Journal of Orthopaedic Research®最新文献

{"title":"Quantitative Assessment of Knee Pain and Proprioception in Tibial Rotation in Individuals With Knee Osteoarthritis","authors":"Zongpan Li,&nbsp;Raziyeh Baghi,&nbsp;Giovanni Oppizzi,&nbsp;Peter Bowman,&nbsp;Frank Henn,&nbsp;Li-Qun Zhang","doi":"10.1002/jor.70022","DOIUrl":"10.1002/jor.70022","url":null,"abstract":"<p>Patients with knee osteoarthritis (OA) exhibit reduced tibial rotations, possibly as a compensatory adaptation to mitigate mechanical stimuli on surrounding tissues. Hence, the passive threshold angle at which knee pain is sensed may reflect that surrounding tissues have received mechanical stimuli sufficient to exceed the nociceptive threshold. This study aimed to measure knee pain and proprioception during tibial rotation quantitatively. Twelve patients with symptomatic medial knee OA and 12 age- and sex-matched controls were included. For patients with knee OA, knee pain was quantified using the pain threshold angle (PTA), at which pain was first perceived during robot-controlled tibial internal rotation (IR) and external rotation (ER) at 0.5°/sec. Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were also collected. Knee proprioception was measured as the threshold of passive movement detection (TPMD), at which participants first perceived the motion. Pearson's correlations were performed to assess relationships between KOOS/WOMAC and PTA. Independent t-tests compared TPMD between OA and control groups, while paired t-tests compared PTA and TPMD between IR and ER. In knee OA patients, smaller PTA in IR was correlated with worsened scores on KOOS/WOMAC (r = 0.59–0.70; <i>p</i> &lt; 0.05); and PTA in IR was lower than in ER (<i>p</i> = 0.009), indicating increased pain sensitivity in IR. Patients with medial knee OA exhibited impaired proprioception, with a larger TPMD in tibial ER than controls (<i>p</i> = 0.019). This study presents a novel method for quantifying knee pain and proprioception, potentially enhancing the precision of knee OA rehabilitation.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 10","pages":"1748-1756"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Baseplate Position and Screws in Reverse Total Shoulder Arthroplasty Using 3D Printed Patient-Specific Instrumentation","authors":"Wonhee Lee,&nbsp;Woojin Yu,&nbsp;HwaYong Lee,&nbsp;Guk Bae Kim,&nbsp;In-Ho Jeon,&nbsp;Kyoung Hwan Koh","doi":"10.1002/jor.70023","DOIUrl":"10.1002/jor.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Patient-specific instrumentation (PSI) in shoulder arthroplasty has been used to translate preoperative surgical planning into precise implant positioning. However, screws for baseplate fixation using PSI have not been preoperatively planned or verified for proper location and length. This study aims to assess the reproducibility of the 3D-printed PSI system for baseplate and screw positioning in reverse total shoulder arthroplasty (rTSA) and the role of preoperative screw planning. Postoperative CT data from 30 patients who underwent primary rTSA using PSI were collected. After ideal position planning of the baseplate and screws, a PSI guide was 3D-printed. Postoperative CT evaluated baseplate version, inclination, and translation. Screw length, insertion angle, and potential penetration of the spinoglenoid and suprascapular notch were investigated. The mean differences between planned and actual implantation were 2.7° ± 5.8° for version, 0.9° ± 3.5° for inclination, and 1.0° ± 5.4° for rotation. The mean translation difference was 1.7 ± 1.0 mm. The mean screw angulation differences were −0.5° ± 6.4° anteroposteriorly and −1.4° ± 7.1° superior-inferiorly. There was no risk of nerve injury from suprascapular notch involvement because it was considered that the screw was positioned away from the nerve path. The posterior screw was abandoned in 93.3% of patients due to proximity to the suprascapular nerve or insufficient length for bone purchase (mean length: 9.3 ± 2.0 mm). Using PSI, the reproducibility of baseplate and screw placement in rTSA was confirmed. The posterior screw has a limited role due to its length and direction constraints.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical significance</h3>\u0000 \u0000 <p>Preoperative planning and PSI enable precise surgery, including proper screw insertion and baseplate positioning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 10","pages":"1695-1704"},"PeriodicalIF":2.