Journal of Orthopaedic Research®最新文献

{"title":"Dysplastic Hips in Young Adults Demonstrate Different Relationships Between Acetabular Coverage, Joint Congruity, and Contact Mechanics Than Asymptomatic Hips","authors":"Holly D. Aitken,&nbsp;Jessica E. Goetz,&nbsp;Wyatt M. Sailer,&nbsp;Dominic J. L. Rivas,&nbsp;Krit Petrachaianan,&nbsp;Natalie A. Glass,&nbsp;Michael C. Willey,&nbsp;Joshua B. Holt","doi":"10.1002/jor.70048","DOIUrl":"10.1002/jor.70048","url":null,"abstract":"<p>This study investigated the relationship between three-dimensional (3D) acetabular coverage and contact mechanics in dysplastic and ostensibly normal hips. Fifty asymptomatic hips previously imaged with CT scans/angiograms were matched on a 2:1 basis to 25 dysplastic hips with previous CT imaging, based on age, gender, weight, and BMI. CT imaging was used to create 3D patient-specific hip models from which the 3D coverage metrics of subchondral arc angle (i.e., acetabular weight-bearing morphology) and hip joint coverage angle (i.e., femoral head coverage), and the congruity metrics of acetabular sphericity index <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <mi>SI</mi>\u0000 </mrow>\u0000 </mrow>\u0000 </semantics></math> (i.e., sphericity of the acetabulum) and joint congruity index <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <mi>CI</mi>\u0000 </mrow>\u0000 </mrow>\u0000 </semantics></math> were assessed globally and in five octants spanning the weight-bearing acetabulum. Discrete element analysis was used to calculate hip contact mechanics, with results assessed globally and subdivided into the same five octants. Increasing superior-anterior subchondral arc angle was associated with <i>increasing</i> superior-anterior mean chronic contact stress-time exposure in dysplastic hips, which was significantly (<i>p</i> &lt; 0.001) different from asymptomatic hips where increasing superior-anterior subchondral arc angle was associated with <i>decreasing</i> superior-anterior mean chronic contact stress-time exposure. Similarly, increasing joint congruity <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <mi>CI</mi>\u0000 </mrow>\u0000 </mrow>\u0000 </semantics></math> anteriorly was associated with <i>increasing</i> anterior mean chronic contact stress-time exposure in dysplastic hips, which was significantly (<i>p</i> = 0.003) different from the trend of <i>decreasing</i> anterior mean exposure with increasing anterior <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <mi>CI</mi>\u0000 </mrow>\u0000 </mrow>\u0000 </semantics></math> in asymptomatic hips. These results indicate fundamental differences in how contact mechanics in asymptomatic and dysplastic hips respond to differences in acetabular coverage and joint congruity, suggesting that asymptomatic hips follow the expected geometry-based trend, while dysplastic hips do not.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 11","pages":"2009-2022"},"PeriodicalIF":2.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Validation and Excellent Interobserver Agreement of Volumetric Matching Micromotion Analysis (V3MA) in Total Knee Arthroplasty.","authors":"Nienke N de Laat, Lennard A Koster, Jessie E Robertson, Rob G H H Nelissen, Bart L Kaptein","doi":"10.1002/jor.70049","DOIUrl":"https://doi.org/10.1002/jor.70049","url":null,"abstract":"<p><p>CT-based radiostereometric analysis (CT-RSA) is an alternative to RSA to measure implant migration. We performed a clinical validation study using VoluMetric Matching Micromotion Analysis (V3MA) software for CT-RSA. The aims of this study were to assess the agreement between V3MA and Model-based RSA software (for RSA), and to determine the interobserver agreement in V3MA. On a subset of patients included in a clinical trial, knee prosthesis tibial implant migration was measured between 1 and 5 years postoperative with V3MA and Model-based RSA software. V3MA and Model-based RSA results were compared by assessing the mean differences and limits of agreement (mean ± 1.96* standard deviation) using Bland-Altman analysis. V3MA migration results of two observers were compared using intraclass correlation (ICC) and Bland-Altman analysis. Twenty-four patients were included in the analysis. The mean difference (limits of agreement [LOA]) was -0.14 mm [-0.88 to 