Journal of Orthopaedic Research®最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148092029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148092028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148092027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip Joint Loading During Walking Is Associated With Cartilage Defect Severity in Young Adult Football Players With Hip/Groin Pain","authors":"Kay M. Crossley,&nbsp;Yi-Chung Lin,&nbsp;Anthony G. Schache,&nbsp;Anne J. Smith,&nbsp;Matthew G. King,&nbsp;Joshua J. Heerey,&nbsp;Rintje Agricola,&nbsp; Sharmila Majumdar,&nbsp;Richard B. Souza,&nbsp;Thomas M. Link,&nbsp;Benjamin F. Mentiplay,&nbsp;Mark J. Scholes,&nbsp;Adam I. Semciw,&nbsp;Peter R. Lawrenson,&nbsp;Joanne L. Kemp,&nbsp;Marcus G. Pandy","doi":"10.1002/jor.70219","DOIUrl":"10.1002/jor.70219","url":null,"abstract":"<p>Understanding factors associated with early hip osteoarthritis (OA) in young active adults may facilitate hip OA prevention. We investigated the cross-sectional association between hip contact force (HCF) during walking and cartilage defect severity, accounting for cam morphology size (alpha angle), hip pain severity, sex, age, and walking speed, in football players with hip/groin pain. One hundred and twenty-one football players (18–50 years; 26 women) with &gt; 6-month hip/groin pain and no radiographic OA underwent MRI and a Dunn 45° radiograph. Outcome: Scoring Hip Osteoarthritis with MRI (SHOMRI) score for cartilage defect severity (0–20), categorized into three SHOMRI groups: (a) SHOMRI = 0; (b) SHOMRI = 1–3; and (c) SHOMRI = 4+. Movement and ground force data were captured whilst participants walked at their self-selected pace. Musculoskeletal modeling was used to calculate HCF for one stride cycle. The exposure variable was HCF impulse (body weight times seconds [BW.s]). Differences in HCF impulse based on SHOMRI group (for the most symptomatic hip) were assessed using linear models, controlling for alpha angle, sex, age, walking speed, hip pain, and contralateral hip pain status. Resultant HCF impulse was significantly higher for participants in the 0 versus 4+ SHOMRI group (mean difference; 95%CI: 0.142BW.s; 0.028–0.256 for swing and 0.106BW.s; 0.029–0.184 for stance) and 0 versus 1–3 SHOMRI group (0.071 BW.s; 0.016–0.125 for swing). Participants with more severe cartilage defects walked with lower hip joint loading, and other variables (e.g., alpha angle size, hip pain severity, age) contributed little to this relationship. Hip joint under-loading could be a possible target for hip OA prevention.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Exercise Habits for Preventing Osteoporosis in Postmenopausal Women: Insights From the COVID-19 Pandemic","authors":"Issei Shinohara,&nbsp;Masaya Kusunose,&nbsp;Hanako Nishimoto,&nbsp;Atsuyuki Inui,&nbsp;Yutaka Mifune,&nbsp;Kohei Yamaura,&nbsp;Yutaka Ehara,&nbsp;Shunsaku Takigami,&nbsp;Shin Osawa,&nbsp;Daiji Nakabayashi,&nbsp;Takanobu Higashi,&nbsp;Ryota Wakamatsu,&nbsp;Tomoyuki Matsumoto,&nbsp;Ryosuke Kuroda","doi":"10.1002/jor.70225","DOIUrl":"10.1002/jor.70225","url":null,"abstract":"<div>\u0000 \u0000 <p>This study aimed to investigate the impact of COVID-19–related activity restrictions on bone mineral density (BMD) and muscle mass in postmenopausal women undergoing treatment for osteoporosis. Patients who maintained regular clinic visits and continued pharmacological therapy were retrospectively analyzed. BMD and whole-body muscle mass were assessed using dual-energy X-ray absorptiometry during the pre-pandemic and pandemic periods, and changes were evaluated using the percentage of the young adult mean (%YAM). Exercise habits and dietary patterns were assessed using structured questionnaires. During the pandemic, approximately 40% of participants discontinued regular exercise. In contrast, dietary patterns and nutritional markers, including albumin and total protein, remained stable. Significant declines in %YAM were observed at the