Journal of Orthopaedic Research®最新文献

{"title":"The Influence of the Chondrocyte Microenvironment on Multiscale Articular Cartilage Mechanics: A Computational Study","authors":"Malek Adouni,&nbsp;Afif Gouissem,&nbsp;Tanvir Faisal,&nbsp;Yasin Y. Dhaher","doi":"10.1002/jor.70253","DOIUrl":"10.1002/jor.70253","url":null,"abstract":"<div>\u0000 \u0000 <p>Chondrocytes are mechanosensitive cells whose biosynthetic activity is governed by their local mechanical environment within articular cartilage. This environment is strongly influenced by the pericellular matrix (PCM), a specialized region enriched in collagen VI and a distinct non-fibrillar ground substance. However, the individual mechanical roles of these PCM constituents in regulating chondrocyte mechanotransduction remain poorly understood. In this study, an explicit, concurrent multiscale finite element model of articular cartilage was developed to directly link tissue-level loading to cellular-scale mechanics. The model incorporates anatomically realistic chondrocyte distributions, depth-dependent collagen II fibril architecture, and distinct representations of collagen VI fibrils and the non-fibrillar PCM matrix. Unconfined compression simulations were performed under reference conditions and following targeted alterations (±20%) in collagen VI stiffness, PCM matrix stiffness, or both. Results showed that tissue-level reaction forces were most sensitive to collagen VI stiffness. At the cellular scale, changes in collagen VI and PCM matrix properties significantly modulated chondrocyte circumferential forces and volumetric deformation, particularly in the superficial zone. Stress redistribution analyses revealed a load-sharing mechanism between fibrillar and non-fibrillar PCM components. These findings clarify the distinct mechanical roles of PCM constituents and provide mechanistic insight into how their degradation may disrupt chondrocyte mechanotransduction and contribute to cartilage degeneration.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Angiotensin II Receptor Blocker Suppresses Glucose-Induced Oxidative Stress in Human Rotator Cuff-Derived Cells","authors":"Shunsaku Takigami,&nbsp;Yutaka Mifune,&nbsp;Atsuyuki Inui,&nbsp;Kohei Yamaura,&nbsp;Issei Shinohara,&nbsp;Masaya Kusunose,&nbsp;Shuya Tanaka,&nbsp;Shin Osawa,&nbsp;Tomoyuki Matsumoto,&nbsp;Ryosuke Kuroda","doi":"10.1002/jor.70256","DOIUrl":"10.1002/jor.70256","url":null,"abstract":"<p>Rotator cuff tears are among the most common shoulder disorders, and their incidence increases with age. Hyperglycemic conditions are known to enhance oxidative stress and inflammatory signaling in various tissues, potentially contributing to tendon degeneration. Angiotensin II receptor blockers (ARBs) are widely used antihypertensive agents known to possess antioxidant and anti-inflammatory properties. However, their effects on hyperglycemia-induced oxidative stress in tendon tissues remain unclear. This study investigated whether losartan, an ARB, suppresses high glucose-induced oxidative stress in human rotator cuff-derived cells. Tendon-derived cells obtained during arthroscopic rotator cuff repair were cultured and divided into four groups: control (C), control with losartan (CL; 100 μM), high glucose (H; 33 mM), and high glucose with losartan (HL). Cell viability was evaluated using the Cell Counting Kit-8. Expression of RAGE, NOX1, NOX4, IL-6, IL-1β, COL1, and COL3 was analyzed by quantitative real-time PCR. Reactive oxygen species (ROS) were detected by DCFH-DA staining, and apoptosis was assessed by TUNEL staining. High glucose exposure significantly reduced cell viability and increased ROS production and inflammatory gene expression. Losartan treatment under high-glucose conditions mitigated these changes, maintaining cell viability and suppressing the expression of RAGE, NOX1, IL-6, and IL-1β. These findings suggest that losartan modulates oxidative stress pathways under hyperglycemic conditions and may represent a potential therapeutic strategy.