0.60] for maximum total point motion (MTPM). LOA for translations and rotations did not exceed ±0.5 mm and ±1°, respectively. The ICC (95% confidence interval) for MTPM between observers was 0.995 (0.989-0.998), and the mean difference [LOA] was 0.04 mm [-0.17 to 0.24]. We showed that between 1 and 5 years postoperative, V3MA migration results were comparable to those of Model-based RSA for cemented tibial component migration in a clinical study. The interobserver variability showed excellent agreement for V3MA. Overall, V3MA is a valid alternative to Model-based RSA for the analysis of tibial component migration in TKA with medium-term follow-up.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Evaluation of Hemiarthroplasty Bearing Materials Using Animal Models: A Scoping Review (Part II).","authors":"Landon M Begin, Victoria P Marino, Francesca De Vecchi, Douglas C Moore, Markus A Wimmer, Joseph J Crisco","doi":"10.1002/jor.70050","DOIUrl":"https://doi.org/10.1002/jor.70050","url":null,"abstract":"<p><p>Hemiarthroplasty is commonly used to treat damage localized to one side of a synovial joint, maximally preserving the patient's opposing healthy bone and cartilage; however, challenges remain due to accelerated wear of the cartilage articulating with the implant surface. This scoping review summarized investigations of hemiarthroplasty bearing materials (HBMs) utilizing animal models. The review focused on HBMs tested, animal models used, duration of animal survival, and outcome assessments (e.g., gait analysis, image analysis, histological staining, and cartilage scoring). The initial search was designed to broadly capture all studies evaluating HBMs articulating against articular cartilage. A total of 1798 studies were identified, which after screening yielded 72 that met the inclusion criteria. Of these, 24 were classified as in vivo and were included in this review. The HBMs evaluated included metals (63%), hard and soft polymers (33%), ceramics (17%), and synthetic carbons (17%). HBMs were predominantly studied in canines (46%), rabbits (25%), and sheep (21%), with survival durations from 2 to 104 weeks. Outcome assessment of cartilage wear varied across studies and histological staining was performed in all studies with the most common stains being Safranin-O (58%) and Hematoxylin and Eosin (54%). Commonly used cartilage scoring systems were Mankin and Modified Mankin (38%); however, among all studies, scales and sub-categories for scoring criteria varied drastically. While similarities were identified with respect to HBMs, animal models, and some outcome measures, the diversity of testing methodologies and lack of comparative evaluations limited the ability to identify the best practice for evaluating HBM performance.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial Osteochondral Defect Drives Matrix and Cell Pathology in Compartment-Matched Meniscus","authors":"Serafina G. Lopez,&nbsp;John Dankert,&nbsp;James J. Butler,&nbsp;John G. Kennedy,&nbsp;Lawrence J. Bonassar,&nbsp;Rebecca M. Irwin","doi":"10.1002/jor.70051","DOIUrl":"10.1002/jor.70051","url":null,"abstract":"<div>\u0000 \u0000 <p>Patients with cartilage defects often experience increased meniscal degeneration. It remains unclear whether meniscal damage occurs concurrently with cartilage injury or due to later joint pathology. Limited data exists on how isolated cartilage injuries affect meniscal structure and degeneration. In osteoarthritis models, alterations to the structure and composition of meniscal ECM components have been observed, including meniscus hypertrophy characterized by excessive glycosaminoglycan deposition and fibrochondrocyte rounding. Although proteoglycan deposition increases in early OA, the timing of GAG changes relative to collagen disruption remains unclear. This study examined the correlation between changes in local proteoglycan deposition, cell morphology, and the collagen network in the meniscus following cartilage damage using an in vivo rabbit model. A medial osteochondral defect was created on the femoral condyle of New Zealand white male rabbits, and menisci were harvested 12 weeks later. Our results indicate that a medial osteochondral defect drives pathology in the underlying meniscus, likely due to altered loading conditions. The