Journal of Orthopaedic Research®最新文献_第8页

Issue Information - Editorial Board and TOC 期刊信息 - 编辑委员会和目录

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-15 DOI: 10.1002/jor.25620

引用次数: 0

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-15 DOI: 10.1002/jor.25621

引用次数: 0

Accuracy and precision of Volumetric Matching Micromotion Analysis (V3MA) is similar to RSA for tibial component migration in TKA 体积匹配微动分析法（V3MA）在 TKA 胫骨组件移位方面的准确性和精确度与 RSA 相似。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-15 DOI: 10.1002/jor.25989

Nienke N. de Laat, Lennard A. Koster, Berend C. Stoel, Rob G. H. H. Nelissen, Bart L. Kaptein

{"title":"Accuracy and precision of Volumetric Matching Micromotion Analysis (V3MA) is similar to RSA for tibial component migration in TKA","authors":"Nienke N. de Laat, Lennard A. Koster, Berend C. Stoel, Rob G. H. H. Nelissen, Bart L. Kaptein","doi":"10.1002/jor.25989","DOIUrl":"10.1002/jor.25989","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 Radiostereometric analysis (RSA) is the current gold standard to determine implant migration, but it requires bone markers and special equipment. Therefore, we developed VoluMetric Matching Micromotion Analysis (V3MA), a software program for Computed Tomography-based radiostereometric analysis (CT-RSA). This study aimed to determine the accuracy and precision of V3MA in vitro compared to RSA and provide a clinical proof of concept. The accuracy (RMSE (Root Mean Squared Error)) and precision (SD (standard deviation)) of V3MA were compared to RSA. A tibial component was placed in 21 different positions within a cadaveric bone to assess accuracy. For precision, a total of 20 repeated zero-migration examinations from 4 cadaveric bones with cemented tibial components were performed. In 6 total knee arthroplasty (TKA) patients 1 to 5 year migration was measured with V3MA and RSA. V3MA accuracy ranged between 0.02 and 0.09 mm for translations and was 0.01° for internal–external rotations. For RSA, the accuracy ranged between 0.03 and 0.09 mm for translations and was 0.09° for internal-external rotations. V3MA precision ranged between 0.01 and 0.06 mm for translations and 0.02 to 0.07° for rotations. RSA precision ranged between 0.00 and 0.06 mm for translations and 0.04 to 0.25° for rotations. V3MA was successful in 6 clinical cases and no systematic bias was present. In conclusion, the accuracy and precision of V3MA were similar to RSA. Therefore, V3MA is a promising alternative to RSA in migration measurements of tibial components in TKA.\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"311-321"},"PeriodicalIF":2.1,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25989","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a novel rabbit model for femoroacetabular impingement through surgically induced acetabular overcoverage 通过手术诱导髋臼过度覆盖，建立新型股骨髋臼撞击兔模型。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-13 DOI: 10.1002/jor.25994

Siqi Zhang, Guanying Gao, Xiang Zhou, Cancan Du, Yichuan Zhu, Tong-Chuan He, Yan Xu