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Attenuation of Cartilage Pathogenesis in Post-Traumatic Osteoarthritis (PTOA) in Mice by Blocking the Stromal Derived Factor 1 Receptor (CXCR4) With the Specific Inhibitor, AMD3100","authors":"","doi":"10.1002/jor.70239","DOIUrl":"10.1002/jor.70239","url":null,"abstract":"<p><b>RETRACTION:</b> N. P. Thomas, P. Li, B. C. Fleming, Q. Chen, X. Wei, P. Xiao-Hua, G. Li, and L. Wei, “Attenuation of Cartilage Pathogenesis in Post-Traumatic Osteoarthritis (PTOA) in Mice by Blocking the Stromal Derived Factor 1 Receptor (CXCR4) With the Specific Inhibitor, AMD3100,” <i>Journal of Orthopaedic Research</i> 33, no. 7 (2015): 1071–1078, https://doi.org/10.1002/jor.22862.</p><p>The above article, published online on 2 March 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Edward M. Schwarz; the Orthopaedic Research Society; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, a duplication has been identified within Figure 3, and image elements in Figures 3 and 4A were found to have been previously published by the author group in different scientific contexts. The clarification provided by the authors was found to be insufficient to address the concerns. Furthermore, additional scientific inconsistencies have been identified. Accordingly, the article has been retracted as the editors consider its results and conclusions to be invalid.</p><p>The authors have been informed of the retraction decision. The corresponding author, Lei Wei, stated that the concerns had been partially addressed. However, due to the unavailability of the co-author responsible for the experiments affected by the unresolved issues, the experiments could not be readily repeated. Co-author Qian Chen agreed with the decision to retract the article, noting that their contribution was limited to providing reagents and therefore did not meet the criteria for authorship. No response was received from the remaining co-authors.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Joint Pain Through Tibiofemoral Flexion: A Novel Approach to Assess Pain Behavior and Analgesic Profiles in Rats","authors":"Kauê Franco Malange,&nbsp;Douglas Menezes de Souza,&nbsp;Júlia Borges Paes Lemes,&nbsp;Ana Carolina dos Santos Machado,&nbsp;Alex Dias de Assis,&nbsp;Luciane Candeloro Portugal,&nbsp;Carlos Amílcar Parada","doi":"10.1002/jor.70250","DOIUrl":"10.1002/jor.70250","url":null,"abstract":"<div>\u0000 \u0000 <p>Assessing knee joint pain in experimental osteoarthritis (OA) models remains a significant challenge. Our study demonstrates that the use of an adapted electronic von Frey (aVF) device, featuring a modified tip, surpasses the standard von Frey (sVF) in detecting knee joint pain behavior and evaluating the efficacy of analgesic treatments in an OA model induced by monoiodine acetate (MIA) in male rats. The sVF induced a behavior profile in naïve animals characterized by a hind paw flinching and withdrawal reflex. This behavioral response was affected by intraplantar lidocaine, which increased mechanical thresholds related to sVF and validated it as pain related behavior. In the aVF method, rats displayed no alterations in their mechanical thresholds in absence or presence of lidocaine, suggesting minimal stimulation of hind paw by the modified methodology. In MIA-OA rats, the aVF was able to detect a significant reduction on joint mechanical thresholds. The behavior linked to aVF was significantly affected by systemic delivery of morphine, confirming a nociceptive-like phenotype and suggesting a pain behavior predominantly triggered by joint flexion. The aVF was also able to detect an analgesic profile in MIA-OA rats treated with dexamethasone, LPS-RS, and fucoidan, indicating effectiveness in measuring differential responses triggered by analgesic drugs. Our results suggest aVF as a more appropriate method to evaluate joint pain in rats.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initiation of Collapse in Osteonecrosis of the Femoral Head: A Patient-Specific Finite Element Simulation Study","authors":"Kosei Sakamoto,&nbsp;Goro Motomura,&nbsp;Ryosuke Yamaguchi,&nbsp;Takeshi Utsunomiya,&nbsp;Yusuke Ayabe,&nbsp;Yasuharu Nakashima","doi":"10.1002/jor.70252","DOIUrl":"10.1002/jor.70252","url":null,"abstract":"<p>Collapse in osteonecrosis of the femoral head (ONFH) is thought to result from stress concentration at the sclerotic boundary zone, but its precise initiation site has not been identified. We aimed to identify the initiation of collapse using patient-specific finite element models (FEMs) that