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Cover","authors":"","doi":"10.1002/jor.25893","DOIUrl":"https://doi.org/10.1002/jor.25893","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 8","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board and TOC","authors":"","doi":"10.1002/jor.25892","DOIUrl":"https://doi.org/10.1002/jor.25892","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 8","pages":"1363-1366"},"PeriodicalIF":2.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25892","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Machine Learning Approach to Microcalorimetric Pattern Classification of Pathogens in Synovial Fluid","authors":"Manuel Lozano-García,&nbsp;Luis Estrada-Petrocelli,&nbsp;Roger Rosselló Román,&nbsp;Raimon Jané,&nbsp;Andrej Trampuz,&nbsp;Christian Morgenstern","doi":"10.1002/jor.70024","DOIUrl":"10.1002/jor.70024","url":null,"abstract":"<p>Isothermal microcalorimetry (IMC) is a promising tool for diagnosing periprosthetic joint infection (PJI), based on real-time measurement of growth-related heat production of pathogens, and faster than conventional microbial cultures. However, the feasibility of identifying specific pathogens in clinical samples using IMC has yet to be proven. This study implements machine learning and transfer learning convolutional neural network (CNN) models to detect and identify pathogens causing PJI, using IMC data alone. IMC data were obtained from synovial fluid samples, including 174 aseptic samples and 239 PJI samples containing five different bacterial strains. XGBoost, multi-layer perceptron, support vector machine, random forest, and three transfer learning CNN models were implemented to detect PJI and identify five bacterial strains in PJI samples. The binary XGBoost classifier yielded a 100% accuracy in PJI detection, whereas the multiclass XGBoost classifier and the combined transfer learning CNN classifier reached an overall accuracy of 90.3% and 91.5%, respectively, in PJI identification, with biological significance of extracted features in the XGBoost model facilitating its interpretability and usage in clinical practice. The strain with the lowest recall (83.3%) was PA, whereas SE was the strain with the lowest precision (78.9%). The results demonstrate the feasibility of automatic detection and identification of pathogens causing PJI using their IMC growth patterns and machine learning models. This adds a critical missing feature to IMC, contributing to accelerating the diagnosis of PJI and the selection of antibiotic therapy.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 10","pages":"1855-1864"},"PeriodicalIF":2.3,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Assisted Standard Plane Detection in Hip Ultrasound for Developmental Dysplasia of the Hip: A Novel Real-Time Deep Learning Approach","authors":"Muhammed Furkan Darilmaz,&nbsp;Mehmet Demirel,&nbsp;Hüseyin Oktay Altun,&nbsp;Mevlüt Can Adiyaman,&nbsp;Fuat Bilgili,&nbsp;Hayati Durmaz,&nbsp;Yavuz Sağlam","doi":"10.1002/jor.70020","DOIUrl":"10.1002/jor.70020","url":null,"abstract":"<div>\u0000 \u0000 <p>Developmental dysplasia of the hip (DDH) includes a range of conditions caused by inadequate hip joint development. Early diagnosis is essential to prevent long-term complications. Ultrasound, particularly the Graf method, is commonly used for DDH screening, but its interpretation is highly operator-dependent and lacks standardization, especially in identifying the correct standard plane. This variability often leads to misdiagnosis, particularly among less experienced users. This study presents AI-SPS, an AI-based instant standard plane detection software for real-time hip ultrasound analysis. Using 2,737 annotated frames, including 1,737 standard and 1,000 non-standard examples extracted from 45 clinical ultrasound videos, we trained and evaluated two object detection models: SSD-MobileNet V2 and YOLOv11n. The software was further validated on an independent set of 934 additional frames (347 standard and 587 non-standard) from the same video sources. YOLOv11n achieved an accuracy of 86.3%, precision of 0.78, recall of 0.88, and F1-score of 0.83, outperforming SSD-MobileNet V2, which reached an accuracy of 75.2%. These results indicate that AI-SPS can detect the standard plane with expert-level performance and improve consistency in DDH screening. By reducing operator variability, the software supports more reliable ultrasound assessments. Integration with live systems and Graf typing may enable a fully automated DDH diagnostic workflow.