Journal of Orthopaedic Research®最新文献

{"title":"Issue Information - Editorial Board and TOC","authors":"","doi":"10.1002/jor.25886","DOIUrl":"https://doi.org/10.1002/jor.25886","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"889-892"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Cover","authors":"","doi":"10.1002/jor.25887","DOIUrl":"https://doi.org/10.1002/jor.25887","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritic Human Synovial Fluid Alters CoCrMo Electrochemical Properties on a Patient-Specific Basis","authors":"Bailey Bond,&nbsp;Madison N. Brown,&nbsp;Michael A. Kurtz,&nbsp;Alayna Robinson,&nbsp;Marc J. Mihalko,&nbsp;John R. Crockarell Jr.,&nbsp;Christopher T. Holland,&nbsp;James L. Guyton,&nbsp;William M. Mihalko","doi":"10.1002/jor.26079","DOIUrl":"10.1002/jor.26079","url":null,"abstract":"<div>\u0000 \u0000 <p>Cobalt-chromium-molybdenum (CoCrMo) femoral components are widely used in total knee arthroplasty (TKA). However, recent retrospective clinical trials associate moderate adverse local tissue reactions with CoCrMo release in the knee. Additionally, gaps persist in our understanding of the fundamental corrosion processes that occur at the CoCrMo-synovial fluid interface. In this study, we investigated the electrochemical behavior of CoCrMo in human synovial fluid obtained at the time of primary TKA, using CoCrMo in phosphate-buffered saline (PBS) as a comparison. Synovial fluid was collected from 118 patients immediately before arthroplasty, then transferred to a three-electrode electrochemical cell with a wrought CoCrMo alloy working electrode. To quantify electrochemical properties, open circuit potential (OCP), electrochemical impedance spectroscopy, and linear polarization tests were run. Generally, the properties varied on a patient-by-patient basis and significantly differed (<i>p</i> &lt; 0.05) from comparison tests performed in PBS. In human synovial fluid, we measured OCPs between a range of −0.38 and 0.15 V and corrosion potentials (<i>E</i>_corr) between −0.95 and −0.2 V. Additionally, we reported instantaneous corrosion rates (1/<i>R_p</i>) spanning nearly four orders of magnitude. The variability we documented suggested that the electrochemical properties of CoCrMo implants may depend on the patient's local physiological environment, influenced by the biological and chemical components of synovial fluid.</p>\u0000 <p><b>Statement of Clinical Significance:</b> This study shows that human synovial fluid affects the electrochemical behavior of CoCrMo, evidenced by the variation on a patient-by-patient basis. This study may have implications for long-term biological response to orthopaedic implants, including total knee arthroplasty.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1144-1154"},"PeriodicalIF":2.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humeral Development Throughout the Arc of Childhood—A 3D MRI Study","authors":"Paige M. Lind,&nbsp;Michael L. Pearl,&nbsp;Katharine E. Alter,&nbsp;Euan A. Forrest,&nbsp;Frances T. Sheehan","doi":"10.1002/jor.26081","DOIUrl":"10.1002/jor.26081","url":null,"abstract":"<p>A quantitative understanding of humeral morphology through the arc of pediatric development is crucial in optimizing the treatment of pediatric shoulder-related orthopedic disorders and athletic overuse injuries. However, data regarding modern normative humeral development are not available. Thus, the aim of this study is to derive biomechanically relevant humeral size and shape measures from a pediatric cohort spanning infancy to adulthood (age 0.6–18.8 years, <i>n</i> = 52). Three-dimensional models were generated by segmenting axial MR images from typically developing, dominant-side humeri. Quadratic regression defined the relationship between each parameter and age. In a sub-cohort, we compared humeral morphological parameters between dominant and nondominant humeri from the same child. Children exhibited a pattern of steady growth, anteversion, and declination throughout development that gradually tapered off toward adulthood. Size measurements had the strongest regressions with age (head diameter: <i>R</i>² = 0.908; humeral length: <i>R</i>² = 0.960; epicondylar width: <i>R</i>² = 0.889, <i>p</i> &lt; 0.001). Version was more variable and less strongly related to age (<i>R</i>² = 0.238, <i>p</i> &lt; 0.001), whereas inclination demonstrated the weakest relationship with age (<i>R</i>² = 0.128, <i>p</i> &lt; 0.05). The shallow curve fits indicated that there is not a single age where adult values were attained. In the sub-cohort analysis, the data from the right and left limbs were no different and correlated, supporting the use of the contralateral limb as a comparator when unilateral pathology is present, if the contralateral parameters fall within the normative range. Our data set provides a unique asset for pediatric clinical interventional planning as it provides the only current in vivo humeral development measures throughout the arc of childhood.