Journal of Orthopaedic Research®最新文献_第7页

Understanding the variability of the proximal femoral canal: A computational modeling study 了解股骨近端管道的可变性：计算模型研究

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-18 DOI: 10.1002/jor.25971

Angelika Ramesh, Johann Henckel, Alister Hart, Anna Di Laura

{"title":"Understanding the variability of the proximal femoral canal: A computational modeling study","authors":"Angelika Ramesh, Johann Henckel, Alister Hart, Anna Di Laura","doi":"10.1002/jor.25971","DOIUrl":"10.1002/jor.25971","url":null,"abstract":"Statistical shape modeling (SSM) offers the potential to describe the morphological differences in similar shapes using a compact number of variables. Its application in orthopedics is rapidly growing. In this study, an SSM of the intramedullary canal of the proximal femur was built, with the aim to better understanding the complexity of its shape which may, in turn, enhance the preoperative planning of total hip arthroplasty (THA). This includes the prediction of the prosthetic femoral version (PFV) which is known to be highly variable amongst patients who have undergone THA. The model was built on three dimensional (3D) models of 64 femoral canals which were generated from pelvic computed tomography images including the proximal femur in the field of view. Principal component analysis (PCA) was performed on the mean shape derived from the model and each segmented canal. Five prominent modes of variations representing approximately 84% of the total 3D variations in the population of shapes were found to capture variability in size, proximal torsion, intramedullary femoral anteversion, varus/valgus orientation, and distal femoral shaft twist/torsion, respectively. It was established that the intramedullary femoral canal is highly variable in its size, shape, and orientation between different subjects. PCA-driven SSM is beneficial for identifying patterns and extracting valuable features of the femoral canal.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"173-182"},"PeriodicalIF":2.1,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of biocompatibility and osseointegration of multi-component TiAl6V4 titanium alloy implants 评估多组分 TiAl6V4 钛合金植入体的生物相容性和骨整合性。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-16 DOI: 10.1002/jor.25974

Zaina Jacobs, Rossana Schipani, Maria Pastrama, Seyed Mohammad Ahmadi, Banafsheh Sajadi

{"title":"Evaluation of biocompatibility and osseointegration of multi-component TiAl6V4 titanium alloy implants","authors":"Zaina Jacobs, Rossana Schipani, Maria Pastrama, Seyed Mohammad Ahmadi, Banafsheh Sajadi","doi":"10.1002/jor.25974","DOIUrl":"10.1002/jor.25974","url":null,"abstract":"This study aimed to investigate the biocompatibility and osseointegration of novel titanium (Ti) implants with a perforated part with high surface roughness (Ra >4 μm) and a smooth solid part (test group), as compared to smooth solid Ti implants (control group; Ra < 0.8 μm). Test and control implants were implanted in rabbit femurs. After 4 and 15 weeks, host tissue reaction and quality of tissue formed were evaluated with histopathology, while micro-CT scans were used to quantitatively assess bone–implant contact (BIC), surrounding bone formation, and bone ingrowth.After 4 and 15 weeks, minimal host reaction was found in the test group. Histopathological analysis showed new bone formation around the implants in both the test and control groups after 4 weeks. Furthermore, additional bone growth was often observed within the holes of the test implants. After 15 weeks, the test implants showed high bone ingrowth and the presence of mature bone in direct contact with the implant surface, whereas, bone ingrowth was poorer for the control group with 30% of the control implants, showing larger gaps at the bone–implant interface. Quantitative micro-CT analysis revealed comparable BIC and bone formation in both groups at 4 weeks, but higher BIC and more bone formation in the test group than in the control group after 15 weeks. No significant differences were observed in any of the analyses. In conclusion, partially perforated, high-roughness Ti implants showed excellent osseointegration and minimal host reaction, indicating their potential for orthopedic applications in bone repair and regeneration.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"139-152"},"PeriodicalIF":2.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capsule release surgery temporarily reduces contracture in a rat elbow model of arthrofibrosis 胶囊松解手术可暂时减轻大鼠肘关节纤维化模型的挛缩。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-15 DOI: 10.1002/jor.25967

Austin J. Scholp, Jordan A. Jensen, Timothy P. Fowler, Emily Petersen, Douglas Fredericks, Aliasger K. Salem, Dongrim Seol, Mitchell Coleman, Spencer P. Lake, James A. Martin, Edward A. Sander

