Journal of Orthopaedic Research®最新文献

{"title":"OREF Resident Research Symposia: An Important Pipeline for Prospective Orthopaedic Surgeon-Scientists","authors":"Mathangi Sridharan,&nbsp;Nicole J. Newman-Hung,&nbsp;Charlotte Wahle,&nbsp;Frank Petrigliano,&nbsp;Nicholas M. Bernthal,&nbsp;Lauren E. Wessel","doi":"10.1002/jor.26083","DOIUrl":"10.1002/jor.26083","url":null,"abstract":"<div>\u0000 \u0000 <p>Non-governmental educational programs such as the annual Orthopaedic Research and Education Foundation (OREF) Resident Research Symposia aim to elevate and fund trainee research endeavors. This study investigates the translation of research recognized at the Resident Research Symposia into peer-reviewed publication and the rate of awardees who pursue academic careers after training. Awards from the OREF Resident Research Symposia between 2008 and 2023 were aggregated. Characteristics of awardees and projects were noted. Conversion to publication and journal characteristics were identified by indexing major research databases. The current practice type and specialty of each trainee was queried using the American Academy of Orthopedic Surgeons roster and institutional sites. Descriptive statistics, univariate and multivariate regression models were performed. Primary outcomes included rates of OREF symposia presentation conversion to publication and trainees pursuing a career in academia. Three hundred and eighty-nine awards were included with 72 (18.5%) females and 317 (81.5%) males. One hundred and forty-two (36.5%) were first place awards, 101 (25.9%) second place, 131 (33.7%) third place, and 15 (3.9%) presenter's choice, across five regions. Basic science projects were more likely to win first-place awards (<i>p</i> = 0.001). Awarded projects translated to 300 (77%) peer-reviewed publications, with an average impact factor of 1.78 ± 1.65. Male and first-place awardees were more likely to publish (<i>p</i> = 0.014, <i>p</i> = 0.001). The current practice types of 376 distinct awardees were identified with 149 awardees currently practicing in academia (42.3%). Awardees that successfully published their projects (<i>p</i> &lt; 0.001), and those from the Mid-Atlantic region (<i>p</i> = 0.01) were more likely to pursue academic careers. Research awarded at the OREF symposium translates to peer-reviewed publication at a high rate, and awardees enter academia at a disproportionately high rate. OREF provides an effective platform to identify and support budding surgeon-scientists, which is vital given that musculoskeletal research is historically underfunded at a national level.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1355-1361"},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic Tilt Increases the Risk of Impingement and Alters Impingement Type in Total Hip Arthroplasty: A Patient-Specific Simulation Study","authors":"Arnab Palit,&nbsp;Mark A. Williams,&nbsp;Vineet Seemala,&nbsp;Mike Donnelly,&nbsp;Tobias Renkawitz,&nbsp;Markus Weber","doi":"10.1002/jor.26085","DOIUrl":"10.1002/jor.26085","url":null,"abstract":"<p>Impingement is a significant complication following total hip arthroplasty (THA), resulting in restricted range of motion (ROM). Pelvic tilt (PT) and its variation could alter both post-THA ROM and impingement types, which remains relatively unexplored in the literature. Therefore, this study aims to investigate the impact of PT changes on post-THA ROM and impingement types. Subject-specific ROM was simulated using 3D-CT and clinical data for 56 THA patients. Subsequently, the effect of no-PT, standing preoperative (StPT₀) and postoperative PT at 6 (StPT₆) and 12 months (StPT₁₂) on maximum ROM (flexion, extension, abduction, adduction, external rotation (ER) and internal rotation at 90° Flexion (IR@90°Flex)) and impingement types (implant-to-implant impingement (ITII), implant-to-bone impingement (ITBI), and bone-to-bone impingement (BTBI)) were investigated. Stong correlations existed between PT and flexion (<i>R</i>² ≥ 0.686), extension (<i>R</i>² ≥ 0.527), and IR@90°Flex (<i>R</i>² ≥ 0.547). Anterior PT exceeding 8.1° and 11.8° were linked to decreased flexion below 110° and IR@90°Flex below 30°, respectively. Each 10° increase in anterior PT resulted in a 10° reduction in flexion and a 10.7° reduction in IR@90°Flex. Impingement types due to PT remained unchanged for flexion/extension, with increased ITII for abduction (8.9%), adduction (23.2%), and IR@90°Flex (16.1%), and increased BTBI (16.1%) for ER. In total, 12.5% and 19.6% of patients experienced clinically relevant ROM change for flexion and IR@90°Flex, respectively for StPT₀–StPT₆. However, it affected below 5.4% cases when comparing StPT₆ and StPT₁₂. Minor changes in impingement type (&lt; 6% of cases) were observed due to changes in PT before and after THA, as well as temporal changes in PT post-THA. However, PT had a substantial impact on impingement types when comparing ROM without considering PT to ROM with PT included. Specifically, anterior PT was associated with reduced flexion and IR@90°Flex, indicating a higher risk of impingement. PT changes over time may lead to clinically relevant alterations in ROM but not impingement types.