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1230-1238"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Structure and Age in Healthy Achilles Tendons","authors":"Kayla D. Seymore,&nbsp;Shawn L. Hanlon,&nbsp;Ryan T. Pohlig,&nbsp;Dawn M. Elliott,&nbsp;Karin Grävare Silbernagel","doi":"10.1002/jor.26080","DOIUrl":"10.1002/jor.26080","url":null,"abstract":"<div>\u0000 \u0000 <p>Age is an important factor to consider with Achilles tendon injury, as variability in tendon structure during developmental growth and aging influence lower limb function and mobility. However, the overlap in structural alterations with aging and Achilles tendon injury makes it unclear which structural changes are related to age separate from tendon pathology. The objective of this study was to determine the relationship between structure and age in healthy Achilles tendons. Healthy Achilles tendons from 389 children and adults (8–79 years) were included in this retrospective analysis. Achilles tendon morphology was assessed via B-mode ultrasound of Achilles tendon length, cross-sectional area (CSA), and thickness. Mechanical properties of Achilles tendon shear modulus and viscosity were assessed via continuous shear wave elastography. The relationship between Achilles tendon structure and age was determined using General Linear Models and White's test of heteroscedasticity (to assess for unequal variance across the age span), controlling for sex, weight, and physical activity level. Healthy free Achilles tendon length (<i>p</i> = 0.002), thickness (<i>p</i> &lt; 0.001), CSA (<i>p</i> &lt; 0.001), and viscosity (<i>p</i> = 0.009) increased with age, supporting age-related changes in tendon structure that may limit its capacity to store and transfer energy in older adults. Full Achilles tendon length and CSA varied across the age span (<i>p</i> &lt; 0.05), suggesting the Achilles tendon undergoes natural aging processes seen with most musculoskeletal tissue. Normative data on Achilles tendon structure with age will contribute to our understanding and interpretation of Achilles tendon injury pathogenesis; aiding in the design of injury prevention and treatment strategies.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1250-1258"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology of the Effects of Oxidative Stress on the Skeletal System","authors":"Issei Shinohara,&nbsp;Mayu Morita,&nbsp;Simon Kwoon-Ho Chow,&nbsp;Masatoshi Murayama,&nbsp;Yosuke Sususki,&nbsp;Qi Gao,&nbsp;Stuart B. Goodman","doi":"10.1002/jor.26075","DOIUrl":"10.1002/jor.26075","url":null,"abstract":"<div>\u0000 \u0000 <p>Reactive oxygen species (ROS) are molecules that are generated primarily during energy production in cells. ROS are involved in critical biological functions such as signal transduction; when the production of ROS is imbalanced, excessive ROS causes oxidative stress, and subsequent cellular damage. Oxidative stress is linked to numerous pathological disorders in major organs including the skeletal system. In an aging society, understanding the role of ROS in skeletal health is critical to developing preventative and therapeutic interventions. Oxidative stress causes defects in cellular differentiation, apoptosis, mitochondrial dysfunction, and inflammation. The effects of oxidative stress on the skeletal system have been implicated in the development of osteoporosis, knee osteoarthritis, and osteonecrosis by inhibiting bone remodeling, increasing osteoclast activity, and decreasing osteoblast function. ROS are also involved in many signaling pathways that regulate immune defense, cell proliferation, and inflammation. This underscores the importance of maintaining a balance between ROS and antioxidants to prevent oxidative stress and related diseases. Targeting ROS and oxidative stress mechanisms may offer new treatments for diseases affecting the skeletal system and other organs, potentially improving health outcomes, and extending healthy lifespans. This review highlights the significant impact of oxidative stress on skeletal health and explores potential preventative and therapeutic strategies to mitigate the adverse effects of ROS.