Journal of Orthopaedic Research®最新文献_第6页

Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy 代谢风险因素与跟腱病患者肌腱健康状况恶化有关

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-01-06 DOI: 10.1002/jor.26038

Kayla D. Seymore, Hayley Powell Smitheman, Andy K. Smith, Ryan T. Pohlig, Christian Couppé, Karin Grävare Silbernagel

{"title":"Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy","authors":"Kayla D. Seymore, Hayley Powell Smitheman, Andy K. Smith, Ryan T. Pohlig, Christian Couppé, Karin Grävare Silbernagel","doi":"10.1002/jor.26038","DOIUrl":"https://doi.org/10.1002/jor.26038","url":null,"abstract":"<div>\u0000 \u0000 <p>A high proportion of individuals with Achilles tendinopathy continue to demonstrate long-term symptoms and functional impairments after exercise treatment. Thus, there is a need to delineate patient presentations that may require alternative treatment. The objective of this study was to evaluate if the presence of metabolic risk factors relates to tendon symptoms, psychological factors, triceps surae structure, and lower limb function in individuals with Achilles tendinopathy. One hundred and fifty-eight individuals (88 female) with diagnosed midportion Achilles tendinopathy were divided into three groups based on the number of metabolic risk factors linked to cardiovascular disease present at baseline: two or more factors, one factor, no factors. Metabolic risk factors were determined by clinical evaluation and past medical history. Achilles tendinopathy symptoms (Victorian Institute of Sport Assessment-Achilles, Patient Reported Outcome Measurement Information System, movement-evoked pain ratings), psychological factors (Tampa Scale for Kinesiophobia), triceps surae structure (B-mode ultrasound of tendon and muscle morphology, continuous shear wave elastography of tendon mechanical properties), and lower limb function (test battery) were compared among groups. Individuals with two or more metabolic risk factors had worse symptoms with loading (<i>p</i> = 0.011), smaller Achilles tendon size relative to body mass (<i>p</i> = 0.002), and worse lower limb function compared to individuals without metabolic risk factors (<i>p</i> < 0.02). No differences were observed between individuals with one metabolic risk factor and those without metabolic risk factors. Future consideration of multiple metabolic risk factors for individuals with Achilles tendinopathy could facilitate understanding the underlying impairments of tendon pathology and recovery that may be addressed with treatment.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 4","pages":"728-738"},"PeriodicalIF":2.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finite Element Model of Patient-Specific Flanged Acetabular Components Highlights Biomechanical Effects of Bone Density and Cortical Shell Thickness 患者特有的法兰髋臼部件的有限元模型强调骨密度和皮质壳厚度的生物力学效应。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2025-01-05 DOI: 10.1002/jor.26037

Haena-Young Lee, Friedrich Boettner, Jason L. Blevins, Jose A. Rodriguez, Joseph D. Lipman, Fernando J. Quevedo González, Mathias P. Bostrom, Timothy M. Wright, Peter K. Sculco

