Journal of Nutrition最新文献

{"title":"Chenodeoxycholic acid (CDCA) alleviates high fat diet-induced lipid deposition via FXR/SHP/PIAS1/SUMO1-dependent SREBP1^K264 SUMOylation in yellow catfish.","authors":"Hua Zheng, Zhi Luo, Xiao-Lei Wei, Chong-Chao Zhong, Chang-Chun Song, An-Gen Yu, Xiao-Ying Tan","doi":"10.1016/j.tjnut.2025.08.039","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.08.039","url":null,"abstract":"<p><strong>Background: </strong>High-fat diet (HFD) induced intestinal lipid accumulation and impaired intestinal health. Chenodeoxycholic acid (CDCA) have a positive effect on attenuating lipid accumulation, but its mechanism in HFD-induced lipid metabolism disorders and intestinal health remained unclear.</p><p><strong>Objectives: </strong>The study explored the mechanism of dietary CDCA alleviating lipid deposition and metabolic changes induced by HFD.</p><p><strong>Methods: </strong>Yellow catfish were fed diets containing control (10.58% lipid, CON), HFD (15.96% lipid), control supplemented with 0.90 g/kg CDCA (CDCA), and HFD supplemented with 0.90 g/kg CDCA (HFD+CDCA) for 10 weeks. Intestinal epithelial cells (IECs) were incubated 24 h in 0.5 mM fatty acid (FA) or 50 μM CDCA after 4 h with or without farnesoid X receptor (fxr), small ubiquitin-related modifier 1 (sumo1) or protein inhibitor of activated signal transducer and activators of transcription 1 (pias1)-siRNA. Triglyceride, quantitative polymerase chain reaction, immunoblotting, electrophoretic mobility shift assay and chromatin immunoprecipitation were performed in intestine and IECs. SUMOylation of sterol regulatory element binding protein 1 (SREBP1) was investigated in IECs and HEK293T cells.</p><p><strong>Results: </strong>Dietary CDCA ameliorated HFD-induced increase of triglyceride concentrations, lipogenesis and FA uptake, and reduction of lipolysis and lipid transport, bile acid absorption and transport, and SUMOylation. FXR activated SUMO1 transcription, which promoted SUMOylation of SREBP1 and inhibited SREBP1 nuclear translocation and accordingly helped CDCA alleviate FA-induced lipid accumulation. Lysine 264 was the important SUMOylation site of SREBP1 by SUMO1, whose SUMOylation reduced binding ability to FA synthase (FAS), acetyl-CoA carboxylase α (ACCα) and stearoyl-CoA desaturase 1 (SCD1) promoters. Activation of FXR enhanced interaction between short heterodimeric partners (SHP) and PIAS1, which promoted SUMO1 attachment to SREBP1, inhibited transcription of fas, accα and scd1.</p><p><strong>Conclusions: </strong>CDCA alleviated HFD-induced lipid accumulation by promoting SUMOylation of SREBP1 at lysine 264 via FXR/SHP/PIAS1/SUMO1 pathway, providing innovative mechanisms for CDCA alleviating HFD-induced lipid accumulation in vertebrates.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances and clues of nutritional adjuvant therapy for Charcot-Marie-Tooth disease.","authors":"Yuqing Chen, Junying Zhu, Mingxin Wang, Qiuling Zhao, Chengyu Huang, Saule Tarjibayeva, Ling Wang, Litao Sun, Ji-Chang Zhou","doi":"10.1016/j.tjnut.2025.09.026","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.09.026","url":null,"abstract":"<p><p>Charcot-Marie-Tooth disease (CMT) is an inherited peripheral neuropathy with significant genetic heterogeneity and clinical variability. Currently, there are no specific drugs to cure the disease, and adjuvant therapies are used to alleviate the symptoms. By supporting the functions of nerves, bones, and muscles, as well as systemic metabolism, personalized intakes of energy and nutrients help slow down disease progression, delay CMT onset, relieve the suffering and pain of patients, and improve their quality of life. This review mainly discussed the research progress on energy and fat-manipulated diets (caloric restriction diet, ketogenic diet, and high-fat diet) and several nutrients (polyunsaturated fatty acids, phospholipids, copper, iron, zinc, selenium, vitamin A/D/E/C, and some vitamin Bs) in the treatment of CMT and related peripheral neuropathies, which is expected to encourage explorations on and applications of healthy diets and nutritional intakes from the viewpoint of clinical nutrition to improve the symptoms of CMT.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacticaseibacillus rhamnosus and Limosilactobacillus reuteri probiotics modulate inflammation, attenuating chronic stress-induced liver injury and behavior in rats.","authors":"Lívia Bruni de Souza, Ana Beatriz P Brandão, Fabiana G Ferreira, Vinicius Guzzoni, Raquel C M F Albuquerque, Lys A Mendes, Rodrigo Yokota, Fernando G Porto, Dulce E Casarini, Flavio Aimbire, Nilsa R Damaceno-Rodrigues, Nádia Bertoncello, Karina R Casali, Tatiana S Cunha","doi":"10.1016/j.tjnut.