Journal of Obstetrics and Gynaecology最新文献

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The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy. 妊娠期血脂与肝内胆汁淤积综合征的相关性。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-07-04 DOI: 10.1080/01443615.2024.2369929
Huibin Huang, Juan Li, Tianhua Chen, Meidan Lu, Gunsang Zhuoma, Lijin Chen, Yuebin Gan, Huiming Ye
{"title":"The correlation between blood lipids and intrahepatic cholestasis syndrome during pregnancy.","authors":"Huibin Huang, Juan Li, Tianhua Chen, Meidan Lu, Gunsang Zhuoma, Lijin Chen, Yuebin Gan, Huiming Ye","doi":"10.1080/01443615.2024.2369929","DOIUrl":"https://doi.org/10.1080/01443615.2024.2369929","url":null,"abstract":"<p><strong>Background: </strong>To analyse changes in lipid levels during the development of intrahepatic cholestasis of pregnancy (ICP) and identify new biomarkers for predicting ICP.</p><p><strong>Methods: </strong>A retrospective case-control study was conducted to analyse 473 pregnant women who underwent regular prenatal examinations and delivered at the Women and Children's Hospital, School of Medicine, Xiamen University, between June 2020 and June 2023, including 269 normal pregnancy controls and 204 pregnant women with cholestasis.</p><p><strong>Results: </strong>Patients with ICP with gestational diabetes mellitus (GDM) have lower high-density lipoprotein (HDL) levels than in those without GDM. Total bile acid (TBA) levels were significantly higher in pregnant women with GDM than those without. The apolipoprotein A (APOA) level was lower in patients with ICP and hypothyroidism than those without hypothyroidism. TBA levels were significantly higher in pregnant women with hypothyroidism than those without. Triglyceride (TG) levels were significantly higher in patients with preeclampsia (PE) than those without. HDL and APOA levels were lower in women with ICP complicated by preterm delivery than those with normal delivery. The AUC (area under the curve) of the differential diagnosis of cholestasis of pregnancy for the APOA/APOB (apolipoprotein B) ratio was 0.727, with a sensitivity of 85.9% and specificity of 47.5%.</p><p><strong>Conclusions: </strong>The results suggested that dyslipidaemia is associated with an increased risk of ICP and its complications. The timely detection of blood lipid and bile acid levels can assist in the diagnosis of ICP and effectively prevent ICP and other complications.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2369929"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between affordable care act implementation and the prevalence of women having ever received a Pap smear. 负担得起的医疗保健法案》的实施与妇女接受过子宫颈抹片检查的比例之间的关系。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-08-23 DOI: 10.1080/01443615.2024.2393359
Eric M Ganz, Benjamin Brown, Heather Smith, Lawren Wellisch, Megha Gupta, Stephen M Wagner
{"title":"The association between affordable care act implementation and the prevalence of women having ever received a Pap smear.","authors":"Eric M Ganz, Benjamin Brown, Heather Smith, Lawren Wellisch, Megha Gupta, Stephen M Wagner","doi":"10.1080/01443615.2024.2393359","DOIUrl":"https://doi.org/10.1080/01443615.2024.2393359","url":null,"abstract":"<p><strong>Background: </strong>To assess if implementation of the 2010 Patient Protection and Affordable Care Act (ACA) was associated with changes in the prevalence of women having ever received a pap smear.</p><p><strong>Methods: </strong>This study utilised the publicly available Centre for Disease Control National Survey of Family Growth (NSFG) data set. This was a serial cross-sectional study. The comparison groups were defined as women who received cancer screening and prevention interventions prior to full implementation of the ACA (2011-2013) and post full implementation (2017-2019). The primary outcome was self-reporting receipt of a Papanicolaou (Pap) smear. Secondary outcomes included HPV vaccination and mammogram rates. Anonymized patient information was collected from the nationally representative dataset, and analyses were performed utilising STATA 18.