Journal of Orthopaedic Research®最新文献

{"title":"Coordination of Glucose and Glutamine Metabolism in Tendon Is Lost in Aging.","authors":"Samuel J Mlawer, Felicia R Pinto, Katie J Sikes, Brianne K Connizzo","doi":"10.1002/jor.26100","DOIUrl":"10.1002/jor.26100","url":null,"abstract":"<p><p>Tendinopathy is a chronic, degenerative disease that has increased prevalence in aged populations, and is characterized by a loss in extracellular matrix (ECM) integrity. Recent work has clearly demonstrated age-related deficits in ECM synthesis with aging, as well as some changes to metabolic activity. Since glucose metabolism is critical to protein synthesis and known to be altered in aging, we sought to investigate if age-related changes in metabolism are linked to changes in ECM remodeling. We used our previously developed flexor tendon explant model to expose young and aged tendon explants to various concentrations of glucose and glutamine supplementation and observe changes in metabolic activity, matrix composition, matrix biosynthesis, and expression of metabolic and ECM genes. We hypothesized that elevated levels of glucose and glutamine would lead to increased ECM remodeling as well as elevated gene expression of their respective pathways in young tendons, with no such effect in aged tendons. Interestingly, we found that glutamine processing is affected by glucose levels with increased expression of key glutamine processing pathways with increased glucose, but this effect was lost with aging. We also observed that ECM remodeling is directly related to both glucose and glutamine processing with altered glycosaminoglycan and collagen synthesis with glucose and glutamine media concentration. Overall, our work reveals that glucose and glutamine are intricately linked for both tenocyte health and ECM homeostasis and that their metabolism could be one of the key drivers of age-related deficiencies in tissue maintenance.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Patients' Lifestyle Affects the Wear of Hip Implants: An In-Silico Study","authors":"Lorenza Mattei,&nbsp;Andrea Di Pietro,&nbsp;Francesca Di Puccio","doi":"10.1002/jor.26098","DOIUrl":"10.1002/jor.26098","url":null,"abstract":"<div>\u0000 \u0000 <p>The validation of new hip replacement designs traditionally relies on lengthy and costly In-Vitro wear tests that replicate basic In-Vivo conditions, as the simplified walking recommended in the ISO 14242 guidelines. These tests overlook the diverse motor tasks and lifestyle differences among patients. This study seeks to establish the foundation for In-Silico clinical trials of total hip replacements, enabling wear simulations of patients with different lifestyles, not feasible with In-Vitro tests. The impact of diverse kinematic and loading histories on the wear of metal-on-plastic hip replacements is investigated in a novel way, considering the combined effect of six daily activities (e.g., walking, fast walking, sit/stand, stairs up/down, lunging), different activity frequencies across five patient profiles (from sedentary elderly to active young), and the effect of load sequence. The results reveal that both the type and frequency of motor tasks significantly influence implant wear. The most critical tasks and at-risk patients were stair climbing and the most active individuals, regardless of age. Load sequence also plays a key role in long-term wear predictions. Accuracy and computational cost were balanced by simulating walking, stair climbing, and sit/stand cycles, ensuring equivalent wear to a complete motor task sequence. ISO standards conditions notably tend to underestimate volumetric wear by up to 60% compared to the simulated patient types. They also fail to predict realistic wear patterns for activities like squatting and lunging where edge contact occurs.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 8","pages":"1472-1484"},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board and TOC","authors":"","doi":"10.1002/jor.25888","DOIUrl":"https://doi.org/10.1002/jor.25888","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1055-1058"},"PeriodicalIF":2.