Journal of Obstetrics and Gynaecology最新文献

{"title":"PCOS to PMOS: a critical appraisal of the proposed name change.","authors":"Namrata Gaikwad, Abha Govind","doi":"10.1080/01443615.2026.2705089","DOIUrl":"https://doi.org/10.1080/01443615.2026.2705089","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2705089"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental 3D Doppler and uterine artery Doppler for predicting adverse outcomes in placenta accreta: a retrospective cohort study.","authors":"Man Gao, Yanan Yang, Yanyan Peng, Yu Liang, Yingfeng Liu, Liman Fu","doi":"10.1080/01443615.2026.2703752","DOIUrl":"https://doi.org/10.1080/01443615.2026.2703752","url":null,"abstract":"<p><strong>Background: </strong>Placenta accreta spectrum (PAS) poses high maternal morbidity from adverse pregnancy outcomes (APOs), yet uterine artery Doppler has limited predictive value, and the additive role of three‑dimensional power Doppler (3D‑PD) remains unclear.</p><p><strong>Methods: </strong>A retrospective study was carried out on 180 patients with PAS, who were divided into an APO group (<i>n</i> = 76) and a non-APO (<i>n</i> = 104) group. Placental 3D-PD parameters, including the vascularisation index (VI), flow index (FI) and vascularisation-flow index (VFI), as well as uterine artery flow parameters, including the pulsatility index (PI), resistance index (RI) and systolic/diastolic ratio (S/D), were collected and compared between the two groups. Multivariate logistic regression was used to identify independent predictors. Internal validation was performed with 1,000 bootstrap resamples, and calibration was evaluated using the Hosmer-Lemeshow test. The predictive value of each parameter and of a combined model was assessed using receiver operating characteristic curves.</p><p><strong>Results: </strong>The overall incidence of APOs in patients with PAS was 42.22% (76/180). The APO group had higher VI, FI and VFI values but lower PI, RI and S/D values than the non-APO group (all <i>p</i> < 0.05). After adjusting for gestational age at delivery, all six parameters remained independent predictors (<i>p</i> < 0.05). Each single parameter showed only poor predictive value, with AUCs ranging from 0.604 to 0.656. The combined model based on all six parameters demonstrated better predictive ability (AUC = 0.793; 95% confidence interval: 0.726-0.859), with a sensitivity of 83.65% and a specificity of 61.84%.</p><p><strong>Conclusion: </strong>APOs in patients with PAS are associated with increased placental vascularisation and reduced uterine artery resistance. The combined model outperforms any single parameter and may aid in early risk stratification.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2703752"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of lifestyle, surgery, and semaglutide for weight management in endometrial cancer: a prospective observational study.","authors":"Yuxuan Wei, Yuanyuan Gong, Jingjing Gong, Hui Zeng, Zhaohui Zhong, Yingchao Xiong, Xiaodan Li","doi":"10.1080/01443615.2026.2701996","DOIUrl":"10.1080/01443615.2026.2701996","url":null,"abstract":"<p><strong>Background: </strong>To compare sleeve gastrectomy, semaglutide therapy, and the Diet, Exercise, Accompany and Refresh (DEAR) weight management programme for weight control, metabolic improvement, and oncological outcomes in patients with endometrial cancer receiving fertility-sparing treatment.</p><p><strong>Methods: </strong>In this prospective observational study, 53 patients received sleeve gastrectomy (<i>n</i> = 10), semaglutide therapy (<i>n</i> = 23), or the DEAR programme (<i>n</i> = 20) after multidisciplinary assessment and shared decision-making. Anthropometric and metabolic measures and tumour response were assessed over two years.</p><p><strong>Results: </strong>At 1 year, all groups lost weight; the sleeve gastrectomy group had the largest body mass index reduction compared with the semaglutide group (difference = 4.04 kg/m², <i>p</i> < 0.05) and the DEAR group (difference = 2.12 kg/m², <i>p</i> < 0.05). By 2 years, weight regain was less frequent in the DEAR group (14.3%) than in the semaglutide (55.6%) and sleeve gastrectomy (66.7%) groups (<i>p</i> = 0.037). The DEAR group showed more stable metabolic improvements and the highest complete tumour remission rate (85.0%), followed by the semaglutide group (73.9%) and the sleeve gastrectomy group (60.0%).