{"title":"Development of a novel rabbit model for femoroacetabular impingement through surgically induced acetabular overcoverage","authors":"Siqi Zhang, Guanying Gao, Xiang Zhou, Cancan Du, Yichuan Zhu, Tong-Chuan He, Yan Xu","doi":"10.1002/jor.25994","DOIUrl":"10.1002/jor.25994","url":null,"abstract":"There is a lack of validated small animal models for femoroacetabular impingement (FAI) that induce intra-articular lesions and cause osteoarthritis (OA) progression. The gene expression profile of articular cartilage in patients with FAI has not been characterized in animal studies. The purpose of this study is to describe a novel rabbit model for FAI with validated induction of intra-articular lesions and OA progression and to characterize the gene expression pattern in impinged cartilage using this model. Thirty 6-month-old New Zealand White rabbits underwent unilateral endobutton implant placement at the acetabular rim to surgically create overcoverage. Radiological assessment confirmed secure placement of endobutton at the acetabular rim for all operated hips with a mean alteration in lateral center-edge angle (ΔLCEA) of 16.2 ± 6.6°. Gross inspection revealed secondary cartilage injuries in the anterosuperior region of the femoral head for the operated hips. Cartilage injuries were shown to exacerbate with increased impingement duration, as demonstrated by the modified Outerbridge scores and Mankin scores. Immunostaining and quantitative real-time polymerase chain reaction revealed elevated expression of inflammatory, anabolic and catabolic genes in impinged cartilage. RNA sequencing analysis of cartilage tissue revealed a distinct transcriptome profile and identified C-KIT, CD86, and CD68 as central markers. Our study confirmed that the novel rabbit FAI model created acetabular overcoverage and produced articular cartilage injury at the impingement zone. Cartilage from the impingement zone demonstrated a heightened metabolic state, corroborating with the gene expression pattern observed in patients with FAI.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"407-418"},"PeriodicalIF":2.1,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage 人体间充质干细胞/基质细胞衍生的细胞外囊泡在半月板纤维软骨中的运输。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-13 DOI: 10.1002/jor.25993

Gabi Schwartz, Samir Rana, Alicia R. Jackson, Clarissa Leñero, Thomas M. Best, Dimitrios Kouroupis, Francesco Travascio

{"title":"Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage","authors":"Gabi Schwartz, Samir Rana, Alicia R. Jackson, Clarissa Leñero, Thomas M. Best, Dimitrios Kouroupis, Francesco Travascio","doi":"10.1002/jor.25993","DOIUrl":"10.1002/jor.25993","url":null,"abstract":"Extracellular vesicles (EVs) derived from endometrial-derived mesenchymal stem/stromal cells (eMSC) play a crucial role in tissue repair due to their immunomodulatory and reparative properties. Given these properties, eMSC EVs may offer potential benefits for meniscal repair. The meniscus, being partly vascularized, relies on diffusivity for solute trafficking. This study focuses on EVs transport properties characterization within fibrocartilage that remains unknown. Specifically, EVs were isolated from Crude and CD146+ eMSC populations. Green fluorescence-labeled EVs transport properties were investigated in three structurally distinct layers (core, femoral, and tibial surfaces) of porcine meniscus. Diffusivity was measured via custom fluorescence recovery after photobleaching (FRAP) technique. Light spectrometry was used to determine EVs solubility. Both Crude and CD146+ eMSC EVs exhibited high purity (>90% CD63CD9 marker expression) and an average diffusivity of 10.924 (±4.065) µm²/s. Importantly, no significant difference was observed between Crude and CD146+ eMSC EV diffusivity on the meniscal layer (p > 0.05). The mean partitioning coefficient was 0.2118 (±0.1321), with Crude EVs demonstrating significantly higher solubility than CD146+ EVs (p < 0.05). In conclusion, this study underscores the potential of both Crude and CD146+ eMSC EVs to traverse all layers of the meniscus, supporting their capacity to enhance delivery of orthobiologics for cartilaginous tissue healing.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"457-465"},"PeriodicalIF":2.1,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining the segmental tension generated in a vertebral body tethering system for scoliosis 确定脊柱侧弯椎体系绳系统产生的节段张力。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-10 DOI: 10.1002/jor.25995

Vidyadhar V. Upasani, Christine L. Farnsworth, Jason P. Caffrey, Tony Olmert, Ian Brink, Phoebe Cain, Erin Mannen