</p><p><strong>Results: </strong>The two study cohorts obtained from the NSFG included women who responded in 2011-2013 (<i>n</i> = 5601), deemed to be 'Pre-ACA implementation' (Pre ACA), and those who responded in 2017-2019 (<i>n</i> = 6141) 'Post-ACA implementation' (Post ACA). The proportion of women who were 21 years and older and ever had a Pap smear in the Pre ACA group (96.0%) was higher than that of the Post ACA group (94.1%) (OR 0.66 (0.49-0.91)). In contrast, HPV vaccination rates rose, and mammogram rates remained stable in the Post ACA period.</p><p><strong>Conclusion: </strong>A decrease in proportion of women ever having had a Pap smear despite implementation of health policies to increase access to preventive measures suggests further interventions to improve access to cervical cancer screening are warranted.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2393359"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between early-onset preeclampsia and the prognostic nutritional index and inflammatory markers. 早发型子痫前期与预后营养指数和炎症指标之间的关系。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1080/01443615.2024.2408680
Alev Esercan, Cigdem Cindoglu
{"title":"The relationship between early-onset preeclampsia and the prognostic nutritional index and inflammatory markers.","authors":"Alev Esercan, Cigdem Cindoglu","doi":"10.1080/01443615.2024.2408680","DOIUrl":"https://doi.org/10.1080/01443615.2024.2408680","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia is still a disease whose cause and treatment have not been fully characterised. Early-onset preeclampsia occurs before the 34th week of pregnancy, and late-onset preeclampsia occurs at 34 weeks or older. In our study, we investigated whether the prognostic nutritional index (PNI) and pan immune inflammation value (PIV), which are used in the prognosis and prediction of diseases in new studies in the literature, are useful for predicting early-onset preeclampsia.</p><p><strong>Methods: </strong>The first group consisted of healthy pregnant women who had a single foetus without any additional disease between 24 and 34 gestational weeks, and the second group consisted of pregnant women who were diagnosed with early-onset preeclampsia and did not have any additional disease or foetal anomalies during the same gestational week. Neutrophil, lymphocyte, monocyte, thrombocyte, ALB, pan immune inflammation value (PIV) and prognostic nutritional index (PNI) scores were recorded.</p><p><strong>Results: </strong>In our case control study, 70 patients with early-onset preeclampsia and 140 pregnant women composed the normotensive (control) group. There was a significant difference between the groups according to PIV (p = 0.04). The prognostic nutritional index (PNI) was significantly lower in the early-onset preeclampsia group than in the normotensive group (p < 0,001). A PNI lower than 36, 30 could only predict early-onset preeclampsia with a low sensitivity of 31.1% and specificity of 45%; the area under the curve was 0,24 (95% confidence interval 0.18-0.31), <i>p</i> < 0,001.</p><p><strong>Conclusion: </strong>Patients with PNI scores lower than 36,30 may have early-onset preeclampsia.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2408680"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of minimal access retroperitoneal para-aortic lymphadenectomy in patients with locally advanced cervical cancer. 局部晚期宫颈癌患者腹膜后主动脉旁淋巴结切除术的疗效。
IF 1.3 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-05-06 DOI: 10.1080/01443615.2024.2344529
Claire Newton, Radha Graham, Viola Liberale, Matthew Burnell, Usha Menon, Tim Mould, Adeola Olaitan, Nicola Macdonald, Martin Widschwendter, Kostas Doufekas, Mary McCormack, Anita Mitra, Rupali Arora, Ranjit Manchanda
