Journal of Nutrition最新文献

{"title":"Water as a Source of Iodine","authors":"Tor A Strand","doi":"10.1016/j.tjnut.2025.01.031","DOIUrl":"10.1016/j.tjnut.2025.01.031","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1017-1018"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intimate Partner Violence and Women’s Dietary Diversity: A Population-Based Investigation in 8 Low- and Middle-Income Countries","authors":"Luissa Vahedi ,&nbsp;Manuela Orjuela-Grimm ,&nbsp;Pui Man (Pamela) Chan ,&nbsp;Sarah R Meyer","doi":"10.1016/j.tjnut.2025.01.024","DOIUrl":"10.1016/j.tjnut.2025.01.024","url":null,"abstract":"<div><h3>Background</h3><div>Intimate partner violence (IPV) poses a significant threat to the well-being of women and girls and is a highly prevalent form of gender-based violence. Evidence regarding the nutritional implications of IPV has focused primarily on intergenerational relationships with child nutrition and growth. There remains a knowledge gap regarding the association with women’s own dietary intake.</div></div><div><h3>Objectives</h3><div>We investigated relationships between past-year IPV (physical, emotional, and sexual) and women's dietary habits, using the Minimum Dietary Diversity for Women tool.</div></div><div><h3>Methods</h3><div>The data sources analyzed were the cross-sectional Demographic and Health Surveys conducted in Cambodia (2021, <em>N</em> = 5618), Nepal (2022, <em>N</em> = 4155), Sierra Leone (2019, <em>N</em> = 3808), Nigeria (2018, <em>N</em> = 8313), Tajikistan (2017, <em>N</em> = 4792), Cote D’Ivoire (2022, <em>N</em> = 3654), Kenya (2022, <em>N</em> = 10,717), and the Philippines (2022, <em>N</em> = 12,240). Utilizing multivariable generalized linear models, we assessed the overall relationship between women’s exposure to IPV and <em>1</em>) the number of food groups consumed and <em>2</em>) minimum dietary diversity.</div></div><div><h3>Results</h3><div>Our results reveal heterogeneous relationship patterns between IPV and women’s diet. Although none of the pooled estimates were significant and there were a large number of nonsignificant associations, IPV was associated with consuming a lower number of total food groups and reduced consumption of a diverse diet in Nigeria, Kenya, and the Philippines. There is evidence that in Tajikistan, physical violence relates to an increased number of food groups consumed.</div></div><div><h3>Conclusions</h3><div>IPV is associated with altered dietary intake patterns within certain low- and middle-income countries. The directionality of associations may depend on local food environments and food access. Further research is needed to clarify the pathways underlying these findings. These pathways may involve impacts of IPV that influence diet and food access, for example, mental health symptoms and disorders and related coping mechanisms.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1236-1245"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional Association of Gut Microbiota-Derived Trimethylamine N-Oxide and its Precursors with Estimated Glomerular Filtration Rate: A Cross-Lagged Cohort Study","authors":"Ruiheng Peng ,&nbsp;Peiying Tian ,&nbsp;Ying Lu ,&nbsp;He Bai ,&nbsp;Yani Wu ,&nbsp;Bin Liang ,&nbsp;Wenli Ruan ,&nbsp;Enmao Cai ,&nbsp;Xiaohong Zhang ,&nbsp;Mingfeng Ma ,&nbsp;Liqiang Zheng","doi":"10.1016/j.tjnut.2025.02.002","DOIUrl":"10.1016/j.tjnut.2025.02.002","url":null,"abstract":"<div><h3>Background</h3><div>It is unclear whether trimethylamine N-oxide (TMAO) and its precursors are bidirectionally associated with kidney dysfunction.</div></div><div><h3>Objectives</h3><div>This study aims to investigate whether increased TMAO and its precursors are linked to decreased estimated glomerular filtration rate (eGFR) and whether reduced eGFR is associated with elevated TMAO and its precursors.</div></div><div><h3>Methods</h3><div>Our study consists of participants with creatinine, TMAO, and its precursors (choline, carnitine, and betaine) repeatedly measured from the Fuxin rural cohort. We utilized cross-lagged panel models to assess the potential bidirectional associations of TMAO and its precursors with eGFR. Age (≥60 and &lt;60 y) and sex-specified associations and interaction effects were examined using multi-group cross-lagged panel models. The Bonferroni method was applied for multiple comparisons.