medial menisci of defect joints exhibited increased proteoglycan deposition and hypertrophy, with increased cell roundness and area in regions of elevated GAGs. Local collagen architecture showed increased fiber diameter in the medial menisci of defect joints, which positively correlated with increased GAG coverage. Abnormal collagen structures were observed, including wider variations in fiber diameters and areas of small fibers with low second harmonic generation signals, indicating poorly organized collagen. A deeper understanding of GAG regulation and fibrochondrocyte pathology in injured meniscus tissue could aid in the development of therapeutics and inform disease progression.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 11","pages":"2031-2042"},"PeriodicalIF":2.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Medial Tibial Overresection on Bone Mineral Density in Unicompartmental Knee Arthroplasty","authors":"Sayako Sakai,&nbsp;Shinichi Kuriyama,&nbsp;Yugo Morita,&nbsp;Kohei Nishitani,&nbsp;Shinichiro Nakamura,&nbsp;Shuichi Matsuda","doi":"10.1002/jor.70045","DOIUrl":"10.1002/jor.70045","url":null,"abstract":"<div>\u0000 \u0000 <p>Early failure of tibial implants following unicompartmental knee arthroplasty might result from a decrease in bone mineral density in the medial tibial plateau. This study quantitatively assessed this bone mineral density decrease caused by tibial overresection during medial unicompartmental knee arthroplasty, using Hounsfield units, and investigated factors influencing significant reductions in Hounsfield units in 40 knees (34 patients) before surgery. A three-dimensional tibial model was reconstructed from computed tomography scans, and mean Hounsfield units of the central, anterior, anteromedial, medial, posteromedial, and posterior regions of the medial tibial plateau were extracted in 2-mm-thick layers at depth of 4, 6, and 8 mm beneath the articular surface. Differences in Hounsfield units among the layers and the correlation between Hounsfield units at the central region and hip-knee-ankle angle (+valgus) were analyzed. The lowest Hounsfield units were observed in the posterior region for all layers, with a distal decrease in all regions. The most significant decrease was from the 4-mm layer (353.6 ± 118.1) to 6-mm layer (223.1 ± 94.4) in the central region (<i>p</i> &lt; 0.001). The Hounsfield units at the central region were negatively correlated with the hip-knee-ankle angle in the 6-mm (<i>r</i> = −0.34; <i>p</i> = 0.029) and 8-mm (<i>r</i> = −0.33; <i>p</i> = 0.038) layers. Even a 2-mm tibial overresection during medial unicompartmental knee arthroplasty caused a significant decrease in Hounsfield units. Altogether, the posterior tibial cortex should be covered with the tibial component and tibial overresection should be avoided, particularly in cases with mild varus knees.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 11","pages":"1954-1963"},"PeriodicalIF":2.3,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Computer Vision and Machine Learning Approach to Classify Views in Distal Radius Radiographs","authors":"Rohan Vemu,&nbsp;Dion Birhiray,&nbsp;Bassem Darwish,&nbsp;Raven Hollis,&nbsp;Sai Unnam,&nbsp;Srikhar Chilukuri,&nbsp;Lorenzo Deveza","doi":"10.1002/jor.70046","DOIUrl":"10.1002/jor.70046","url":null,"abstract":"<p>Advances in computer vision and machine learning have augmented the ability to analyze orthopedic radiographs. A critical but underexplored component of this process is the accurate classification of radiographic views and localization of relevant anatomical regions, both of which can impact the performance of downstream diagnostic models. This study presents a deep learning object detection model and mobile application designed to classify distal radius radiographs into standard views—anterior-posterior (AP), lateral (LAT), and oblique (OB)— while localizing the anatomical region most relevant to distal radius fractures. A total of 1593 deidentified radiographs were collected from a single institution between 2021 and 2023 (544 AP, 538 LAT, and 521 OB). Each image was annotated using Labellerr software to draw bounding boxes encompassing the region spanning from the second digit MCP joint to the distal third of the radius, with annotations verified by an