lumbar spine, femoral neck, and total hip, with greater reductions in the lumbar spine. Muscle mass also decreased significantly across all regions, with more pronounced reductions in the upper extremities. Changes in bone turnover markers suggested a shift toward a high-turnover state. Despite continued treatment and clinical follow-up, both bone and muscle parameters deteriorated during the pandemic. These findings indicate that reduced physical activity may adversely affect musculoskeletal health in patients with osteoporosis, even under appropriate pharmacological management. Strategies incorporating home-based exercise interventions may be essential to mitigate such effects during periods of restricted mobility.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Evaluation of Hip Center Shift After Periacetabular Osteotomy for Hip Dysplasia","authors":"Kenji Kitamura,&nbsp;Masanori Fujii,&nbsp;Satoshi Hamai,&nbsp;Daisuke Hara,&nbsp;Yuki Nakao,&nbsp;Itaru Kawashima,&nbsp;Shinya Kawahara,&nbsp;Goro Motomura,&nbsp;Ryosuke Yamaguchi,&nbsp;Takeshi Utsunomiya,&nbsp;Soichiro Yoshino,&nbsp;Yasuharu Nakashima,&nbsp;Scott A. Banks","doi":"10.1002/jor.70223","DOIUrl":"10.1002/jor.70223","url":null,"abstract":"<p>To quantify the three-dimensional shift of the femoral head after periacetabular osteotomy and to identify the relevant morphological factors. This retrospective study included 26 patients (30 hips) who underwent periacetabular osteotomy at a single institution. Pre- and postoperative supine and standing anteroposterior two-dimensional images and pelvic computed tomography scans were obtained. Using three-dimensional-to-two-dimensional model-image registration techniques, we quantified acetabular and femoral head center shifts in both the supine and standing positions along three axes based on the anterior pelvic plane. Correlations between femoral head shift and pre- and postoperative hip morphological parameters on standardized supine radiographs were examined. In the supine position, the femoral head center shifted significantly (5.0 ± 2.3 mm), with medial (−1.5 ± 3.8 mm) and posterior (−1.8 ± 3.5 mm) displacement. Similarly, in standing, the femoral head center shifted significantly (4.8 ± 2.4 mm), with medial (−1.5 ± 3.8 mm) and posterior (−1.4 ± 3.6 mm) displacement. Lower preoperative anterior wall index was correlated with greater medial shift (<i>r</i> = 0.37, <i>p</i> = 0.04) and less posterior shift (<i>r</i> = −0.40, <i>p</i> = 0.03). Periacetabular osteotomy was associated with measurable three-dimensional reorientation of the hip center in both supine and standing positions. Lower preoperative anterior wall index was correlated with greater medial shift and less posterior shift, although the effect sizes were modest. These findings suggest that hip center shift after periacetabular osteotomy is a secondary effect of multiplanar acetabular reorientation and that three-dimensional assessment may provide information beyond conventional two-dimensional evaluation, particularly for anteroposterior changes.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achilles Tendon Injury Alters Lymphatic and Venous Clearance in Rats","authors":"Jarod M. Forer,&nbsp;Kaitlyn A. Link,&nbsp;Bella Yannello,&nbsp;Michael E. Hahn,&nbsp;Nick J. Willett","doi":"10.1002/jor.70212","DOIUrl":"10.1002/jor.70212","url":null,"abstract":"<p>The Achilles tendon is a frequently injured component of the musculoskeletal system. Like other musculoskeletal tissues, its homeostasis depends in part on microcirculatory pathways, including the lymphatic system. While previous studies have shown that Achilles tendon interstitial fluid content increases in clinical disease states, microcirculatory clearance pathways in tendon remain poorly understood. We characterized lymphatic and venous clearance pathways in naïve and surgically ruptured female Sprague-Dawley rat Achilles tendons using size-specific near-infrared tracers. We hypothesized that Achilles