Journal of Obstetrics and Gynaecology最新文献

{"title":"Abnormal expression of Hippo-YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps.","authors":"Xinyu Yu, Weijia Kong, Kaiyue Shang, Hongxin Xing, Wenjing Sun, Qianqian Li, Hui Zhang","doi":"10.1080/01443615.2025.2533965","DOIUrl":"https://doi.org/10.1080/01443615.2025.2533965","url":null,"abstract":"<p><strong>Background: </strong>Endometrial polyps (EPs) are a localised hyperproliferative disorder of the endometrium, and its pathogenesis remains unclear. Progesterone resistance may influence the recurrence rate of progesterone-treated EPs. Expression of the Hippo-YAP1 signalling pathway has been studied in various diseases. However, few studies have explored their expression in EPs and association with progesterone resistance. Prolactin (PRL), a molecular marker of endometrial mesenchymal cell metaplasia, indirectly reflects progesterone action <i>in vivo</i>. This study aimed to explore the role of Hippo-YAP1 signalling pathway in EPs.</p><p><strong>Methods: </strong>Endometrial tissue specimens obtained by surgical resection from 35 patients with a normal endometrium and 35 with EPs were collected between July 2023 and July 2024. Immunohistochemically, the expressions of mammalian STE20-like kinase 1 (MST1), Yes-associated protein 1 (YAP1), progesterone receptor (PR) and PRL in the normal endometrium and EPs tissues were detected.</p><p><strong>Results: </strong>Compared to normal endometrial tissues, the expression of MST1 was relatively low in EPs (<i>p</i> < .05), while the total and nuclear expression of YAP1 was relatively high in EPs (<i>p</i> < .0001). The expression of PR in EPs tissues was significantly lower than that in normal endometrial tissues (<i>p</i> < .05), and the expression level of PRL was lower than that of normal endometrium in EPs tissues (<i>p</i> < .001).</p><p><strong>Conclusions: </strong>EPs have progesterone resistance, and the Hippo-YAP1 signalling pathway may be involved in the development and progression of EPs by acting on the progesterone resistance mechanism.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2533965"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immune-inflammation index and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis.","authors":"Tingting Zhang, Xingxing He","doi":"10.1080/01443615.2025.2548814","DOIUrl":"10.1080/01443615.2025.2548814","url":null,"abstract":"<p><strong>Background: </strong>The systemic immune-inflammation index (SII) has been a marker and prognostic indicator of several diseases. However, its utility in pregnancy is unknown. Herein, we reviewed the evidence on the ability of SII to predict gestational diabetes mellitus (GDM) and preeclampsia (PE).</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, Scopus and Web of Science was conducted for studies comparing SII between GDM/PE and non-GDM/non-PE groups. Studies reporting diagnostic accuracy data were also included. The last date of the search was 5 November 2024. Risk of bias was assessed using Newcastle Ottawa Scale. Random-effect meta-analysis was conducted comparing values of SII between GDM/PE and non-GDM/non-PE groups.</p><p><strong>Results: </strong>Nine studies were eligible. Four studies reported data on GDM and five on PE. Most studies measured SII in the first trimester. The pooled analysis showed no statistically significant difference in the SII values between PE and non-PE groups (MD: 13.07, 95% confidence interval (CI): -117.21, 143.35, <i>I</i>² = 78%). Meta-analysis of four studies comparing data of GDM and non-GDM groups showed that SII was significantly higher in GDM females (MD: 210.32, 95% CI: 57.3, 363.34, <i>I</i>² = 94%). The sensitivity of SII to predict PE varied from 40 to 77.5% while specificity varied from 53.8 to 67.5%. For studies on GDM, the sensitivity and specificity values varied from 66 to 80.2% and 34.4 to 65%, respectively.</p><p><strong>Conclusions: </strong>SII values are significantly higher in GDM compared to non-GDM females. However, SII values did not correlate with PE. SII may have potential in predicting GDM which needs to be explored by further studies.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2548814"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cannabis use with female infertility based on NHANES.","authors":"Chao Chen, Yang Wu, Lipeng Pei, Wei Ren","doi":"10.1080/01443615.2025.2502663","DOIUrl":"https://doi.org/10.1080/01443615.2025.2502663","url":null,"abstract":"<p><strong>Background: </strong>With the gradual legalisation of recreational cannabis, associated health effects have received widespread attention, but their association with female infertility remains unclear. The aim of this study was to explore the association between cannabis use and infertility among females of childbearing age in the United States.