{"title":"Defining the segmental tension generated in a vertebral body tethering system for scoliosis","authors":"Vidyadhar V. Upasani, Christine L. Farnsworth, Jason P. Caffrey, Tony Olmert, Ian Brink, Phoebe Cain, Erin Mannen","doi":"10.1002/jor.25995","DOIUrl":"10.1002/jor.25995","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 Vertebral body tethering (VBT) uses a flexible tether affixed across the curve convexity with tension applied at each segment to treat scoliosis. Intraoperative tether tension may be achieved directly with a counter-tensioner or with an extension spring tube. The purpose of this study was to quantify the force generated with and without the extension spring tube using current FDA-approved VBT instrumentation, to understand the variation between surgeons using the same instrumentation, and to define the force range that is generated intra-operatively. Using a benchtop mechanical testing setup to simulate a spinal segment, we affixed the tether and applied tension using a tensioner and counter-tensioner alone (method T1) or by adding an extension spring tube (method T2). Eight orthopedic surgeons used T1 and T2 at six tensioner settings, and one surgeon completed three trials. A two-way ANOVA with a Tukey's HSD post hoc test (p < 0.05) compared the tensioner methods and testing levels. Inter- and intra-rater reliabilities were calculated using intraclass correlation coefficients (ICCs). Methods T1 and T2 exhibited linear tension-setting relationships, with high determination coefficients (R2 > 0.93). T2 consistently produced higher forces (increase of 62.1 N/setting), compared to T1 (increase of 50.6 N/setting, p < 0.05). Inter-rater reliability exhibited excellent agreement (ICC = 0.951 and 0.943 for T1 and T2, respectively), as did intra-rater reliability (ICC = 0.971).\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"441-445"},"PeriodicalIF":2.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoarthritis early-, mid- and late-stage progression in the rat medial meniscus transection model 大鼠内侧半月板横断模型的骨关节炎早期、中期和晚期进展。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-10 DOI: 10.1002/jor.25969

Jay M. McKinney, Krishna A. Pucha, Fabrice C. Bernard, J. Brandon Dixon, Thanh N. Doan, Nick J. Willett

{"title":"Osteoarthritis early-, mid- and late-stage progression in the rat medial meniscus transection model","authors":"Jay M. McKinney, Krishna A. Pucha, Fabrice C. Bernard, J. Brandon Dixon, Thanh N. Doan, Nick J. Willett","doi":"10.1002/jor.25969","DOIUrl":"10.1002/jor.25969","url":null,"abstract":"Osteoarthritis is a degenerative disease of synovial joints affecting all tissues, including articular cartilage and subchondral bone. Osteoarthritis animal models can recapitulate aspects of human disease progression and are used to test efficacy of drugs, biomaterials, and cell therapies. The rat medial meniscus transection (MMT) model is a surgically induced posttraumatic osteoarthritis model commonly used for preclinical therapeutic screening. We describe herein, the qualitative and quantitative changes to articular cartilage, subchondral bone, and formation of osteophytes at early-, mid-, and late-stages of osteoarthritis progression. Tibia of MMT-operated animals showed proteoglycan loss and fibrillation along articular cartilage surfaces as early as 3-weeks post-surgery. With contrast-enhanced micro-CT technique, quantitative, 3-dimensional analysis of the tibia showed that the articular cartilage thickened at 3- and 6-weeks post-surgery and decreased at 12-weeks post-surgery. This decreased cartilage thickness corresponded with increased lesions in the articular cartilage that led to its full degradation and exposing the subchondral bone layer. Further, subchondral bone thickening was significant at 6-weeks post-surgery and followed cartilage damage. Osteophytes were found as early as 3-weeks post-surgery and coincided with articular cartilage degradation. Cartilaginous osteophytes preceded mineralization, suggesting endochondral ossification. The rat MMT model has predominantly been used out to 3-weeks, and most studies determined the effect of therapies to delay or prevent the onset of osteoarthritis. We provide evidence that an extension of the rat MMT model out to 6- and 12-weeks more resembled severe phenotypes of human osteoarthritis. Thus, evaluating novel therapeutics at late-stage will be important for eventual clinical translation.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"102-116"},"PeriodicalIF":2.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gait stability improves following unilateral total ankle arthroplasty 单侧全踝关节置换术后步态稳定性得到改善。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-10 DOI: 10.1002/jor.25992