{"title":"Finite Element Model of Patient-Specific Flanged Acetabular Components Highlights Biomechanical Effects of Bone Density and Cortical Shell Thickness","authors":"Haena-Young Lee, Friedrich Boettner, Jason L. Blevins, Jose A. Rodriguez, Joseph D. Lipman, Fernando J. Quevedo González, Mathias P. Bostrom, Timothy M. Wright, Peter K. Sculco","doi":"10.1002/jor.26037","DOIUrl":"10.1002/jor.26037","url":null,"abstract":"<div>\u0000 \u0000 <p>Patient-specific flanged acetabular components are utilized to treat failed total hip arthroplasties with severe acetabular defects. We previously developed and published a finite element model that investigated the impact of hip joint center lateralization on construct biomechanics during gait conditions. This model consisted of a patient-specific implant designed to address a superior-medial defect created in a standard pelvic geometry. This study aims to utilize the same model and examine how cortical shell thickness and ischial cancellous bone density affect the strain distribution in the bone and bone–implant micromotion. Using published studies and bone density analyses of patients who had undergone total hip arthroplasties with flanged acetabular components, we established a thickness range for the cortical shell (1.5, 1, and 0.75 mm) and two levels of ischial cancellous bone density (100% and 25%). We compared the resulting bone strains against the fatigue strength of the bone (0.3% strain) as a criterion for local bone failure and the bone–implant micromotion against the threshold associated with bone ingrowth (20 µm). A thinner pelvic cortical shell and lower ischial cancellous bone density increased areas of bone at risk of failure, particularly at the ischial screws (from 6% to 38%), and decreased areas compatible with bone ingrowth. These findings agree with our clinical knowledge that compromised ischial bone and inadequate ischial fixation negatively impact the survivorship of flanged acetabular components. This series establishes our modeling approach of a computational model that can be utilized to guide implant design to best treat unique acetabular defects.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 4","pages":"834-841"},"PeriodicalIF":2.1,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophoretic Deposition of Gentamicin Into Titania Nanotubes Prevents Evidence of Infection in a Mouse Model of Periprosthetic Joint Infection 庆大霉素在钛纳米管中的电泳沉积阻止了假体周围关节感染小鼠模型的感染证据。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-12-31 DOI: 10.1002/jor.26029

John L. Hamilton, Sofia Gianotti, Julia Fischer, Greta Della Fara, Amandine Impergre, Francesca De Vecchi, Mohammed AbuAlia, Alfons Fischer, Adrienn Markovics, Markus A. Wimmer

{"title":"Electrophoretic Deposition of Gentamicin Into Titania Nanotubes Prevents Evidence of Infection in a Mouse Model of Periprosthetic Joint Infection","authors":"John L. Hamilton, Sofia Gianotti, Julia Fischer, Greta Della Fara, Amandine Impergre, Francesca De Vecchi, Mohammed AbuAlia, Alfons Fischer, Adrienn Markovics, Markus A. Wimmer","doi":"10.1002/jor.26029","DOIUrl":"10.1002/jor.26029","url":null,"abstract":"<div>\u0000 \u0000 <p>Periprosthetic joint infection (PJI) is a leading cause and major complication of joint replacement failure. As opposed to standard-of-care systemic antibiotic prophylaxis for PJI, we developed and tested titanium femoral intramedullary implants with titania nanotubes (TNTs) coated with the antibiotic gentamicin and slow-release agent chitosan through electrophoretic deposition (EPD) in a mouse model of PJI. We hypothesized that these implants would enable local gentamicin delivery to the implant surface and surgical site, effectively preventing bacterial colonization. In the mouse PJI model, C57BL/6 mice received implants with TNTs coated with chitosan (chitosan group; control group) or with TNTs coated with chitosan and gentamicin (chitosan + gentamicin group; experimental group). Following implant placement, the surgical site was inoculated with 1 × 10<sup>3</sup> CFUs of Xen36 bioluminescent <i>Staphylococcus aureus</i>. All the mice in the chitosan group and none in the chitosan + gentamicin group had evidence of infection based on CFU analysis and bioluminescence imaging through the 14-day assessment postsurgery. Correspondingly, scanning electron microscopy analysis at the implant surface demonstrated bacterial biofilm only in the chitosan group. Furthermore, periosteal reaction and peri-implant bone loss at the femur were significantly reduced in the chitosan + gentamicin group. The chitosan + gentamicin group had reduced pain behavior, improved weight-bearing, and increased weight compared to the chitosan-control group. This study provides preclinical evidence supporting the efficacy of implants with TNTs coated with chitosan and gentamicin through EPD for preventing bacterial colonization and biofilm formation in a mouse model of PJI.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 3","pages":"671-681"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Msx1-Modified Rat Bone Marrow Mesenchymal Stem Cell Therapy for Rotator Cuff Repair: A Comprehensive Analysis of Tendon-Bone Healing and Cellular Mechanisms 用于肩袖修复的 Msx1 改性大鼠骨髓间充质干细胞疗法：腱-骨愈合和细胞机制的综合分析。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-12-31 DOI: 10.1002/jor.26039