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.09.011","url":null,"abstract":"<p><strong>Background: </strong>Chronic stress disrupts systemic homeostas and contributes to metabolic, psychiatric, and inflammatory disorders, often involving alterations in gut microbiota. Probiotics such as Lacticaseibacillus rhamnosus (L. rhamnosus) and Limosilactobacillus reuteri (L. reuteri) possess anti-inflammatory properties, but their combined effects on liver health and cognitive function remain underexplored.</p><p><strong>Objective: </strong>Investigate whether supplementation with L. rhamnosus and L. reuteri mitigates inflammation, liver damage, and behavioral changes induced by chronic stress.</p><p><strong>Methods: </strong>Forty-seven male Wistar rats were assigned to four groups: Control (C, n=12), Stress (S, n=12), Control Probiotic (CP, n=11), and Stress Probiotic (SP, n=12). All animals received standard laboratory chow. A combined dose of L. rhamnosus and L. reuteri (1×10⁹ CFU/strain/day) was administered by gavage for 8 weeks. Groups S and SP were subjected to a chronic mild unpredictable stress protocol during weeks 3-5, including stressors such as food/water deprivation, restraint, and light/dark cycle inversion. Behavioral, biochemical, inflammatory, hepatic, metabolic, and physiological parameters were assessed.</p><p><strong>Results: </strong>Probiotic supplementation significantly restored body weight gain (SP: 123.5±17.5% vs. S: 98.2±12.2%) and sucrose preference (SP: 19.96±0.31% vs. S: 14.48±4.16%). SP rats showed reduced levels of corticosterone (SP: 65.2±31.2 ng/mL; S: 188±112.6 ng/mL), noradrenaline (SP: 243±163.6 pg/mL; S: 887.6±476 pg/mL), and dopamine (SP: 318.6±169 pg/mL; S: 582.8±271 pg/mL). Supplementation also decreased ALT levels (SP: 131.6±9.4 U/L vs. S: 147.6±7.5 U/L) and hepatocyte nuclear area (SP: 11.35±1.5 μm² vs. S: 12.63 ± 1.7 μm²). In circulating analyses, probiotics modulated inflammation by reducing IL-1β (SP: 115±43 pg/mg; S: 343±64 pg/mg) and IL-17 (SP: 356.5±93 pg/mg; S: 674±48 pg/mg), while increasing IL-10 levels (SP: 196.5±11 pg/mg; S: 65±28.6 pg/mg) (all p < 0.05).</p><p><strong>Conclusion: </strong>L. rhamnosus and L. reuteri supplementation attenuated the metabolic, hormonal, inflammatory, and behavioral effects of chronic stress and preserved liver integrity in rats.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable Isotopes Can Transform Nutritional Epidemiology - If We Let Them.","authors":"Gunter G C Kuhnle","doi":"10.1016/j.tjnut.2025.09.016","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.09.016","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between dietary pattern networks derived from machine learning algorithms and cardiovascular risk in the NutriNet-Santé cohort.","authors":"Mélina Côté, Joy M Hutchinson, Mathilde Touvier, Bernard Srour, Laurent Bourhis, Benoît Lamarche, Léopold K Fezeu","doi":"10.1016/j.tjnut.2025.09.014","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.09.014","url":null,"abstract":"<p><strong>Background: </strong>Major advances in the fields of data science and machine learning have enabled novel methods, like Gaussian Graphical Models (GGM) and the Louvain algorithm, for identifying dietary patterns (DP).</p><p><strong>Objective: </strong>To identify DP networks using novel computational approaches and to investigate the associations between these DP networks and cardiovascular disease (CVD) risk in a sample of the French population.</p><p><strong>Methods: </strong>A sample of 99 362 participants aged ≥15 years from the NutriNet-Santé cohort was used. Dietary intakes were assessed using ≥2 24-hour dietary records, which were then classified into 42 food groups (grams/day). CVD events were assessed using health questionnaires and subsequently validated based on medical records. GGM were employed with the Louvain algorithm to derive DP networks. GGM are network models that depict relationships among many variables (food groups) based on conditional correlation matrices. The Louvain algorithm extracts non-overlapping communities from large networks. The relationship between the DP networks and CVD incidence was evaluated using proportional hazard Cox models, adjusted for confounding variables.