{"title":"Outcomes of minimal access retroperitoneal para-aortic lymphadenectomy in patients with locally advanced cervical cancer.","authors":"Claire Newton, Radha Graham, Viola Liberale, Matthew Burnell, Usha Menon, Tim Mould, Adeola Olaitan, Nicola Macdonald, Martin Widschwendter, Kostas Doufekas, Mary McCormack, Anita Mitra, Rupali Arora, Ranjit Manchanda","doi":"10.1080/01443615.2024.2344529","DOIUrl":"https://doi.org/10.1080/01443615.2024.2344529","url":null,"abstract":"<p><strong>Background: </strong>To evaluate outcomes of laparoscopic retroperitoneal para-aortic lymphadenectomy for stage 1b3-3b cervical cancer.</p><p><strong>Methods: </strong>Pathology databases searched for all para-aortic lymphadenectomy cases 2005-2016. Descriptive statistics were used to analyse baseline characteristics, cox models for treatment affect after accounting for variables, and Kaplan Meier curves for survival (STATA v15).</p><p><strong>Results: </strong>191 patients had 1b3-3b cervical cancer of which 110 patients had Para-aortic lymphadenectomy. 8 (7.3%) patients stage 1b3, 82 (74.6%) stage 2b, and 20 (18.1%) stage 3b cervical cancer. Mean lymph node count 11.7 (SD7.6). The intra-operative and post-operative 30 day complication rates were 8.8% (CI: 4.3%, 15.7%) and 5.3% (CI: 1.9%, 11.2%) respectively.Para-aortic nodes were apparently positive on CT/MRI in 5/110 (5%) cases. Cancer was found in 10 (8.9%, CI: 4.3%, 15.7%) cases on histology, all received extended field radiotherapy. Only 2 were identified on pre-operative CT/MRI imaging. 3 of 10 suspected node-positive cases on CT/MRI had negative histology. Para-aortic lymphadenectomy led to alteration in staging and radiotherapy management in 8 (8%, CI: 3.7%, 14.6%) patients. Mean overall survival 42.81 months (SD = 31.79 months). Survival was significantly higher for women undergoing PAN (50.57 (SD 30.7) months) compared to those who didn't (31.27 (SD 32.5) months).</p><p><strong>Conclusion: </strong>Laparoscopic retroperitoneal para-aortic lymphadenectomy is an acceptable procedure which can guide treatment in women with locally advanced cervical cancer.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2344529"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 更正。
IF 1.3 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-05-08 DOI: 10.1080/01443615.2024.2348429
{"title":"Correction.","authors":"","doi":"10.1080/01443615.2024.2348429","DOIUrl":"https://doi.org/10.1080/01443615.2024.2348429","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2348429"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140876691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, attitudes, and practices of pregnant women regarding epidural analgesia: a multicentre study from a developing country. 孕妇对硬膜外镇痛的认识、态度和做法:一项来自发展中国家的多中心研究。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-05-21 DOI: 10.1080/01443615.2024.2354575
Ramzi Shawahna, Dana Khaskia, Donya Ali, Hajar Hodroj, Mohammad Jaber, Iyad Maqboul, Hatim Hijaz
{"title":"Knowledge, attitudes, and practices of pregnant women regarding epidural analgesia: a multicentre study from a developing country.","authors":"Ramzi Shawahna, Dana Khaskia, Donya Ali, Hajar Hodroj, Mohammad Jaber, Iyad Maqboul, Hatim Hijaz","doi":"10.1080/01443615.2024.2354575","DOIUrl":"10.1080/01443615.2024.2354575","url":null,"abstract":"<p><strong>Background: </strong>Epidural analgesia has emerged as one of the best methods that can be used to reduce labour pain. This study was conducted to assess awareness, attitudes, and practices of pregnant women who visited maternity and antenatal healthcare clinics about epidural analgesia during normal vaginal birth.</p><p><strong>Methods: </strong>This multicentre study was conducted in a cross-sectional design among pregnant women using a pre-tested questionnaire. The study population in this study was pregnant women who visited maternity and antenatal healthcare clinics in Palestine.