Journal of Obstetrics and Gynaecology最新文献

{"title":"A reading of Good Medical Practice 2024.","authors":"Marwan Habiba","doi":"10.1080/01443615.2026.2618966","DOIUrl":"https://doi.org/10.1080/01443615.2026.2618966","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2618966"},"PeriodicalIF":1.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Association of cannabis use with female infertility.","authors":"Katrina Mark, David A Gorelick","doi":"10.1080/01443615.2025.2569472","DOIUrl":"https://doi.org/10.1080/01443615.2025.2569472","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2569472"},"PeriodicalIF":1.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics analysis implicates ferroptosis and key hub genes in the pathogenesis of endometriosis.","authors":"Jia-Yan Xu, Qin Liu","doi":"10.1080/01443615.2026.2661210","DOIUrl":"10.1080/01443615.2026.2661210","url":null,"abstract":"<p><strong>Objective: </strong>Endometriosis (EMs) is a chronic gynaecological condition characterised by the ectopic growth of endometrial tissue; however, its molecular mechanisms remain insufficiently understood. Ferroptosis, an iron-dependent form of regulated cell death, has been suggested as a potential contributor to its pathogenesis. This study aimed to identify differentially expressed ferroptosis-related genes (DE-FRGs) in EMs through bioinformatics analysis and to explore their underlying molecular mechanisms.</p><p><strong>Methods: </strong>The gene expression datasets GSE7305 and GSE25628 were obtained from the GEO database. Ferroptosis-related genes (FRGs) were extracted from the FerrDb database. DE-FRGs were identified by intersecting differentially expressed genes (DEGs) with FRGs across the two datasets. Protein-protein interaction (PPI) networks were constructed using STRING and Cytoscape software, while core genes were identified through the cytoHubba plugin. Functional enrichment analysis was performed via the KEGG pathway.</p><p><strong>Results: </strong>A total of 11 DE-FRGs were identified, all of which demonstrated consistently upregulated expression in EMs tissues across both datasets. Four core genes - GATA6, KLF2, BGN and AEBP1 - were selected for further analysis owing to their significant enrichment. KEGG analysis indicated that these genes were particularly enriched in the 'taurine and hypo-taurine metabolism' and 'muscle cell cytoskeleton' pathways.</p><p><strong>Conclusion: </strong>This study identified GATA6, KLF2, BGN, and AEBP1 as potential core genes associated with ferroptosis in EMs, highlighting their roles in metabolic and cytoskeletal pathways. These findings provide a novel perspective on the pathogenesis of EMs and suggest new therapeutic targets that warrant further experimental validation.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2661210"},"PeriodicalIF":1.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated non-esterified fatty acids in obese women with late-onset preeclampsia: a cross-sectional study.","authors":"Annisa Dewi Nugrahani, Adhi Pribadi, Muhammad Alamsyah Aziz, Dhanny Primantara Johari Santoso, Bagas Satriyo Wicaksono, Azka Ardian Nugraha, Herlambang Herlambang, Mas Rizky A A Syamsunarno","doi":"10.1080/01443615.2026.2681758","DOIUrl":"https://doi.org/10.1080/01443615.2026.2681758","url":null,"abstract":"<p><strong>Background: </strong>Pre-eclampsia is a pregnancy-specific multisystem disorder and a major cause of maternal and neonatal morbidity and mortality. Late-onset preeclampsia, occurring at or after 34 weeks of gestation, is estimated to account for approximately 70-80% of cases and is more strongly associated with maternal metabolic factors, although placental involvement is not absent and is generally less pronounced. Maternal obesity and altered lipid metabolism may be associated with this phenotype; however, the relationship between non-esterified fatty acids (NEFA) and obesity in late-onset preeclampsia remains unclear.</p><p><strong>Methods: </strong>This cross-sectional study assessed differences and correlations in circulating NEFA levels between obese and normal-weight women with late-onset preeclampsia. Seventy-three women with singleton pregnancies were consecutively recruited, including 44 obese and 29 normal-weight participants classified using WHO Asia-Pacific BMI criteria. Clinical and biochemical data were obtained from medical records and maternal serum NEFA levels were measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses were performed using appropriate parametric or non-parametric tests, and correlations were assessed using Pearson or Spearman analysis.