</div></div><div><h3>Results</h3><div>Of 1746 participants [mean age 59.4 ± 9.3 y, 584 (33%) male], TMAO was inversely related to eGFR after 2 years [cross-lagged coefficient, 95% confidence interval: –0.030, –0.058, –0.002, <em>P</em> = 0.035], and eGFR was negatively associated with carnitine after 2 years (–0.138, –0.198, –0.078, <em>P</em> &lt; 0.001). Subgroup analysis showed significant associations between baseline TMAO and eGFR after 2 years in individuals aged 60 and older (–0.061, –0.107, –0.014, <em>P</em> = 0.011) and between baseline eGFR and carnitine after 2 years in individuals aged 60 and older (–0.093, –0.164, –0.022, <em>P</em> = 0.010), in those under 60 (–0.153, –0.226, –0.079, <em>P</em> &lt; 0.001), and in females (–0.154, –0.229, –0.079, <em>P</em> &lt; 0.001). Additionally, baseline eGFR is nominally associated with choline after 2 years in those aged under 60 (0.092, 0.017, 0.167, <em>P</em> = 0.017) and in males (0.114, 0.015, 0.213, <em>P</em> = 0.025).</div></div><div><h3>Conclusions</h3><div>Deceased eGFR is related to elevated serum carnitine concentrations and may be linked to choline. Conversely, elevated TMAO may be linked to reduced kidney function. This provides novel evidence that managing healthy kidney function helps keep TMAO and its precursors at optimal levels, whereas maintaining low TMAO concentrations reduces risk of kidney disease.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1057-1067"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Muscle Building Potential of Vegan Eating for Older Folks","authors":"Takeshi M Barnes ,&nbsp;Nicholas A Burd","doi":"10.1016/j.tjnut.2025.01.029","DOIUrl":"10.1016/j.tjnut.2025.01.029","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1009-1011"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium and Phosphorus Retention and Excretion in Different Strains of Laying Hens during Brooding Period and Key Genes Regulating Calcium and Phosphate Transport","authors":"Ruochen Yang ,&nbsp;Bowen Lu ,&nbsp;Tengchuan Li ,&nbsp;Zhonghao Liu ,&nbsp;Lihong Zhao ,&nbsp;Shimeng Huang ,&nbsp;Qiugang Ma","doi":"10.1016/j.tjnut.2025.02.018","DOIUrl":"10.1016/j.tjnut.2025.02.018","url":null,"abstract":"<div><h3>Background</h3><div>Calcium (Ca) and phosphorus (P) intake during brooding affects laying hens’ later production and health, with availability varying among strains, necessitating further investigation of the factors influencing these differences.</div></div><div><h3>Objectives</h3><div>This study aimed to compare the availability of Ca and P and related gene expression among 3 high-yielding layer strains during the first 6 wk and identify genes strongly associated with nutrient absorption.</div></div><div><h3>Methods</h3><div>Ninety pullets (1-d-old, female) from 3 strains [medium size, large egg layer (ML), light size, medium egg layer (LM), and dwarf, small egg layer (DS) weighted 31.533 ± 0.63 g, 39.367 ± 1.40 g, and 34.099 ± 0.64 g, respectively] were randomly assigned to 6 replicates of 15 birds each for 6-wk cage rearing. Feces were collected weekly to track the Ca and P availability. Initial and final body weights and tibial lengths were recorded to determine growth performance. Intestinal samples were collected to determine the gene expression of Ca and P transporters [transient receptor potential cation channel subfamily V member 6<em>,</em> calbindin D28k, Na+/Ca2+ exchanger 1 (<em>NCX1</em>), plasma membrane Ca-ATPase 1b, and sodium-dependent phosphate transporter IIb (<em>NPt2b</em>)] as well as tight junction proteins (claudin-2 and claudin-12).