Journal of Obstetrics and Gynaecology最新文献

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Foetal sex and nonstress test characteristics. 胎儿性别和非压力测试特征。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-07-16 DOI: 10.1080/01443615.2025.2531371
Jonathan Schaffir, Emily McCauley, Samantha Gawrys, Alyssa Thompson
{"title":"Foetal sex and nonstress test characteristics.","authors":"Jonathan Schaffir, Emily McCauley, Samantha Gawrys, Alyssa Thompson","doi":"10.1080/01443615.2025.2531371","DOIUrl":"10.1080/01443615.2025.2531371","url":null,"abstract":"<p><p>Male foetuses have historically been perceived as more active than females, and foetal movement has been observed to be greater in male foetuses in late pregnancy. Nonstress tests (NSTs), a common form of antepartum assessment, rely on movement in their interpretation. To see if this difference could influence their interpretation, NSTs of patients undergoing clinically indicated testing at 36 weeks' gestation were evaluated. In this cross-sectional observational study, tests were compared between male and female foetuses for maternal indicators of foetal movement and heart rate characteristics including baseline, variability, and number of accelerations. Among 287 foetuses analysed, recordings of foetal movement and heart rate characteristics were similar between the two groups. The results suggest no difference in movement or NST parameters between males and females, and foetal sex should not affect NST interpretation.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2531371"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy outcome in women with hearing disability: systematic review and meta-analysis. 听力障碍妇女的妊娠结局:系统回顾和荟萃分析。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-06-23 DOI: 10.1080/01443615.2025.2519379
Hui Zhang, Yue Du, Jianwei Qiu, Yu Wang, Yinjing Song
{"title":"Pregnancy outcome in women with hearing disability: systematic review and meta-analysis.","authors":"Hui Zhang, Yue Du, Jianwei Qiu, Yu Wang, Yinjing Song","doi":"10.1080/01443615.2025.2519379","DOIUrl":"10.1080/01443615.2025.2519379","url":null,"abstract":"<p><strong>Background: </strong>Hearing disabilities are a significant risk factor for adverse pregnancy outcomes. This study aimed to analyse the impact of hearing impairment on maternal and neonatal outcomes, and to evaluate the adequacy of prenatal care among women diagnosed with hearing disabilities.</p><p><strong>Methods: </strong>A literature search of the PubMed, Medline, Cochrane Library, Embase, and Scopus databases for relevant studies published in English was performed. Two researchers independently performed screening and quality assessments. Adverse maternal outcomes (gestational diabetes, preeclampsia, and caesarean delivery), adverse neonatal outcomes (preterm birth and low birth weight), and utilisation of prenatal care resources were primary outcomes of this review. A comparative effects meta-analysis and a narrative synthesis were performed.</p><p><strong>Results: </strong>Ten retrospective cohort studies comprising 97,251,223 participants, of whom 63,387 had a hearing disability, were included in this review. Meta-analysis revealed a significantly higher risk for gestational diabetes, preeclampsia, eclampsia, caesarean delivery, placental abruption, preterm birth, low birth weight, and adequate-plus utilisation of prenatal care resources. The results were similar in the sensitivity analyses based on different statistical models. There were no statistical differences in pooled estimates of the incidence of chorioamnionitis, although a significantly higher risk was observed when the model was modified.</p><p><strong>Conclusion: </strong>Compared to women without disabilities, those with hearing disabilities exhibited a higher risk for adverse maternal and neonatal outcomes and excessive use of prenatal care services.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2519379"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual dysfunction in women with Sjögren's syndrome: a cross-sectional observational study. Sjögren综合征女性性功能障碍:一项横断面观察研究。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-02-13 DOI: 10.1080/01443615.2025.2463413
Meiyu Wang, Zhenlei Gao