incorporate the sclerotic boundary zone. Ten hips from 10 patients with type C ONFH who had both pre-collapse (stage 2) and post-collapse (stage 3) computed tomography (CT) images were analyzed. Actual collapse sites were identified on post-collapse CT images or, when inconclusive, determined using micro-CT and subsequent histopathological examination of resected specimens. Patient-specific FEMs were constructed from pre-collapse CT scans with incorporation of the sclerotic boundary zone. For comparison, FEMs were also generated for four femoral heads without sclerotic changes on the articular surface. Equivalent stress on the articular surface and simulated initiation sites of collapse were evaluated and compared with actual collapse sites. In all 10 femoral heads, actual collapse occurred at the interface between the lateral sclerotic boundary and the adjacent necrotic lesion. FEMs demonstrated stress concentration at the sclerotic boundary, and simulated initiation sites corresponded to actual collapse sites. In contrast, femoral heads without sclerotic changes showed no stress concentration at the articular surface, and no simulated collapse was observed on the femoral head surface. In conclusion, collapse in ONFH initiates at the interface between the lateral sclerotic boundary and the adjacent necrotic lesion, highlighting the critical biomechanical role of the sclerotic boundary zone.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Pelvic Tilt and Bone Morphology on Extra-Articular Bony Impingement in Total Hip Arthroplasty","authors":"Xuzheng Han,&nbsp;Adam S. Driesman,&nbsp;Casey A. Myers,&nbsp;Chadd W. Clary","doi":"10.1002/jor.70249","DOIUrl":"10.1002/jor.70249","url":null,"abstract":"<div>\u0000 \u0000 <p>Extra-articular bony impingement may contribute to posture-specific groin pain after total hip arthroplasty (THA), but the relative roles of bony morphology and functional pelvic tilt remain unclear. CT reconstructions from 100 cadavers (200 hips) were used to build three-dimensional bone-on-bone collision detection models to quantify impingement-free range of motion (RoM). Femora were rotated in internal/external rotation and abduction/adduction from 30° hyperextension to 120° flexion in 5° flexion increments. Simulations were repeated with pelvic tilt ranging ±30° from neutral as extreme boundaries. The contribution of bony anatomy to early impingement was evaluated using Pearson correlations and two-stage regression, with nested cross-validation used for supplementary internal validation. Mean external rotation to extra-articular bony impingement in extension was 46.6° ± 14.8°, and mean internal rotation to impingement at 90° flexion was 34.4° ± 14.1°. In standing, 30° posterior pelvic tilt reduced external rotation clearance by 13.2° ± 10.2° (<i>p</i> &lt; 0.001); while sitting, 30° anterior pelvic tilt reduced internal rotation clearance by 33.0° ± 12.1° (<i>p</i> &lt; 0.001). Standing impingement was most frequently between the ischial tuberosity and posterior intertrochanteric crest or lesser trochanter, whereas seated impingement predominantly involved the anterior inferior iliac spine (AIIS) and intertrochanteric crest. Multivariable models showed strong in-sample fit and retained good held-out performance on nested cross-validation. High-risk morphologies combined with adverse pelvic tilt produced markedly earlier impingement, with the greatest reduction observed in the seated high-risk subgroup under extreme anterior tilt. These findings quantify posture-dependent extra-articular bony constraints and identify morphology-based phenotypes associated with reduced clearance, providing a biomechanical framework for future patient-specific and implant-based studies after THA.