</p><p><strong>Results: </strong>Analyses revealed five distinct DP networks reflecting consumption of: 1- appetizer foods, 2- breakfast foods, 3- plant-based foods, 4- ultra-processed sweets and snacks and 5- healthy foods. Among those, only the DP network of ultra-processed sweets and snacks was associated with greater CVD risk when adjusted for energy and potential confounders including overall diet quality (HR_Q5vsQ1=1.32, 95%CI=1.11 to 1.57, P for trend=0.0002).</p><p><strong>Conclusions: </strong>Results suggest that a DP network reflecting the consumption of ultra-processed sweets and snacks is associated with incident CVD in a sample of the French population, independent of diet quality. The innovative approach to derive empirical DP networks may assist in the identification of food groups that are likely to be consumed together in a population, thereby helping to identify dietary habits to target for the prevention of CVD.</p><p><strong>Study registration: </strong>NCT03335644,https://clinicaltrials.gov/study/NCT03335644.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of vinegar powder on ⁶⁰Coγ radiation-injured mice and its potential mechanism.","authors":"He Huang, Yanling Shi, Xin Liu, Limin Hao, Jiaqing Zhu, Jike Lu","doi":"10.1016/j.tjnut.2025.08.038","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.08.038","url":null,"abstract":"<p><strong>Background: </strong>Ionizing radiation (IR) induces significant oxidative stress, immune dysregulation, and cellular injury. Nevertheless, conventional chemical radioprotectants usually exhibit considerable toxicity and undesirable side effects, thereby restricting their applicability for prolonged administration.</p><p><strong>Objectives: </strong>This study aimed to assess the radioprotective efficacy of vinegar powder (VP), a natural and non-toxic agent with potential for long-term administration.</p><p><strong>Methods: </strong>Male Kunming mice were randomly allocated into six groups and orally administered saline, leucogen (12 mg/kg), and VP at doses of 1.35, 2.7, or 5.4 g/kg for 30 consecutive days. Except for the control group, all mice were subjected to 6 Gy of ⁶⁰Co γ-irradiation to establish a radiation injury model.</p><p><strong>Results: </strong>Compared with the irradiated model group, VP treatment significantly increased white blood cell (WBC) count by 36.69% and bone marrow DNA content by 27.65%, demonstrating potent radioprotective effects. VP also effectively restored radiation-induced depletion of reduced glutathione (GSH) and suppressed malondialdehyde (MDA) accumulation. Histopathological analysis of the spleen and liver revealed that VP administration substantially preserved tissue architecture compared to the radiation-damaged model group. Furthermore, network pharmacology and molecular validation were employed to elucidate VP's radioprotective mechanisms. Bioinformatic analysis indicated that VP primarily modulated the apoptosis and NF-κB (p65) signaling pathways, targeting key molecules including RELA, Bcl-2, IKBKB, PARP1, XIAP, and CFLAR. Western blot analysis confirmed that VP alleviated radiation-induced oxidative damage by suppressing NF-κB (p65) and Bax expression while upregulating Bcl-2.</p><p><strong>Conclusion: </strong>Collectively, VP effectively ameliorated radiation-induced oxidative stress, hematopoietic dysfunction, and tissue damage in mice, highlighting its promise as a novel, naturally derived radioprotective agent.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of serum n-6 polyunsaturated fatty acid concentrations with heart rate-corrected QT and JT intervals in middle-aged males.","authors":"Haleh Esmaili, Behnam Tajik, Tomi-Pekka Tuomainen, Jussi Kauhanen, Sudhir Kurl, Jukka T Salonen, Jyrki K Virtanen","doi":"10.1016/j.tjnut.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.09.012","url":null,"abstract":"<p><strong>Background: </strong>Although n-6 polyunsaturated fatty acids (PUFAs), particularly the main n-6 PUFA linoleic acid (LA), have been shown to be inversely related to cardiovascular disease (CVD) risk, their associations with ventricular repolarization, a marker of ventricular arrhythmias, remain unclear.</p><p><strong>Objective: </strong>This study examined the relationships between serum n-6 PUFA concentrations and heart rate-corrected QT (QTc) and JT (JTc) intervals.