</p><p><strong>Results: </strong>A total of 73 women with late-onset preeclampsia were included (44 obese and 29 normal weight). Serum NEFA levels were significantly higher in obese women compared with normal-weight women (<i>p</i> = .008). BMI showed a weak but statistically significant positive correlation with NEFA levels (<i>r</i> = .23, 95% CI 0.007-0.442; <i>p</i> = .04), indicating a limited association between obesity and circulating NEFA levels within this study.</p><p><strong>Conclusions: </strong>In women with late-onset preeclampsia, circulating NEFA levels were higher in the obese group and were weakly associated with BMI. These findings suggest an association between obesity and circulating NEFA levels within this clinical phenotype. However, due to the cross-sectional design and absence of normotensive control groups, causality and disease specificity cannot be determined. Further studies are needed to clarify the role of NEFA in preeclampsia.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2681758"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed childbearing and reproductive ageing: a narrative review.","authors":"Ding Yang, Huan Huang, Yemei He","doi":"10.1080/01443615.2026.2681760","DOIUrl":"10.1080/01443615.2026.2681760","url":null,"abstract":"<p><strong>Background: </strong>Delayed childbearing is increasingly common worldwide, with more women conceiving at age ≥35 years. This demographic shift intersects with age-related fertility decline, affecting natural conception, assisted reproductive technology (ART) outcomes and perinatal health.</p><p><strong>Methods: </strong>We conducted a narrative review based on structured searches of PubMed, Embase and Web of Science (2015-2025), supplemented by landmark earlier studies. We included peer-reviewed original research, systematic reviews, meta-analyses and clinical guidelines. Findings were synthesised narratively.</p><p><strong>Results: </strong>Social, economic and cultural factors drive pregnancy postponement, increasing demand for ART. Female reproductive ageing involves declining oocyte quantity and quality, mitochondrial dysfunction, and aneuploidy - reducing fecundability and live birth rates. Advanced maternal age (AMA) elevates risks of gestational diabetes, hypertensive disorders, preterm birth, foetal growth restriction, stillbirth and congenital anomalies. Advanced paternal age independently contributes to miscarriage, preterm birth and offspring neurodevelopmental risks via epigenetic alterations and <i>de novo</i> mutations. Donor oocytes partially offset embryonic decline, but uterine ageing persists, especially after 45 years. Social oocyte freezing offers age-dependent efficacy, with optimal cost-effectiveness when performed in the early 30s.</p><p><strong>Conclusions: </strong>The health challenges of delayed childbearing may stem from a fundamental mismatch between enabling societal structures and immutable biological timelines. Clinical practice should adopt proactive, age-stratified care that includes preconception education, timely ART, risk-adapted obstetric management and advocacy for supportive social policies.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2681760"},"PeriodicalIF":1.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second stage labour duration and pelvic floor outcomes in primiparous women delivering macrosomic foetuses: a prospective study.","authors":"Jiaxi Jin, Yunlong Fan, Minyuan Wang, Jun Wu, Jun Zhu, Haibo Ruan","doi":"10.1080/01443615.2026.2640272","DOIUrl":"10.1080/01443615.2026.2640272","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association between the duration of the second stage of labour (SSL) and early postpartum pelvic floor dysfunction (PFD) in primiparous women delivering macrosomic foetuses.