</p><p><strong>Conclusion: </strong>Sleeve gastrectomy produced rapid short-term weight loss, whereas the DEAR programme showed better medium-term weight maintenance, metabolic stability, and tumour response. Integrated lifestyle support may be a useful medium-term strategy for patients seeking fertility preservation.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2701996"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical and subjective short-term outcomes of transperineal tape procedures and Burch colposuspension: a prospective ultrasound study.","authors":"Gizem Boz Izceyhan, Zeynep Sena Erakkaya, Muzne Elberri, Çetin Kılıççı","doi":"10.1080/01443615.2026.2658325","DOIUrl":"10.1080/01443615.2026.2658325","url":null,"abstract":"<p><strong>Background: </strong>To compare the short-term (three-month) anatomical alterations and subjective outcomes of transobturator tape (TOT), tension-free vaginal tape (TVT), and Burch colposuspension using transperineal ultrasound (TPUS).</p><p><strong>Methods: </strong>This prospective observational study, reported in accordance with TREND guidelines, included 80 women with stress urinary incontinence (SUI) (TOT: <i>n =</i> 30; TVT: <i>n =</i> 30; Burch: <i>n =</i> 20) assigned based on institutional protocols. Pre- and postoperative assessments included TPUS (alpha/beta angles, bladder neck descent) and validated questionnaires (UDI-6, IIQ-7). Multivariate regression models were utilised to adjust for baseline age, BMI, and parity.</p><p><strong>Results: </strong>All procedures resulted in significant intra-group anatomical and symptomatic improvements (<i>p</i> < 0.05). In adjusted analyses, the TVT procedure was associated with a significantly greater reduction in the alpha angle (<i>p</i> = 0.046). Furthermore, TVT showed a statistically significant association with greater UDI-6 score improvement compared with the Burch procedure (Adjusted OR: 0.04; 95% CI: 0.003-0.71; <i>p</i> = 0.032). Non-responder analysis confirmed that attrition bias was minimal (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>TOT, TVT, and Burch procedures are all effective in providing significant short-term restoration of anatomy and symptoms. While TVT demonstrated more pronounced anatomical and subjective gains in adjusted models, clinical satisfaction remains high across all techniques. Findings should be interpreted with caution due to the observational design and short follow-up.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2658325"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin in preeclampsia prevention: a narrative Review of clinical and mechanistic evidence.","authors":"Kejie Wu, Jinlai Meng","doi":"10.1080/01443615.2026.2747011","DOIUrl":"https://doi.org/10.1080/01443615.2026.2747011","url":null,"abstract":"<p><strong>Background: </strong>Low-dose aspirin reduces preterm preeclampsia, but its mechanisms remain uncertain because circulating concentrations of unchanged aspirin are substantially lower than those used in many experimental studies. This narrative review evaluates proposed mechanisms according to their clinical relevance and compatibility with prophylactic exposure.</p><p><strong>Methods: </strong>Evidence concerning platelet inhibition, placentation, inflammatory resolution, angiogenic regulation and epigenetic modification was narratively reviewed, with particular attention to experimental concentrations, model limitations and clinical pharmacological findings.</p><p><strong>Results: </strong>Clinical pharmacology most strongly supports irreversible platelet cyclooxygenase-1(COX-1) inhibition and sustained suppression of thromboxane A₂ (TXA₂) generation. These effects may improve uteroplacental perfusion and secondarily influence placental inflammation and endothelial regulation. Experimental studies suggest that aspirin may promote trophoblast migration and survival through protein kinase B (Akt), mitogen-activated protein kinase (MAPK) and cAMP response element-binding protein (CREB) signalling and attenuate nuclear factor kappa B (NF-κB) activation, but these effects were generally observed at concentrations exceeding clinical exposure. Aspirin-associated increases in circulating 15-epi-lipoxin A₄ (15-epi-LXA₄) and interleukin-10(IL-10) and decreases in interleukin-8(IL-8) provide translational evidence for a pro-resolving response, without establishing a direct placental effect. Preclinical studies suggest effects on soluble fms-like tyrosine kinase-1(sFlt-1) and placental growth factor (PlGF)-related pathways; however, a secondary analysis of the Aspirin for Evidence-Based Preeclampsia Prevention (ASPRE) analysis found no significant difference in PlGF trajectories between aspirin and placebo. Epigenetic mechanisms remain exploratory.