Journal of Orthopaedic Research®最新文献

{"title":"Posterior Horn Meniscus Centroid Position Is Altered Soon After Noncontact ACL Injury in Males and Females","authors":"Benjamin T. Hamilton,&nbsp;Daniel Sturnick,&nbsp;Erin C. Argentieri,&nbsp;Niccolo Fiorentino,&nbsp;Timothy W. Tourville,&nbsp;Matthew Failla,&nbsp;Mack Gardner-Morse,&nbsp;Pamela M. Vacek,&nbsp;Bruce D. Beynnon","doi":"10.1002/jor.70208","DOIUrl":"10.1002/jor.70208","url":null,"abstract":"<p>Anterior cruciate ligament (ACL) injury and subsequent changes in the magnitude and distribution of contact stress about the articular surfaces of the knee are associated with post-traumatic osteoarthritis. Soon after ACL injury, changes in tibial articular cartilage thickness occur that can be explained, in part, by abnormal positioning of the tibia relative to the femur. However, little is known about the effects of ACL injury on the positions of the menisci. The purpose of this case-control study was to determine the effect of ACL injury on posterior horn meniscus centroid (PHMC) position relative to the tibia in males and females. ACL-injured and matched control subjects with normal knees underwent bilateral magnetic resonance imaging soon after the index injury and prior to ACL reconstruction. The PHMC position was defined in three dimensions at the point of maximal tibial articular cartilage concavity in the lateral and medial compartments of the knee. In control subjects, there were no significant differences in PHMC position between knees in the lateral and medial compartments. In ACL-injured knees, there were significant posterior-directed changes in PHMC position in both compartments for males and females when compared to their contralateral normal knees. These changes in PHMC position may alter the distribution of articular cartilage contact stress and explain a portion of the changes in knee biomechanics and cartilage thickness that occur following ACL injury. In addition, these findings suggest that the menisci should not be used as landmarks to establish regions of interest when measuring cartilage thickness and matrix components.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Deformity Severity Dictate Which Side Initially Develops Symptoms in Bilaterally Dysplastic Hips?","authors":"Madison M. Wissman,&nbsp;Jiayi Sun,&nbsp;Benjamin E. Northrup,&nbsp;Mohammadreza Movahhedi,&nbsp;Ata M. Kiapour,&nbsp;John C. Clohisy,&nbsp;Michael D. Harris","doi":"10.1002/jor.70215","DOIUrl":"10.1002/jor.70215","url":null,"abstract":"<div>\u0000 \u0000 <p>Most patients with developmental dysplasia of the hip (DDH) have bilateral deformities, yet have asymmetric symptom development that is not well understood. This study aimed to identify relationships between deformity severity and symptom asymmetry in patients with bilateral DDH. Hip geometry from <i>N</i> = 230 patients was measured using lateral center-edge angle (LCEA), acetabular inclination, neck-shaft angle, alpha angle, and femoral version, and compared between initially symptomatic and contralateral hips. Patients were grouped into those with a “more dysplastic hip” (<i>n</i> = 133, based on &gt;3° side-to-side LCEAs) or similar side-to-side deformities. Self-reported activity levels were also compared between those whose symptomatic hips were more severely deformed and those whose contralateral hips were more severely deformed. Symptomatic hips had more severe acetabular deformities, based on the LCEA and acetabular inclination, in 80% of subjects (<i>p</i> &lt; 0.001). The only femoral measure to reveal differences between symptomatic and contralateral hips was neck-shaft angle; most patients had more severe angles on their symptomatic side (<i>p</i> = 0.003) though with a small effect (<i>d</i> = 0.14). Thus, acetabular deformities appear to drive asymmetric symptom development more than femoral deformities. Among the 20% of patients with more deformed contralateral hips, activity levels were not different from those with more deformed symptomatic hips. While self-reported activity was not linked to symptom asymmetry, factors not captured, such as limb dominance and activity type, may contribute. These findings further understanding of disease progression and symptom onset in bilateral DDH and can inform anticipatory interventions to reduce pain and promote long-term joint health.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetic Biomarkers of Cumulative Loading and Daily Step Count as Predictors of Functional Recovery Following Primary Unilateral Total Hip Arthroplasty","authors":"Jesse C. Christensen,&nbsp;Dana L. Judd,&nbsp;Peter B. Thomsen-Freitas,&nbsp;Hope Davis-Wilson,&nbsp;Cory L. Christiansen,&nbsp;Jennifer E. Stevens-Lapsley","doi":"10.1002/jor.70203","DOIUrl":"10.1002/jor.70203","url":null,"abstract":"<div>\u0000 \u0000 <p>Many adults experience persistent limitations in physical activity following total hip arthroplasty (THA) despite improvements in pain. Although atypical limb loading and reduced daily step count have each been linked to poorer recovery, these factors are typically evaluated independently and do not reflect cumulative mechanical exposure during daily ambulation. Integrating load