</p><p><b>Trial Registration:</b> German Clinical Trials Register; Main ID: DRKS00000739.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1303-1314"},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Assessment in Osteoarthritis: Present Practices and Future Prospects Including the Use of Biomarkers and Wearable Technologies, and AI-Driven Personalized Medicine","authors":"Shujaa T. Khan,&nbsp;Nick Huffman,&nbsp;Xiaojuan Li,&nbsp;Anukriti Sharma,&nbsp;Carl S. Winalski,&nbsp;Eric T. Ricchetti,&nbsp;Kathleen Derwin,&nbsp;Suneel S. Apte,&nbsp;Daniel Rotroff,&nbsp;Carl Y. Saab,&nbsp;Nicolas S. Piuzzi","doi":"10.1002/jor.26082","DOIUrl":"10.1002/jor.26082","url":null,"abstract":"<p>Osteoarthritis (OA) is a highly prevalent chronic joint disorder affecting ~600 million individuals worldwide and is characterized by complex pain mechanisms that significantly impair patient quality of life. Challenges exist in accurately assessing and measuring pain in OA due to variations in pain perception among individuals and the heterogeneous nature of the disease. Conventional pain assessment methods, such as patient-reported outcome measures and clinical evaluations, often fail to fully capture the heterogeneity of pain experiences among individuals with OA. This review will summarize and evaluate current methods of pain assessment in OA and highlight future directions for standardized pain assessment. We discuss the role of animal models in enhancing our understanding of OA pain pathophysiology and highlight the necessity of translational research to advance pain assessment strategies. Key challenges explored include identifying phenotypes of pain susceptibility, integrating biomarkers into clinical practice, and adopting personalized pain management approaches through the incorporation of multi-modal data and multilevel analysis. We underscore the imperative for continued innovation in pain assessment and management to improve outcomes for patients with OA.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1217-1229"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board and TOC","authors":"","doi":"10.1002/jor.25886","DOIUrl":"https://doi.org/10.1002/jor.25886","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"889-892"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Cover","authors":"","doi":"10.1002/jor.25887","DOIUrl":"https://doi.org/10.1002/jor.25887","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritic Human Synovial Fluid Alters CoCrMo Electrochemical Properties on a Patient-Specific Basis","authors":"Bailey Bond,&nbsp;Madison N. Brown,&nbsp;Michael A. Kurtz,&nbsp;Alayna Robinson,&nbsp;Marc J. Mihalko,&nbsp;John R. Crockarell Jr.,&nbsp;Christopher T. Holland,&nbsp;James L. Guyton,&nbsp;William M. Mihalko","doi":"10.1002/jor.26079","DOIUrl":"10.1002/jor.26079","url":null,"abstract":"<div>\u0000 \u0000 <p>Cobalt-chromium-molybdenum (CoCrMo) femoral components are widely used in total knee arthroplasty (TKA). However, recent retrospective clinical trials associate moderate adverse local tissue reactions with CoCrMo release in the knee. Additionally, gaps persist in our understanding of the fundamental corrosion processes that occur at the CoCrMo-synovial fluid interface. In this study, we investigated the electrochemical behavior of CoCrMo in human synovial fluid obtained at the time of primary TKA, using CoCrMo in phosphate-buffered saline (PBS) as a comparison. Synovial fluid was collected from 118 patients immediately before arthroplasty, then transferred to a three-electrode electrochemical cell with a wrought CoCrMo alloy working electrode. To quantify electrochemical properties, open circuit potential (OCP), electrochemical impedance spectroscopy, and linear polarization tests were run. Generally, the properties varied on a patient-by-patient basis and significantly differed (<i>p</i> &lt; 0.05) from comparison tests performed in PBS. In human synovial fluid, we measured OCPs between a range of −0.38 and 0.15 V and corrosion potentials (<i>E</i>_corr) between −0.95 and −0.2 V. Additionally, we reported instantaneous corrosion rates (1/<i>R_p</i>) spanning nearly four orders of magnitude. The variability we documented suggested that the electrochemical properties of CoCrMo implants may depend on the patient's local physiological environment, influenced by the biological and chemical components of synovial fluid.