Kang Liu, Xia-wei Fu, Zi-min Wang

{"title":"Msx1-Modified Rat Bone Marrow Mesenchymal Stem Cell Therapy for Rotator Cuff Repair: A Comprehensive Analysis of Tendon-Bone Healing and Cellular Mechanisms","authors":"Kang Liu, Xia-wei Fu, Zi-min Wang","doi":"10.1002/jor.26039","DOIUrl":"10.1002/jor.26039","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigates the therapeutic potential of Msx1-overexpressing bone marrow mesenchymal stem cells (BMSCs) in enhancing tendon-bone healing in rotator cuff injuries. BMSCs were genetically modified to overexpress Msx1 and were evaluated in vitro for their proliferation, migration, and differentiation potential. Results demonstrated that Msx1 overexpression significantly increased BMSC proliferation and migration while inhibiting osteogenic and chondrogenic differentiation. In a rat model of acute rotator cuff injury, Msx1-BMSCs embedded in a hydrogel scaffold were implanted at the tendon-bone junction. Micro-CT analysis revealed substantial new bone formation in the Msx1-BMSC group, and histological evaluation showed organized collagen and cartilage structures at the repair site. Biomechanical testing further confirmed enhanced structural strength in the Msx1-BMSC-treated group. These findings suggest that Msx1 modification enhances BMSC-mediated repair by promoting cell proliferation and migration, facilitating tendon-bone integration. This Msx1-based approach presents a promising strategy for advancing regenerative therapies for rotator cuff injuries.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 4","pages":"859-869"},"PeriodicalIF":2.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tensor Fasciae Latae and Gluteus Maximus Muscles: Do They Contribute to Hip Abduction? 阔筋膜张肌和臀大肌：它们是否与髋外展有关？

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-12-28 DOI: 10.1002/jor.26036

Armando Hoch, Dimitris Dimitriou, Jessica Wolf-Wettstein, Jan Rosner, Martin Schubert, Jose Aguirre, Urs Eichenberger, Patrick Zingg, Paul Borbas

{"title":"Tensor Fasciae Latae and Gluteus Maximus Muscles: Do They Contribute to Hip Abduction?","authors":"Armando Hoch, Dimitris Dimitriou, Jessica Wolf-Wettstein, Jan Rosner, Martin Schubert, Jose Aguirre, Urs Eichenberger, Patrick Zingg, Paul Borbas","doi":"10.1002/jor.26036","DOIUrl":"10.1002/jor.26036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Hip abductors are essential for hip function. To understand abduction weakness, it is important to know which muscles contribute to abduction force. Our aim was to investigate the effects of an experimentally induced weakness of the different muscles (tensor fasciae latae [TFL], gluteus medius and minimus (Gmed/min), gluteus maximus [Gmax]) on the abduction force. Ten participants received sequential nerve blocks of the TFL, the Gmed/min, and the Gmax. Subsequently, abduction force was measured in the lateral decubitus position in three sagittal positions of the hip (30° flexion, neutral, 30° extension). In 30° flexion, the average abduction force was 220 N without block, 187 N with block of the TFL, 83 N with block of the Gmed/min, and 97 N with block of the Gmax, respectively. In neutral position, average abduction force was 213 N without block, 200 N with block of the TFL, 82 N with block of the Gmed/min, and 115 N with block of the Gmax, respectively. In 30° extension, average abduction force was 116 N without block, 146 N with block of TFL, 61 N with block of the Gmed/min, and 94 N with block of the Gmax, respectively. An induced weakness of the TFL reduces abduction force only in 30° of hip flexion by 15%. It is not highly relevant as an abductor. An induced weakness of the Gmax reduces abduction force in flexion by 43%−56%, depending on the position. It is, therefore, highly relevant as an abductor of the hip.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 4","pages":"828-833"},"PeriodicalIF":2.1,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Marker-Based RSA and CT-RSA for Analyzing Micromotions After Distal Radius Osteotomy: A 1-Year Retrospective Study of 24 Patients 基于标记的RSA与CT-RSA在桡骨远端截骨术后微运动分析中的比较：24例患者1年回顾性研究。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-12-27 DOI: 10.1002/jor.26031

