Journal of Obstetrics and Gynaecology最新文献

{"title":"The Effect of Relugolix Combination Therapy in Black/African American Women with Uterine Fibroids.","authors":"Elizabeth A Stewart, Thierry Schulmann, Sateria Venable","doi":"10.1080/01443615.2025.2487106","DOIUrl":"https://doi.org/10.1080/01443615.2025.2487106","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2487106"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual dysfunction in women with Sjögren's syndrome: a cross-sectional observational study.","authors":"Meiyu Wang, Zhenlei Gao","doi":"10.1080/01443615.2025.2463413","DOIUrl":"10.1080/01443615.2025.2463413","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the prevalence of female sexual dysfunction (FSD) and its association with clinical characteristics in female patients with Sjögren's syndrome (SS).</p><p><strong>Methods: </strong>In this cross-sectional study, 158 female patients with SS admitted to the Department of Rheumatology and Immunology of three Grade-III Class-A hospitals in Beijing between January 2021 and December 2023 were included. The general clinical data, sexual function feelings, medication use, psychological status, and socioeconomic factors of the patients were collected with a standardised questionnaire and assessed.</p><p><strong>Results: </strong>Of the 158 patients, 124 (78.5%) were diagnosed with FSD based on Female Sexual Function Index scores <26.5. The mean age and course of disease were significantly higher in the FSD group than in the non-FSD group (<i>p</i> < 0.05), with a higher proportion of patients aged ≥40 years in the former (71.8%) than the latter (11.8%). After adjusting for potential confounding factors, including medication use, psychological status and socioeconomic factors, the association between SS and FSD remained significant (<i>p</i> < 0.05). In the FSD group, decreased libido (79.0%), difficulty in sexual arousal (71.8%), difficulty in vaginal lubrication (66.1%), orgasmic disorder (77.4%), decreased sexual satisfaction (81.5%) and dyspareunia (75.0%) were commonly reported.</p><p><strong>Conclusions: </strong>The findings of this study suggest that early identification and intervention of FSD for female patients with SS is essential to improve their quality of life.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2463413"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simvastatin-loaded liposomal nanoparticles as treatment for adenomyosis in a patient-derived xenograft mouse model: a pilot study.","authors":"Rachel Michel, Kathleen L Vincent, Gregory W Kirschen, Massoud Motamedi, Jamal Saada, Jinping Yang, Bulent Ozpolat, Gokhan S Kilic, Mostafa A Borahay","doi":"10.1080/01443615.2025.2502083","DOIUrl":"10.1080/01443615.2025.2502083","url":null,"abstract":"<p><strong>Background: </strong>Adenomyosis is a common gynaecological condition where ectopic endometrial glands and stroma grow within the myometrium. This condition has a high clinical burden impacting those afflicted with debilitating symptoms including heavy painful periods. Simvastatin is an oral hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, typically used to treat hyperlipidaemia. Simvastatin has recently shown promise for treating gynaecological conditions such as endometriosis and uterine fibroids with nanoliposomal formulations demonstrating improved efficacy. In this pilot study, we tested simvastatin-loaded liposomal nanoparticles on xenografted adenomyosis tissues in a patient-derived mouse model.</p><p><strong>Methods: </strong>We surgically inserted oestrogen/progesterone pellets into mice, followed by adenomyosis tissue xenografts 15 days later. Mice were then randomised into three groups: control, simvastatin, and simvastatin-loaded liposomal nanoparticles (simvastatin-NP). We quantified the changes in adenomyosis xenograft size weekly using a calliper as well as ultrasound imaging 28 days after treatment, prior to sacrifice. We also measured the proliferation of biomarker Ki67 in the xenografted tissues using immunohistochemistry after animal sacrifice.</p><p><strong>Results: </strong>Treatment with simvastatin-NP significantly reduced volume and weight of adenomyosis xenografts while attenuating Ki67 expression when compared to the control and simvastatin groups. <b><i>Conclusions:</i></b> This pilot study demonstrates promising improved efficacy of simvastatin delivered via liposomal nanoparticles. However, larger studies are needed to fully explore the potential of simvastatin-NP in adenomyosis.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2502083"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing postpartum hemorrhage training by integrating case-problem based learning with simulation: a quasi experimental study.","authors":"Yike Yang, Zhichao Guo, Xiaoyue Guo, Yangyu Zhao","doi":"10.1080/01443615.2024.2443617","DOIUrl":"https://doi.org/10.1080/01443615.2024.2443617","url":null,"abstract":"<p><strong>Background: </strong>Postpartum haemorrhage (PPH) is the leading cause of maternal mortality worldwide, and effective training in PPH rescue techniques is crucial. This study aims to evaluate the effectiveness of combining case-based learning (CBL) and problem-based learning (PBL) with simulation teaching methods in improving midwifery trainees' technical proficiency in managing PPH.