</p>\u0000 <p><b>Statement of Clinical Significance:</b> This study shows that human synovial fluid affects the electrochemical behavior of CoCrMo, evidenced by the variation on a patient-by-patient basis. This study may have implications for long-term biological response to orthopaedic implants, including total knee arthroplasty.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1144-1154"},"PeriodicalIF":2.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humeral Development Throughout the Arc of Childhood—A 3D MRI Study","authors":"Paige M. Lind,&nbsp;Michael L. Pearl,&nbsp;Katharine E. Alter,&nbsp;Euan A. Forrest,&nbsp;Frances T. Sheehan","doi":"10.1002/jor.26081","DOIUrl":"10.1002/jor.26081","url":null,"abstract":"<p>A quantitative understanding of humeral morphology through the arc of pediatric development is crucial in optimizing the treatment of pediatric shoulder-related orthopedic disorders and athletic overuse injuries. However, data regarding modern normative humeral development are not available. Thus, the aim of this study is to derive biomechanically relevant humeral size and shape measures from a pediatric cohort spanning infancy to adulthood (age 0.6–18.8 years, <i>n</i> = 52). Three-dimensional models were generated by segmenting axial MR images from typically developing, dominant-side humeri. Quadratic regression defined the relationship between each parameter and age. In a sub-cohort, we compared humeral morphological parameters between dominant and nondominant humeri from the same child. Children exhibited a pattern of steady growth, anteversion, and declination throughout development that gradually tapered off toward adulthood. Size measurements had the strongest regressions with age (head diameter: <i>R</i>² = 0.908; humeral length: <i>R</i>² = 0.960; epicondylar width: <i>R</i>² = 0.889, <i>p</i> &lt; 0.001). Version was more variable and less strongly related to age (<i>R</i>² = 0.238, <i>p</i> &lt; 0.001), whereas inclination demonstrated the weakest relationship with age (<i>R</i>² = 0.128, <i>p</i> &lt; 0.05). The shallow curve fits indicated that there is not a single age where adult values were attained. In the sub-cohort analysis, the data from the right and left limbs were no different and correlated, supporting the use of the contralateral limb as a comparator when unilateral pathology is present, if the contralateral parameters fall within the normative range. Our data set provides a unique asset for pediatric clinical interventional planning as it provides the only current in vivo humeral development measures throughout the arc of childhood.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1230-1238"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Structure and Age in Healthy Achilles Tendons","authors":"Kayla D. Seymore,&nbsp;Shawn L. Hanlon,&nbsp;Ryan T. Pohlig,&nbsp;Dawn M. Elliott,&nbsp;Karin Grävare Silbernagel","doi":"10.1002/jor.26080","DOIUrl":"10.1002/jor.26080","url":null,"abstract":"<div>\u0000 \u0000 <p>Age is an important factor to consider with Achilles tendon injury, as variability in tendon structure during developmental growth and aging influence lower limb function and mobility. However, the overlap in structural alterations with aging and Achilles tendon injury makes it unclear which structural changes are related to age separate from tendon pathology. The objective of this study was to determine the relationship between structure and age in healthy Achilles tendons. Healthy Achilles tendons from 389 children and adults (8–79 years) were included in this retrospective analysis. Achilles tendon morphology was assessed via B-mode ultrasound of Achilles tendon length, cross-sectional area (CSA), and thickness. Mechanical properties of Achilles tendon shear modulus and viscosity were assessed via continuous shear wave elastography. The relationship between Achilles tendon structure and age was determined using General Linear Models and White's test of heteroscedasticity (to assess for unequal variance across the age span), controlling for sex, weight, and physical activity level. Healthy free Achilles tendon length (<i>p</i> = 0.002), thickness (<i>p</i> &lt; 0.001), CSA (<i>p</i> &lt; 0.001), and viscosity (<i>p</i> = 0.009) increased with age, supporting age-related changes in tendon structure that may limit its capacity to store and transfer energy in older adults. Full Achilles tendon length and CSA varied across the age span (<i>p</i> &lt; 0.05), suggesting the Achilles tendon undergoes natural aging processes seen with most musculoskeletal tissue. Normative data on Achilles tendon structure with age will contribute to our understanding and interpretation of Achilles tendon injury pathogenesis; aiding in the design of injury prevention and treatment strategies.