{"title":"Sexual dysfunction in women with Sjögren's syndrome: a cross-sectional observational study.","authors":"Meiyu Wang, Zhenlei Gao","doi":"10.1080/01443615.2025.2463413","DOIUrl":"10.1080/01443615.2025.2463413","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the prevalence of female sexual dysfunction (FSD) and its association with clinical characteristics in female patients with Sjögren's syndrome (SS).</p><p><strong>Methods: </strong>In this cross-sectional study, 158 female patients with SS admitted to the Department of Rheumatology and Immunology of three Grade-III Class-A hospitals in Beijing between January 2021 and December 2023 were included. The general clinical data, sexual function feelings, medication use, psychological status, and socioeconomic factors of the patients were collected with a standardised questionnaire and assessed.</p><p><strong>Results: </strong>Of the 158 patients, 124 (78.5%) were diagnosed with FSD based on Female Sexual Function Index scores <26.5. The mean age and course of disease were significantly higher in the FSD group than in the non-FSD group (<i>p</i> < 0.05), with a higher proportion of patients aged ≥40 years in the former (71.8%) than the latter (11.8%). After adjusting for potential confounding factors, including medication use, psychological status and socioeconomic factors, the association between SS and FSD remained significant (<i>p</i> < 0.05). In the FSD group, decreased libido (79.0%), difficulty in sexual arousal (71.8%), difficulty in vaginal lubrication (66.1%), orgasmic disorder (77.4%), decreased sexual satisfaction (81.5%) and dyspareunia (75.0%) were commonly reported.</p><p><strong>Conclusions: </strong>The findings of this study suggest that early identification and intervention of FSD for female patients with SS is essential to improve their quality of life.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2463413"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shatavari (Asparagus racemosus Willd) root extract for postpartum lactation: A randomised, double-blind, placebo-controlled study. 野总状芦笋根提取物用于产后哺乳:一项随机、双盲、安慰剂对照研究。
IF 1.2 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-10-07 DOI: 10.1080/01443615.2025.2564168
Ashutosh Ajgaonkar, Tanisha Debnath, Sunanda Bhatnagar, Khokan Debnath, Jayshree Langade
{"title":"Shatavari (<i>Asparagus racemosus</i> Willd) root extract for postpartum lactation: A randomised, double-blind, placebo-controlled study.","authors":"Ashutosh Ajgaonkar, Tanisha Debnath, Sunanda Bhatnagar, Khokan Debnath, Jayshree Langade","doi":"10.1080/01443615.2025.2564168","DOIUrl":"https://doi.org/10.1080/01443615.2025.2564168","url":null,"abstract":"<p><strong>Background: </strong>Inadequate milk production during the immediate postpartum period is a common problem. Shatavari (<i>Asparagus racemosus</i>), a revered herb in Ayurveda, is traditionally used as a galactagogue. The objective of this study is to assess the safety and effectiveness of Shatavari root extract (SHT) on lactation in post-partum women.</p><p><strong>Methods: </strong>This prospective, randomised, double-blind, placebo-controlled study enrolled post-partum women (≥37 weeks' gestation, aged 20-40 years) with uncomplicated vaginal or caesarean deliveries who intended to breastfeed. Participants received either Shatavari root extract (SHT; 300 mg) or placebo (PL) capsules twice daily for 72 h postpartum. The primary outcomes included time to evident breast fullness after the last feeding and the total milk volume expressed at 72 h. The secondary outcomes were maternal and investigator-rated satisfaction (e.g. noticeable breast fullness, maternal/infant wellbeing), assessed by a five-point Likert scale. Safety was assessed through adverse event reports.</p><p><strong>Results: </strong>From the 120 enrolled participants, seven participants (3 SHT, 4 PL) did not complete the study, yielding a per-protocol dataset of 113 women (57 SHT and 56 PL). The baseline characteristics were comparable across groups. The time to evident breast fullness after the last feeding was significantly shorter in the SHT group (<i>p</i> = 0.002), and milk volume at 72 h was significantly higher (<i>p</i> < 0.001). Maternal satisfaction with lactation was higher in the SHT group (52.63% vs. 25.00%, <i>p</i> = 0.008). SHT participants also reported greater satisfaction with infant well-being. Investigators rated maternal and infant well-being higher for SHT than placebo (80.70% vs. 64.29%). No adverse events occurred, and treatment compliance was high.</p><p><strong>Conclusion: </strong>Shatavari root extract improved the milk volume and maternal satisfaction about lactation, indicating its potential as a safe, effective galactagogue.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2564168"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing postpartum hemorrhage training by integrating case-problem based learning with simulation: a quasi experimental study. 以案例问题为基础的学习与模拟相结合,加强产后出血培训:一项准实验研究。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2024-12-26 DOI: 10.1080/01443615.2024.2443617