tendon rupture would impair microcirculatory transport, as measured by altered size-specific tracer clearance rates. In naïve tendons, clearance was tracer size-dependent, with venous tracers clearing significantly faster than lymphatic tracers. Tendon rupture significantly increased lymphatic clearance rates at 2-weeks post-injury but decreased lymphatic clearance rates at 8 weeks compared to both uninjured contralateral and naïve controls. Venous clearance rates were significantly elevated in injured tendons compared to uninjured contralateral limbs at 4- and 8-weeks post-injury. Qualitative histology showed disruption of both the tendon sheath and core structure after injury. Elevated pain and decreased function were quantified post-injury by measuring tactile allodynia (Von Frey), limb loading (Dynamic Weight Bearing), and tendon mechanical properties (tensile testing). Limb loading returned to baseline by 4 weeks, while tactile allodynia did so at 8 weeks. Injured tendon stiffness returned to contralateral levels by 8 weeks. Together, these data demonstrate that microcirculatory function is significantly altered following surgical tendon rupture. Strategies targeting tendon microcirculatory function and fluid accumulation may represent a promising treatment approach for injured and diseased tendons.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric Quantification of Articular Depression Adds Prognostic Value to Three-Dimensional Gap Area Assessment in Schatzker Type III Tibial Plateau Fractures","authors":"Fatih Emre Topsakal,&nbsp;Başak Sinem Sezgin,&nbsp;Ekrem Özdemir,&nbsp;Nasuhi Altay,&nbsp;Yavuz Şahbat,&nbsp;Esra Demirel","doi":"10.1002/jor.70224","DOIUrl":"10.1002/jor.70224","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Three-dimensional (3D) assessment of tibial plateau fractures has traditionally relied on surface-based parameters such as gap area, which may not fully reflect the severity of articular injury. This study investigated whether volumetric quantification of articular depression provides independent prognostic information beyond conventional surface-based 3D measurements in Schatzker type III tibial plateau fractures. A retrospective analysis was performed on 38 patients with isolated Schatzker type III lateral tibial plateau fractures treated operatively between 2017 and 2023. Preoperative computed tomography scans were used to generate 3D reconstructions. Three-dimensional gap area, depression surface area, and depression volume were quantified. Patients with a postoperative articular step-off ≥ 2 mm were excluded. Radiological outcomes were graded using the Kellgren–Lawrence (KL) classification, and functional outcomes were assessed using the KOOS. Mean depression volume was 5650 ± 2459 mm3. Depression volume showed only moderate correlation with depression surface area (<i>r</i> = 0.42, <i>p</i> = 0.01) and 3D gap area (<i>r</i> = 0.41, <i>p</i> = 0.01). Patients with depression volumes ≥ 6000 mm3 demonstrated significantly lower KOOS compared with those with volumes &lt; 6000 mm3 (<i>p</i> = 0.01). In multivariable logistic regression analyses adjusted for demographic variables and surface-based fracture parameters, depression volume remained significantly associated with poor radiological outcome (KL ≥ 2; odds ratio 2.34 per 1000 mm3 increase, <i>p</i> = 0.02). Volumetric quantification of articular depression provides clinically relevant prognostic information beyond surface-based 3D measurements and may improve risk stratification in Schatzker type III tibial plateau fractures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Prognostic Level III.