</p><p><strong>Conclusions: </strong>Aspirin prophylaxis is most plausibly anchored in sustained platelet COX-1 inhibition, with potential indirect effects on perfusion, inflammation and angiogenic regulation. Direct trophoblast and epigenetic effects at clinical exposure levels remain unproven. Future studies should integrate placental drug exposure with platelet pharmacodynamic and longitudinal placental measurements.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2747011"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SHC1 affects oestrogen-driven differentiation and barrier function of vaginal epithelial cells via EGFR/Ras/ERK pathway.","authors":"Jing Li, Juan Li, Darong Mou, Dongyan Li","doi":"10.1080/01443615.2026.2732092","DOIUrl":"https://doi.org/10.1080/01443615.2026.2732092","url":null,"abstract":"<p><strong>Background: </strong>Vaginal atrophy (VA), a common condition associated with oestrogen deficiency, significantly impacts women's quality of life. Src homology 2 domain-containing transforming protein 1 (SHC1) is implicated in various hormone-dependent processes. This project aims to investigate whether oestrogen promotes the proliferation, migration and differentiation of vaginal epithelial cells by regulating SHC1, and delineates the underlying mechanism.</p><p><strong>Methods: </strong>An ovariectomised (OVX) mouse model of VA was established and treated with 17β-estradiol (E2). Human vaginal epithelial VK2/E6E7 cells were stimulated with E2 (dose-dependent), transfected with SHC1 overexpression (OE-SHC1), SHC1 knockdown (sh-SHC1) or epidermal growth factor receptor (EGFR) overexpression (OE-EGFR) plasmids. Histological and immunohistochemical analyses were performed on vaginal tissues. Cellular proliferation and migration were assessed via CCK-8 and wound healing assays, respectively. Western blot analysed cellular/tissue proteins (differentiation/barrier markers, Ras/ERK pathway components).</p><p><strong>Results: </strong>E2 upregulated SHC1 expression both in atrophic vaginal tissue and in VK2/E6E7 cells in a dose-dependent manner. SHC1 overexpression enhanced, while its knockdown attenuated, E2-induced cell proliferation, migration, and the expression of differentiation (Keratin 6a (krt6a), Keratin 13 (krt13)) and barrier (E-cadherin, occludin) markers. Mechanistically, SHC1 mediated the effects of E2 by acting as an adaptor of EGFR and subsequent activation of the downstream Ras/ERK pathway. EGFR overexpression rescued SHC1 deficiency phenotypes in E2-treated VK2/E6E7 cells. In OVX mice, SHC1 knockdown reversed E2-mediated restoration of vaginal epithelial architecture, proliferation (Ki67) and Ras/ERK signalling.</p><p><strong>Conclusions: </strong>SHC1 is a critical mediator of E2-induced vaginal epithelial homeostasis through the EGFR/Ras/ERK axis, representing a potential downstream therapeutic target for intervention in VA, particularly via localised delivery strategies.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2732092"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive outcomes after hysteroscopic myoma resection and septal surgery in infertile women - a retrospective study.","authors":"Lara Drogosch, Jana Adams, Gohar Rahimi, Bernd Morgenstern","doi":"10.1080/01443615.2026.2693660","DOIUrl":"https://doi.org/10.1080/01443615.2026.2693660","url":null,"abstract":"<p><strong>Background: </strong>To evaluate reproductive outcomes after hysteroscopic myoma resection and septal surgery in women with primary or secondary infertility.</p><p><strong>Methods: </strong>This monocentric retrospective cohort study included women with infertility who underwent hysteroscopic myoma resection or septal surgery between 2014 and 2021. Patients with uterine septa were divided into three groups, depending on the extent of the septa (mild, moderate and sub-/total). All procedures were performed by a single experienced surgeon. Pregnancy rates and live birth rates before and after surgery were compared.