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1059-1072"},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Pursuit of Quantifying Patient Knee Contact Mechanics: Finite Element Model Validation of Cadaveric Knees in Axially Loaded MRI Scans","authors":"Brett D. Steineman,&nbsp;Kalle L. Chastain,&nbsp;Sean C. Letendre,&nbsp;Joshua Leadem,&nbsp;Kathryn Colone,&nbsp;Manuela Montes de Oca,&nbsp;Lila Pender,&nbsp;Madison Lang,&nbsp;Erin R. Leatherman,&nbsp;Erin Argentieri,&nbsp;Amanda Wach,&nbsp;Matthew F. Koff,&nbsp;Scott A. Rodeo,&nbsp;Amy L. Lerner,&nbsp;Suzanne A. Maher","doi":"10.1002/jor.26077","DOIUrl":"10.1002/jor.26077","url":null,"abstract":"<div>\u0000 \u0000 <p>Our long-term objective is to quantify patient-specific changes in contact mechanics after partial meniscectomy (PM) using knee-specific finite element (FE) models created from clinical MR scans under axial load. Before creating patient-specific models, a validation of our workflow and processes is required. The objective of this study was to validate knee-specific FE models of tibiofemoral joint contact mechanics by comparison to direct measurements of contact by electronic pressure sensors. We hypothesized that knee-specific FE model data would fall within direct measurements of the contact area and pressure values from sensors, but that detected differences in outcomes would be smaller than differences reported after PM. The workflow consisted of performing MRIs on five cadaveric knees using a patient-based loading system adapted to cadaveric knees where loaded and unloaded scans were acquired with and without a sensor in place, segmenting images to develop FE models, running those models with statistical approaches to model material property variation and comparing the model outputs to the outputs quantified physically by sensors. Overall, 53% of outcomes (32/60) from the FE models fell within the ranges of those directly measured. Of the values that fell outside, differences were lower than those identified from a literature review of the mechanical effects of partial meniscectomies, especially when meniscectomies were 30% or 60% of the meniscus volume. FE models developed using this workflow may be helpful in assessing or anticipating changes in joint force redistribution following partial meniscectomies in patients.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1132-1143"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane Filtration of Sonication Fluid—A Promising Adjunctive Method for the Diagnosis of Low-Grade Infection in Presumed Aseptic Nonunion","authors":"Katharina Trenkwalder,&nbsp;Sandra Erichsen,&nbsp;Ferdinand Weisemann,&nbsp;Peter Augat,&nbsp;SAND Research Group,&nbsp;Simon Hackl","doi":"10.1002/jor.26076","DOIUrl":"https://doi.org/10.1002/jor.26076","url":null,"abstract":"<p>Treatment guidelines for fracture nonunion differ based on the presence or absence of infection. Low-grade infections without preoperative clinical signs of infection are difficult to distinguish from aseptic cases. Membrane filtration of sonication fluid (MF) has been shown to be a useful method for identifying septic nonunion. Therefore, the aim of this study was to evaluate the diagnostic value of MF in differentiating low-grade infected nonunion from aseptic cases. A prospective multicenter clinical study enrolled 75 patients with femoral or tibial shaft nonunion with planned revision surgery and without clinical suspicion of infection. During revision surgery, tissue from the nonunion zone was sampled for culture and histopathology, and the implant for sonication with MF and colony forming unit (CFU) quantification. Infection was diagnosed according to the diagnostic criteria for fracture-related infection. The diagnostic performance of MF CFU count was evaluated by receiver operating characteristic (ROC) curve and compared with that of tissue culture (TC), sonication fluid broth culture (SFC), and Histopathological Osteomyelitis Evaluation Score (HOES). Fifty-three nonunion cases were aseptic, and 22 had a low-grade infection. ROC curve had an area under the curve of 0.84. The optimal CFU cutoff to discriminate between low-grade infected and aseptic nonunion was 11.1 CFU/10 mL sonication fluid with 64% sensitivity and 89% specificity. SFC showed a higher sensitivity of 82% but a lower specificity of 81%. The sensitivity and specificity of TC were 77% and 96%, respectively, and those of HOES were 9% and 87%, respectively. Implementation of MF in clinical diagnostics as an adjunct to TC may improve the differential diagnosis between low-grade infected nonunion and aseptic nonunion.