Vasileios Angelomenos, Olof Sandberg, Bita Shareghi, Michael Ullman

{"title":"Comparison of Marker-Based RSA and CT-RSA for Analyzing Micromotions After Distal Radius Osteotomy: A 1-Year Retrospective Study of 24 Patients","authors":"Vasileios Angelomenos, Olof Sandberg, Bita Shareghi, Michael Ullman","doi":"10.1002/jor.26031","DOIUrl":"10.1002/jor.26031","url":null,"abstract":"<p>Radiostereometric Analysis (RSA) is the most accurate method for determining early micromotions of orthopedic implants. Computed Tomography Radiostereometric Analysis (CT-RSA) is a method that can be used to determine implant and bone micromovements using low-dose CT scans. This study aimed to evaluate the reliability of the CT-RSA method in measuring the interfragmental mobility in patients who have undergone a correction osteotomy due to a malunited distal radius fracture. Twenty-four patients were included and operated with a radiolucent volar plate. Markers were embedded in the plate and bone. RSA and CT examinations were obtained postoperatively up to 1-year postoperative. Micromovements of the distal radius segment relative to the proximal were compared between the methods with paired analysis and Bland–Altman plots. The limits of clinical significance were: dorsal/volar tilt < 10°, radial shortening < 5 mm, radial inclination ≥ 15°, and radial shift < 5 mm. For the dorsal/volar tilt, the paired analysis between the two methods, showed a mean difference (95% CI) of −0.06° (−0.67 to 0.55), for radial compression-0.04 mm (−0.09 to 0.01), for radial inclination 0.21° (−0.06 to 0.48), and for radial shift −0.07 mm (−0.21 to 0.07). The paired analysis for micromotions showed that the thresholds of clinical significance are excluded from the difference's 95% CI. The Bland–Altman plots showed comparable results up to 1 year, considering clinically relevant thresholds. In conclusion, the CT-RSA method is comparable to that of marker-based RSA in measuring micromotions after wrist osteotomy, as the differences between the methods are not clinically significant.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 3","pages":"660-670"},"PeriodicalIF":2.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate- and High-Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon 中等和高速跑步机运动对大鼠跟腱的影响最小。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-12-27 DOI: 10.1002/jor.26030

Margaret K. Tamburro, Kelsey A. Bonilla, Snehal S. Shetye, Thomas P. Leahy, Jeremy D. Eekhoff, Min-Soo Kim, Christopher Petucci, John W. Tobias, Daniel C. Farber, Louis J. Soslowsky

{"title":"Moderate- and High-Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon","authors":"Margaret K. Tamburro, Kelsey A. Bonilla, Snehal S. Shetye, Thomas P. Leahy, Jeremy D. Eekhoff, Min-Soo Kim, Christopher Petucci, John W. Tobias, Daniel C. Farber, Louis J. Soslowsky","doi":"10.1002/jor.26030","DOIUrl":"10.1002/jor.26030","url":null,"abstract":"<p>Exercise influences clinical Achilles tendon health in humans, but animal models of exercise-related Achilles tendon changes are lacking. Moreover, previous investigations of the effects of treadmill running exercise on rat Achilles tendon demonstrate variable outcomes. Our objective was to assess the functional, structural, cellular, and biomechanical impacts of treadmill running exercise on rat Achilles tendon with sensitive in and ex vivo approaches. Three running levels were assessed over the course of 8 weeks: control (cage activity), moderate-speed (treadmill running at 10 m/min, no incline), and high-speed (treadmill running at 20 m/min, 10° incline). We hypothesized that moderate-speed treadmill running would beneficially impact tendon biomechanics through increased tenocyte cellularity, metabolism, and anabolism whereas high-speed treadmill running would cause a tendinopathic phenotype with compromised tendon biomechanics due to pathologic tenocyte differentiation, metabolism, and catabolism. Contrary to our hypothesis, treadmill running exercise at these speeds had a nominal effect on the rat Achilles tendon. Treadmill running modestly influenced tenocyte metabolism and nuclear aspect ratio as well as viscoelastic tendon properties but did not cause a tendinopathic phenotype. These findings highlight the need for improved models of exercise- and loading-related tendon changes that can be leveraged to develop strategies for tendinopathy prevention and treatment.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 3","pages":"519-530"},"PeriodicalIF":2.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Micro-CT Based Cadaveric Study Investigating Bone Density Changes During Hip Arthroplasty Surgery 一项基于显微ct的尸体研究探讨了髋关节置换术中骨密度的变化。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-12-26 DOI: 10.1002/jor.26032