</p>\u0000 <p><b>Level of Evidence:</b> Level III, diagnostic study</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 10","pages":"1813-1825"},"PeriodicalIF":2.3,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen and Progesterone Exhibit Distinct Yet Coordinated Roles in the Regulation of Tendon Extracellular Matrix Remodeling.","authors":"Allison M Sander, Brianne K Connizzo","doi":"10.1002/jor.70018","DOIUrl":"10.1002/jor.70018","url":null,"abstract":"<p><p>Remodeling of the extracellular matrix (ECM) is required for the proper healing, strengthening, and maintenance of tendon tissue. There are well-documented sex differences in tendon injury rates and healing outcomes, often attributed to either innate differences in tissue structure and resident cell signaling or the influence of sex hormones. However, these factors are rarely decoupled. Estrogen (17β-estradiol) and progesterone (P4) receptors are expressed in both male and female tendons and thus could participate in the remodeling process, but studies are extremely limited. Therefore, the objective of this study was to address whether biological sex differences are present in tendon remodeling and to determine the individual and combined roles of estrogen and progesterone in the remodeling process. We capitalized on a three-dimensional explant model to directly examine hormone-mediated ECM turnover without disruption to the native cell microenvironment. Flexor digitorum longus tendon explants harvested from mature male and female mice were stimulated continuously with chemically endogenous hormones for 1 week, after which we examined synthesis and degradation of matrix components as well as overall tissue composition. We found sex differences in the absence of hormonal stimulation, indicating a chromosomal influence to observed functional sex differences. We also demonstrate that the response to exogenous hormone delivery is sex-dependent, and that progesterone and estrogen serve complementary yet independent roles. Overall, this study demonstrates the importance of hormones in the regulation of tissue structure and function and underscores the critical need for additional research in this area.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways","authors":"Julia Matthias,&nbsp;Sara Buckley,&nbsp;Michael David,&nbsp;Cheryl L. Ackert-Bicknell,&nbsp;Joshua A. Metzl,&nbsp;Daniel K. Moon,&nbsp;Courtney Miller,&nbsp;Michael J. Zuscik,&nbsp;Kenneth J. Hunt","doi":"10.1002/jor.70016","DOIUrl":"10.1002/jor.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Osteoarthritis of the ankle is a debilitating condition affecting nearly 20% of adults in the United States. The tissue, cellular, and molecular basis of this disease remains poorly understood, particularly the role of the synovial membrane. This prospective case-control study examined the gene expression profile of synovial tissue in ankle osteoarthritis to uncover biological pathways altered in the disease. Synovial biopsies were obtained from twenty-six patients with ankle osteoarthritis undergoing joint replacement and eight patients with minimal or no evidence of osteoarthritis. Bulk RNA-sequencing and differential gene expression analysis were performed, followed by biological pathway enrichment, unsupervised cluster, and network-based analysis. Synovium from ankle osteoarthritis patients showed distinct gene expression patterns compared to controls, with enrichment in pathways related to extracellular matrix remodeling and tissue morphogenesis. Age and a prior history of ankle fracture were identified as significant factors influencing the transcriptomic profile of osteoarthritic synovium. After accounting for these variables, transcriptomic clustering perfectly distinguished osteoarthritic from non-osteoarthritic synovium and revealed upregulation of pathways involved in muscle development, neural signaling, immune response, and carbohydrate metabolism. Conversely, pathways related to ribosome production, protein synthesis, and cellular signaling were downregulated. Multiple WNT signaling pathways remained significantly enriched in osteoarthritic ankle synovium. This study identifies a distinct gene expression profile in the synovium of ankle osteoarthritis patients, highlighting key molecular pathways possibly involved in disease progression. These findings provide valuable insights into the molecular mechanisms driving ankle osteoarthritis and have the potential to inform the development of novel targeted therapeutic strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 10","pages":"1736-1747"},"PeriodicalIF":2.