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining Anterior Talofibular Ligament Ultrasonography With Anterior Drawer Displacement Refines Stratification of Chronic Ankle Instability","authors":"Takumi Kobayashi,&nbsp;Yuta Koshino,&nbsp;Atsushi Teramoto","doi":"10.1002/jor.70248","DOIUrl":"10.1002/jor.70248","url":null,"abstract":"<p>Chronic ankle instability (CAI) is commonly defined using symptom-based criteria, but these do not explicitly incorporate structural instability after lateral ankle sprain. Whether ATFL findings and anterior displacement reflect symptoms and function remains unclear. This study examined the relationships among ATFL ultrasonography findings, anterior ankle displacement, perceived ankle instability, and self-reported function. This cross-sectional study included 187 participants classified as healthy, coper, or CAI using International Ankle Consortium criteria and the Cumberland Ankle Instability Tool (CAIT). ATFL ultrasonographic classification and instrumented anterior displacement were assessed by blinded examiners. Self-reported function was assessed using the Foot and Ankle Ability Measure (FAAM) in a subsample. Five groups defined by symptom classification and ATFL ultrasonographic classification were compared. Median anterior ankle displacement was 5.25, 5.63, 7.49, 6.14, and 9.02 mm in the healthy-ATFL normal, coper-ATFL normal, coper-ATFL abnormal, CAI-ATFL normal, and CAI-ATFL abnormal groups, respectively. Displacement was greater in the coper-ATFL abnormal and CAI-ATFL abnormal groups than in the healthy-ATFL normal and coper-ATFL normal groups (all <i>p</i> ≤ 0.004). The CAI-ATFL abnormal group also showed greater displacement than the CAI-ATFL normal group (<i>p</i> = 0.012). CAIT scores did not differ between CAI subgroups. In the FAAM subsample, the CAI-ATFL abnormal group had lower scores than several comparison groups. Section Specialty Area: Section IV: Sports Medicine &amp; Orthopaedics. Investigation performed: Hokkaido Chitose College of Rehabilitation. ATFL ultrasonography stratified anterior ankle displacement within symptom-defined coper and CAI groups, whereas symptom-defined classification and self-reported function did not consistently reflect structural and mechanical findings. Structural assessment may refine phenotypic stratification in CAI research.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Dependent Susceptibility to Mechanical Unloading-Induced Femoral Morphological Changes and Patellar Instability in a Rat Model","authors":"Junya Ozawa,&nbsp;Norikazu Nishida,&nbsp;Yugo Furukawa,&nbsp;Miwa Matsuda,&nbsp;Akinori Kaneguchi","doi":"10.1002/jor.70255","DOIUrl":"10.1002/jor.70255","url":null,"abstract":"<div>\u0000 \u0000 <p>Abnormal bone morphology and joint malalignment are key risk factors for several musculoskeletal disorders, including patellar instability and lateral patellar dislocation (LPD). Insufficient weight loading can affect bone formation in immature joints; however, its impact on mature joints remains unclear. The aim of this study was to compare the effects of hindlimb suspension (HS) on femur morphology and knee alignment associated with patellar instability and LPD in rats with different levels of musculoskeletal maturity. Immature (4-week-old) and mature (12-week-old) female rats underwent 8 weeks of HS. Age-matched untreated rats served as controls. Both knee joints were harvested and analyzed using computed tomography. Anatomical risk factors for patellar dislocation and LPD, including the femoral anteversion angle (FeAV), lateral trochlear inclination (LTI), patellar tilt angle (PTA), bisect offset (BO), and tibial tuberosity–trochlear groove (TT–TG) distance, were measured. After HS, LPD was observed in five of eight knees of immature rats (<i>p</i> &lt; 0.05), whereas no LPD was observed in mature rats. An increased FeAV, PTA, BO, and TT–TG distance, as well as decreased LTI, were observed in the HS knees of immature rats. In contrast, in mature rats, only LTI was significantly lower. Correlation analysis demonstrated strong to moderate relationships between the FeAV and other parameters in immature rats, whereas no significant relationships were detected in mature rats. These findings suggest that insufficient weight loading during skeletal immaturity predisposes individuals to morphological alterations associated with patellar instability, whereas mature joints appear resistant to such changes.