</div></div><div><h3>Results</h3><div>ML and LM pullets exhibited significantly greater body weight (443 g, 436 g compared with 319 g, <em>P</em> &lt; 0.001) and tibial length (70.6 mm, 69.6 mm compared with 59.2 mm, <em>P</em> &lt; 0.001) than DS. Notably, during the sixth week, the Ca and P retention in DS (0.847 g/wk compared with 1.648 g/wk, 0.662 g/wk compared with 1.141 g/wk) was significantly lower than that in ML, and in most weeks, DS exhibited the lowest Ca availability among the 3 strains. Gene expression analysis revealed higher expression levels of Ca transporters in the duodenum of ML and LM than in DS, whereas DS demonstrated elevated transporter expression in the jejunum. Furthermore, ML and LM exhibited more pronounced expression of tight junction proteins across most intestinal segments.</div></div><div><h3>Conclusions</h3><div>The study indicated that expression of Ca and P transporter is highest in the duodenum, and duodenal <em>NCX1</em>, <em>NPt2b</em> were the genes most significantly positively correlated with the retention and excretion of Ca and P in pullets.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1099-1107"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Honokiol, a Neolignan from Magnolia officinalis, Attenuated Fructose-Induced Hepatic Fat Accumulation by Improving Intestinal Barrier Function in Mice","authors":"Anja Baumann ,&nbsp;Verena Freutsmiedl ,&nbsp;Julia Jelleschitz ,&nbsp;Raphaela Staltner ,&nbsp;Annette Brandt ,&nbsp;Daniel Schachner ,&nbsp;Verena M Dirsch ,&nbsp;Ina Bergheim","doi":"10.1016/j.tjnut.2025.02.017","DOIUrl":"10.1016/j.tjnut.2025.02.017","url":null,"abstract":"<div><h3>Background</h3><div>Fructose (Fru) consumption has been suggested to contribute to metabolic diseases including metabolic dysfunction-associated steatotic liver disease (MASLD), at least in part, by disturbing intestinal barrier function and intestinal nitric oxide (NO) homeostasis. Honokiol (Hon), a neolignan found in <em>Magnolia officinalis</em>, has been suggested to affect intestinal integrity and barrier function.</div></div><div><h3>Objectives</h3><div>We assessed whether Hon affects Fru-induced small intestinal permeability in settings of early MASLD.</div></div><div><h3>Methods</h3><div>Female 8–10-wk-old C57BL/6J mice (<em>n =</em> 7/group) received either a 30% Fru solution + vehicle or plain drinking water + vehicle ± Hon (10 mg/kg bw/d) for 4 wk. Liver damage [e.g. nonalcoholic fatty liver disease activity score (NAS), number of neutrophils, interleukin-6 (IL-6) protein concentration], markers of intestinal permeability (bacterial endotoxin, tight junction proteins), and NO homeostasis in the small intestine were determined in vivo as well as ex vivo in an everted sac model and in Caco-2 cells. One-way and 2-way analysis of variance were performed, respectively.</div></div><div><h3>Results</h3><div>Hon diminished the development of MASLD, which was associated with a significant lower NAS (–38%), number of neutrophils (–48%), and IL-6 protein concentrations (–38%) in livers of Fru-fed mice. Hon also attenuated Fru-induced alterations of markers of intestinal barrier function with Fru+Hon-fed mice showing lower bacterial toxin levels in portal plasma (–29%, <em>P</em> = 0.075), higher tight junction protein concentrations (+2.4-fold, <em>P</em> &lt; 0.05), and lower NOx concentration (–44%, <em>P</em> &lt; 0.05) as well as NO synthase activity (–35%) in the small intestine compared with Fru+vehicle-fed mice. Moreover, the decrease in AMP-activated protein kinase phosphorylation found in the small intestine of Fru-fed mice was significantly attenuated (+5.3-fold) by the concomitant treatment with Hon in Fru-fed mice. In support of the in vivo findings, Hon significantly attenuated Fru-induced intestinal permeability ex vivo and in Caco-2 cells.</div></div><div><h3>Conclusions</h3><div>Our data suggest that Hon diminished the development of Fru-induced early MASLD by alleviating impairments in intestinal barrier function.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1173-1182"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Daily Consumption of a Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota (LcS) on Stool Consistency in United States Adults with Hard or Lumpy Stools: A Randomized Controlled Trial","authors":"Chad M Cook ,&nbsp;Takuya Akiyama ,&nbsp;Traci Blonquist ,&nbsp;Eunice Mah ,&nbsp;Linda Derrig ,&nbsp;Hideyuki Shibata","doi":"10.1016/j.tjnut.2025.02.021","DOIUrl":"10.1016/j.tjnut.2025.02.021","url":null,"abstract":"<div><h3>Background</h3><div><em>Lacticaseibacillus paracasei</em> strain Shirota (LcS) has shown benefits for stool consistency in populations with certain bowel complaints (e.g., constipation), but data in a United States population are limited.