Journal of Orthopaedic Research®最新文献

{"title":"Knee Flexion Excursion Mediates the Association Between Quadriceps Stiffness and Knee Loads During the Mid-Stance Phase of Gait","authors":"Zongpan Li,&nbsp;Aaron Kam-Lun Leung,&nbsp;Xiuping Huang,&nbsp;Chen Huang,&nbsp;Shan Su,&nbsp;Raymond C. K. Chung,&nbsp;Changhai Ding,&nbsp;Siu Ngor Fu","doi":"10.1002/jor.26090","DOIUrl":"10.1002/jor.26090","url":null,"abstract":"<p>Lower strength and higher passive stiffness of the quadriceps have been associated with a higher risk of knee osteoarthritis/pain in aging populations. It is proposed that altered quadriceps properties would cause excessive knee loads, thus contributing to knee mechanical damages, but the relevant evidence is limited. This study aimed to explore relationships amongst quadriceps properties, knee flexions, and knee moments during gait. This study included 87 community-dwelling elders (65.9 ± 4.1 years; 57.5% females). Quadriceps strength was assessed using a Cybex dynamometer, and the passive stiffness of three superficial quadriceps heads was evaluated using shear-wave ultrasound elastography. Gait analysis was conducted to compute the knee adduction moment (KAM), knee flexion moment (KFM), KAM index, and knee flexion excursion (KFE) during the mid-stance phase. Associations amongst quadriceps properties, KFE, and knee moments were examined by partial correlations. Mediation analysis was used to explore the mediating role of KFE in associations between quadriceps properties and knee moments. Greater quadriceps strength was associated with a higher KAM (<i>r</i> = 0.304; <i>p</i> = 0.006). Greater stiffness of the rectus femoris (RF) was indirectly associated with a higher KAM index (mediation-effect [95% CI]: 0.084 [0.011, 0.191], <i>p</i> = 0.017) but a lower KFM (mediation-effect [95% CI]: −0.139 [−0.270, −0.041], <i>p</i> = 0.004), via a smaller KFE. Stronger quadriceps are correlated with a higher frontal knee moment. Stiffer RF is indirectly associated with a higher frontal knee load sharing through reduced sagittal knee motions, which could be a potential mechanism of stiffer RF for knee osteoarthritis.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1275-1283"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Biomechanical Recovery Following Total Hip Arthroplasty Is Associated With Preoperative Hip Muscle Fat-Fraction","authors":"Ryan T. Halvorson,&nbsp;Erin Archibeck,&nbsp;Karim Khattab,&nbsp;Herve Ngwe,&nbsp;Jessica Ornowski,&nbsp;Zehra Akkaya,&nbsp;Richard B. Souza,&nbsp;Grace D. O'Connell,&nbsp;Jeffrey Lotz,&nbsp;Claudio Diaz,&nbsp;Thomas P. Vail,&nbsp;Jeannie F. Bailey","doi":"10.1002/jor.26072","DOIUrl":"https://doi.org/10.1002/jor.26072","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Understanding risk factors for delayed functional recovery following total hip arthroplasty (THA) is a critical gap in postoperative rehabilitation. The purpose of this study was to assess for imaging factors associated with change in biomechanical function following THA. We hypothesized that muscle quality (as quantified by fat-fraction) and arthritis (OA) severity, as determined from advanced magnetic resonance imaging (MRI) sequences, would be associated with biomechanical recovery. Ten patients undergoing primary THA for OA were prospectively recruited and underwent preoperative MRI with advanced sequences to assess hip muscle fat-fraction and OA severity. Biomechanical function was assessed using 3D motion analysis of sit-to-stand movement tasks. Relationships between muscle fat-fraction, OA severity, and biomechanical function were assessed using a Spearman's rank correlation coefficient (<i>ρ</i>). Preoperative biomechanical function was most strongly associated with OA severity (<i>ρ</i> = −0.68, <i>p</i> = 0.03), with more severe OA predicting worse biomechanical function. Muscle fat-fraction was not related to preoperative function. Postoperative biomechanical function was most strongly associated with preoperative muscle fat fraction (gluteus medius: <i>ρ</i> = −0.58, <i>p</i> = 0.08; gluteus minimus: <i>ρ</i> = −0.72, <i>p</i> = 0.02; tensor fascia lata: <i>ρ</i> = −0.59, <i>p</i> = 0.07), with worse muscle