Yike Yang, Zhichao Guo, Xiaoyue Guo, Yangyu Zhao
{"title":"Enhancing postpartum hemorrhage training by integrating case-problem based learning with simulation: a quasi experimental study.","authors":"Yike Yang, Zhichao Guo, Xiaoyue Guo, Yangyu Zhao","doi":"10.1080/01443615.2024.2443617","DOIUrl":"https://doi.org/10.1080/01443615.2024.2443617","url":null,"abstract":"<p><strong>Background: </strong>Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide, and effective training in PPH rescue techniques is crucial. This study aims to evaluate the effectiveness of combining case-based learning (CBL) and problem-based learning (PBL) with simulation teaching methods in improving midwifery trainees' technical proficiency in managing PPH.</p><p><strong>Methods: </strong>This quasi-experimental study involved 76 trainees who received PPH training at Peking University Third Hospital from March to July 2023. They were divided into two groups: the control group (<i>n</i> = 50) followed traditional simulation training methods, and the research group (<i>n</i> = 26) used a combination of CBL-PBL and scenario simulation. After the training, all participants completed a theoretical examination and questionnaire to assess their satisfaction with the program and self-assessment of clinical management skills in PPH. Statistical analysis was performed using unpaired t-tests and chi-square tests to compare the groups.</p><p><strong>Results: </strong>The combination of CBL-PBL and scenario simulation was highly satisfactory compared to traditional simulation training, significantly enhancing self-assessed skills in clinical thinking (100% vs. 61.8%, <i>p</i> = .03), operant skills related to PPH (100% vs. 57.4%, <i>p</i> < .01), relevant knowledge pertaining to PPH (100% vs. 58.7%, <i>p</i> < .01), and management abilities (97.1% vs. 39%, <i>p</i> < .01) among midwifery trainees in the research group, who also scored significantly higher on post-training assessments of PPH knowledge than control groups(91.7 ± 6.0 vs 76.0 ± 7.1, <i>p</i> < .01). A majority of trainees expressed a preference for regular simulation exercises (98.7%) and detailed discussions on PPH cases (93.4%) in future training sessions.</p><p><strong>Conclusion: </strong>Combining CBL-PBL with simulation practice is a more effective teaching method for PPH management training in maternity staffs with a certain level of clinical experience, compared to traditional methods. Future studies should explore the implementation of regular PPH rescue skill training in real clinical settings to support these findings.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2443617"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophylactic internal iliac artery balloon for caesarean in placenta accreta reduces haemoglobin drop - Retrospective comparative study. 预防性髂内动脉球囊术用于增生胎盘剖宫产可减少血红蛋白下降——回顾性比较研究。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-05-09 DOI: 10.1080/01443615.2025.2495600
Yuen Yee Yannie Chan, Ellen Lok-Man Yu, Tsz Kin Lo
{"title":"Prophylactic internal iliac artery balloon for caesarean in placenta accreta reduces haemoglobin drop - Retrospective comparative study.","authors":"Yuen Yee Yannie Chan, Ellen Lok-Man Yu, Tsz Kin Lo","doi":"10.1080/01443615.2025.2495600","DOIUrl":"https://doi.org/10.1080/01443615.2025.2495600","url":null,"abstract":"<p><strong>Background: </strong>This study compared maternal and foetal outcomes of managing placenta accreta spectrum (PAS) disease with and without prophylactic internal iliac balloon occlusion (IIABO) at a tertiary hospital between 2002 and 2021.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with confirmed PAS disorder, comparing maternal and foetal outcomes between those who underwent IIABO before caesarean delivery and those who did not, both receiving standardised multidisciplinary care. Primary outcomes included perioperative haemoglobin drop. Secondary outcomes included estimated blood loss, transfusion rate, operative duration, ICU stay, hysterectomy rates, and newborns' Apgar scores.</p><p><strong>Results: </strong>Thirty-one antenatally diagnosed PAS patients were analysed (IIABO <i>n</i> = 21, non-IIABO <i>n</i> = 10). Over 90% had prior caesarean deliveries. IIABO is associated with lower intraoperative haemoglobin drop (<i>p</i> < .001) and higher postoperative haemoglobin (<i>p</i> = 0.047). The linear regression model demonstrated that IIABO and classical caesarean significantly reduced intraoperative blood loss (<i>p</i> = 0.019). No differences were seen in operative time, ICU stay, hysterectomy rates, or newborn Apgar scores. No IIABO-related complications were reported.