</p><p><strong>Methods: </strong>This quasi-experimental study involved 76 trainees who received PPH training at Peking University Third Hospital from March to July 2023. They were divided into two groups: the control group (<i>n</i> = 50) followed traditional simulation training methods, and the research group (<i>n</i> = 26) used a combination of CBL-PBL and scenario simulation. After the training, all participants completed a theoretical examination and questionnaire to assess their satisfaction with the program and self-assessment of clinical management skills in PPH. Statistical analysis was performed using unpaired t-tests and chi-square tests to compare the groups.</p><p><strong>Results: </strong>The combination of CBL-PBL and scenario simulation was highly satisfactory compared to traditional simulation training, significantly enhancing self-assessed skills in clinical thinking (100% vs. 61.8%, <i>p</i> = .03), operant skills related to PPH (100% vs. 57.4%, <i>p</i> < .01), relevant knowledge pertaining to PPH (100% vs. 58.7%, <i>p</i> < .01), and management abilities (97.1% vs. 39%, <i>p</i> < .01) among midwifery trainees in the research group, who also scored significantly higher on post-training assessments of PPH knowledge than control groups(91.7 ± 6.0 vs 76.0 ± 7.1, <i>p</i> < .01). A majority of trainees expressed a preference for regular simulation exercises (98.7%) and detailed discussions on PPH cases (93.4%) in future training sessions.</p><p><strong>Conclusion: </strong>Combining CBL-PBL with simulation practice is a more effective teaching method for PPH management training in maternity staffs with a certain level of clinical experience, compared to traditional methods. Future studies should explore the implementation of regular PPH rescue skill training in real clinical settings to support these findings.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2443617"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic internal iliac artery balloon for caesarean in placenta accreta reduces haemoglobin drop - Retrospective comparative study.","authors":"Yuen Yee Yannie Chan, Ellen Lok-Man Yu, Tsz Kin Lo","doi":"10.1080/01443615.2025.2495600","DOIUrl":"https://doi.org/10.1080/01443615.2025.2495600","url":null,"abstract":"<p><strong>Background: </strong>This study compared maternal and foetal outcomes of managing placenta accreta spectrum (PAS) disease with and without prophylactic internal iliac balloon occlusion (IIABO) at a tertiary hospital between 2002 and 2021.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with confirmed PAS disorder, comparing maternal and foetal outcomes between those who underwent IIABO before caesarean delivery and those who did not, both receiving standardised multidisciplinary care. Primary outcomes included perioperative haemoglobin drop. Secondary outcomes included estimated blood loss, transfusion rate, operative duration, ICU stay, hysterectomy rates, and newborns' Apgar scores.</p><p><strong>Results: </strong>Thirty-one antenatally diagnosed PAS patients were analysed (IIABO <i>n</i> = 21, non-IIABO <i>n</i> = 10). Over 90% had prior caesarean deliveries. IIABO is associated with lower intraoperative haemoglobin drop (<i>p</i> < .001) and higher postoperative haemoglobin (<i>p</i> = 0.047). The linear regression model demonstrated that IIABO and classical caesarean significantly reduced intraoperative blood loss (<i>p</i> = 0.019). No differences were seen in operative time, ICU stay, hysterectomy rates, or newborn Apgar scores. No IIABO-related complications were reported.</p><p><strong>Conclusion: </strong>Prophylactic IIABO during caesarean delivery for PAS is associated with less haemoglobin drop and higher postoperative haemoglobin. IIABO under local anaesthesia was feasible, possibly reducing risks tied to extended general anaesthesia. Larger studies are recommended to support the role of IIABO in PAS disorders.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2495600"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long noncoding RNA CCDC144NL-AS1: prognosis significance and potential biological functions in cervical carcinoma.","authors":"Xuemei Hu, Yulong Wang, Hongyu Guo, Yuzhen Guo","doi":"10.1080/01443615.2025.2463416","DOIUrl":"10.1080/01443615.2025.2463416","url":null,"abstract":"<p><strong>Background: </strong>Recent research has shown that long noncoding RNA (lncRNA) performs a critical regulatory function across multiple malignancies. The involvement of RNA in the progression of multiple human cancer types has been elucidated; however, there is limited understanding regarding the importance of the lncRNA CCDC144NL-AS1 in cervical carcinoma (CC).</p><p><strong>Methods: </strong>CCDC144NL-AS1 expression was measured in 86 CC samples by RT-PCR. CC cell lines were engineered with CCDC144NL-AS1 overexpression using plasmid vectors, allowing for the exploration of its impact on the migration of tumour cells. Additionally, we studied how CCDC144NL-AS1 impacts epithelial-mesenchymal transition signalling, focusing on its expression levels and functional roles.