Vineet Seemala, Mark A. Williams, Richard King, Sofia Goia, Paul F. Wilson, Arnab Palit

{"title":"A Micro-CT Based Cadaveric Study Investigating Bone Density Changes During Hip Arthroplasty Surgery","authors":"Vineet Seemala, Mark A. Williams, Richard King, Sofia Goia, Paul F. Wilson, Arnab Palit","doi":"10.1002/jor.26032","DOIUrl":"10.1002/jor.26032","url":null,"abstract":"<p>The impact of broaching and uncemented implantation on bone density during total hip arthroplasty (THA) remains unclear. Previous studies have typically examined extracted bone sections, which may not directly correlate with outcomes in human hip systems. This study aimed to evaluate bone density changes resulting from broaching and uncemented implantation using micro-computed tomography (μCT) on cadaveric samples. An in-house density calibration phantom (DCP) was developed by validating the densities of polymer inserts through mass and volume measurements. Its performance was then evaluated using lamb bone in comparison with a commercial DCP (QRM-50124). The sensitivity of density predictions to μCT scan parameters was also evaluated with the lamb bone. Additionally, density predictions from medical-CT and μCT scans were compared using the in-house DCP. Finally, uncemented THA procedures were performed on three cadaveric femurs, each undergoing three μCT scans at various surgical stages to assess changes in bone density. The density predictions obtained using the in-house DCP achieved an accuracy of ±0.097 g/cc compared to QRM-50124, with a precision of ±0.052 g/cc. The sensitivity to changes in μCT scan parameters was ±0.022 g/cc. Notably, density predictions from medical-CT and μCT scans were similar, particularly in cortical bone. Broaching and implantation led to an average increase in bone density of 0.137 g/cc, which was attributed to the accumulation of bone debris around the bone-implant interface. This accumulation raised the bone volume fraction, ranging from 3.31% to 20.69%, which acts as an autograft. These measurements have been made for the first time using a µCT and an in-house DCP.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 4","pages":"818-827"},"PeriodicalIF":2.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Glenohumeral Joint Kinematics Following the Latarjet and Eden-Hybinette Procedures a Dynamic Radiostereometric Cadaver Study Latarjet和Eden-Hybinette手术后肩关节运动学的评估——一项动态放射体测尸体研究。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-12-24 DOI: 10.1002/jor.26028

Josephine Olsen Kipp, Theis Muncholm Thillemann, Emil Toft Petersen, Sepp de Raedt, Lærke Borgen, Annemarie Brüel, Thomas Falstie-Jensen, Maiken Stilling