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25888","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Cover","authors":"","doi":"10.1002/jor.25889","DOIUrl":"https://doi.org/10.1002/jor.25889","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25889","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the Reliability of Cartilage Repair Evaluation: A Simplified Volume-Based Approach","authors":"Jani Puhakka,&nbsp;Teemu Paatela,&nbsp;Eve Salonius,&nbsp;Virpi Muhonen,&nbsp;Anna Meller,&nbsp;Anna Vasara,&nbsp;Hannu Kautiainen,&nbsp;Jussi Kosola,&nbsp;Ilkka Kiviranta","doi":"10.1002/jor.26096","DOIUrl":"10.1002/jor.26096","url":null,"abstract":"<div>\u0000 <section>\u0000 \u0000 <h3> ABSTRACT</h3>\u0000 \u0000 <p>The purpose of this study was to explore methods for enhancing the reliability of arthroscopic cartilage repair evaluation. We compared a new volume-based scoring technique that assessed the extent of high-quality cartilage repair tissue in four quadrants of the repair tissue with the International Cartilage Repair Society (ICRS) score. Using a porcine cartilage repair model, we evaluated the inter- and intrarater reliability of the new volume-based technique. Nine defects were treated with a recombinant human Type III collagen/polylactide scaffold, whereas nine were left to heal spontaneously. The reliability of the volume-based score was analyzed using intraclass correlation coefficients (ICCs), and external validation was performed by comparing the score with histological ICRS II results. The volume-based score demonstrated moderate to good interrater reliability (ICC 0.67–0.78) and intrarater reliability (ICC 0.58–0.84), outperforming the ICRS score in consistency. Moderate positive correlations were observed between the volume-based score and histological ICRS II subscores (<i>r</i>_s = 0.62–0.64, <i>p</i> &lt; 0.001). These findings suggest that the volume-based approach may improve the reliability of arthroscopic cartilage repair assessment without significantly compromising the alignment with histological evaluations. Although the simplified system offers advantages in reproducibility, further refinement is necessary to balance reliability with the need for comprehensive tissue evaluation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>Diagnostics, Level III (based on comparative studies in an animal model with blinding between observers).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Statement of Clinical Significance</h3>\u0000 \u0000 <p>This study provides insights into improving the reliability of arthroscopic cartilage repair evaluations, potentially leading to more consistent and accurate assessments in both clinical and research settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 8","pages":"1387-1395"},"PeriodicalIF":2.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Article Processing Charges of Orthopaedic Journals in the United States","authors":"Allyson N. Pfeil,&nbsp;Zachary Rickmeyer,&nbsp;Joshua H. Taylor,&nbsp;Davin K. Fertitta,&nbsp;Anay R. Patel,&nbsp;T. Bradley Edwards,&nbsp;Corey F. Hryc","doi":"10.1002/jor.26097","DOIUrl":"10.1002/jor.26097","url":null,"abstract":"<div>\u0000 \u0000 <p>In the United States, article processing charges for orthopaedic journals can be excessive and may offer a poor cost-to-benefit ratio regarding article engagement. This study hypothesizes that article processing charges will not strongly correlate with metrics of engagement such as citations, regardless of publication model. The Journal Citation Reports (Clarivate, Philadelphia, PA) identified 136 orthopaedic journals, of which 83 were non-United States journals and six were not suitable for analysis, resulting in 47 journals for analysis. The collected variables included access options, article processing charge, publisher, impact factor with and without self-citations, immediacy index, normalized Eigenfactor (journal influence), article influence score, total citations, total articles, citations per open access article, and citations per restricted and free article. T- and Chi-square tests statistically compared continuous and categorical variables, respectively, and significance was determined at <i>p</i> &lt; 0.05. Linear regressions computed a coefficient of determination to assess any correlation between cost and metrics of engagement, with strong correlation assessed at ≥ 0.80. Publishing unrestricted open access was significantly more expensive in hybrid journals. Hybrid journals received significantly more total citations than open access, however, no difference between hybrid or open access journals was noted when comparing citations per article within 3 years. No other differences or correlations were found in engagement metrics, publication models, or cost. Access and incorporation of novel findings into clinical practice may depend on scientific publishing practices and, specifically, our ability to maximize viewership while maintaining cost-effectiveness.