</p><p><strong>Methods: </strong>Data were obtained from the National Health and Nutrition Examination Survey 2013-2018; 1694 female participants aged 18-45 years were included. The association between cannabis use and female infertility was analysed by logistic regression analysis. All data were weighted before analysis.</p><p><strong>Results: </strong>After adjusting for all covariates, former cannabis users demonstrated significantly elevated odds of infertility compared with never-users (odds ratio: 2.04, 95% confidence interval: 1.21-3.43, <i>P</i> = 0.012), whereas current cannabis users exhibited no significant difference in infertility odds relative to never-users. In subgroup analysis, former users aged 18-35 years exhibited higher odds of infertility than never-users (odds ratio: 2.37, 95% confidence interval: 1.11-5.04, <i>P</i> = 0.027); but former cannabis users aged 36-45 years demonstrated no significant difference in infertility odds compared with never-users. Among former cannabis users aged 18-35 years, those with sustained abstinence exceeding 3 years demonstrated significantly elevated odds of infertility compared with never-users (odds ratio: 2.94, 95% confidence interval: 1.29-6.71, <i>P</i> = 0.005). In contrast, individuals with shorter abstinence durations (<3 years) showed no significant difference in infertility odds relative to never-users.</p><p><strong>Conclusions: </strong>Among females of childbearing age, the odds of infertility was not elevated among current cannabis users compared with never-users, while the odds of infertility was elevated among former users. This relationship between cannabis use and female fertility is more often reflected in the distant term (>3 years of cessation), and this adverse association is more pronounced among females in the most active reproductive years (18-35).</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2502663"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating endometrial metabolic characteristics in patients with adenomyosis using gas chromatography/mass spectrometry.","authors":"Ju Ren, Jiashuo Liu, Jingcong Dai, Li Wang, Fan He, Lina Hu","doi":"10.1080/01443615.2025.2503446","DOIUrl":"https://doi.org/10.1080/01443615.2025.2503446","url":null,"abstract":"<p><strong>Background: </strong>The aetiology and pathogenesis of adenomyosis remain unclear. This study utilised untargeted metabolomics to explore the aberrant amino acid metabolism in adenomyosis. Among the studied metabolites, hydroxyproline is known to promote the proliferation and invasion of tumour cells. Due to detection limitations, hydroxyproline levels were inferred <i>via</i> the expression of prolyl 4-hydroxylase subunit alpha 1 (P4HA1), a crucial enzyme that catalyses the conversion of proline to hydroxyproline.</p><p><strong>Methods: </strong>Endometrial metabolomic analysis was performed using gas chromatography-mass spectrometry (GC-MS) in 15 and 20 patients with and without adenomyosis. The expression levels of P4HA1 mRNA and protein were detected using quantitative PCR (qPCR), western blotting, and immunohistochemistry. <i>In vitro</i>, Cell Counting Kit-8, and 5-Ethynyl-2'-deoxyuridine (EdU) assays were used to investigate the effect of hydroxyproline on the proliferation of human endometrial stromal cells (hESCs). Additionally, a wound-healing assay was conducted to examine the effect of hydroxyproline on hESCs migration.</p><p><strong>Results: </strong>In total, 22 differentially expressed metabolites were identified in the adenomyosis group compared to the control group. qPCR results demonstrated that P4HA1 mRNA expression levels were significantly higher in the adenomyosis group than in the control group (<i>p</i> < 0.01), which was further validated at the protein level by western blotting and immunohistochemistry. <i>In vitro</i>, functional assays revealed that hydroxyproline promoted hESCs proliferation and migration in a dose-dependent manner. EdU assays showed a significant increase in the number of EdU-positive hESCs in the 5 mM hydroxyproline treatment group than that in the control group (<i>p</i> < 0.01). Additionally, wound healing assays demonstrated enhanced migration of hESCs after treatment with 5 mM hydroxyproline (<i>p</i> = 0.002).</p><p><strong>Conclusion: </strong>Hydroxyproline levels were significantly elevated in the endometrial tissues of patients with adenomyosis. Furthermore, hydroxyproline promotes the proliferation and migration of hESCs. These findings provide new insights into the pathogenesis of adenomyosis and suggest potential therapeutic strategies.