</p><p><strong>Conclusion: </strong>Prophylactic IIABO during caesarean delivery for PAS is associated with less haemoglobin drop and higher postoperative haemoglobin. IIABO under local anaesthesia was feasible, possibly reducing risks tied to extended general anaesthesia. Larger studies are recommended to support the role of IIABO in PAS disorders.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2495600"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The long noncoding RNA CCDC144NL-AS1: prognosis significance and potential biological functions in cervical carcinoma. 长链非编码RNA CCDC144NL-AS1在宫颈癌中的预后意义及潜在生物学功能
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-04-08 DOI: 10.1080/01443615.2025.2463416
Xuemei Hu, Yulong Wang, Hongyu Guo, Yuzhen Guo
{"title":"The long noncoding RNA CCDC144NL-AS1: prognosis significance and potential biological functions in cervical carcinoma.","authors":"Xuemei Hu, Yulong Wang, Hongyu Guo, Yuzhen Guo","doi":"10.1080/01443615.2025.2463416","DOIUrl":"10.1080/01443615.2025.2463416","url":null,"abstract":"<p><strong>Background: </strong>Recent research has shown that long noncoding RNA (lncRNA) performs a critical regulatory function across multiple malignancies. The involvement of RNA in the progression of multiple human cancer types has been elucidated; however, there is limited understanding regarding the importance of the lncRNA CCDC144NL-AS1 in cervical carcinoma (CC).</p><p><strong>Methods: </strong>CCDC144NL-AS1 expression was measured in 86 CC samples by RT-PCR. CC cell lines were engineered with CCDC144NL-AS1 overexpression using plasmid vectors, allowing for the exploration of its impact on the migration of tumour cells. Additionally, we studied how CCDC144NL-AS1 impacts epithelial-mesenchymal transition signalling, focusing on its expression levels and functional roles.</p><p><strong>Results: </strong>CCDC144NL-AS1 expression showed a notable increase in gynaecological tumour specimens and cell lines in contrast to normal control (all <i>p</i> < 0.05). This expression exhibited relationships with the clinical stage (<i>p</i> = 0.003), histologic grade (<i>p</i> = 0.020), and lymph node metastasis (<i>p</i> = 0.013). Additionally, survival rates were found to be lower in CC patients with increased CCDC144NL-AS1 expression, as confirmed by multivariate analysis, compared to individuals with reduced expression levels (Hazard ratio = 1.960; <i>p</i> = 0.020). CCDC144NL-AS1 also facilitated increased cell viability and migration while triggering the EMT pathway. Xenograft models demonstrated that lower CCDC144NL-AS1 levels resulted in smaller tumours and longer survival (median survival: 43.5 vs. 35.5 days, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>CCDC144NL-AS1 significantly influences cell migration, making it a promising target for CC treatment and a valuable prognostic indicator.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2463416"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Life's Essential 8 and mortality in urinary incontinence among US female adults. 美国成年女性尿失禁与生命要素8与死亡率之间的关系
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-06-04 DOI: 10.1080/01443615.2025.2512774
Xiaoping Xu, Ruiqian Liu
{"title":"Association between Life's Essential 8 and mortality in urinary incontinence among US female adults.","authors":"Xiaoping Xu, Ruiqian Liu","doi":"10.1080/01443615.2025.2512774","DOIUrl":"https://doi.org/10.1080/01443615.2025.2512774","url":null,"abstract":"<p><strong>Background: </strong>Urinary incontinence (UI) may be associated with cardiovascular disease. Life's Essential 8 (LE8), a recently updated measure of cardiovascular health (CVH), has been investigated for its association with all-cause and cardiovascular mortality among US female adults with UI.</p><p><strong>Methods: </strong>This population-based retrospective cohort study utilised data from 6314 US female adults aged ≥20 years with UI (weighted population: 4.14 million) derived from the National Health and Nutrition Examination Survey (NHANES) 2005-2018, along with their linked mortality data up to December 2019. The LE8 metric, ranging from 0 to 100, was categorised into low, moderate, and high levels. UI status was determined by self-report. Multivariable Cox proportional hazards regression models were employed to assess the associations between LE8 and both all-cause and cardiovascular disease (CVD) mortality. A stratified analysis and sensitivity analysis were also conducted.