</p><p><strong>Methods: </strong>This cross-sectional study included 1,420 Finnish males (aged 42-60 years) free of CVD from the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). Fasting serum n-6 PUFA concentrations were determined by gas chromatography, and electrocardiographic intervals were automatically derived. QTc and JTc intervals were calculated using Bazett's formula. Associations were analyzed using multivariable-adjusted ANCOVA and logistic regression.</p><p><strong>Results: </strong>Higher serum total n-6 PUFA concentrations were associated with shorter QTc and JTc intervals (QTc: extreme-quartile difference = -3.36 ms; 95% CI -6.69, -0.41; P-trend = 0.02; JTc: extreme-quartile difference = -3.38 ms; 95% CI -6.79, -0.27; P-trend = 0.03). Similar inverse associations were found for serum LA (QTc: -4.64 ms; 95% CI -8.00, -1.27; P-trend = 0.009; JTc: -3.99 ms; 95% CI -7.44, -0.54; P-trend = 0.02). The other n-6 PUFAs gamma-linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid showed no significant associations.</p><p><strong>Conclusions: </strong>Higher serum total n-6 PUFA and LA concentrations were associated with shorter QTc and JTc intervals, suggesting a potential protective effect on ventricular arrythmias.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does diet quality change from periconception to 3 years postpartum?: findings from a large U.S. cohort.","authors":"Qianhui Jin, Sara M Parisi, Sharon I Kirkpatrick, Ashley I Naimi, Lisa M Bodnar","doi":"10.1016/j.tjnut.2025.09.007","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.09.007","url":null,"abstract":"<p><strong>Background: </strong>Little is known about diet quality changes during the transition from periconception to postpartum.</p><p><strong>Objective: </strong>We aimed to describe within-person changes in diet quality and related factors from the periconceptional period to 3 years postpartum in a socioeconomically and geographically diverse cohort of U.S. pregnant individuals.</p><p><strong>Methods: </strong>We analyzed data from 4,423 participants in the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be Heart Health Study, followed from 6‒13 weeks of gestation to approximately 3 years postpartum. Usual dietary intake in the 3 months around conception and the 3 months before the postpartum visit were estimated from a food frequency questionnaire. We calculated the proportion of participants meeting food group recommendations from the 2020-2025 Dietary Guidelines for Americans. For each food group, we estimated the proportion of participants with meaningful increases or decreases (defined as an increase or decrease by at least 20% of the recommended intake) in intake density, and determined differences by maternal characteristics.</p><p><strong>Results: </strong>For all food groups, adherence to recommendations was consistently low during both the periconceptional and postpartum periods, with few individuals' diets changing over time. Across food groups, the proportions of participants who improved adherence to recommendations ranged from 4% to 19%, while 7% to 15% of participants experienced declines in adherence. Although few participants met recommendations, meaningful increases were observed in intake densities of vegetables, protein foods, oils, added sugars, and saturated fats (30%-49%), while decreases were common for fruits, grains, dairy, and added sugars (27%-47%). These changes primarily varied according to race and ethnicity, and education.</p><p><strong>Conclusions: </strong>Improving the current food environment and providing sustained, accessible nutritional support that extends into the postpartum period may help individuals of reproductive age meet the Dietary Guidelines, which is crucial for promoting maternal and child health outcomes and reducing related inequities.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A translational model for in vivo intestinal permeability assessment in pigs.","authors":"Evelien Van Rymenant, Christof Van Poucke, Koen Van Loo, Christophe Casteleyn, Bart Ampe, Els Van Pamel, Marc Heyndrickx, Sam Millet","doi":"10.1016/j.tjnut.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.09.013","url":null,"abstract":"<p><strong>Background: </strong>Several non-communicable diseases in humans are associated with increases in intestinal permeability, which can be modulated by dietary factors. To investigate diet-induced changes in intestinal permeability, relevant translational models are required. Pigs are relevant models for nutrition research, gastro-intestinal tract health and intestinal permeability, but intestinal permeability assessment in pigs needs optimization.