Journal of Orthopaedic Research®最新文献_第7页

Enhanced enchondroma detection from x-ray images using deep learning: A step towards accurate and cost-effective diagnosis. 利用深度学习从 X 射线图像中增强软骨瘤检测：向准确、经济高效的诊断迈出一步。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-15 DOI: 10.1002/jor.25938

Şafak Aydin Şimşek, Ayhan Aydin, Ferhat Say, Tolgahan Cengiz, Caner Özcan, Mesut Öztürk, Erhan Okay, Korhan Özkan

引用次数: 0

Automated design of bone-preserving, insertable, and shape-matching patient-specific acetabular components 自动设计保骨、可插入和形状匹配的患者专用髋臼组件。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-14 DOI: 10.1002/jor.25927

Eric Garner, Alexander Meynen, Lennart Scheys, Jun Wu, Amir A. Zadpoor

{"title":"Automated design of bone-preserving, insertable, and shape-matching patient-specific acetabular components","authors":"Eric Garner, Alexander Meynen, Lennart Scheys, Jun Wu, Amir A. Zadpoor","doi":"10.1002/jor.25927","DOIUrl":"10.1002/jor.25927","url":null,"abstract":"Effective treatment of large acetabular defects remains among the most challenging aspects of revision total hip arthroplasty (THA), due to the deficiency of healthy bone stock and degradation of the support columns. Generic uncemented components, which are favored in primary THA, are often unsuitable in revision cases, where the bone-implant contact may be insufficient for fixation, without significant reaming of the limited residual bone. This study presents a computational design strategy for automatically generating patient-specific implants that simultaneously maximize the bone-implant contact area, and minimize bone reaming while ensuring insertability. These components can be manufactured using the same additive manufacturing methods as porous components and may reduce cost and operating-time, compared to existing patient-specific systems. This study compares the performance of implants generated via the proposed method to optimally fitted hemispherical implants, in terms of the achievable bone-implant contact surface, and the volume of reamed bone. Computer-simulated results based on the reconstruction of a set of 15 severe pelvic defects (Paprosky 2A-3B) suggest that the patient-specific components increase bone-implant contact by 63% (median: 63%; SD: 44%; 95% CI: 52.3%–74.0%; RMSD: 42%), and reduce the volume of reamed bone stock by 97% (median: 98%; SD: 4%; 95% CI: 95.9%–97.4%; RMSD: 3.7%).","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging cutting-edge transcriptomics to inform precision therapeutic targeting for soft tissue joint disease 利用前沿转录组学为软组织关节疾病的精准靶向治疗提供信息。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-11 DOI: 10.1002/jor.25928

Jessica E. Ackerman, Stephanie G. Dakin

引用次数: 0

Bone remodeling after revision total hip arthroplasty for large acetabular defects. 大面积髋臼缺损翻修全髋关节置换术后的骨重塑。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-11 DOI: 10.1002/jor.25936

Angelika Ramesh, Anna Di Laura, Sara De Angelis, Johann Henckel, Alister Hart

{"title":"Bone remodeling after revision total hip arthroplasty for large acetabular defects.","authors":"Angelika Ramesh, Anna Di Laura, Sara De Angelis, Johann Henckel, Alister Hart","doi":"10.1002/jor.25936","DOIUrl":"https://doi.org/10.1002/jor.25936","url":null,"abstract":"Large acetabular bone defects are challenging in hip revision surgery. Clinical assessment is crucial to evaluate modern technologies in surgical reconstruction. We aimed to better understand the bone remodeling that occurs following acetabular reconstruction. Our objectives were: (1) To characterize changes in the shape of the pelvis by studying sequential computed tomography (CT) scans collected immediately and 1-year postoperatively and (2) to identify which part of the pelvis is most susceptible to remodeling. We used the CT scans taken at two timepoints, of 24 patients with acetabular bone defects classified as Paprosky IIIB, treated with three-dimensional (3D)-printed custom-made acetabular implants. Segmented 3D models of the bony pelvis were co-registered using three different techniques. A global co-registration of the full pelvis was conducted, followed by the co-registration of the innominate bone and then ilium only, on the ipsilateral reconstructed side. The relative movements of the ilium, ischium, and pubis were analyzed from visual inspection and using co-registration metrics (root mean square error and intersection over union). No bone remodeling was found in 14/24 patients (58%). The co-registration of the innominate bone indicated bone remodeling in five cases (21%), while the remaining five cases (21%) presented remodeling in the global co-registration but not the innominate bone co-registration, suggestive of changes occurring at the sacroiliac joint. Changes in the pelvic shape were greatest at the pubis and ischium. Bone remodeling may occur in complex cases of Paprosky type IIIB defects, after acetabular reconstruction (occurrence of 21%, 5/24 cases). Surgeons and engineers should consider this when monitoring implant migration.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decorin and/or biglycan knockdown in aged mouse patellar tendon impacts fibril morphology, scar area, and mechanical properties 敲除老化小鼠髌腱中的 Decorin 和/或 biglycan 会影响纤维形态、瘢痕面积和机械性能。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-05 DOI: 10.1002/jor.25931