{"title":"Capsule release surgery temporarily reduces contracture in a rat elbow model of arthrofibrosis","authors":"Austin J. Scholp, Jordan A. Jensen, Timothy P. Fowler, Emily Petersen, Douglas Fredericks, Aliasger K. Salem, Dongrim Seol, Mitchell Coleman, Spencer P. Lake, James A. Martin, Edward A. Sander","doi":"10.1002/jor.25967","DOIUrl":"10.1002/jor.25967","url":null,"abstract":"Elbow trauma can lead to joint contracture and reduced range of motion (ROM). Nonsurgical interventions can improve ROM, but in some cases capsule release surgery is required. Although surgery can improve ROM, it often does not restore full ROM. Thus, alternatives are needed. One approach is to target activated myofibroblasts, which are commonly associated with fibrotic tissue. Mechanical and biochemical cues drive a feedback loop that can result in normal or pathological healing. We hypothesize that this feedback loop exists in joint contracture and can be manipulated so that myofibroblast activity is reduced, normal healing is achieved, and ROM is improved. We previously demonstrated that blebbistatin can inhibit myofibroblast contractile forces and reduce collagen synthesis in vitro. Thus, the purpose of this study was to assess the use of blebbistatin in an animal model of elbow contracture, which was induced in 7 groups of 4 rats each (n = 28). All elbows were mechanically and histologically tested. The uninjured contralateral elbows of each rat were used as a control group. Capsule release surgery significantly improved (p < 0.01) outcomes 1 week after surgery compared to injury alone and was not significantly different from uninjured elbows. Three weeks after surgery, outcomes worsened, indicating joint stiffening consistent with what is observed clinically. The addition of blebbistatin did not significantly improve outcomes. Future work will investigate relationships among treatment, fibrotic tissue deposition, myofibroblast activity, and biomechanics to determine if blebbistatin is a useful adjunctive therapy for treating joint contracture.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"23-36"},"PeriodicalIF":2.1,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanically compliant locking plates for diaphyseal fracture fixation: A biomechanical study 用于骺端骨折固定的机械顺应性锁定钢板：生物力学研究

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-15 DOI: 10.1002/jor.25968

Connor Huxman, Gregory Lewis, April Armstrong, Gary Updegrove, Zachary Koroneos, Jared Butler

{"title":"Mechanically compliant locking plates for diaphyseal fracture fixation: A biomechanical study","authors":"Connor Huxman, Gregory Lewis, April Armstrong, Gary Updegrove, Zachary Koroneos, Jared Butler","doi":"10.1002/jor.25968","DOIUrl":"10.1002/jor.25968","url":null,"abstract":"Axial micromotion between bone fragments can stimulate callus formation and fracture healing. In this study, we propose a novel mechanically compliant locking plate which achieves up to 0.6 mm of interfragmentary motion as flexures machined into the plate elastically deflect under physiological load. We investigated the biomechanical performance of three compliant plate variations in comparison to rigid control plates with small and large working lengths in a comminuted bridge plating scenario using humeral diaphysis surrogates. Under static axial loading, average interfragmentary motion was 6 times larger at 100 N (0.38 vs. 0.05 mm) and nearly three times larger at 350 N (0.58 vs. 0.2 mm) for compliant plates than rigid plates, respectively. Compliant plates delivered between 2.5 and 3.4 times more symmetric interfragmentary motion than rigid plates (p < 0.01). The bi-phasic stiffness of compliant pates provided 74%–96% lower initial axial stiffness up to approximately 100 N (p < 0.01), after which compliant plate stiffness was similar to rigid plates with increased working length (p > 0.3). The strength to failure of compliant plates under dynamic loading was on average 48%–55% lower than rigid plate groups (p < 0.01); however, all plates survived cyclic fatigue loading of 100,000 cycles at 350 N. This work characterizes the improvement in interfragmentary motion and the reduction in strength to failure of compliant plates compared to control rigid plates. Compliant plates may offer potential in comminuted fracture healing due to their ability to deliver symmetric interfragmentary motion into the range known to stimulate callus formation while surviving moderate fatigue loading with no signs of failure.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"217-227"},"PeriodicalIF":2.1,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRI-based radiomic analysis of soft tissue reactions near total hip arthroplasty 基于核磁共振成像的全髋关节置换术附近软组织反应放射学分析

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-13 DOI: 10.1002/jor.25970

Kevin M. Koch, Hollis G. Potter, Matthew F. Koff

引用次数: 0

Ankle osteoarthritis: Toward new understanding and opportunities for prevention and intervention 踝关节骨关节炎：预防和干预的新认识和新机遇

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-13 DOI: 10.1002/jor.25973

Donald D. Anderson, William R. Ledoux, Amy L. Lenz, Jason Wilken, Mark E. Easley, Cesar de Cesar Netto

{"title":"Ankle osteoarthritis: Toward new understanding and opportunities for prevention and intervention","authors":"Donald D. Anderson, William R. Ledoux, Amy L. Lenz, Jason Wilken, Mark E. Easley, Cesar de Cesar Netto","doi":"10.1002/jor.25973","DOIUrl":"10.1002/jor.25973","url":null,"abstract":"The ankle infrequently develops primary osteoarthritis (OA), especially when compared to the hip and the knee. Ankle OA instead generally develops only after trauma. The consequences of end-stage ankle OA can nonetheless be extremely debilitating, with impairment comparable to that of end-stage kidney disease or congestive heart failure. Disconcertingly, evidence suggests that ankle OA can develop more often than is generally appreciated after even low-energy rotational ankle fractures and chronic instability associated with recurrent ankle sprains, albeit at a slower rate than after more severe trauma. The mechanisms whereby ankle OA develops after trauma are poorly understood, but mechanical factors are implicated. A better understanding of the prevalence and mechanical etiology of post-traumatic ankle OA can lead to better prevention and mitigation. New surgical and conservative interventions, including improved ligamentous repair strategies and custom carbon fiber bracing, hold promise for advancing treatment that may prevent residual ankle instability and the development of ankle OA. Studies are needed to fill in key knowledge gaps here related to etiology so that the interventions can target key factors. New technologies, including weight bearing CT and biplane fluoroscopy, offer fresh opportunities to better understand the relationships between trauma, ankle alignment, residual ankle instability, OA development, and foot/ankle function. This paper begins by reviewing the epidemiology of post-traumatic ankle OA, presents evidence suggesting that new treatment options might be successful at preventing ankle OA, and then highlights recent technical advances in understanding of the origins of ankle OA to identify directions for future research.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"42 12","pages":"2613-2622"},"PeriodicalIF":2.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information - Editorial Board and TOC 期刊信息 - 编辑委员会和目录