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 8","pages":"1501-1507"},"PeriodicalIF":2.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Artificial Vertebral Body Analogs to Evaluate Initial Stability of Cervical Disc Replacements","authors":"Jenna M. Wahbeh,&nbsp;Labiba Alam,&nbsp;Edward Ebramzadeh,&nbsp;Sophia N. Sangiorgio","doi":"10.1002/jor.26095","DOIUrl":"10.1002/jor.26095","url":null,"abstract":"<div>\u0000 \u0000 <p>Recent studies have raised concerns regarding migration of cervical disc replacements as a significant clinical complication associated with failure. To date, no laboratory models have addressed migration. Bone analog models have been established for fixation studies of large joint replacements. Therefore, this study aimed to develop models to assess micromotions of cervical disc replacements. Five cervical disc replacement designs were biomechanically tested in flexion/extension, lateral bending, and axial rotation. These were selected to represent different clinical outcomes, including some with significant in vivo migration. Each device was tested in a (1) previously validated 3D-printed biomimetic model and (2) commercially available rigid polyurethane foam blocks. Sagittal and coronal plane micromotions were continuously measured throughout testing. Cyclic displacements were compared as a function of device design and bone analog model type. One ball-and-socket cervical device, the PCM, exhibited significantly greater micromotion in the polyurethane foam model than in the 3D-printed biomimetic model during flexion-extension and lateral bending, specifically 25.8 ± 11.4 µM versus 15.0 ± 9.5 µM (<i>p</i> = 0.04) and 122 ± 64 µM versus 14.5 ± 6.4 µM (<i>p</i> = 0.06), respectively. The large amount of micromotion with the PCM device design was consistent with clinical reports of migration leading to failure. In contrast, motions measured in the 3D-printed biomimetic model did not establish the same differences. In summary, the polyurethane foam model indicated differences between devices better in comparison to the 3D-printed biomimetic model. However, the 3D-printed model has greater potential for further material refinements to more precisely predict clinical performance with better simulation of bone mechanical properties.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1344-1354"},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of T1ρ With Properties of Articular Cartilage Depend on the Spin-Lock Amplitude and Orientation of the Sample","authors":"Nina E. Hänninen,&nbsp;Isabel Stavenuiter,&nbsp;Olli Nykänen,&nbsp;Mikko J. Nissi","doi":"10.1002/jor.26094","DOIUrl":"10.1002/jor.26094","url":null,"abstract":"<p>Various findings on the correlations of the continuous wave (CW-) T1ρ relaxation with properties of articular cartilage have been reported, suggesting its potential for cartilage diagnostics. The aim of the study was to combine all the previously reported aspects and investigate the association of CW-T1ρ relaxation time in healthy bovine cartilage to different properties of cartilage with a range of spin-lock amplitudes and cartilage orientations. Bovine cartilage-bone plugs (<i>n</i> = 11) were imaged in four orientations at 9.4T to measure T1, T2, and CW-T1ρ with spin-lock amplitudes varying between 100 and 5000 Hz. For reference, biomechanical moduli, polarized light microcopy anisotropy and optical density were measured. Correlation between the relaxation times and the reference parameters were determined for each spin-lock amplitude and sample orientation. Significant increase in both CW-T1ρ and T2 relaxation times was observed, especially in the deep layers of cartilage, when the sample was oriented to 55° orientation. The CW-T1ρ relaxation anisotropy was reduced with increasing spin-lock amplitude and reached a stable level of about 10% at a spin-lock amplitude of 1500 Hz or higher. Young's modulus, instantaneous modulus and optical density correlated negatively with the T1ρ relaxation times measured with spin-lock amplitudes higher than 500 Hz. The results demonstrate that CW-T1ρ relaxation time is highly dependent on the orientation of cartilage with respect to the main magnetic field (<i>B</i>₀), and the level of orientation dependence is related to the spin-lock amplitude. Correlation of CW-T1ρ with cartilage properties is dependent both on the orientation and spin-lock amplitude.