magnitude, loading rate, and activity volume into kinetic biomarkers may provide novel insight into functional recovery post-THA. This study included 56 adults who underwent primary unilateral THA. Three kinetic biomarkers were evaluated: cumulative loading rate (vertical ground reaction force [vGRF] loading rate × daily step count), cumulative force (peak vGRF × daily step count), and cumulative impulse (vGRF × time × daily step count). Physical function outcomes included the 6-min walk test (6MWT), 30-s sit-to-stand (STS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and lower-extremity muscle strength (hip abductor, knee extensor, knee flexor), assessed 26 weeks post-THA. Multivariable regression models were used, adjusting for confounders. Cumulative loading rate of the surgical limb demonstrated the strongest positive associations with 6MWT distance (<i>p</i> &lt; 0.01), STS performance (<i>p</i> = 0.03), hip abductor strength (<i>p</i> = 0.01), and WOMAC physical function (<i>p</i> = 0.01), whereas cumulative force and impulse were less predictive.</p>\u0000 <p><b>Clinical Significance:</b> By integrating limb loading rate with activity volume, cumulative loading rate may better capture clinically meaningful deficits in physical function post-THA than gait measures or step count alone.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate Humeral Version Angle Prediction From Limited Anatomical Data Using Statistical Shape Models","authors":"François Bruyer-Montéléone,&nbsp;Maxence Lavaill,&nbsp;Graham Kerr,&nbsp;Natalia M. Castoldi,&nbsp;Jeffrey E. Bischoff,&nbsp;Saulo Martelli,&nbsp;Peter Pivonka","doi":"10.1002/jor.70209","DOIUrl":"10.1002/jor.70209","url":null,"abstract":"<p>Shoulder replacement is challenged by the need to approximate the patient's pre-morbid humeral version angle (HVA) with limited information. Statistical Shape Models (SSMs) can reconstruct bone shapes and predict HVA by identifying the best global shape match. However, SSMs require visible humeral anatomy, and optimal global reconstruction does not necessarily ensure accurate HVA. Multisegmented SSMs (MSSMs) combine adjacent bones to leverage inter-bone shape correlations, but their potential remains largely unexplored. This project uses scale-free humeral SSM and three-shoulder-bone MSSM to estimate HVA from clinically available surfaces and examine how HVA accuracy relates to global and local bone reconstruction. Sixty-one registered bones were segmented (29 males and 32 females, 36.1 ± 14.3 years) from medical images. A leave-one-out method tested the models' ability to reconstruct the humerus and HVA under surgical scenarios: the SSM for cases with visible humeral parts (distal- or proximal-limited), and the MSSM for cases with no humeral information (solely on adjoining segments). SSM-based cases produced higher HVA accuracy than MSSM scenarios (max error: 3.3° ± 2.3° vs. 6.6° ± 5.4°). In both models, errors were driven primarily by marker-level discrepancies rather than global shape error. These results highlight that, when predicting anatomical measurements, SSM predictions should prioritize anatomical accuracy over achieving the best-fitting global shape.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148113127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148080773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148073264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait Biomechanical Profiles Following Anterior Cruciate Ligament Reconstruction in Sexually-Immature Pediatrics","authors":"Elizabeth Bjornsen,&nbsp;J. Troy Blackburn,&nbsp;Jason R. Franz,&nbsp;W. Zachary Horton,&nbsp;Darin Padua,&nbsp;Sandra Shultz,&nbsp;Samantha Tayne,&nbsp;Brian Pietrosimone","doi":"10.1002/jor.70196","DOIUrl":"10.1002/jor.70196","url":null,"abstract":"<p>Aberrant gait biomechanics following ACL reconstruction (ACLR) are linked to knee osteoarthritis development in adult patients. However, limited research exists to characterize walking biomechanics profiles of pediatric ACLR patients. The study purpose was to determine (1) differences in biomechanical profiles between pediatric ACLR patients (Tanner Stage I–IV) and two comparison-control groups (i.e., uninjured, matched pediatrics, adult-matched ACLR); (2) associations between biomechanical and Knee Osteoarthritis Outcomes Score (KOOS)-Child outcomes in pediatric ACLR patients. Gait biomechanics were collected in pediatric ACLR (<i>n</i> = 25), pediatric controls (<i>n</i> = 25), and adult ACLR groups (<i>n</i> = 25). Pediatric patients completed the KOOS-Child at the same session. A functional mixed effects model determined between-group differences in biomechanical variables. Uncorrected partial correlations, controlling for gait speed, were utilized to determine the association between discrete biomechanics and KOOS-Child scores. Pediatric ACLR patients demonstrated lesser first and second peak vertical ground reaction force (vGRF) and greater midstance vGRF than pediatric controls. Pediatric ACLR patients exhibited lesser midstance and greater late stance vGRF compared to the adult ACLR group. Pediatric ACLR patients demonstrated lesser knee flexion angle, knee extension moment, and knee abduction moment profiles compared to pediatric controls and adult ACLR patients throughout the majority of the stance phase. Greater midstance vGRF was associated with greater KOOS-Child Quality of Life scores in the contralateral limb (<i>r</i> = 0.54, <i>p</i> = 0.006). Pediatric ACLR patients exhibit unique biomechanical profiles compared to pediatric controls and adult ACLR patients; however, the associations with patient-reported outcomes remain unclear. Pediatrics may experience an exaggerated response to ACLR that may impact knee joint health.