fat-fraction predicting poor function. OA severity was not associated with postoperative function (<i>ρ</i> = 0.22, <i>p</i> = 0.54). Importantly, muscle fat-fraction was not related to OA severity. Radiographic OA severity was the best predictor of preoperative biomechanical function, but postoperative function was best predicted by preoperative muscle fat-fraction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>While the impact of OA on biomechanical function may be corrected with arthroplasty, muscle quality is not addressed with THA and may represent a target for patient-specific optimization and rehabilitation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 6","pages":"1113-1121"},"PeriodicalIF":2.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury","authors":"Sydney J. Womack,&nbsp;Camila B. Carballo,&nbsp;Erica J. Secor,&nbsp;Scott A. Rodeo,&nbsp;Heidi L. Reesink","doi":"10.1002/jor.26078","DOIUrl":"10.1002/jor.26078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Posttraumatic osteoarthritis (PTOA) is a common sequela to anterior cruciate ligament (ACL) injury in humans and dogs. Identification of conserved targets between species may hasten biomarker identification and therapeutic development. To identify differentially regulated synovial fluid (SF) proteins in ACL injury, SF samples were collected from knees with ACL injury or control knees (<i>n</i> = 8 per species) in human and dog patients. The SF proteome was evaluated using nano-scale reverse-phase chromatography and tandem mass spectrometry. Associations between proteins and ACL injury were analyzed in both species. Immunoassays were used to validate key proteins identified via mass spectrometry, including periostin, α-2-macroglublin, and lubricin, in additional SF samples (dog: <i>n</i> = 57 ACL, <i>n</i> = 31 controls; human: <i>n</i> = 20 ACL, <i>n</i> = 15 advanced OA) and plasma samples (human: <i>n</i> = 18 ACL, <i>n</i> = 15 advanced OA, and <i>n</i> = 12 controls). Periostin was the most upregulated SF protein (log₂ fold change) in both dogs (2.6) and humans (3.5) with ACL injury, followed by complement C1q (2.3) and α-2-macroglobulin (1.8) in dogs and fibrinogen (1.1) and α-2-macroglobulin (1.1) in humans. Most downregulated proteins included serum amyloid A1 (−1.9) and aggrecan (−1.8) in dogs and carbonic anhydrase 2 (−3.2) and hemoglobin subunit β (−2.8) in humans. Approximately 60% of proteins detected were shared between species, and immunoregulatory and macromolecular transport proteins were the most common families. Findings in both species support further investigation into periostin as a potential biomarker or therapeutic target for joint injury and the use of spontaneous ACL injury in dogs as a translational large animal model for human ACL injury.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1239-1249"},"PeriodicalIF":2.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Intra-Articular Diclofenac Etalhyaluronate on Pain and Osteoarthritic Changes in Advanced and End-Stage Hip Osteoarthritis","authors":"Hiroakira Terakawa,&nbsp;Yuya Kawarai,&nbsp;Ikuko Tajiri,&nbsp;Kazuhide Inage,&nbsp;Miyako Suzuki-Narita,&nbsp;Jun Takeuchi,&nbsp;Rui Hirasawa,&nbsp;Shigeo Hagiwara,&nbsp;Junichi Nakamura,&nbsp;Seiji Ohtori","doi":"10.1002/jor.26088","DOIUrl":"10.1002/jor.26088","url":null,"abstract":"<div>\u0000 \u0000 <p>Diclofenac etalhyaluronate combines the sustained-release properties of diclofenac with the therapeutic benefits of hyaluronic acid, providing extended analgesic effects for osteoarthritis management. This study investigated the effects of diclofenac etalhyaluronate and subsequent osteoarthritic changes in rat models of advanced and end-stage osteoarthritis. Monosodium iodoacetate (0.5 or 2.0 mg) was injected directly into the right hip joint of rats (<i>n</i> = 8 rats/group) using a posterior approach to induce osteoarthritis. Four weeks after monosodium iodoacetate administration, diclofenac etalhyaluronate (0.25 mg/25 µL) or 25 µL saline was administered in the same way. Pain behavior, number of microglia in the dorsal horn of the spinal cord, radiological features on microcomputed tomography, and histology of the hip