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2503446"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographics of epithelioid trophoblastic tumour and placental site trophoblastic tumour: a 21 year UK population study.","authors":"P Savage, F Froeling, M Lythgoe, R Fisher, G Maher, M Winter, K Eremeishvili, N Sarwar, X Aguiar, K Singh, B Hancock, R Coleman, J Tidy, M J Seckl","doi":"10.1080/01443615.2025.2571184","DOIUrl":"https://doi.org/10.1080/01443615.2025.2571184","url":null,"abstract":"<p><strong>Background: </strong>Epithelioid and placental site trophoblastic tumours are rare gestational malignancies which have little detailed information on their population incidence or risk related to maternal age.</p><p><strong>Methods: </strong>We performed a retrospective UK national population-based study examining all of the cases registered between 2000 and 2020 using the databases at the UK's two gestational trophoblastic treatment centres at Charing Cross Hospital in London and Weston Park Hospital in Sheffield. The data obtained was compared with the contemporary UK birth and pregnancy statistics.</p><p><strong>Results: </strong>Over the 21-year study period, there were 132 cases of ETT or PSST. PSTT comprised 57% of the cases, 30% were ETT and 13% had mixed pathology. The combined incidence of ETT and PSTT was 1:118,736 relative to live births and 1:150,872 compared to total viable conceptions. For women aged under 20 the incidence relative to live births was 1:412,488, increasing to 1:188,292 for women 30-34 years, and 1:1,426 for women aged 45 and above. The median interval from the antecedent pregnancy to the time of diagnosis was 15 months (0-288) for the PSTT patients compared to 24 months (0-336) for patients with a diagnosis of ETT.</p><p><strong>Conclusions: </strong>ETT and PSTT are both rare diagnoses with little detailed information on their demographics. The data in this study indicates a wide range in the interval from the antecedent pregnancy to diagnosis and confirms a close relationship between increasing incidence and rising maternal age.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2571184"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the postoperative survival rate of obese Asian patients with endometrial cancer.","authors":"Huiqiao Gao, Qi Lu, Jianxin Zhang","doi":"10.1080/01443615.2025.2480856","DOIUrl":"10.1080/01443615.2025.2480856","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to explore the factors that influence overall survival in obese patients with endometrial cancer (EC).</p><p><strong>Methods: </strong>The retrospective study included patients with EC who were treated between 2000 and April 2013. Subjects were divided into the following groups based on body mass index (BMI): non-obese (<24.0 kg/m²), overweight (24.0-28.0 kg/m²) and obese (>28.0 kg/m²). Survival data were estimated using Kaplan-Meier's curves and compared using log-rank statistics.</p><p><strong>Results: </strong>A total of 280 cases were enrolled, including 22.5% in non-obese group, 42.9% in overweight group and 34.6% in obese group. Among different BMI groups, obese EC patients with diabetes have a lower survival rate (<i>p</i> = .041), and obese EC patients with menopause have a lower survival rate (<i>p</i> = .021). The survival rate of overweight EC patients was significantly reduced if vascular thrombus and lymph node metastasis were found during operation (<i>p</i> < .001).</p><p><strong>Conclusions: </strong>Our data suggest that the association of obese EC patients with menstrual status, diabetes and intraoperative vasculature embolus and lymph node metastasis significantly affects postoperative survival. In all subjects, the relevant factors were independent prognostic factors in patients with obese.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2480856"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of high maternal body mass index (≥35 kg/m²) on haemodynamic parameters during pregnancy: a prospective observational study.","authors":"Majedah Hmeidan, Francesca M T Leone, Mohammed W Osman, David Webb, Hatem A Mousa","doi":"10.1080/01443615.2025.2552408","DOIUrl":"10.1080/01443615.2025.2552408","url":null,"abstract":"<p><strong>Background: </strong>Maternal obesity is a growing global health concern, yet its impact on maternal haemodynamic throughout pregnancy remains underexplored. We investigated haemodynamic adaptations across gestation in women with high body mass index (BMI) (≥35 kg/m²) and results were compared to low-risk controls (BMI 18.5-24.9 kg/m²).</p><p><strong>Methods: </strong>This prospective observational study used non-invasive cardiac output monitoring (NICOM; Baxter Healthcare, Deerfield, IL) to assess maternal haemodynamic parameters, including cardiac output (CO), stroke volume (SV), total peripheral resistance (TPR), systolic blood pressure (sBP) and mean arterial pressure (MAP) in pregnant women with high BMI. Assessments were carried out across five gestational windows (11-19 + 6, 20-27 + 6, 28-33 + 6, 34-37 + 6 and ≥38 weeks). Results were compared to low-risk healthy controls (BMI 18.5-24.9 kg/m²).