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1250-1258"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology of the Effects of Oxidative Stress on the Skeletal System","authors":"Issei Shinohara,&nbsp;Mayu Morita,&nbsp;Simon Kwoon-Ho Chow,&nbsp;Masatoshi Murayama,&nbsp;Yosuke Sususki,&nbsp;Qi Gao,&nbsp;Stuart B. Goodman","doi":"10.1002/jor.26075","DOIUrl":"10.1002/jor.26075","url":null,"abstract":"<div>\u0000 \u0000 <p>Reactive oxygen species (ROS) are molecules that are generated primarily during energy production in cells. ROS are involved in critical biological functions such as signal transduction; when the production of ROS is imbalanced, excessive ROS causes oxidative stress, and subsequent cellular damage. Oxidative stress is linked to numerous pathological disorders in major organs including the skeletal system. In an aging society, understanding the role of ROS in skeletal health is critical to developing preventative and therapeutic interventions. Oxidative stress causes defects in cellular differentiation, apoptosis, mitochondrial dysfunction, and inflammation. The effects of oxidative stress on the skeletal system have been implicated in the development of osteoporosis, knee osteoarthritis, and osteonecrosis by inhibiting bone remodeling, increasing osteoclast activity, and decreasing osteoblast function. ROS are also involved in many signaling pathways that regulate immune defense, cell proliferation, and inflammation. This underscores the importance of maintaining a balance between ROS and antioxidants to prevent oxidative stress and related diseases. Targeting ROS and oxidative stress mechanisms may offer new treatments for diseases affecting the skeletal system and other organs, potentially improving health outcomes, and extending healthy lifespans. This review highlights the significant impact of oxidative stress on skeletal health and explores potential preventative and therapeutic strategies to mitigate the adverse effects of ROS.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1059-1072"},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Pursuit of Quantifying Patient Knee Contact Mechanics: Finite Element Model Validation of Cadaveric Knees in Axially Loaded MRI Scans","authors":"Brett D. Steineman,&nbsp;Kalle L. Chastain,&nbsp;Sean C. Letendre,&nbsp;Joshua Leadem,&nbsp;Kathryn Colone,&nbsp;Manuela Montes de Oca,&nbsp;Lila Pender,&nbsp;Madison Lang,&nbsp;Erin R. Leatherman,&nbsp;Erin Argentieri,&nbsp;Amanda Wach,&nbsp;Matthew F. Koff,&nbsp;Scott A. Rodeo,&nbsp;Amy L. Lerner,&nbsp;Suzanne A. Maher","doi":"10.1002/jor.26077","DOIUrl":"10.1002/jor.26077","url":null,"abstract":"<div>\u0000 \u0000 <p>Our long-term objective is to quantify patient-specific changes in contact mechanics after partial meniscectomy (PM) using knee-specific finite element (FE) models created from clinical MR scans under axial load. Before creating patient-specific models, a validation of our workflow and processes is required. The objective of this study was to validate knee-specific FE models of tibiofemoral joint contact mechanics by comparison to direct measurements of contact by electronic pressure sensors. We hypothesized that knee-specific FE model data would fall within direct measurements of the contact area and pressure values from sensors, but that detected differences in outcomes would be smaller than differences reported after PM. The workflow consisted of performing MRIs on five cadaveric knees using a patient-based loading system adapted to cadaveric knees where loaded and unloaded scans were acquired with and without a sensor in place, segmenting images to develop FE models, running those models with statistical approaches to model material property variation and comparing the model outputs to the outputs quantified physically by sensors. Overall, 53% of outcomes (32/60) from the FE models fell within the ranges of those directly measured. Of the values that fell outside, differences were lower than those identified from a literature review of the mechanical effects of partial meniscectomies, especially when meniscectomies were 30% or 60% of the meniscus volume. FE models developed using this workflow may be helpful in assessing or anticipating changes in joint force redistribution following partial meniscectomies in patients.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1132-1143"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}