</p><p><strong>Objective: </strong>The aim of this study was to develop and optimize protocols to induce and quantify intestinal permeability in pigs as a translational model.</p><p><strong>Methods: </strong>We treated pigs (age 10.9 - 13.5 weeks) with indomethacin (3 experiments) or dextran sodium sulfate (DSS, 2 experiments) and assessed intestinal permeability via urinary recovery (baseline to 120h) of orally administered sucralose (SL), erythritol (E) and Co-EDTA. Faecal inflammatory biomarkers and consistency were investigated at baseline, during treatment and during treatment washout. Body weight and villus and crypt dimensions in intestinal tissue were investigated at the end of the experiment.</p><p><strong>Results: </strong>Indomethacin increased intestinal permeability as evidenced by increased cumulative excretion of SL from 332.7±64.2 to 559.8±98.6 mg (p<0.001) and Co-EDTA from 356.2±84.6 to 572.0±82.6 mg (p<0.001) in 120h urine. SL:E ratios increased 1.83 fold and Co-EDTA:E ratios 1.79 fold. Faecal consistency scores and faecal S100-A12 as a biomarker for intestinal inflammation increased while width of duodenal villi decreased from 191.9±10.8 to 166.7±10.1 μm (p =0.014). DSS treatment did not alter intestinal permeability but increased faecal S100-A12 and colon crypt depth from 507.1±33.7 to 657.9±364 76.8 μm (p=0.012) and decreased duodenum villi width from 191.5±17.5 to 154.5±9.8μm (p=0.022).</p><p><strong>Conclusions: </strong>We successfully developed a model to disrupt intestinal health in pigs and optimized methods to assess intestinal permeability and health. We provided recommendations on intestinal permeability assessment protocols relevant for future implementation in pigs and humans. Our model can be used to study the effects of food (components) on intestinal permeability and health.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Postpartum Depressive Symptoms and Complementary Feeding Practices of Infants during the First Twelve Months of Life.","authors":"Xuanxuan Zhu, Jihong Liu, Edward A Frongillo, Anwar T Merchant, Bo Cai, Sara Wilcox","doi":"10.1016/j.tjnut.2025.09.008","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.09.008","url":null,"abstract":"<p><strong>Background: </strong>Complementary feeding is critical to infant growth, yet its association with maternal postpartum depressive symptoms is not well understood.</p><p><strong>Objectives: </strong>To estimate the association between maternal postpartum depressive symptoms and infant complementary feeding.</p><p><strong>Methods: </strong>Data were obtained from the Infant Feeding Practices Study II, a national prospective cohort following mother-infant dyads from late pregnancy throughout the first year of life. Possible postpartum depressive symptoms were measured using the Edinburgh Postpartum Depression Scale. Mothers reported foods fed to infants in the past seven days every 1-1.5 months throughout the first year. The timing of introducing complementary foods throughout the first year (n=2,265), the meal frequency (n=1,990) and dietary diversity scores (n=2,005) between 6-12 months of age were calculated.</p><p><strong>Results: </strong>The mean of postpartum depression scores (6.6 4.5) remained similar across analytical samples. Women with possible postpartum depression were more likely than those without to introduce complementary foods at an earlier time (adjusted hazard ratio: 1.30, 95% Confidence Interval [95% CI]: 1.02, 1.66). The association was weakened among older infants. A one-point higher postpartum depression score was associated with a 10% higher odds of meeting WHO's minimum meal frequency recommendations between 6-12 months of age (adjusted odds ratio: 1.10, 95% CI: 1.03, 1.17). Possible postpartum depressive symptoms were not associated with dietary diversity scores.</p><p><strong>Conclusions: </strong>Women with possible postpartum depression were more inclined to introduce complementary foods earlier, though this association weakened as infants aged. Elevated possible postpartum depressive symptoms were associated with a higher likelihood of meeting WHO recommended minimum meal frequency during 6-12 months of age, while it was not associated with dietary diversity. Interventions aimed at alleviating postpartum depressive symptoms should be designed and implemented in the early postpartum period to prevent the premature introduction of complementary foods.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}