Joseph B. Newton, Stephanie N. Weiss, Courtney A. Nuss, Christelle Darrieutort-Laffite, Jeremy D. Eekhoff, David E. Birk, Louis J. Soslowsky

{"title":"Decorin and/or biglycan knockdown in aged mouse patellar tendon impacts fibril morphology, scar area, and mechanical properties","authors":"Joseph B. Newton, Stephanie N. Weiss, Courtney A. Nuss, Christelle Darrieutort-Laffite, Jeremy D. Eekhoff, David E. Birk, Louis J. Soslowsky","doi":"10.1002/jor.25931","DOIUrl":"10.1002/jor.25931","url":null,"abstract":"Small leucine-rich proteoglycans, such as decorin and biglycan, play pivotal roles in collagen fibrillogenesis during development, healing, and aging in tendon. Previous work has shown that the absence of decorin and biglycan affects fibril shape and mechanical properties during tendon healing. However, the roles of decorin and biglycan in the healing process of aged tendons are unclear. Therefore the objective of this study was to evaluate the differential roles of decorin and biglycan during healing of patellar tendon injury in aged mice. Aged (300 days old) female Dcn+/+/Bgn+/+ control (WT, n = 52), Dcnflox/flox (I-Dcn−/−, n = 36), Bgnflox/flox (I-Bgn−/−, n = 36), and compound Dcnflox/flox/Bgnflox/flox (I-Dcn−/−/Bgn−/−, n = 36) mice with a tamoxifen-inducible Cre were utilized. Targeted gene expression, collagen fibril diameter distributions, mechanical properties, and histological assays were employed to assess the effects of knockdown of decorin and/or biglycan at the time of injury. Knockdown resulted in alterations in fibril diameter distribution and scar area, but surprisingly did not lead to many differences in mechanical properties. Biglycan played a larger role in early healing stages, while decorin is more significant in later stages, particularly in scar remodeling. This study highlights some of the differential roles of biglycan and decorin in the regulation of fibril structure and scar area, as well as influencing gene expression during healing in aged mice.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional evidence for transient regulation of muscle regeneration by brown adipose transplant in the rotator cuff 转录证据表明棕色脂肪移植对肩袖肌肉再生的瞬时调控作用

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-05 DOI: 10.1002/jor.25933

Chang Gui, Gretchen Meyer

{"title":"Transcriptional evidence for transient regulation of muscle regeneration by brown adipose transplant in the rotator cuff","authors":"Chang Gui, Gretchen Meyer","doi":"10.1002/jor.25933","DOIUrl":"10.1002/jor.25933","url":null,"abstract":"Chronic rotator cuff (RC) injuries can lead to a degenerative microenvironment that favors chronic inflammation, fibrosis, and fatty infiltration. Recovery of muscle structure and function will ultimately require a complex network of muscle resident cells, including satellite cells, fibro-adipogenic progenitors (FAPs), and immune cells. Recent work suggests that signaling from adipose tissue and progenitors could modulate regeneration and recovery of function, particularly promyogenic signaling from brown or beige adipose (BAT). In this study, we sought to identify cellular targets of BAT signaling during muscle regeneration using a RC BAT transplantation mouse model. Cardiotoxin injured supraspinatus muscle had improved mass at 7 days postsurgery (dps) when transplanted with exogeneous BAT. Transcriptional analysis revealed transplanted BAT modulates FAP signaling early in regeneration likely via crosstalk with immune cells. However, this conferred no long-term benefit as muscle mass and function were not improved at 28 dps. To eliminate the confounding effects of endogenous BAT, we transplanted BAT in the “BAT-free” uncoupling protein-1 diphtheria toxin fragment A (UCP1-DTA) mouse and here found improved muscle contractile function, but not mass at 28 dps. Interestingly, the transplanted BAT increased fatty infiltration in all experimental groups, implying modulation of FAP adipogenesis during regeneration. Thus, we conclude that transplanted BAT modulates FAP signaling early in regeneration, but does not grant long-term benefits.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gait asymmetry persists following unilateral and bilateral total ankle arthroplasty 单侧和双侧全踝关节置换术后仍存在步态不对称。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-04 DOI: 10.1002/jor.25932