joint were evaluated. Administration of diclofenac etalhyaluronate increased the pain threshold and reduced the number of microglia in the dorsal horn of the spinal cord in both models. However, radiological and histological examinations did not detect significant arthritic changes in either group that received diclofenac etalhyaluronate. Intra-articular administration, therefore, contributes to pain relief and improvement of central sensitization in advanced and end-stage osteoarthritis of the hip without subsequent progression of osteoarthritis. These findings highlight the potential of intra-articular administration of diclofenac etalhyaluronate as a conservative treatment option for advanced and end-stage hip osteoarthritis, particularly for patients who may be unsuitable for surgery or have limited response to oral nonsteroidal anti-inflammatory drugs.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1325-1335"},"PeriodicalIF":2.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Single Joint Arthritis Changes Joint Power in Unaffected Joints","authors":"James Campbell,&nbsp;Daniel Schmitt,&nbsp;Laura P. Sands,&nbsp;Robin M. Queen","doi":"10.1002/jor.26087","DOIUrl":"10.1002/jor.26087","url":null,"abstract":"<p>Pain and disability associated with arthritis of the hip, knee, or ankle is well-documented. However, data on joint power and how arthritis in one joint affects power in that joint and in unaffected joints are limited. This study asks if arthritis in any one joint leads to (1) loss of power in that affected joint compared to the contralateral, unaffected joint; (2) loss of total power in the affected limb as compared to the contralateral, unaffected limb; and (3) increased power production in the joints of the ipsilateral limb. Ground reaction forces and joint angles during self-selected speed walking were collected from participants with symptomatic, unilateral ankle (<i>N</i> = 183), hip (<i>N</i> = 63), and knee arthritis (<i>N</i> = 20). Bilateral joint power from the hip, knee, and ankle joints as well as total limb power was calculated for the last third of the stance phase. Arthritis in the hip (<i>p</i> &lt; 0.001), knee (<i>p</i> = 0.008), or ankle (<i>p</i> &lt; 0.001) lead to a loss of power at the affected joint and in the affected limb, though the knee on the affected side does offset some of that loss in participants with hip and ankle arthritis (<i>p</i> &lt; 0.001). The contralateral, unaffected limb (<i>p</i> &lt; 0.001), especially the ankle, produces greater power. Clinical Significance: Isolated lower limb joint arthritis leads to a loss of power on the affected side and compensation by contralateral, unaffected joints. Those joints may be subsequently impacted through repetitive loading and could lead to further degeneration without intervention.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1269-1274"},"PeriodicalIF":2.1,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Cup Orientation on the Primary Fixation of a Hemispherical Cementless Acetabular Cup: A Cohort Based Finite Element Study","authors":"Mark Taylor,&nbsp;Stuart Callary,&nbsp;Dominic Thewlis,&nbsp;Rebecca Bryan","doi":"10.1002/jor.26084","DOIUrl":"10.1002/jor.26084","url":null,"abstract":"<p>Cup orientation has been investigated in detail with respect to risk of dislocation, however, the impact on the primary fixation of cementless cups is poorly understood. The aim of this study was to assess the influence acetabular component orientation on the primary fixation of cementless acetabular cups using an in silico clinical trial framework. Finite element models of 57 implanted hemi-pelves were generated from CT scans of a cohort of end stage osteoarthritis patients. Each hemi-pelvis was implanted with the with cup orientations that bounded the Lewinnek safe zone (mechanical alignment +/−10 degrees) and an approximation of the extreme orientations reported in the literature (mechanical alignment +/−20 degrees). Bone strain immediately adjacent to the implant and micromotions (gap and shear micromotions) were used to assess primary fixation. Analysis was performed at the levels of the individual subjects and the entire cohort. There was