</p><p><strong>Results: </strong>In this study, a total of 389 pregnant women completed the questionnaire. Of the pregnant women, 381 (97.9%) were aware of the existence of epidural analgesia, 172 (44.2%) had already used epidural analgesia, and 57 (33.1%) experienced complications as a result of epidural analgesia. Of the pregnant women, 308 (79.2%) stated that epidural analgesia should be available during vaginal birth. Of the pregnant women, 243 (62.5%) stated that they would use epidural analgesia if offered for free or covered by insurance. Multivariate logistic regression showed that women who were younger than 32 years, who have used epidural analgesia, and those who stated that epidural analgesia should be available during vaginal birth were 2.78-fold (95% CI: 1.54-5.04), 4.96-fold (95% CI: 2.71-9.10), and 13.57-fold (95% CI: 6.54-28.16) more likely to express willingness to use epidural analgesia, respectively.</p><p><strong>Conclusions: </strong>Pregnant women had high awareness of the existence, moderate knowledge, and positive attitudes towards epidural analgesia for normal vaginal birth. Future studies should focus on educating pregnant women about all approaches that can be used to reduce labour pain including their risks and benefits.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2354575"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incorporating low haemoglobin into a risk prediction model for conversion in minimally invasive gynaecologic oncology surgeries. 将低血红蛋白纳入妇科肿瘤微创手术转换风险预测模型。
IF 1.3 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-05-23 DOI: 10.1080/01443615.2024.2349960
Kevin H Nguyen, Hyundeok Joo, Solmaz Manuel, Lee-May Chen, Lee-Lynn Chen
{"title":"Incorporating low haemoglobin into a risk prediction model for conversion in minimally invasive gynaecologic oncology surgeries.","authors":"Kevin H Nguyen, Hyundeok Joo, Solmaz Manuel, Lee-May Chen, Lee-Lynn Chen","doi":"10.1080/01443615.2024.2349960","DOIUrl":"10.1080/01443615.2024.2349960","url":null,"abstract":"<p><strong>Background: </strong>A well-known complication of laparoscopic management of gynaecologic masses and cancers is the need to perform an intraoperative conversion to laparotomy. The purpose of this study was to identify novel patient risk factors for conversion from minimally invasive to open surgeries for gynaecologic oncology operations.</p><p><strong>Methods: </strong>This was a retrospective cohort study of 1356 patients ≥18 years of age who underwent surgeries for gynaecologic masses or malignancies between February 2015 and May 2020 at a single academic medical centre. Multivariable logistic regression was used to study the effects of older age, higher body mass index (BMI), higher American Society of Anaesthesiologist (ASA) physical status, and lower preoperative haemoglobin (Hb) on odds of converting from minimally invasive to open surgery. Receiver operating characteristic (ROC) curve analysis assessed the discriminatory ability of a risk prediction model for conversion.</p><p><strong>Results: </strong>A total of 704 planned minimally invasive surgeries were included with an overall conversion rate of 6.1% (43/704). Preoperative Hb was lowest for conversion cases, compared to minimally invasive and open cases (11.6 ± 1.9 vs 12.8 ± 1.5 vs 11.8 ± 1.9 g/dL, p<.001). Patients with preoperative Hb <10 g/dL had an adjusted odds ratio (OR) of 3.94 (CI: 1.65-9.41, p=.002) for conversion while patients with BMI ≥30 kg/m<sup>2</sup> had an adjusted OR of 2.86 (CI: 1.50-5.46, p=.001) for conversion. ROC curve analysis using predictive variables of age >50 years, BMI ≥30 kg/m<sup>2</sup>, ASA physical status >2, and preoperative haemoglobin <10 g/dL resulted in an area under the ROC curve of 0.71. Patients with 2 or more risk factors were at highest risk of requiring an intraoperative conversion (12.0%).</p><p><strong>Conclusions: </strong>Lower preoperative haemoglobin is a novel risk factor for conversion from minimally invasive to open gynaecologic oncology surgeries and stratifying patients based on conversion risk may be helpful for preoperative planning.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2349960"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is it time to agree upon a standardised approach to the assessment of contributing factors and impacts of adolescent pelvic pain? 是时候就评估青少年盆腔疼痛的诱因和影响的标准化方法达成一致意见了吗?
