical capability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A short-duration combined intervention of intravenous bolus amino acids and cycle ergometry, limited to the acute phase of critical illness, did not reduce muscle loss or improve muscle quality, strength, or physical capability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"170-182"},"PeriodicalIF":4.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145867148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between protein dose in the early and late acute phases of critical illness and time-to-discharge-alive: A secondary analysis of a randomized clinical trial","authors":"Lauren E. Tweel DCN, RD,&nbsp;Rebecca Brody PhD, RD,&nbsp;Hamed Samavat PhD, RDN,&nbsp;Andrew G. Day MSc,&nbsp;Xuran Jiang MSc,&nbsp;Laura Byham-Gray PhD, RDN,&nbsp;Jayshil Patel MD,&nbsp;Charlene Compher PhD, RD,&nbsp;Daren K. Heyland MD, MSc","doi":"10.1002/jpen.70033","DOIUrl":"10.1002/jpen.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Research has sought to identify optimal protein doses during acute phases of critical illness to optimize outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A secondary analysis of the EFFORT Protein trial, which compared high vs usual protein (<i>N</i> = 1301). Only participants with 8 evaluable days of protein intake were included in our analysis. Mean protein intake was categorized as low (&lt;0.8), medium (0.8–1.3), or high (&gt;1.3 g/kg/day). Acute illness phases were define as early (days 1–4) and late (days 5–8). Participants were grouped by protein dose received in each phase. Based on prior evidence, early phase medium protein/late phase high protein served as the referent. The primary outcome was time-to-discharge-alive; secondary outcomes included 60-day mortality and discharge home.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 819 participants (median [IQR] age 59.0 [46.0, 69.0] years; 60% male). Time-to-discharge-alive did not differ significantly across groups (<i>P</i> = 0.19). The early low/late high-protein and early high/late high-protein groups had hazard ratios of 0.63 (95% CI, 0.35–1.11) and 0.70 (95% CI, 0.46–1.06), respectively. Mortality and discharge-home rates did not differ significantly across protein dose/acute phase groups (<i>P</i> = 0.85 and 0.65, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We hypothesized that early medium and late high protein would improve outcomes; however, no significant differences between were observed across protein dose/acute phase groups. These findings are hypothesis-generating and highlight the need for future research to identify biomarkers or scoring tools that better define phase transitions in critical illness, enabling more precise nutrition strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration (Primary)</h3>\u0000 \u0000 <p>NCT03160547</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"183-191"},"PeriodicalIF":4.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral parenteral nutrition use outside of a dedicated nutrition support service: A descriptive cohort study","authors":"Alysia Bastas MPH,&nbsp;Monique Fernandez MD,&nbsp;Samuel Hui MPH,&nbsp;Darren Wong PhD","doi":"10.1002/jpen.70014","DOIUrl":"10.1002/jpen.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hospitalized patients may require nutrition support because of inadequate intake or impaired gut function. Enteral nutrition is preferred over parenteral nutrition because of fewer complications and earlier return of gut function. This study describes peripheral parenteral nutrition (PPN) use in an Australian tertiary center, evaluating its indications, incidence of adverse effects, and outcomes without the support of a nutrition support service.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All PPN prescriptions from May 2019 to December 2023 were retrospectively identified from pharmacy dispensing records. Demographic, admission, and clinical outcome data were collected from electronic medical records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the study period, 761 patients were identified to have received an initial course of PPN. Of these, 335 (44.0%) patients were women, with a median age of 66 (interquartile range [IQR], 54–77). The median duration of PPN was 3 days (IQR, 1.5–4), with a maximum of 20 days. The most frequent contraindication to enteral nutrition was bowel obstruction or ileus (<i>n</i> = 273). For 334 (43.9%) patients who received PPN, there was no documented contraindication to enteral nutrition. After cessation of PPN, most patients transitioned to oral intake alone after a median of 3 days. Thrombophlebitis and venous thrombosis were reported in 2.0% and 0.8% of cases, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>When unrestricted, a high proportion of individuals were inappropriately prescribed PPN. The unnecessary use of PPN exposed patients to potential complications and risks. As a result, PPN prescription should be managed by a dedicated nutrition support service.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"210-218"},"PeriodicalIF":4.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the gut microbiome and neurodevelopmental outcomes in infants with congenital heart disease: A prospective cohort study","authors":"Michael P. Fundora MD,&nbsp;Lily Dressner BS,&nbsp;Christina Calamaro PhD,&nbsp;Ann-Marie Brown PhD,&nbsp;Amelia St. John,&nbsp;Rachael Keiffer MPH,&nbsp;Nneka Alexander PhD,&nbsp;Hui Huang MS,&nbsp;Scott Gillespie MSPH,&nbsp;Patricia Wei Denning MD,&nbsp;Kolby Sanders-Lewis,&nbsp;Jinbing Bai PhD","doi":"10.1002/jpen.70038","DOIUrl":"10.1002/jpen.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Children with congenital heart disease are at risk for poor neurodevelopment. The gut microbiome may influence neurodevelopmental outcomes through the gut-brain axis. This study investigated the association of early-life gut microbiome with neurodevelopmental outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective cohort study was conducted in the cardiac intensive care unit. Fecal samples were collected before surgery, after surgery, and before discharge. Neurodevelopmental testing used Bayley Scales of Infant and Toddler Development between 9 and 12 months. Microbial data of the 16S ribosomal RNA V4 region were processed. Microbiome data were analyzed using Quantitative Insights Into Microbial Ecology 2 and MicrobiomeAnalyst 2.0.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-four patients were analyzed: 15 (62.5%) were male and 12 (50%) were White. Children with lower cognitive (Chao1 <i>P</i> = 0.024) and language scores (Chao1 <i>P</i> = 0.018) had lower alpha diversity; beta diversity showed marginally significant dissimilarities (Jaccard <i>P</i> = 0.102 and <i>P</i> = 0.051, respectively). Lower cognitive scores were associated with less <i>Parabacteroides</i> (<i>P</i> = 0.031), <i>Bacteroides</i> (<i>P</i> = 0.041), and <i>Bifidobacterium</i> (<i>P</i> = 0.047), and lower language scores were associated with less <i>Bifidobacterium</i> (<i>P</i> = 0.044) and <i>Enterococcus</i> (<i>P</i> = 0.024). Lower motor scores were associated with less <i>Rothia</i> (<i>P</i> = 0.017) but a higher abundance of <i>Serratia</i> (<i>P</i> &lt; 0.001), <i>Acinetobacter</i> (<i>P</i> = 0.016), and <i>Proteus</i> (<i>P</i> = 0.013).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Children with congenital heart disease with lower cognitive and language scores had lower diversity and less anti-inflammatory flora (eg, <i>Bifidobacterium</i>), whereas those with lower motor scores had a higher abundance of pro-inflammatory flora (eg, <i>Serratia</i>, <i>Acinetobacter</i>, and <i>Proteus</i>). Further studies are needed to understand the longitudinal effect of gut microbial dysbiosis on neurodevelopment in children with congenital heart disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"236-246"},"PeriodicalIF":4.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}