</p><p><strong>Methods: </strong>200 eligible primiparous women were stratified by SSL duration into Group A (t ≥ 3h), Group B (2h ≤ t < 3h), and Group C (t < 2h). At six weeks postpartum, transperineal ultrasound was performed to determine bladder neck position and levator ani hiatus (LAH) area. Pelvic floor muscle (PFM) strength was evaluated using the Oxford scale, while PFM function was measured via vaginal pressure testing. The occurrences of stress urinary incontinence (SUI) and pelvic organ prolapse (POP) were recorded.</p><p><strong>Results: </strong>The incidence of POP was significantly higher in Group A (23.33%) compared with Group B (6.67%) and C (5%) (<i>P</i> < 0.05). Weak PFM strength was observed in 56.67% of women in Group A versus 21.67% and 21.25% in Groups B and C, respectively (P < 0.05). Vaginal pressure in Group A (class I fibres: 61.38 ± 4.97; class II fibres: 80.63 ± 3.18) was markedly lower than in Group B (I: 78.35 ± 5.08; II: 93.73 ± 4.39) and C (I: 76.55 ± 4.49; II: 92.10 ± 4.40) (<i>P</i> < 0.001). Muscle fatigue was notably higher in Group A (I: 8.65 ± 0.95; II: 3.98 ± 0.65) compared with Group B (I: 4.78 ± 0.61; II: 2.28 ± 0.49) and C (I: 4.25 ± 0.56; II: 2.53 ± 0.55) (P < 0.001). LAH area during Valsalva was significantly larger in Group A (25.48 ± 3.77) than in Groups B (18.55 ± 2.87) and C (17.68 ± 2.72) (<i>P</i> < 0.001), with corresponding LAH expansion rate of 75%, 40%, and 43.75% (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>A prolonged SSL (≥ 3 h) is associated with weaker PFM strength, greater muscle fatigue, enlarged levator hiatus, and a higher incidence of POP in primiparous women delivering macrosomic foetuses.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2640272"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hysteroscopic resection of a submucosal fibroid: hints and tips for a successful procedure.","authors":"Thomas Mosedale, Ee Thong Lim, Nikolaos Tsampras","doi":"10.1080/01443615.2026.2710389","DOIUrl":"https://doi.org/10.1080/01443615.2026.2710389","url":null,"abstract":"<p><p>The authors present a case of a successful two-stage hysteroscopic resection of a submucosal fibroid and share helpful hints and tips for a successful procedure.A 41 year old female presented with subfertility and heavy, prolonged periods. An MRI scan confirmed a submucosal fibroid measuring 40 mm arising from the posterior wall and projecting in the endometrial cavity by more than 50% (FIGO type 1). A hysteroscopic resection removed approximately 70% of the fibroid. The procedure had to be stopped due to loss of pressure and suboptimal view. Following a course of Prostap, a second hysteroscopic procedure was undertaken 3 months later successfully resecting the remainder of the fibroid.The video demonstrates the importance of case selection with good preoperative planning and imaging, e.g., MRI, to assess the feasibility of resection. Large fibroids extending towards the serosa of the uterus may not be suitable cases for hysteroscopic resection. There is discussion about optimal dilation of the endocervical canal, improving visualisation and trouble shooting techniques if this is suboptimal during the operation. Attention is also given to safe surgical technique and the use of a post-surgical adhesion prevention barrier. Reference is made to the BSGE/ESGE guidance on fluid management and systems to prevent overload, as well as consideration of a two-step procedure should be considered for larger fibroids if necessary.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2710389"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement: Relation between <i>Helicobacter pylori</i> infection and severe pre-eclampsia complicated by intrauterine growth restriction in a rural area in Egypt.","authors":"","doi":"10.1080/01443615.2026.2702722","DOIUrl":"https://doi.org/10.1080/01443615.2026.2702722","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2702722"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of ZEB1 and its association with miR-7641 in triple-negative breast cancer: a correlative and in vitro study.","authors":"Wentian Zheng, Dongxing Xu, Huan Yang","doi":"10.1080/01443615.2026.2736876","DOIUrl":"https://doi.org/10.1080/01443615.2026.2736876","url":null,"abstract":"<p><strong>Background: </strong>Triple-negative breast cancer (TNBC) is characterised by the absence of specific therapeutic targets and a high tendency for metastasis. This research explored the clinical relevance and functional interaction between the EMT regulator ZEB1 and the oncomir miR-7641 in the progression of TNBC.