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1203-1211"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Characterization and In Vivo Performance of Vancomycin-Loaded PLGA Microspheres Prepared by Using Microfluidics for the Management of Orthopedic Infections","authors":"Dinesh Dhamecha,&nbsp;Mehmet D. Asik,&nbsp;Cecilia Nepple,&nbsp;Yingfang Fan,&nbsp;Amita Sekar,&nbsp;Keita Fujino,&nbsp;Fawaz Malick,&nbsp;Madeline McCanne,&nbsp;Ebru Oral,&nbsp;Orhun Muratoglu","doi":"10.1002/jor.26070","DOIUrl":"10.1002/jor.26070","url":null,"abstract":"<div>\u0000 \u0000 <p>Periprosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA), leading to high rates of revision surgeries, long-term morbidity, and mortality. Conventional antibiotic treatments often suffer from limited bioavailability and systemic toxicity. This study explores a novel approach using vancomycin-loaded poly(lactic-<i>co</i>-glycolic) acid (PLGA) microparticles (VMP) formulated via a microfluidic double emulsion method for controlled, localized drug delivery for managing PJI. The PLGA microparticles were synthesized to achieve high loading capacity and sustained vancomycin release, aiming to maintain therapeutic intra-articular concentrations. In vitro characterization demonstrated optimal loading capacity (up to 28% w/w), morphology with a homogeneous particle size distribution (49–65 µm), and sustained release profiles over 8 weeks. In vivo efficacy was evaluated using a rat joint infection model, showing significant reductions in bacterial viability and enhanced bone healing compared to controls. Weight-bearing recovery assessments showed that VMP-treated rats regained functionality significantly earlier than controls (<i>p</i> &lt; 0.05). Radiographic, histological, and immunofluorescent analyses confirmed reduced inflammation and improved bone integrity with VMP treatment. These findings suggest that microfluidic-synthesized PLGA microparticles provide a promising strategy for localized, controlled release of antibiotics, potentially helping the management of PJI and improving postsurgical outcomes. Future research should explore the long-term effects and scalability of clinical applications. This study lays the foundation for advancing controlled release systems in orthopedic postoperative care.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1191-1202"},"PeriodicalIF":2.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Detection of Microcracks Within Second Harmonic Generation Images of Cartilage Using Deep Learning","authors":"Kosar Safari,&nbsp;Borja Rodriguez Vila,&nbsp;David M. Pierce","doi":"10.1002/jor.26071","DOIUrl":"10.1002/jor.26071","url":null,"abstract":"<div>\u0000 \u0000 <p>Articular cartilage, essential for smooth joint movement, can sustain micrometer-scale microcracks in its collagen network from low-energy impacts previously considered non-injurious. These microcracks may propagate under cyclic loading, impairing cartilage function and potentially initiating osteoarthritis (OA). Detecting and analyzing microcracks is crucial for understanding early cartilage damage but traditionally relies on manual analyses of second harmonic generation (SHG) images, which are labor-intensive, limit scalability, and delay insights. To address these challenges, we established and validated a YOLOv8-based deep learning model to automate the detection, segmentation, and quantification of cartilage microcracks from SHG images. Data augmentation during training improved model robustness, while evaluation metrics, including precision, recall, and F1-score, confirmed high accuracy and reliability, achieving a true positive rate of 95%. Our model consistently outperformed human annotators, demonstrating superior accuracy, repeatability, all while reducing labor demands. Error analyses indicated precise predictions for microcrack length and width, with moderate variability in estimations of orientation. Our results demonstrate the transformative potential of deep learning in cartilage research, enabling large-scale studies, accelerating analyses, and providing insights into soft tissue damage and engineered material mechanics. Expanding our data set to include diverse anatomical regions and disease stages will further enhance performance and generalization of our YOLOv8-based model. By automating microcrack detection, this study advances understanding of microdamage in cartilage and potential mechanisms of progression of OA. Our publicly available model and data set empower researchers to develop personalized therapies and preventive strategies, ultimately advancing joint health and preserving quality of life.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1101-1112"},"PeriodicalIF":2.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}