{"title":"Evaluation of Glenohumeral Joint Kinematics Following the Latarjet and Eden-Hybinette Procedures a Dynamic Radiostereometric Cadaver Study","authors":"Josephine Olsen Kipp, Theis Muncholm Thillemann, Emil Toft Petersen, Sepp de Raedt, Lærke Borgen, Annemarie Brüel, Thomas Falstie-Jensen, Maiken Stilling","doi":"10.1002/jor.26028","DOIUrl":"10.1002/jor.26028","url":null,"abstract":"<div>\u0000 \u0000 <p>Anterior shoulder instability with glenoid bone lesion can be treated with the Eden-Hybinette procedure utilizing a tricortical iliac crest bone graft or the Latarjet procedure. This study aimed to evaluate the glenohumeral joint (GHJ) kinematics throughout an external shoulder rotation following the Eden-Hybinette and Latarjet procedures. Nine human specimens were examined with dynamic radiostereometry during a GHJ external rotation with anteriorly directed loads from 0 to 30 N. In 30- and 60-degree GHJ abduction, the kinematics (measured as the humeral head center and contact point) was sequentially recorded for a 15% anterior glenoid bone lesion, the Eden-Hybinette, and the Latarjet procedure. The Latarjet and Eden-Hybinette procedures resulted in up to 9.7 mm (95%CI 0.5; 18.8) more posterior and a 7.4 mm (95%CI 0.3; 14.4) superior humeral head center location compared to the glenoid bone lesion. With 0–20 N anterior directed loads, the Latarjet procedure resulted in a more posterior humeral head center and contact point of up to 7.6 mm (95%CI 3.6; 11.5), especially in 60 degrees of GHJ abduction, compared to the Eden-Hybinette procedure. Opposite, at 30 N anterior-directed load, the Eden-Hybinette procedure resulted in a more posterior humeral head center of up to 7.6 mm (95%CI 0.3; 14.9) in 30 degrees GHJ abduction compared to the Latarjet procedure. The results support considering the Latarjet procedures in patients who need the stabilizing effect with the arm in the abducted and externally rotated position (e.g., throwers) and the Eden-Hybinette procedure in patients exposed to high anterior-directed loads with the arm at lower abduction angles (e.g., epilepsia).</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 3","pages":"492-504"},"PeriodicalIF":2.1,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synovial fluid dual-biomarker algorithm accurately differentiates osteoarthritis from inflammatory arthritis 滑液双生物标志物算法可准确区分骨关节炎和炎性关节炎。

IF 2.1 3区医学

Journal of Orthopaedic Research® Pub Date : 2024-12-18 DOI: 10.1002/jor.26005

Daniel Keter, Van Thai-Paquette, John Miamidian, Simmi Gulati, Krista Toler

{"title":"Synovial fluid dual-biomarker algorithm accurately differentiates osteoarthritis from inflammatory arthritis","authors":"Daniel Keter, Van Thai-Paquette, John Miamidian, Simmi Gulati, Krista Toler","doi":"10.1002/jor.26005","DOIUrl":"10.1002/jor.26005","url":null,"abstract":"<p>Osteoarthritis (OA) prevalence increases as the population ages. Diagnosing osteoarthritis often occurs in the late stages when cartilage degradation is severe, making it difficult to distinguish from other types of arthritis. Accurate differentiation of primary osteoarthritis from other arthritic conditions is crucial for effective treatment planning. A new diagnostic test has been developed that uses a dual-biomarker algorithm to inform osteoarthritis diagnosis. Synovial fluid from patients with confirmed primary osteoarthritis showed elevated levels of cartilage oligomeric matrix protein. However, this biomarker alone could not distinguish primary osteoarthritis from other inflammatory conditions that also cause cartilage deterioration. Therefore, a combinatorial algorithm using cartilage oligomeric matrix protein and Interleukin-8 concentrations was developed to differentiate primary osteoarthritis from inflammatory arthritis. Clinical decision limits for cartilage oligomeric matrix protein concentration and the cartilage oligomeric matrix protein to Interleukin-8 ratio were established and validated using 171 human knee synovial fluid specimens. The osteoarthritis algorithm demonstrated clinical sensitivity and specificity of 87.0% and 88.9%, respectively. This is the first report of a biomarker test that can differentiate primary osteoarthritis from inflammatory arthritis with a high degree of accuracy.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"304-310"},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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