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type III Collagen Promotes a Pro-Fibrotic Microenvironment for In Vitro Tendon Healing Microphysiological Systems","authors":"Victor Z. Zhang,&nbsp;Tresa Elias,&nbsp;Mariana Rodriguez,&nbsp;Elio Abbondanzieri,&nbsp;Edward Brown,&nbsp;James L. McGrath,&nbsp;Hani A. Awad","doi":"10.1002/jor.70192","DOIUrl":"10.1002/jor.70192","url":null,"abstract":"<div>\u0000 \u0000 <p>Microphysiological systems of tendon healing, or Tendon-on-Chips, are promising platforms for studying scarring and fibrotic repair and can be relevant for the development of novel anti-fibrotic therapeutics. Effective fibrosis models must accurately recreate the myofibroblast microenvironment of signals that modulate their activation and drive peritendinous adhesions. These include not only the cellular interactions between resident tendon cells and proliferating immune and endothelial cells, but importantly, the dynamic extracellular matrix changes. In this study, we explore the extracellular matrix of healing tendon by investigating the role of type III collagen in inflammatory fibrosis. To address this, we evaluated the structural and biological effects of increased type III collagen ratio in an in vitro hydrogel model. Collagen hydrogels with 20% type III and 80% type I collagen had smaller fibrils and pores compared to those with 5% type III and 95% type I collagen. While these structural differences did not significantly alter viscoelastic or diffusive transport properties, higher type III collagen led to significant cellular effects that correlate with known in vivo features. Activated myofibroblasts were less contractile in high type III collagen hydrogels. Monocytes exhibited significantly hindered migration in a chemotaxis experiment. Furthermore, endothelial cells demonstrated increased angiogenic sprouting and microvascular network formation when suspended in high type III collagen hydrogels. These findings demonstrate that type III collagen precipitates a vascular fibrotic phenotype in injured tendons. Clinical Significance: Use of type III collagen to simulate fibrotic extracellular matrix will increase the accuracy of human-relevant tendon microphysiological systems for improved antifibrotic drug development.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response","authors":"Victoria R. Duke,&nbsp;Marc J. Philippon Jr.,&nbsp;Dane R. G. Lind,&nbsp;Herbert Kasler,&nbsp;Kohei Yamaura,&nbsp;Matt Huard,&nbsp;Molly Czachor,&nbsp;Justin Hollenbeck,&nbsp;Justin Brown,&nbsp;Alex Garcia,&nbsp;Jacob D. Matityahu,&nbsp;Naomasa Fukase,&nbsp;Ralph S. Marcucio,&nbsp;Anna-Laura Nelson,&nbsp;William S. Hambright,&nbsp;Dustin M. Snapper,&nbsp;Johnny Huard,&nbsp;Chelsea S. Bahney","doi":"10.1002/jor.70193","DOIUrl":"10.1002/jor.70193","url":null,"abstract":"<p>An estimated 189 million bone fractures occurred in 2019 making it one of the most globally prevalent injuries. Delayed union or nonunion occurs in up to 15% of normal fractures with higher rates in aged individuals. Preclinical testing supports the translation of novel strategies to promote improved fracture repair, but there is a paucity of small animal models that recapitulate delayed fracture healing. Here, we evaluated the <i>Zmpste24</i>⁻^/⁻ (Z24⁻^/⁻) murine model of Hutchinson-Gilford progeria syndrome as a model of delayed fracture healing. Leveraging the previously characterized Z24⁻^/⁻ phenotype of genomic instability, epigenetic changes, and fragility, we hypothesize that progeria mice will present with significantly delayed fracture healing relative to age-matched wild type (WT) controls. Mice received intramedullary-fixed tibia fractures with healing and immunosenescence evaluated throughout repair. Z24⁻^/⁻ mice demonstrated significantly delayed healing with smaller fracture calli containing more cartilage and less bone relative to WT mice. The fracture healing phenotype of the Z24⁻^/⁻ phenocopied naturally aged mice with increased systemic senescence noted in animals relative to adult WT. Unlike naturally aged mice, Z24⁻^/⁻ also presented with frail bones. Z24⁻^/⁻ showed a dysregulated immune composition, with decreased lymphopoiesis, increased myelopoiesis and neutrophil accumulation. Aspects of the macrophage phenotype in Z24⁻^/⁻ reflected changes in natural aging, but with different systemic T cell responses. Given the Z24⁻^/⁻ progeria mouse model demonstrates the delayed fracture healing phenotype of naturally aged animal at 3 rather than 20 months of age, we suggest this model provides an accelerated model of age-related delayed fracture healing.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}