</p><p><strong>Results: </strong>During a median follow-up period of 92 months (with a maximum of 180 months) among US adult females with UI, 684 all-cause deaths were recorded, including 169 deaths attributable to cardiovascular disease. A 10-point increase in the LE8 score was associated with a 14% reduction in the risk of all-cause mortality (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.79-0.93) and a 17% reduction in the risk of CVD mortality (HR, 0.83; 95% CI, 0.71-0.97). Physical activity has the most significant effect. In the stratified subgroups and sensitivity analyses, the results remained robust.</p><p><strong>Conclusions: </strong>An elevated LE8 score was independently correlated with reduced risks of all-cause and cardiovascular mortality among US female adults with UI. Future prospective studies are required to further strengthen our findings.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2512774"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between 1400 metabolites and subtypes of endometriosis: a two-sample Mendelian randomisation study. 1400种代谢物与子宫内膜异位症亚型之间的关联:一项双样本孟德尔随机研究
IF 1.2 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.1080/01443615.2025.2552402
Fei Yan, Zhouxiang Chen, Lingfeng Wu, Zongju Huang
{"title":"Associations between 1400 metabolites and subtypes of endometriosis: a two-sample Mendelian randomisation study.","authors":"Fei Yan, Zhouxiang Chen, Lingfeng Wu, Zongju Huang","doi":"10.1080/01443615.2025.2552402","DOIUrl":"https://doi.org/10.1080/01443615.2025.2552402","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis is a chronic inflammatory disease with a prevalence of approximately 10% in women of childbearing age. Metabolic pathways have been demonstrated by previous studies to be potential avenues for the development of new therapeutic strategies and may be used for early diagnosis of the disease. This study aimed to investigate the potential causal relationships between 1400 metabolites and various endometriosis subtypes using Mendelian randomisation (MR) analysis.</p><p><strong>Methods: </strong>Data from a genome-wide association study were analysed. MR analysis was performed using the inverse-variance weighted, MR-Egger, and weighted-median methods, accompanied by heterogeneity testing, sensitivity analysis, and pleiotropy analysis. Metabolic-pathway enrichment analysis was conducted on the preliminarily screened differential metabolites, and colocalisation analysis was subsequently performed for exposure-outcome pairs that remained causally associated after multiple-testing correction.</p><p><strong>Results: </strong>After multiple-testing correction, only the glycerol-to-palmitoylcarnitine (C16) ratio reduced the risk of stage 1-2 endometriosis (<i>P</i><sub>FDR</sub> = 0.045; odds ratio [OR], 0.737; 95% confidence interval [CI], 0.638-0.852) and pelvic peritoneal endometriosis (<i>P</i><sub>FDR</sub> = 0.039; OR, 0.721; 95% CI, 0.619-0.841). Colocalisation analysis revealed that they did not share causal variant loci at the genetic level. No reverse causal associations were found in the reverse Mendelian analysis. Metabolic pathway enrichment analysis identified major metabolic pathways, including caffeine metabolism, glutathione metabolism, arginine biosynthesis, sphingolipid metabolism, pantothenate and CoA biosynthesis, plasmalogen synthesis, and biosynthesis of unsaturated fatty acids.</p><p><strong>Conclusions: </strong>Our study suggests potential causal relationships between metabolites and various endometriosis subtypes from an MR perspective. However, the limited number of associations that survived multiple-testing correction indicates that these findings are preliminary and require validation in larger cohorts. This exploratory analysis may contribute to advancing future research on metabolomics-based diagnosis, treatment, and prevention of endometriosis.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2552402"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using robotic single-port vNOTES for gynaecological oncology: omentectomy in a patient with an ovarian granulosa cell tumor-a case study. 使用机器人单端口vNOTES用于妇科肿瘤:卵巢颗粒细胞瘤患者的网膜切除术-一个案例研究。
IF 1.2 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2025-12-01 Epub Date: 2025-09-07 DOI: 10.1080/01443615.2025.2556279
Chunhua Zhang, Qing Li, Fang Fang, Xiaoming Guan
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