</p><p><strong>Methods: </strong>We analysed ZEB1 expression in the triple-negative breast cancer (TNBC) subset of the TCGA-BRCA cohort. A cohort of 60 TNBC patients was used to validate ZEB1 and miR-7641 expression via qRT-PCR and IHC. Associations with clinicopathological parameters were assessed. In vitro, loss-of-function and rescue experiments were conducted in TNBC cell lines to evaluate the functional relationship between miR-7641 and ZEB1.</p><p><strong>Results: </strong>ZEB1 and miR-7641 were co-overexpressed in TNBC tissues and metastatic subgroups. Elevated expression of both molecules is associated with advanced TNM stage, lymphovascular invasion, lymph node metastasis, and reduced survival. Functionally, ZEB1 knockdown inhibited malignant behaviours, but this inhibition was rescued by miR-7641 overexpression, indicating a functional interdependence between the two molecules rather than a simple unidirectional regulatory relationship.</p><p><strong>Conclusions: </strong>The co-overexpression of ZEB1 and miR-7641 characterises an aggressive TNBC subtype with poor prognosis. Our findings reveals a significant positive expression correlation and functional interdependence between miR-7641 and ZEB1 in metastatic TNBC, this molecule pair represents a promising candidate prognostic biomarker panel, while the underlying molecular regulatory mechanism requires further rigorous validation.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2736876"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of chronic pelvic pain after adenomyosis surgery: an observational comparative study.","authors":"Jingjing Zhang, Juan Sun, Xiaohang Ye, Xiaolei Yang, Wei Jin, Le Bu","doi":"10.1080/01443615.2026.2739152","DOIUrl":"10.1080/01443615.2026.2739152","url":null,"abstract":"<p><strong>Background: </strong>Chronic pelvic pain (CPP) remains a common and clinically challenging outcome after uterus-preserving surgery for adenomyosis. Identifying patients at higher risk of postoperative CPP may facilitate individualised postoperative management.</p><p><strong>Methods: </strong>The clinical data of 150 patients with adenomyosis admitted to our hospital from January 2022 to January 2025 were prospectively collected for observation. Uterine volume, Pictorial Blood Loss Assessment Chart (PBAC) score, Cox Menstrual Symptom Scale (CMSS) score, cancer antigen 125 (CA125) level, haemoglobin (Hb) level, and three-level version of the EuroQol five-dimensional questionnaire (EQ-5D-3L) score were recorded preoperatively and at 3 and 6 months postoperatively. Patients were divided into CPP (<i>n</i> = 38) and non-CPP (<i>n</i> = 112) groups based on 6‑month CPP status. Independent risk factors were identified using logistic regression, and a predictive model was developed and validated.</p><p><strong>Results: </strong>Significant improvements were observed in uterine volume, PBAC score, CMSS score, CA125 level, and Hb level postoperatively (<i>P</i> < 0.05). EQ-5D-3L scores improved in usual activities, pain/discomfort, and anxiety/depression (<i>P</i> < 0.05). Preoperative CMSS score, CA125 level, and diffuse-type adenomyosis were identified as independent factors associated with CPP, while preoperative hormonal pre-treatment and postoperative regular hormonal therapy showed significant associations in univariate analysis. The predictive model incorporating these variables showed good calibration (Hosmer-Lemeshow <i>χ²</i> = 15.477, <i>P</i> = 0.051) and strong discrimination (AUC = 0.820, 95% <i>CI</i>: 0.743-0.897). At the maximum Youden's index (0.567), sensitivity was 76.30% and specificity was 80.40% (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>High preoperative CMSS score, high CA125 level, and diffuse-type adenomyosis are independent risk factors for postoperative CPP, while preoperative hormonal pre-treatment and postoperative regular hormonal therapy may be associated with a lower risk of CPP. The predictive model effectively identifies high-risk patients, supporting targeted nursing interventions.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2739152"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}