minimal variation in all metrics within the Lewinnek safe zone. Micromotion, particularly inferior gaping, was more sensitive to cup orientation than peri-prosthetic bone strain, tending to increase with inclination angle. Both the peri-prosthetic bone strains and micromotions were moderately correlated to the average bone modulus. Individuals with low bone modulus were shown to be more sensitive to changes in cup orientation for both peri-prosthetic bone strains and micromotions both within and outside the Lewinnek safe zone. This suggests that assessing bone quality should be routinely incorporated into the planning process, particularly when considering cup orientations outside of the Lewinnek safe zone.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1293-1302"},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OREF Resident Research Symposia: An Important Pipeline for Prospective Orthopaedic Surgeon-Scientists","authors":"Mathangi Sridharan,&nbsp;Nicole J. Newman-Hung,&nbsp;Charlotte Wahle,&nbsp;Frank Petrigliano,&nbsp;Nicholas M. Bernthal,&nbsp;Lauren E. Wessel","doi":"10.1002/jor.26083","DOIUrl":"10.1002/jor.26083","url":null,"abstract":"<div>\u0000 \u0000 <p>Non-governmental educational programs such as the annual Orthopaedic Research and Education Foundation (OREF) Resident Research Symposia aim to elevate and fund trainee research endeavors. This study investigates the translation of research recognized at the Resident Research Symposia into peer-reviewed publication and the rate of awardees who pursue academic careers after training. Awards from the OREF Resident Research Symposia between 2008 and 2023 were aggregated. Characteristics of awardees and projects were noted. Conversion to publication and journal characteristics were identified by indexing major research databases. The current practice type and specialty of each trainee was queried using the American Academy of Orthopedic Surgeons roster and institutional sites. Descriptive statistics, univariate and multivariate regression models were performed. Primary outcomes included rates of OREF symposia presentation conversion to publication and trainees pursuing a career in academia. Three hundred and eighty-nine awards were included with 72 (18.5%) females and 317 (81.5%) males. One hundred and forty-two (36.5%) were first place awards, 101 (25.9%) second place, 131 (33.7%) third place, and 15 (3.9%) presenter's choice, across five regions. Basic science projects were more likely to win first-place awards (<i>p</i> = 0.001). Awarded projects translated to 300 (77%) peer-reviewed publications, with an average impact factor of 1.78 ± 1.65. Male and first-place awardees were more likely to publish (<i>p</i> = 0.014, <i>p</i> = 0.001). The current practice types of 376 distinct awardees were identified with 149 awardees currently practicing in academia (42.3%). Awardees that successfully published their projects (<i>p</i> &lt; 0.001), and those from the Mid-Atlantic region (<i>p</i> = 0.01) were more likely to pursue academic careers. Research awarded at the OREF symposium translates to peer-reviewed publication at a high rate, and awardees enter academia at a disproportionately high rate. OREF provides an effective platform to identify and support budding surgeon-scientists, which is vital given that musculoskeletal research is historically underfunded at a national level.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1355-1361"},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic Tilt Increases the Risk of Impingement and Alters Impingement Type in Total Hip Arthroplasty: A Patient-Specific Simulation Study","authors":"Arnab Palit,&nbsp;Mark A. Williams,&nbsp;Vineet Seemala,&nbsp;Mike Donnelly,&nbsp;Tobias Renkawitz,&nbsp;Markus Weber","doi":"10.1002/jor.26085","DOIUrl":"10.1002/jor.26085","url":null,"abstract":"<p>Impingement is a significant complication following total hip arthroplasty (THA), resulting in restricted range of motion (ROM). Pelvic tilt (PT) and its variation could alter both post-THA ROM and impingement types, which remains relatively unexplored in the literature. Therefore, this study aims to investigate the impact of PT changes on post-THA