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1259-1268"},"PeriodicalIF":2.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphologic and Histologic Assessment of Porcine Model of Legg−Calvé−Perthes Disease at a Clinically Relevant Time Point","authors":"Phillip Taboada,&nbsp;Daniel Trautmann,&nbsp;Garrett Croley,&nbsp;Joonoh Lee,&nbsp;Zhuo Deng,&nbsp;Harry K. W. Kim","doi":"10.1002/jor.26093","DOIUrl":"10.1002/jor.26093","url":null,"abstract":"<p>Previous studies using the porcine model of Legg−Calvé−Perthes Disease (LCPD) focused on treatments initiated 1 week following osteonecrosis (ON) induction, which represents the early avascular necrosis (AVN) stage (Stage Ia). Most patients, however, present to the clinic during later stages, like the late AVN (Stage Ib) or the early fragmentation stage (Stage IIa), when development of deformity and revascularization is initiated. This study's purpose was to determine the histologic and morphologic changes in the porcine model at 3 weeks after the ON induction. We hypothesized that the 3-week time point better represents a clinically relevant stage of LCPD when patients present to clinic. Eighteen piglets underwent ON induction surgery. Femoral heads were assessed using X-ray, histology, and micro-CT at 3 weeks post-ON. X-ray and histologic assessments revealed subchondral fracture, mild femoral head deformity, variable degree of revascularization (33 ± 30%, range 0%−88%), and early necrotic bone remodeling changes with significantly decreased osteoblast (<i>p</i> &lt; 0.0001) and osteoclast numbers (<i>p</i> &lt; 0.0001) compared to the normal side. Taken together, the results of this study provide comprehensive morphologic and histologic evidence of the late AVN stage (Stage 1b) in the porcine model, which is a clinically relevant time point to develop and test new treatment strategies. A wide variability of revascularization was seen at the 3-week time point, which stresses the importance of evaluating femoral head perfusion and individualizing treatment even in the early stage of AVN.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1336-1343"},"PeriodicalIF":2.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Kinematics for Various Robotically Performed Total Knee Arthroplasty Implant Designs","authors":"Michael Tim-Yun Ong,&nbsp;Michael T. LaCour,&nbsp;Patrick Shu-Hang Yung,&nbsp;Garett M. Dessinger,&nbsp;Richard D. Komistek","doi":"10.1002/jor.26091","DOIUrl":"10.1002/jor.26091","url":null,"abstract":"<p>Although it is well-documented that robotic-assisted total knee arthroplasty (TKA) can improve surgical precision, evaluations of the postoperative kinematics of patients implanted using robotics remain less common. The objective of this study is to analyze the weight-bearing kinematics for multiple TKAs implanted using two different surgical robots. In vivo knee kinematics were assessed using fluoroscopy for 28 subjects implanted with a Bi-Cruciate Stabilized (BCS) TKA, 23 with a Bi-Cruciate Retaining (BCR) TKA, 13 with a posterior stabilized (PS) TKA, and 22 with a cruciate retaining (CR) TKA. All subjects were implanted by the same surgeon using the respective company's surgical robot. All subjects performed a weight-bearing deep knee bend. Parameters of interest include the femoral condylar anterior/posterior motion, femorotibial axial rotation, and weight-bearing range-of-motion. The BCS TKA experienced the most posterior rollback, 13.4 ± 4.4 mm for the lateral condyle and 5.8 ± 2.5 mm for the medial condyle. These subjects also experienced the most femorotibial axial rotation, +9.3 ± 5.3°. Conversely, CR subjects experienced the least overall rollback and most anterior sliding, 0.4 ± 3.8 mm of lateral rollback and 1.9 ± 4.1 mm of medial anterior sliding. Implant design appears to play a significant role in postoperative kinematics. Improved stability is evident in TKAs that account for the ACL. However, no system behaved significantly better nor worse than previously published literature evaluating standard instrumentation.</p><p><b>Level of Evidence:</b> Level 3, retrospective cohort study.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1284-1292"},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}