</p></div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Based Automatic Screening System for Hip Dysplasia","authors":"Kazuki Miyama,&nbsp;Kenji Kitamura,&nbsp;Masanori Fujii,&nbsp;Goro Motomura,&nbsp;Satoshi Hamai,&nbsp;Shinya Kawahara,&nbsp;Ryosuke Yamaguchi,&nbsp;Takeshi Utsunomiya,&nbsp;Soichiro Yoshino,&nbsp;Makoto Endo,&nbsp;Yasuharu Nakashima","doi":"10.1002/jor.70251","DOIUrl":"10.1002/jor.70251","url":null,"abstract":"<div>\u0000 \u0000 <p>To develop an artificial intelligence-based radiographic screening system for hip dysplasia and to evaluate its diagnostic performance and clinical utility. Seventy-three patients with hip dysplasia who underwent unilateral periacetabular osteotomy and 29 asymptomatic volunteers were included. Radiographs from patients with hip dysplasia were divided into training (<i>n</i> = 40), validation (<i>n</i> = 7), and testing (<i>n</i> = 26) datasets, whereas radiographs from volunteers were used exclusively for testing. The artificial intelligence system detects and segments anatomical landmarks on pelvic radiographs, quantifies parameters reflecting anterior, posterior, and lateral acetabular coverage, and determines whether a patient has hip dysplasia based on these measurements. It comprises two deep learning models: DeepLabCut and U-Net, which can effectively learn anatomical structures from relatively small training data. Ground-truth measurements were obtained from repeated assessments by a hip surgeon and a non-hip surgeon, and hip dysplasia status was independently determined by two hip surgeons in blinded assessments. Agreement with the ground-truth was assessed using intraclass correlation coefficients, and screening performance was compared with that of general orthopaedic residents using the test images. Agreement with the ground-truth was good to excellent [intraclass correlation coefficient: 0.70–0.95]. The system showed the best overall screening performance (sensitivity, 0.96 vs. 0.44–0.97; specificity, 0.92 vs. 0.16–0.92; area under the curve, 0.94 vs. 0.57–0.76; F-measure, 0.96 vs. 0.60–0.81) compared with the residents. Our artificial intelligence-based screening system may serve as a primary care-oriented radiographic screening and referral-support tool for clinicians, including non-specialists, despite being trained on a limited dataset.</p>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Thigh Muscle Cross-Sectional Area Following Anterior Cruciate Ligament Injury Depends on Concomitant Meniscal Injury and Subject Sex","authors":"Kate French,&nbsp;Michael J. Toth,&nbsp;Niccolo Fiorentino,&nbsp;Pamela Vacek,&nbsp;Mike DeSarno,&nbsp;Timothy W. Tourville,&nbsp;Matthew Failla,&nbsp;Andrew Geeslin,&nbsp;Mathew Geeslin,&nbsp;Mack Gardner-Morse,&nbsp;Patrick Parkinson,&nbsp;Bruce Beynnon","doi":"10.1002/jor.70247","DOIUrl":"10.1002/jor.70247","url":null,"abstract":"<p>This study characterized acute changes in thigh muscle cross-sectional area (CSA) in subjects who suffered their first severe knee trauma. Ninety-one males and females who suffered ACL rupture with or without concomitant meniscus injury underwent bilateral mid-thigh axial T1-weighted, fast field echo magnetic resonance imaging early after the index trauma and prior to reconstruction. The extensor and flexor muscle groups were segmented bilaterally, and CSA measured. Within-person injured-to-contralateral normal side differences in CSA (injured minus normal limb) were evaluated. ACL-injured male and female subjects were classified into four meniscal injury groups (lateral, medial, both lateral and medial, or normal meniscus). A separate sample of healthy subjects with no history of knee injury or disease underwent the same protocol to determine the magnitude of side-to-side differences in thigh muscle CSA in uninjured individuals. ACL-injured individuals had a substantially greater between-leg differences in thigh extensor muscle CSA after injury and prior to reconstruction than healthy subjects. The between leg difference in thigh extensor muscle CSA of the injured leg was largest in males with meniscus injury involving both compartments, with males having twice as much atrophy of the extensor muscles in the injured leg compared to females in that group. The sex-specific response of thigh muscle to severe knee trauma involving the ACL and meniscus suggests that males and females may require tailored rehabilitation programs pre- and post-surgery to recover muscle size and improve muscular strength and symmetry.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"44 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.70247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}