Martin Barylak, Sara L. Arena, Stephanie H. Carpentier, Robin M. Queen

{"title":"Gait stability improves following unilateral total ankle arthroplasty","authors":"Martin Barylak, Sara L. Arena, Stephanie H. Carpentier, Robin M. Queen","doi":"10.1002/jor.25992","DOIUrl":"10.1002/jor.25992","url":null,"abstract":"End-stage ankle arthritis is often treated surgically by total ankle arthroplasty (TAA) due to its potential to improve gait through increased joint range of motion and reduce pain. However, TAA's effect on gait stability is not well understood. This study explores the impact of TAA on gait stability, measured by Margin of Stability (MoS), in 148 patients with end-stage ankle arthritis. Kinematic data were collected pre-operatively, at 1-year post-op, and at 2-years post-op and the MoS was determined at heel strike and midstance for the anteroposterior (MoSAP) and mediolateral (MoSML) directions. A linear mixed effects model including gait speed as a factor was used to assess the effects of limb, session, and their interaction on outcome measures. A significant interaction (p < 0.002) between limb (surgical, nonsurgical) and session (pre-op, 1-year post-op, 2-years post-op) was identified for each MoS variable of interest. Cumulatively, our results suggest that the nonsurgical limb, MoSAP at heel strike and MoSML at midstance improved (increased) as time from surgery increased. These results suggest patients developed a compensatory movement pattern to navigate surgical limb single support. TAA reduces this compensation improving side-to-side symmetry, while not fully restoring symmetry by 2-years post-op. These results indicate that TAA could improve gait stability in patients with end-stage ankle arthritis, but further work is needed to understand the impact of TAA on altering fall risk.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"388-395"},"PeriodicalIF":2.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25992","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an ex vivo model to study Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network 开发体外模型，研究金黄色葡萄球菌入侵骨细胞裂隙-髓鞘网络的情况。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-09 DOI: 10.1002/jor.25988

Niels Vanvelk, Karen L. de Mesy Bentley, Michael H. J. Verhofstad, Willem-Jan Metsemakers, Thomas F. Moriarty, Claudia Siverino

{"title":"Development of an ex vivo model to study Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network","authors":"Niels Vanvelk, Karen L. de Mesy Bentley, Michael H. J. Verhofstad, Willem-Jan Metsemakers, Thomas F. Moriarty, Claudia Siverino","doi":"10.1002/jor.25988","DOIUrl":"10.1002/jor.25988","url":null,"abstract":"Staphylococcus aureus has multiple mechanisms to evade the host's immune system and antibiotic treatment. One such mechanism is the invasion of the osteocyte lacuno-canalicular network (OLCN), which may be particularly important in recurrence of infection after debridement and antibiotic therapy. The aim of this study was to develop an ex vivo model to facilitate further study of S. aureus invasion of the OLCN and early-stage testing of antibacterial strategies against bacteria in this niche. The diameter of the canaliculi of non-infected human, sheep, and mouse bones was measured microscopically on Schmorl's picrothionin stained sections, showing a large overlap in canalicular diameter. S. aureus successfully invaded the OLCN in all species in vitro as revealed by presence in osteocyte lacunae in Brown and Brenn-stained sections and by scanning electron microscopy. Murine bones were then selected for further experiments, and titanium pins with either a wild-type or ΔPBP4 mutant S. aureus USA300 were placed trans-cortically and incubated for 2 weeks in tryptic soy broth. Wild-type S. aureus readily invaded the osteocyte lacunae in mouse bones while the ΔPBP4 showed a significantly lower invasion of the OLCN (p = 0.0005). Bone specimens were then treated with gentamicin, sitafloxacin, R14 bacteriophages, or left untreated. Gentamicin (p = 0.0027) and sitafloxacin (p = 0.0280) significantly reduced the proportion of S. aureus-occupied lacunae, whilst bacteriophage treatment had no effect. This study shows that S. aureus is able to invade the OLCN in an ex vivo model. This ex vivo model can be used for future early-stage studies before proceeding to in vivo studies.","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"446-456"},"PeriodicalIF":2.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9-month equine groove model study” 更正 "钝性和锐性软骨损伤对关节结构、组成和功能的影响：为期 9 个月的马槽模型研究"。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-10-08 DOI: 10.1002/jor.25991

引用次数: 0