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Reaction Forces Decrease Following Total Knee Arthroplasty up to 12-Months Post-Surgery","authors":"Salindi P. Herath,&nbsp;David Hobbs,&nbsp;Dominic Thewlis,&nbsp;Christopher Wilson,&nbsp;Mark Taylor","doi":"10.1002/jor.70222","DOIUrl":"10.1002/jor.70222","url":null,"abstract":"<p>Changes in mechanical loading following total knee arthroplasty (TKA) are a critical factor that is important to understand with respect to component fixation. The aims of this study were to estimate medial, lateral, and total knee joint contact forces preoperatively, and then at 3-, 6-, and 12-months postoperatively. Joint reaction forces (JRFs) were estimated using an electromyography (EMG) informed musculoskeletal modeling workflow with models scaled using computed tomography (CT) scans and weightbearing X-rays, for lower limb alignment. Joint loading peak values and impulses were estimated in 22 participants awaiting primary TKA for osteoarthritis (OA) (median age, range: 69, 49–80 years; median BMI, range: 33, 25–40 kg/m²) during level gait and sit-to-stand at each timepoint. Medial, lateral, and total JRF peak values and impulses reduced significantly postoperatively at 3-months and did not return to preoperative values at 12-months for either activity. During level gait, mean total JRF peak values reduced by 0.72 BW (<i>p</i> &lt; 0.001) (medial mean difference: 0.39 BW, <i>p</i> &lt; 0.001; lateral mean difference: 0.23 BW, <i>p</i> &lt; 0.001) at 3-months post-surgery. A similar trend was observed in the sit-to-stand activity with a mean decrease of 0.44 BW in the peak total JRF at 3-months (<i>p</i> &lt; 0.001). Impulse values followed a similar trend to the peak values. Clinical relevance: People do not return to preoperative JRFs even at 12-months post-TKA, and this may be a contributing factor for previously reported decreases in BMD around femoral and tibial components.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Post‑Traumatic Osteoarthritis Features Greater Cartilage Extracellular Matrix Proteoglycan Loss Compared to the Pericellular Matrix","authors":"Rasmus K. Hiltunen,&nbsp;Nina Pesonen,&nbsp;Simo P. Ojanen,&nbsp;Mikko A. J. Finnilä,&nbsp;Sanna Palosaari,&nbsp;Walter Herzog,&nbsp;Simo Saarakkala,&nbsp;Rami K. Korhonen,&nbsp;Juuso T. J. Honkanen,&nbsp;Petri Tanska","doi":"10.1002/jor.70217","DOIUrl":"10.1002/jor.70217","url":null,"abstract":"<p>Proteoglycan loss in articular cartilage is a hallmark of post-traumatic osteoarthritis, and it can affect both chondrocyte biomechanics and tissue health. Previously, we found that 4 weeks after anterior cruciate ligament transection (ACLT) in rabbits, proteoglycan loss was less pronounced in the pericellular matrix (PCM) than in the extracellular matrix (ECM), resulting in a greater PCM-to-ECM proteoglycan content ratio compared to controls. Here, we investigated whether this pattern is already present 2 weeks post-ACLT and whether changes in the PCM-to-ECM proteoglycan content ratio are associated with chondrocyte volumetric strain in superficial cartilage during tissue loading. Unilateral ACLT was performed in eight skeletally mature rabbits. Two weeks post-surgery, cartilage from load-bearing sites of the operated and contralateral knees was collected. Age-matched, non-operated knees from separate animals served as controls. Proteoglycan content in the chondrocyte microenvironment was analyzed in the superficial and middle zones via digital densitometry. Volumetric strain of superficial zone chondrocytes was also measured using two-photon confocal microscopy during compressive loading. In the superficial zone, the PCM-to-ECM proteoglycan content ratio was greater in the ACLT knees than in controls at the lateral tibial plateau (<i>p</i> = 0.043), but this was not clearly linked to changes in chondrocyte volumetric strain. In the middle zone, the PCM-to-ECM proteoglycan content ratio was greater in the ACLT knees than in controls for the medial femoral condyle, femoral groove, and patella (<i>p</i> &lt; 0.05). These results indicate preferential ECM proteoglycan loss relative to the PCM in early post-traumatic osteoarthritis, especially in the middle zone.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13157652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}