</p><p><strong>Results: </strong>CCDC144NL-AS1 expression showed a notable increase in gynaecological tumour specimens and cell lines in contrast to normal control (all <i>p</i> < 0.05). This expression exhibited relationships with the clinical stage (<i>p</i> = 0.003), histologic grade (<i>p</i> = 0.020), and lymph node metastasis (<i>p</i> = 0.013). Additionally, survival rates were found to be lower in CC patients with increased CCDC144NL-AS1 expression, as confirmed by multivariate analysis, compared to individuals with reduced expression levels (Hazard ratio = 1.960; <i>p</i> = 0.020). CCDC144NL-AS1 also facilitated increased cell viability and migration while triggering the EMT pathway. Xenograft models demonstrated that lower CCDC144NL-AS1 levels resulted in smaller tumours and longer survival (median survival: 43.5 vs. 35.5 days, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>CCDC144NL-AS1 significantly influences cell migration, making it a promising target for CC treatment and a valuable prognostic indicator.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2463416"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Life's Essential 8 and mortality in urinary incontinence among US female adults.","authors":"Xiaoping Xu, Ruiqian Liu","doi":"10.1080/01443615.2025.2512774","DOIUrl":"https://doi.org/10.1080/01443615.2025.2512774","url":null,"abstract":"<p><strong>Background: </strong>Urinary incontinence (UI) may be associated with cardiovascular disease. Life's Essential 8 (LE8), a recently updated measure of cardiovascular health (CVH), has been investigated for its association with all-cause and cardiovascular mortality among US female adults with UI.</p><p><strong>Methods: </strong>This population-based retrospective cohort study utilised data from 6314 US female adults aged ≥20 years with UI (weighted population: 4.14 million) derived from the National Health and Nutrition Examination Survey (NHANES) 2005-2018, along with their linked mortality data up to December 2019. The LE8 metric, ranging from 0 to 100, was categorised into low, moderate, and high levels. UI status was determined by self-report. Multivariable Cox proportional hazards regression models were employed to assess the associations between LE8 and both all-cause and cardiovascular disease (CVD) mortality. A stratified analysis and sensitivity analysis were also conducted.</p><p><strong>Results: </strong>During a median follow-up period of 92 months (with a maximum of 180 months) among US adult females with UI, 684 all-cause deaths were recorded, including 169 deaths attributable to cardiovascular disease. A 10-point increase in the LE8 score was associated with a 14% reduction in the risk of all-cause mortality (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.79-0.93) and a 17% reduction in the risk of CVD mortality (HR, 0.83; 95% CI, 0.71-0.97). Physical activity has the most significant effect. In the stratified subgroups and sensitivity analyses, the results remained robust.</p><p><strong>Conclusions: </strong>An elevated LE8 score was independently correlated with reduced risks of all-cause and cardiovascular mortality among US female adults with UI. Future prospective studies are required to further strengthen our findings.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2512774"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of vaginal micronised progesterone tablet and gel for <i>in vitro</i> fertilisation.","authors":"Soo Jin Han, Hoon Kim, Yun Soo Hong, Sung Woo Kim, Seung-Yup Ku, Chang Suk Suh","doi":"10.1080/01443615.2024.2436518","DOIUrl":"https://doi.org/10.1080/01443615.2024.2436518","url":null,"abstract":"<p><strong>Background: </strong>Luteal phase support (LPS) with progesterone is a generally accepted practice after controlled ovarian stimulation, although the best protocols for LPS have been debated. We aimed to compare the efficacy of vaginal micronised progesterone tablets and 8% vaginal progesterone gel for LPS using real-world data.</p><p><strong>Methods: </strong>This retrospective study included 459 <i>in vitro</i> fertilisation/intracytoplasmic sperm injection cycles performed at a university hospital from 2005 to 2019. All cycles were followed by fresh day 3 embryo transfer (ET). Either progesterone tablets or gel was used for LPS. To control the conditional probability of progesterone tablets or gel use, doubly robust inverse probability weighting composed of inverse-probability-of-treatment weighting (IPTW) and regression adjustment (RA). IPTW was performed based on the covariate balancing propensity score (CBPS).</p><p><strong>Results: </strong>Progesterone tablets were administered in 65 cycles, and progesterone gel was administered in 394 cycles. Women who used progesterone tablets were more likely to be older (36 vs. 34 years), have primary infertility (78.5% vs. 61.4%), use gonadotropin-releasing hormone antagonist (60.0% vs. 43.2%), and have fewer retrieved oocytes (seven vs. nine) and transferred embryos (two vs. three) than participants who used progesterone gel. After IPTW-CBPS and RA analysis for the above covariates, the adjusted odds for clinical pregnancy in women who used progesterone tablets were 1.10 times compared with women who used progesterone gel; however, the 95% confidence interval did not reach statistical significance (0.96-1.26).