experienced orthopedic surgeon. A YOLOv5 object detection model was fine-tuned and trained using a 70/15/15 train/validation/test split. The model achieved an overall accuracy of 97.3%, with class-specific accuracies of 99% for AP, 100% for LAT, and 93% for OB. Overall precision and recall were 96.8% and 97.5%, respectively. Model performance exceeded the expected accuracy from random guessing (<i>p</i> &lt; 0.001, binomial test). A Streamlit-based mobile application was developed to support clinical deployment. This automated view classification step reduces feature space by isolating only the relevant anatomy. Focusing subsequent models on the targeted region can minimize distraction from irrelevant areas and improve the accuracy of downstream fracture classification models.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 11","pages":"2023-2030"},"PeriodicalIF":2.3,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate","authors":"Alexandra R. Armstrong,&nbsp;Erick O. Buko,&nbsp;Casey P. Johnson,&nbsp;Ferenc Tóth","doi":"10.1002/jor.70044","DOIUrl":"10.1002/jor.70044","url":null,"abstract":"<p>Osteochondrosis/osteochondritis dissecans (OC/OCD) is a developmental orthopedic disease primarily affecting the knee, ankle, and elbow joints of children and multiple animal species. Subclinical lesions of OC/OCD have been described, but most can be visualized only histologically in cadaveric specimens. To monitor the evolution of these lesions and to allow early separation of lesions that will undergo spontaneous healing versus requiring surgical intervention, Magnetic resonance imaging (MRI) techniques that are precise and can be used in vivo are needed. The purpose of this study was to demonstrate the utility of noninvasive 3 T MRI in the identification of naturally occurring OC lesions in the articular epiphyseal cartilage complex (AECC) and growth plate of the distal humerus in domestic piglets. <i>N</i> = 4 asymptomatic piglets underwent four consecutive, in vivo, bilateral elbow joint MRI exams under anesthesia at 4, 6, 8, and 11 weeks of age. 3D Double echo steady state (DESS) morphological images and cartilage T2 relaxation time maps were acquired using a clinical 3 T MRI scanner. After the last MRI, piglets were euthanized, and distal humeri were harvested for histologic evaluation. Multiple preclinical OC lesions were detected in the AECC and the growth plate of the examined humeri and their temporal progression or resolution was successfully monitored using MRI. Although most lesions resolved by 11 weeks of age, those remaining on MRI were confirmed histologically at necropsy.</p><p><b>Clinical Significance:</b> In vivo 3 T MRI may allow for longitudinal monitoring of early OC lesions and determination of whether a lesion is resolving or progressing to clinical OCD that may necessitate surgical intervention.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 11","pages":"1934-1941"},"PeriodicalIF":2.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Potential of Antimicrobial Blue Light (aBL) to Manage Biofilm Burden at the Skin-Implant Interface of Percutaneous Osseointegrated Implants","authors":"Jemi Ong Watts,&nbsp;Richard Tyler Epperson,&nbsp;Brooke Kawaguchi,&nbsp;Aaron Olsen,&nbsp;Josh Tam,&nbsp;Paul Pasquina,&nbsp;Brad Isaacson,&nbsp;Jeremy Gililland,&nbsp;Dustin Williams","doi":"10.1002/jor.70039","DOIUrl":"10.1002/jor.70039","url":null,"abstract":"<div>\u0000 \u0000 <p>Percutaneous osseointegrated implants offer significant benefits to amputees, including improved mechanical feedback and reduced skin irritation. However, their percutaneous nature increases susceptibility to biofilm-associated infections. This study evaluated the potential efficacy of antimicrobial blue light (aBL) as a preventive strategy to manage biofilm burden in a 12-week ovine model wherein two treatment cycles were implemented. In this study, aBL was applied proactively to reduce surface colonization and prevent infection progression, rather than to treat confirmed or deep infections. Sheep were inoculated with <i>Staphylococcus aureus</i> biofilm and treated with aBL or systemic antibiotics, with or without a washing protocol. aBL with washing achieved the greatest bacterial reduction, lowering CFU levels to 3.0 ± 0.3 log₁₀ during the second treatment