</p><p><strong>Results: </strong>A total of 329 women were recruited, including 125 with high BMI and 189 controls. Across all gestational windows, women with high BMI consistently demonstrated significantly higher CO and SV. Compared to controls, median CO was high among women with high BMI, at 11-19 + 6 weeks [8.8 L/min (IQR 7.2-9.9) versus 6.7 L/min (5.8-7.6); <i>p</i> < .001]; median SV was 104.2 mL (93.7-124.9) versus 81.9 mL (74.3-94.0) (<i>p</i> < .001). This trend persisted at later gestations. In contrast, median TPR was significantly lower in the high BMI group; at 28-33 + 6 weeks, 847 dyn·s·cm^-5 (unit of measurement of TPR: dynes·seconds per centimetre to the fifth power) (783-937) versus 1083 (924-1161) in the controls (<i>p</i> < .001). Despite reduced TPR, sBP and MAP were higher in women with high BMI throughout pregnancy. Heart rate (HR) and diastolic blood pressure (dBP) did not differ significantly between groups at any gestational window.</p><p><strong>Conclusions: </strong>Pregnant women with high BMI have a distinctive haemodynamic profile characterised by high CO with a compensatory reduction in TPR. Further research is required to assess the risk of placental mediated diseases in that group.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2552408"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: Early prediction of the failure of methotrexate treatment by Days 1-4 serum β-hCG change and 48-hour pre-treatment increment in β-hCG.","authors":"","doi":"10.1080/01443615.2025.2560752","DOIUrl":"https://doi.org/10.1080/01443615.2025.2560752","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2560752"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preterm birth rates and risk factors among women with cervical incompetence undergoing prophylactic cerclage: a systematic review and meta-analysis.","authors":"Jing Wang, Hui-Juan Rong, Xiao-Mei Wang, Guo-Yuan Shi, Wen-Hui Song","doi":"10.1080/01443615.2025.2549996","DOIUrl":"10.1080/01443615.2025.2549996","url":null,"abstract":"<p><strong>Background: </strong>Preterm birth is the leading cause of neonatal mortality and long-term health complications. Cervical cerclage (CC) represents a critical intervention for extending pregnancy duration and enhancing neonatal survival in patients diagnosed with cervical insufficiency. The aim of this study was to identify risk factors for preterm birth through a meta-analysis comparing outcomes between preterm and full-term deliveries following non-emergency CC.</p><p><strong>Methods: </strong>PubMed, EMBASE, Cochrane Library, Web of Science (WOS), and Scopus were searched to identify studies fulfilling predefined inclusion and exclusion criteria on 31 March 2025. The primary outcome measure was the preterm birth rate, which was calculated as the proportion of preterm birth cases in the total sample size. The impact of various risk factors on preterm birth was further analysed.</p><p><strong>Results: </strong>A total of 45 studies were included, and the meta-analysis revealed that the aggregate preterm birth rate at 37 weeks was approximately 48.09% following CC. Compared with twin pregnancies, singleton pregnancies were associated with a lower risk of preterm birth (odds ratio [OR]: 0.71; 95% CI: 0.55-0.91; <i>p</i> = 0.008). Among surgery-related factors, CC indicated by physical examination poses a greater risk. Short cervical length prior to CC and elevated inflammatory markers, such as C-reactive protein (CRP), were significantly associated with preterm birth (OR: 0.79; 95% CI: 0.66-0.95; <i>p</i> = 0.011).</p><p><strong>Conclusions: </strong>This study identified critical risk factors for preterm birth following CC, including physical examination indications, a cervical length ≤ 1.5 cm, cervical dilatation, and CRP abnormalities. These findings are instrumental in identifying high-risk individuals and guiding effective medical resource allocation. However, due to study limitations, large-scale studies with multiple PTB cut-off timepoints and comprehensive analyses of risk factors are necessary to refine preventive and therapeutic approaches for preterm birth.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2549996"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: Antepartum and postpartum uterine artery impedance in women with pre-eclampsia: a case control study.","authors":"","doi":"10.1080/01443615.2025.2452656","DOIUrl":"10.1080/01443615.2025.2452656","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2452656"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}