ROM and impingement types. Subject-specific ROM was simulated using 3D-CT and clinical data for 56 THA patients. Subsequently, the effect of no-PT, standing preoperative (StPT₀) and postoperative PT at 6 (StPT₆) and 12 months (StPT₁₂) on maximum ROM (flexion, extension, abduction, adduction, external rotation (ER) and internal rotation at 90° Flexion (IR@90°Flex)) and impingement types (implant-to-implant impingement (ITII), implant-to-bone impingement (ITBI), and bone-to-bone impingement (BTBI)) were investigated. Stong correlations existed between PT and flexion (<i>R</i>² ≥ 0.686), extension (<i>R</i>² ≥ 0.527), and IR@90°Flex (<i>R</i>² ≥ 0.547). Anterior PT exceeding 8.1° and 11.8° were linked to decreased flexion below 110° and IR@90°Flex below 30°, respectively. Each 10° increase in anterior PT resulted in a 10° reduction in flexion and a 10.7° reduction in IR@90°Flex. Impingement types due to PT remained unchanged for flexion/extension, with increased ITII for abduction (8.9%), adduction (23.2%), and IR@90°Flex (16.1%), and increased BTBI (16.1%) for ER. In total, 12.5% and 19.6% of patients experienced clinically relevant ROM change for flexion and IR@90°Flex, respectively for StPT₀–StPT₆. However, it affected below 5.4% cases when comparing StPT₆ and StPT₁₂. Minor changes in impingement type (&lt; 6% of cases) were observed due to changes in PT before and after THA, as well as temporal changes in PT post-THA. However, PT had a substantial impact on impingement types when comparing ROM without considering PT to ROM with PT included. Specifically, anterior PT was associated with reduced flexion and IR@90°Flex, indicating a higher risk of impingement. PT changes over time may lead to clinically relevant alterations in ROM but not impingement types.</p><p><b>Trial Registration:</b> German Clinical Trials Register; Main ID: DRKS00000739.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1303-1314"},"PeriodicalIF":2.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Assessment in Osteoarthritis: Present Practices and Future Prospects Including the Use of Biomarkers and Wearable Technologies, and AI-Driven Personalized Medicine","authors":"Shujaa T. Khan,&nbsp;Nick Huffman,&nbsp;Xiaojuan Li,&nbsp;Anukriti Sharma,&nbsp;Carl S. Winalski,&nbsp;Eric T. Ricchetti,&nbsp;Kathleen Derwin,&nbsp;Suneel S. Apte,&nbsp;Daniel Rotroff,&nbsp;Carl Y. Saab,&nbsp;Nicolas S. Piuzzi","doi":"10.1002/jor.26082","DOIUrl":"10.1002/jor.26082","url":null,"abstract":"<p>Osteoarthritis (OA) is a highly prevalent chronic joint disorder affecting ~600 million individuals worldwide and is characterized by complex pain mechanisms that significantly impair patient quality of life. Challenges exist in accurately assessing and measuring pain in OA due to variations in pain perception among individuals and the heterogeneous nature of the disease. Conventional pain assessment methods, such as patient-reported outcome measures and clinical evaluations, often fail to fully capture the heterogeneity of pain experiences among individuals with OA. This review will summarize and evaluate current methods of pain assessment in OA and highlight future directions for standardized pain assessment. We discuss the role of animal models in enhancing our understanding of OA pain pathophysiology and highlight the necessity of translational research to advance pain assessment strategies. Key challenges explored include identifying phenotypes of pain susceptibility, integrating biomarkers into clinical practice, and adopting personalized pain management approaches through the incorporation of multi-modal data and multilevel analysis. We underscore the imperative for continued innovation in pain assessment and management to improve outcomes for patients with OA.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 7","pages":"1217-1229"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.26082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - Editorial Board and TOC","authors":"","doi":"10.1002/jor.25886","DOIUrl":"https://doi.org/10.1002/jor.25886","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 5","pages":"889-892"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}