</div></div><div><h3>Objectives</h3><div>This study evaluated the effects of LcS on hard or lumpy stools (HLS) in an otherwise healthy population that generally represents the United States adult demographic.</div></div><div><h3>Methods</h3><div>In this randomized, controlled, open-label study, 50 participants (41 females, 9 males) with HLS in ≥25% of bowel movements (BMs) during a 14-d run-in period were randomly assigned to receive either 80 mL fermented milk containing 8.0 × 10⁹ colony forming units LcS/mL for 28 d (active group) or no intervention (control group) followed by a 14-d postintervention period. Bowel habits were recorded daily using a novel smartphone application. The primary endpoint was the presence of HLS in ≥25% of the participant-rated BMs using the Bristol Stool Form Scale over the 28-d intervention. Secondary endpoints included the presence of reduced frequency of BMs with HLS from baseline, stool frequency, straining, incomplete evacuation, artificial intelligence-derived stool image scores, and Patient Assessment of Constipation Quality of Life (PAC-QOL) scores.</div></div><div><h3>Results</h3><div>The active group showed a significantly lower proportion of participants with HLS in ≥25% of BMs [odds ratio: 0.34; 95% confidence interval (CI): 0.14, 0.80; <em>P</em> = 0.014] along with a higher proportion of participants with a reduced frequency of BMs with HLS from baseline (odds ratio: 2.86; 95% CI: 1.03, 7.92; <em>P</em> = 0.043). The active group also demonstrated positive improvements in total PAC-QOL scores (<em>P</em> = 0.003).</div></div><div><h3>Conclusions</h3><div>Daily consumption of LcS-containing fermented milk significantly reduced constipation symptoms and improved quality of life in an otherwise generally healthy United States adult population with a history of intermittent BMs producing HLS. The intervention was well tolerated, with no serious adverse events related to the product, suggesting its safety and potential as a dietary strategy for managing constipation.</div></div><div><h3>Trial registration number</h3><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT06014008 (<span><span>https://clinicaltrials.gov/study/NCT06014008</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1183-1192"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and Infant Predictors of Human Milk Macronutrient and Energy Concentrations in Rural Bangladesh: An Observational Cohort Study","authors":"Krysten North ,&nbsp;Chloe Andrews ,&nbsp;Sophie Driker ,&nbsp;Salahuddin Ahmed ,&nbsp;Nabidul H Chowdhury ,&nbsp;Rasheda Khanam ,&nbsp;Tarik Hasan ,&nbsp;Sayedur Rahman ,&nbsp;Mandy Belfort ,&nbsp;Sara Cherkerzian ,&nbsp;Melanie Gao ,&nbsp;Abdullah Baqui ,&nbsp;Sarbattama Sen ,&nbsp;Anne CC Lee","doi":"10.1016/j.tjnut.2024.12.027","DOIUrl":"10.1016/j.tjnut.2024.12.027","url":null,"abstract":"<div><h3>Background</h3><div>Human milk macronutrient (protein, fat, and carbohydrate) and energy concentrations vary based on maternal and infant factors and time postpartum.</div></div><div><h3>Objectives</h3><div>This study aimed to determine the change in milk macronutrient and energy concentrations from approximately 2 to 5 months postpartum and identify factors associated with this variation among a lactation cohort in Bangladesh.</div></div><div><h3>Methods</h3><div>In this prospective observational lactation cohort in rural Sylhet, Bangladesh, we collected hand-expressed mid-feed human milk samples and analyzed macronutrient concentrations using mid-infrared spectroscopy. We used the Wilcoxon rank-sum test to compare macronutrient and energy concentrations between time points and mixed linear regression to determine associations between predictors [maternal body mass index (BMI), maternal mid-upper arm circumference, infant gestational age, and infant small for gestational age status] and repeated measures of milk macronutrient and energy concentrations in models adjusted for parity, nicotine, and wealth index.