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-09 DOI: 10.1002/jor.25618

引用次数: 0

Issue Information - Cover 发行信息 - 封面

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-09 DOI: 10.1002/jor.25619

引用次数: 0

Locking plate augmentation of polymethylmethacrylate-filled distal femoral defects: A biomechanical study 聚甲基丙烯酸甲酯填充股骨远端缺损的锁定钢板增量术：生物力学研究

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-09-01 DOI: 10.1002/jor.25965

Harrison R. Ferlauto, Bruno Belanger, Alexander L. Lazarides, Julia D. Visgauss, Brian E. Brigman, William C. Eward

{"title":"Locking plate augmentation of polymethylmethacrylate-filled distal femoral defects: A biomechanical study","authors":"Harrison R. Ferlauto, Bruno Belanger, Alexander L. Lazarides, Julia D. Visgauss, Brian E. Brigman, William C. Eward","doi":"10.1002/jor.25965","DOIUrl":"10.1002/jor.25965","url":null,"abstract":"Benign, locally aggressive tumors of the distal femur are typically treated with intralesional curettage and polymethylmethacrylate (PMMA) cementation. However, it is not known whether plate fixation should be added to biomechanically augment these PMMA-filled defects. The purpose of this study was to evaluate the performance of two competing techniques for reconstruction of a distal femoral defect. For this biomechanical study, we used 12 composite femurs with properties comparable to bone. In nine femurs, identical contained medial distal femoral defects were created using a robotic arm. Group A contained three intact femurs, Group B three femurs with an unfilled defect, Group C three femurs reconstructed with PMMA alone, and Group D three femurs reconstructed with PMMA plus a medial locking plate. Locations of greatest stress concentration were determined by PhotoStress analysis, then three strain gauges were applied to each specimen at these high-stress locations. Specimens were loaded within a physiologic range followed by loading to failure. Outcome measures included construct stiffness, strain along the distal femur, and load at failure. Results showed that stiffness and strain were not significantly different between reconstructive techniques; however, both techniques reduced tensile strain along the popliteal surface by approximately 40% compared to non-reconstructed specimens. All specimens failed at the femoral neck before failing at the distal femur. These findings suggest that plate augmentation of PMMA-filled distal femoral defects like the one in this study offers insignificant biomechanical benefit within physiologic loads and therefore may be unnecessary.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"210-216"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individual joint contributions to forward propulsion during treadmill walking in women with hip osteoarthritis 患有髋关节骨关节炎的女性在跑步机上行走时，各关节对向前推进力的贡献。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-08-31 DOI: 10.1002/jor.25964

Francesca Wade, Chun-Hao Huang, Kharma C. Foucher

{"title":"Individual joint contributions to forward propulsion during treadmill walking in women with hip osteoarthritis","authors":"Francesca Wade, Chun-Hao Huang, Kharma C. Foucher","doi":"10.1002/jor.25964","DOIUrl":"10.1002/jor.25964","url":null,"abstract":"As we age, reliance on the ankle musculature for push-off during walking reduces and increased reliance on the hip musculature is observed. It is unclear how joint pathology like osteoarthritis may affect this distal-to-proximal redistribution of propulsion. Here, we revisited a proof-of-concept study to study the effect of split-belt treadmill training, designed to reduce step length asymmetry, on forward propulsion during walking. Eleven women with hip osteoarthritis and five age-matched control participants walked on an instrumented split-belt treadmill at their preferred speed (hip osteoarthritis: 0.73 ± 0.11 m/s; controls: 0.59 ± 0.26 m/s). Women with hip osteoarthritis had less ankle power and propulsive force than controls, and greater hip contributions to forward propulsion on their involved limb. Following split-belt treadmill training, propulsive force increased on the involved limb. Five of 11 participants experienced a change in redistribution ratio that was greater than the minimal clinically meaningful difference. These “responders” had greater variability in pre-training redistribution ratio compared to non-responders. Women with hip osteoarthritis had poorer propulsive gait mechanics than controls yet split-belt treadmill training improved propulsive force. Redistribution ratio also changed in participants with high baseline variability. Our results suggest that split-belt treadmill training may be beneficial to people with hip osteoarthritis who have high variability in walking parameters. Further, the age-related shift to increased hip contributions to propulsion across populations of older adults may be due to increased variability during walking.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"94-101"},"PeriodicalIF":2.1,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0