Stephanie H. Carpentier, Martin Barylak, Sara Arena, Robin Queen

{"title":"Gait asymmetry persists following unilateral and bilateral total ankle arthroplasty","authors":"Stephanie H. Carpentier, Martin Barylak, Sara Arena, Robin Queen","doi":"10.1002/jor.25932","DOIUrl":"10.1002/jor.25932","url":null,"abstract":"Total ankle arthroplasty (TAA) improves gait symmetry in patients with unilateral end-stage ankle arthritis but has not been studied in patients undergoing bilateral TAA (B-TAA), and few studies compare TAA patients to control subjects. The purpose of this study was to compare gait symmetry in U-TAA and B-TAA patients and healthy controls. Using prospective databases, 19 unilateral and 19 bilateral ankle arthritis patients undergoing TAA were matched to 19 control subjects by age, sex, and BMI. The Normalized Symmetry Index (NSI) was determined for joint mechanics and ground reaction forces (GRF) during walking trials at a single visit for controls and preoperatively and 1 to 2 years postoperatively for TAA patients. Data was analyzed using linear mixed-effects models to determine differences among time points and cohorts at a significance of α = 0.05. Following surgery, B-TAA and U-TAA experienced improved peak plantarflexion moment symmetry (p = 0.017) but remained less symmetric than controls. B-TAA patients had more symmetry than U-TAA patients during peak weight acceptance GRF (p = 0.002), while U-TAA patients had greater peak dorsiflexion symmetry than B-TAA patients. TAA patients demonstrated more asymmetry compared to control subjects for all outcome measures. There was no significant impact of TAA on gait symmetry for GRF or peak ankle angles, and neither U-TAA nor B-TAA was consistently associated with higher gait symmetry. These results indicate that TAA improves symmetry during peak plantarflexion moment, and that significant gait asymmetry persists for B-TAA and U-TAA patients compared to healthy participants.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25932","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early signs of osteoarthritis in differing rat osteochondral defects 不同大鼠骨软骨缺损的骨关节炎早期症状

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-04 DOI: 10.1002/jor.25930

Samir Chihab, Tracy Eng, Jarred M. Kaiser, Nazir M. Khan, Thanh N. Doan, Hicham Drissi

{"title":"Early signs of osteoarthritis in differing rat osteochondral defects","authors":"Samir Chihab, Tracy Eng, Jarred M. Kaiser, Nazir M. Khan, Thanh N. Doan, Hicham Drissi","doi":"10.1002/jor.25930","DOIUrl":"10.1002/jor.25930","url":null,"abstract":"Preclinical models of osteochondral defects (OCDs) are fundamental test beds to evaluate treatment modalities before clinical translation. To increase the rigor and reproducibility of translational science for a robust “go or no-go,” we evaluated disease progression and pain phenotypes within the whole joint for two OCD rat models with same defect size (1.5 x 0.8 mm) placed either in the trochlea or medial condyle of femur. Remarkably, we only found subtle transitory changes to gaits of rats with trochlear defect without any discernible effect to allodynia. At 8-weeks post-surgery, anatomical evaluations of joint showed early signs of osteoarthritis with EPIC-microCT. For the trochlear defect, cartilage attenuation was increased in trochlear, medial, and lateral compartments of the femur. For condylar defect, increased cartilage attenuation was isolated to the medial condyle of the femur. Further, the medial ossicle showed signs of deterioration as indicated with decreased bone mineral density and increased bone surface area to volume ratio. Thus, OCD in a weight-bearing region of the femur gave rise to more advanced osteoarthritis phenotype within a unilateral joint compartment. Subchondral bone remodeling was evident in both models without any indication of closure of the articular cartilage surface. We conclude that rat OCD, placed in the trochlear or condylar region of the femur, leads to differing severity of osteoarthritis progression. As found herein, repair of the defect with fibrous tissue and subchondral bone is insufficient to alleviate onset of osteoarthritis. Future therapies using rat OCD model should address joint osteoarthritis in addition to repair itself.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information - Cover 发行信息 - 封面

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-03 DOI: 10.1002/jor.25615

引用次数: 0

Issue Information - Editorial Board and TOC 期刊信息 - 编辑委员会和目录

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-07-03 DOI: 10.1002/jor.25614

引用次数: 0