period, significantly outperforming washing alone, which resulted in 5.6 ± 0.4 log₁₀ (<i>p</i> &lt; 0.05). The study also showed a lower observed infection rate (14% vs. 43%), when comparing aBL with washing to washing only based on histologic, microCT, and gross assessments, though no statistical comparison was performed. Despite these benefits, the aBL treatments induced notable tissue changes, including increased epithelial thickening, rete ridge elongation, and accelerated skin/tissue downgrowth. Systemic antibiotics were effective during the initial treatment period but failed to reduce biofilm burden during the second treatment cycle. Altogether, while aBL combined with washing shows promise as a localized preventive therapy for reducing biofilm burden and implant-related infection, the observed tissue remodeling and accelerated downgrowth highlight the need for further investigation to ensure long-term safety.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 11","pages":"2043-2054"},"PeriodicalIF":2.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-Induced Changes in Knee Cartilage In Vivo: Comparing MRI Sequences","authors":"Natasha K. Ivanochko,&nbsp;Anthony A. Gatti,&nbsp;Emily G. Wiebenga,&nbsp;Michael D. Noseworthy,&nbsp;Feliks Kogan,&nbsp;Monica R. Maly","doi":"10.1002/jor.70043","DOIUrl":"10.1002/jor.70043","url":null,"abstract":"<p>The purpose was to assess the agreement in measures of acute knee cartilage thickness and composition change after loading in clinical knee osteoarthritis (OA) between two magnetic resonance imaging (MRI) acquisition approaches: (1) single sequence approach using quantitative double-echo in steady-state (qDESS), which allows simultaneous morphological and compositional scanning, versus (2) multi-sequence approach that captures morphology (fast spoiled gradient recalled (FSPGR) or qDESS) and composition (multi-echo spin echo (MESE)) separately. Twenty adults with clinical knee OA participated. 3T MR scans were acquired before and immediately after a 25-min treadmill walk at a standardized speed. Changes in knee cartilage thickness and T2 were assessed. Pre-activity, strong agreement was observed in cartilage thickness captured with qDESS and FSPGR (concordant correlation coefficients 0.842–0.935). Pre-activity, we observed greater absolute cartilage thickness with qDESS compared to FSPGR in femoral cartilage. From pre- to post-activity, qDESS showed change in cartilage thickness in the medial femur (−0.088 ± 0.11 mm, <i>p</i> = 0.002), lateral tibia (−0.042 ± 0.65 mm, <i>p</i> = 0.011) and trochlea (−0.027 ± 0.05 mm, <i>p</i> = 0.024); whereas FSPGR showed a change only in the lateral tibia (−0.064 ± 0.08 mm, <i>p</i> = 0.002). From pre- to post-activity, qDESS showed reduced T2 in all cartilage regions; whereas qDESS + MESE and FSPGR + MESE detected T2 changes in the patella (−1.90 ± 3.00 ms, <i>p</i> = 0.013, and −1.80 ± 2.18 ms, <i>p</i> = 0.002, respectively). qDESS detects transient changes in knee cartilage due to loading in clinical knee OA.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 11","pages":"1942-1953"},"PeriodicalIF":2.3,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Establishment and Characterization of a Recurrent Osteosarcoma Cell Line: OSA 1777","authors":"","doi":"10.1002/jor.70025","DOIUrl":"10.1002/jor.70025","url":null,"abstract":"<p><b>RETRACTION</b>: P. Thanindratarn, X. Li, D. C. Dean, S. D. Nelson, F. J. Hornicek, and Z. Duan “Establishment and Characterization of a Recurrent Osteosarcoma Cell Line: OSA 1777,” <i>Journal of Orthopaedic Research</i> 38, no. 4 (2020): 902–901, https://doi.org/10.1002/jor.24528.</p><p>The above article, published online on 18 November 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Edward Schwarz; The Orthopaedic Research Society; and John Wiley &amp; Sons, Inc. US.</p><p>The authors requested their article be retracted after they learned that the cell line, OSA 1777, had become contaminated with synovial sarcoma cell line SYO-1. It is unknown at what stage the cell line was contaminated, but as a result, the reported results and conclusions are no longer reliable. Therefore, the article must be retracted.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 10","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}