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan/Platelet-Rich Plasma Implants in an Ovine Arthroscopic Model of Meniscus Repair","authors":"Margaux Delvaux,&nbsp;Anik Chevrier,&nbsp;Sotcheadt Sim,&nbsp;Éric Quenneville,&nbsp;Mark B. Hurtig,&nbsp;Gregory De Crescenzo,&nbsp;Marc Lavertu","doi":"10.1002/jor.70014","DOIUrl":"10.1002/jor.70014","url":null,"abstract":"<p>Despite the availability of various repair techniques, many meniscal tears remain irreparable. A freeze-dried chitosan-based formulation reconstituted in autologous platelet-rich plasma has shown potential in preclinical studies for enhancing suture-based meniscus repair. This study aimed at developing a fully arthroscopic ovine model of meniscus repair and evaluating chitosan/platelet-rich plasma's efficacy and safety as an augmentation strategy for suture-based meniscus repair. Unilateral radial lesions were induced in the medial menisci mid-body of 22 skeletally mature ewes. Tears were sutured inside-out. Two groups received a chitosan/platelet-rich plasma injection into the sutured lesions (0.5 or 1 mL doses, <i>n</i> = 6/group), while one group received a 1 mL autologous platelet-rich plasma injection (<i>n</i> = 5). The control group was only sutured (<i>n</i> = 5). A multiaxial mechanical tester and a hand-held probe were used respectively for mechanical (menisci and articular cartilages) and electromechanical testing (articular cartilages). All surfaces were then histologically assessed. Chitosan/platelet-rich plasma was resident in tears at 1 day and induced polymorphonuclear cell recruitment (assessed in <i>n</i> = 2 sheep). All operated joints developed signs of osteoarthritis compared to contralateral unoperated joints, with some of them displaying severe structural and functional changes. Instantaneous modulus properties and structural appearance of menisci and articular surfaces from chitosan/platelet-rich plasma treated groups were better than those of the other groups at 6 months postsurgery. Clinical pathology data were similar at baseline and at terminal in all groups, which suggests high safety. Chitosan/platelet-rich plasma implants helped limit cartilaginous degradation in joints with radially incised and sutured medial menisci and show promise as a treatment for meniscal tears.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 10","pages":"1875-1886"},"PeriodicalIF":2.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Murine Supraspinatus Tendons Demonstrate Aging-Related Changes in Multiscale Mechanics, Structure, and Gene Expression.","authors":"Michael S DiStefano, Jeremy D Eekhoff, Stephanie N Weiss, Courtney A Nuss, Rebecca L Betts, Andrew F Kuntz, Louis J Soslowsky","doi":"10.1002/jor.70013","DOIUrl":"https://doi.org/10.1002/jor.70013","url":null,"abstract":"<p><p>Rotator cuff disorders are common in the aging population, often leading to pain, disability, and reduced quality of life. Age-associated changes can occur disproportionately in regions of high mechanical stress, such as the insertion site of the supraspinatus tendon, leading to increased injury rates and tendinopathies. We previously demonstrated site-specific differences in structure, function, and gene expression between the insertion and midsubstance regions of supraspinatus tendons in mature, Day 150 mice. However, a comprehensive study examining the role of aging on site-specific supraspinatus tendon multiscale structure, function, and gene expression is needed. Therefore, our objective was to elucidate the role of aging on supraspinatus tendon multiscale structure, function, and gene expression. Whole-tissue and regional mechanics, as well as regional fibril response to load, cellularity and cell shape, collagen fibril morphology, and gene expression were evaluated in supraspinatus tendons of Day 300 and Day 570 mice. Aging resulted in decreased stiffness, dynamic modulus, and decreased midsubstance modulus. Collagen fibril morphology analysis revealed a more noticeable shift toward smaller fibril diameters with aging in the midsubstance region. Histological evaluation demonstrated reduced cellularity and a transition to more elongated cell morphology in aged tendons. Gene expression profiling highlighted upregulation of pro-inflammatory and catabolic markers and downregulation of major collagens in Day 570 tendons relative to Day 300 tendons. Understanding the effects of aging on tendon structure, function and gene expression provides critical insights into the mechanisms underlying aging-related injury and tendinopathy.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}