IF 1.3 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-05-30 DOI: 10.1080/01443615.2024.2359126
Dehlia Moussaoui, Olivia G Farrell, Sonia R Grover
{"title":"Is it time to agree upon a standardised approach to the assessment of contributing factors and impacts of adolescent pelvic pain?","authors":"Dehlia Moussaoui, Olivia G Farrell, Sonia R Grover","doi":"10.1080/01443615.2024.2359126","DOIUrl":"10.1080/01443615.2024.2359126","url":null,"abstract":"<p><strong>Background: </strong>A biopsychosocial approach to the understanding of pelvic pain is increasingly acknowledged. However, there is a lack of standardised instruments - or their use - to assess risk factors and their impact on pelvic pain in both clinical and research settings. This review aims to identify validated tools used to assess known contributory factors to pelvic pain, as well as the validated tools to measure the impact of pelvic pain in adolescents and young adults, in order to provide a framework for future standardised, adolescent specific assessment and outcome tools.</p><p><strong>Methods: </strong>Literature searches were performed in MEDLINE, PsycInfo and PubMed. Search terms included pelvic pain, dysmenorrhoea, endometriosis, adolescent, pain measurement, quality of life, sleep, mental health, coping strategies and traumatic experience.</p><p><strong>Results: </strong>We found validated instruments to assess adverse childhood experiences and coping strategies, both known contributing factors to pelvic pain. The impact of pain was measured through validated tools for health-related quality of life, mental health and sleep.</p><p><strong>Conclusions: </strong>Pelvic pain evaluation in adolescents should include a multi-factorial assessment of contributing factors, such as childhood adversity and coping strategies, and impacts of pelvic pain on quality of life, mental health and sleep, using validated instruments in this age group. Future research should focus on the development of consensus amongst researchers as well as input from young women to establish a standardised international approach to clinical trials involving the investigation and reporting of pelvic pain in adolescents. This would facilitate comparison between studies and contribute to improved quality of care delivered to patients.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2359126"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy. GPR176 在卵巢癌中的致癌作用:侵袭性和基因治疗的分子靶点。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI: 10.1080/01443615.2024.2347430
Ning Yang, Wen-Jing Yun, Zheng-Guo Cui, Hua-Chuan Zheng
{"title":"The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy.","authors":"Ning Yang, Wen-Jing Yun, Zheng-Guo Cui, Hua-Chuan Zheng","doi":"10.1080/01443615.2024.2347430","DOIUrl":"10.1080/01443615.2024.2347430","url":null,"abstract":"<p><strong>Background: </strong>At present, the discovery of new biomarkers is of great significance for the early diagnosis, treatment and prognosis assessment of ovarian cancer. Previous findings indicated that aberrant G-protein-coupled receptor 176 (GPR176) expression might contribute to tumorigenesis and subsequent progression. However, the expression of GPR176 and the molecular mechanisms in ovarian cancer had not been investigated.</p><p><strong>Methods: </strong>GPR176 expression was compared with clinicopathological features of ovarian cancer using immunohistochemical and bioinformatics analyses. GPR176-related genes and pathways were analysed using bioinformatics analysis. Additionally, the effects of GPR176 on ovarian cancer cell phenotypes were investigated.</p><p><strong>Results: </strong>GPR176 expression positively correlated with elder age, clinicopathological staging, tumour residual status, and unfavourable survival of ovarian cancer, but negatively with purity loss, infiltration of B cells, and CD8+ T cells. Gene Set Enrichment Analysis showed that differential expression of GPR176 was involved in focal adhesion, ECM-receptor interaction, cell adhesion molecules and so on. STRING and Cytoscape were used to determine the top 10 nodes. Kyoto Encyclopaedia of Genes and Genomes analysis indicated that GPR176-related genes were involved in the ECM structural constituent and organisation and so on. GPR176 overexpression promoted the proliferation, anti-apoptosis, anti-pyroptosis, migration and invasion of ovarian cancer cells with overexpression of N-cadherin, Zeb1, Snail, Twist1, and under-expression of gasdermin D, caspase 1, and E-cadherin.</p><p><strong>Conclusion: </strong>GPR176 might be involved in the progression of ovarian cancer. It might be used as a biomarker to indicate the aggressive behaviour and poor prognosis of ovarian cancer and a target of genetic therapy.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"44 1","pages":"2347430"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with dysmenorrhoea and menorrhagia improvement in patients with adenomyosis after uterine artery embolisation. 子宫动脉栓塞术后子宫腺肌症患者痛经和月经改善的相关因素。
IF 0.9 4区 医学
Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-06-29 DOI: 10.1080/01443615.2024.2372645
Siqi Hu, Wenbo Guo, Song Chen, Zhiqiang Wu, Wenquan Zhuang, Jianyong Yang
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