</p><p><strong>Results: </strong>Of 85 women who underwent hysteroscopic surgery, 65 were available for follow-up. After surgery, 55.4% achieved pregnancy and 44.6% had a live birth (<i>p</i> = .001). Live birth rates increased after both septal surgery (14.7 vs. 50%; <i>p</i> = .002; <i>n</i> = 34) and myoma resection (16.1 vs. 38.7%; <i>p</i> = .092; <i>n</i> = 31). In women with uterine septa, live birth rates improved significantly after surgery, independent of septum extent (mild: 16.67% vs. 50%; moderate: 13.64% vs. 50%; sub-/total: 16.67% vs. 50%). Postoperative reproductive treatment increased pregnancy rates (44.44% vs. 63.16%) but did not affect live birth rates (44.44% vs. 44.74%).</p><p><strong>Conclusion: </strong>Hysteroscopic treatment of uterine septa and submucosal fibroids was associated with improved live birth outcomes in women with infertility. These findings suggest that, in suitable cases of infertility, hysteroscopic surgery should be considered.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2693660"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of serum miR-101-3p combined with Doppler ultrasound in polycystic ovarian syndrome: a retrospective study.","authors":"Jing Zhou, Ying Sun","doi":"10.1080/01443615.2026.2697493","DOIUrl":"10.1080/01443615.2026.2697493","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovarian syndrome (PCOS) is a common endocrine disorder with limited diagnostic biomarkers. miR-101-3p is implicated in endocrine regulation and ovarian function, with emerging evidence suggesting its potential as a biomarker for reproductive disorders. This study aimed to explore the diagnostic value of combined detection of serum miR-101-3p and colour Doppler ultrasound parameters for PCOS.</p><p><strong>Methods: </strong>A total of 186 study subjects were enrolled, with samples collected from April 2020 to June 2023. miR-101-3p expression was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The Doppler parameters of the ovary were detected by colour Doppler ultrasound. The Kolmogorov-Smirnov test was used to verify the normality of continuous variables, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic efficacy of single indicators and their combined panel, with <i>P</i> < 0.05 considered statistically significant.</p><p><strong>Results: </strong>Serum miR-101-3p expression was significantly downregulated in PCOS patients compared with the control group (<i>P</i> < 0.001). In PCOS patients, ovarian volume was significantly elevated (<i>P</i> < 0.01), while pulsatility index and resistive index were significantly decreased (both <i>P</i> < 0.05). Additionally, low serum miR-101-3p levels were closely correlated with high luteinising hormone levels in PCOS patients (<i>P</i> < 0.05). ROC curve analysis indicated that the combined panel of miR-101-3p and Doppler parameters achieved an area under the curve (AUC) of 0.947, with a sensitivity of 90.4% and specificity of 85.4%, showing significantly superior diagnostic performance over any single indicator (all <i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>In conclusion, combined detection of serum miR-101-3p and ovarian Doppler parameters exhibits improved diagnostic efficacy for PCOS, representing a promising auxiliary clinical strategy.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2697493"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148829478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement: Knowledge, attitude, and practice of obstetricians towards vaginal birth after caesarean in Egypt.","authors":"","doi":"10.1080/01443615.2026.2697129","DOIUrl":"https://doi.org/10.1080/01443615.2026.2697129","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2697129"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: Can colour Doppler ultrasonography predict the prognosis of endometrial hyperplasia?","authors":"","doi":"10.1080/01443615.2026.2701518","DOIUrl":"https://doi.org/10.1080/01443615.2026.2701518","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2701518"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}