</p><p><strong>Conclusions: </strong>Clinical pregnancy was comparable between vaginal micronised progesterone tablets and vaginal progesterone gel for LPS in fresh day 3 ET cycles.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2436518"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of treatment failure of tubal pregnancy with single-dose methotrexate regimen - a systematic review and meta-analysis.","authors":"Lili Tang, Sipei Nie, Ling Ling, Qian Zhu","doi":"10.1080/01443615.2024.2447997","DOIUrl":"10.1080/01443615.2024.2447997","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancies represent a potentially life-threatening medical emergency, with 95% being tubal. This meta-analysis aimed to identify early predictors for single-dose methotrexate (MTX) treatment failure in tubal pregnancies.</p><p><strong>Methods: </strong>A literature search was conducted across several databases from their inception to December 2023, with references in the selected studies manually reviewed. 14 studies involving 2,804 patients were included in this meta-analysis.</p><p><strong>Results: </strong>The results revealed that higher serum beta-human chorionic gonadotropin (β-hCG) levels on Day 1 (SMD = 1.25, 95% CI 0.73-1.77), foetal cardiac activity presence (OR = 12.64, 95% CI 3.15-50.75), adnexal mass presence (OR = 4.66, 95% CI 2.02-10.74), yolk sac presence (OR = 5.35, 95% CI 2.33-12.27), thicker endometrium (MD = 1.74, 95% CI 0.30-3.19), more number of previous ectopic pregnancies (MD = 0.21, 95% CI 0.13-0.30), history of pelvic inflammatory disease (PID) (OR = 3.97, 95% CI 2.02-7.79), higher progesterone levels on Day 1 (SMD = 0.22, 95% CI 0.07-0.36), a higher 48-hour pre-treatment increment in serum β-hCG percentage (MD = 11.46, 95% CI 2.95-19.98), and a higher percentage of serum β-hCG change from Day 4 to Day 0/1 (SMD = 2.58, 95% CI 1.02-4.14) were early predictive factors for treatment failure of tubal pregnancy with the MTX single-dose regimen.</p><p><strong>Conclusions: </strong>This review clarifies early predictive factors for treatment failure with the MTX single-dose regimen in tubal pregnancies. High-risk tubal pregnancies likely to fail MTX monotherapy could be identified earlier, allowing for personalised intervention measures to be implemented at an early stage to prevent harm and improve treatment outcomes.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2447997"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility preservation counselling and practice among women with lymphomas: a retrospective study.","authors":"Mariola Hernández Martínez, César Lizán Tudela, Blanca Carreras Gamón, Laura Gregori Navarro","doi":"10.1080/01443615.2025.2449679","DOIUrl":"10.1080/01443615.2025.2449679","url":null,"abstract":"<p><strong>Background: </strong>Research on fertility preservation among women diagnosed with lymphoma is very limited. We aimed to assess the receipt of fertility preservation information and use of fertility preservation among women diagnosed with lymphoma.</p><p><strong>Methods: </strong>This was a retrospective, single-centre study. Patients with Hodgkin and non-Hodgkin lymphoma were screened from the electronic medical records of individuals who attended the Haematology Department at the study site between 2000 and 2018 and were followed-up for obstetric outcomes and onset of menopause until December 2023.</p><p><strong>Results: </strong>Forty-three patients had available electronic health records. Overall, 13 (36.1%) of the 36 patients ≤45 years old received fertility preservation counselling; it was more frequent among nulliparous women (11/23, 47.8%), women aged ≤35 years (11/26, 42.3%), and those diagnosed in the latest study period from 2015 to 2018 (9/16, 56.3%). Of the 13 patients who were informed about fertility preservation, 2 patients refused this intervention, and fertility preservation was contraindicated for 3 patients, leading to a total of eight women who underwent fertility preservation strategies: six underwent ovarian cortex cryopreservation, and two underwent oocyte vitrification. Among the participants aged ≤45 years, 10 (27.8%) had at least one live birth after diagnosis. Fifteen (34.9%) of the 43 participants exhibited amenorrhoea after the initiation of chemotherapy, including 4 women ≤35 years of age. The median (range) age at menopause in this series was 45 (27-50) years.</p><p><strong>Conclusion: </strong>Even though the situation appears to have improved in recent years, we are far from reaching the target of all women with lymphoma who are of reproductive age receiving fertility preservation counselling before initiating chemotherapy.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"45 1","pages":"2449679"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}