</div></div><div><h3>Results</h3><div>We enrolled 99 participants. From visit 1 (∼2 mo) to visit 2 (∼5 mo), median milk protein concentration decreased from 1.4 g/dL [interquartile range (IQR): 1.1–1.6 g/dL] to 0.8 g/dL (IQR: 0.6–1.1 g/dL), median fat concentration decreased from 4.6 g/dL (IQR: 3.8–5.5 g/dL) to 2.8 g/dL (IQR: 2.1–3.7 g/dL), and median energy concentration decreased from 22.7 kcal/oz (IQR: 20.6–25.1 kcal/oz) to 17.5 kcal/oz (IQR: 15.6–19.9 kcal/oz). Maternal overweight status was associated with a lower carbohydrate concentration (2 mo—mean difference: −0.16 g/dL; 95% CI: −0.28, −0.03 g/dL; 5 mo—mean difference: −0.14 g/dL; 95% CI: −0.26, −0.02; reference = normal BMI).</div></div><div><h3>Conclusions</h3><div>The decline of protein, fat, and energy concentrations over time is a potential concern for Bangladesh’s vulnerable population of human milk–fed infants, as these nutrients have implications for infant growth and neurodevelopment.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1151-1159"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Carbohydrate Diet Score and Risk of Mortality: The Japan Collaborative Cohort Study","authors":"Tae Sasakabe ,&nbsp;Kenji Wakai ,&nbsp;Sayo Kawai ,&nbsp;Yingsong Lin ,&nbsp;Asahi Hishida ,&nbsp;Hiroyasu Iso ,&nbsp;Shogo Kikuchi ,&nbsp;Akiko Tamakoshi ,&nbsp;Japan Collaborative Cohort Study Group","doi":"10.1016/j.tjnut.2025.02.001","DOIUrl":"10.1016/j.tjnut.2025.02.001","url":null,"abstract":"<div><h3>Background</h3><div>A low-carbohydrate diet (LCD) may be effective for reducing cardiovascular disease (CVD) risk factors. However, its association with mortality remains unclear, especially in populations with higher carbohydrate and lower fat intake.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate the association between LCD scores and mortality risk in participants from the Japan collaborative cohort study.</div></div><div><h3>Methods</h3><div>The analysis included 22,659 males and 35,192 females aged 40–79 y at baseline. A food frequency questionnaire was used to construct the LCD scores, which were further categorized into 3 types based on the fat intake source: animal, fish, and plant. The association between the LCD scores and total and cause-specific mortality was estimated using the Cox proportional hazards model adjusted for confounders.</div></div><div><h3>Results</h3><div>During a median follow-up period of 19.4 y, 10,835 deaths (5835 males and 5000 females) were recorded. For all participants, the overall LCD score was inversely associated with total mortality. The lowest hazard ratio (95% confidence interval) was 0.85 (0.78, 0.93) in the eighth decile (<em>P</em>-linear trend = 0.03). Fish fat-based LCD score had a U-shaped association with total mortality (<em>P</em>-nonlinear trend = 0.01). An inverse association was observed with CVD mortality (<em>P</em>-linear trend = 0.04 of overall LCD score; <em>P</em>-linear trend = 0.04 of fish fat-based LCD score). In females, there was an inverse association between the overall LCD score and total mortality. A U-shaped association was also shown for fish fat-based LCD score. The fish fat-based LCD score was inversely associated with CVD mortality.</div></div><div><h3>Conclusions</h3><div>Moderate overall and fish fat-based LCD scores were associated with a lower risk of total mortality in the Japanese population. Fish fat-based LCD score had a significant inverse association with CVD mortality.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1218-1225"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of Different Sourced Protein Intake, Quantity of Plasma Amino Acid with Chronic Kidney Disease","authors":"Chun Zhou ,&nbsp;Sisi Yang ,&nbsp;Ziliang Ye ,&nbsp;Panpan He ,&nbsp;Mengyi Liu ,&nbsp;Yuanyuan Zhang ,&nbsp;Yanjun Zhang ,&nbsp;Xiaoqin Gan ,&nbsp;Hao Xiang ,&nbsp;Yu Huang ,&nbsp;Jing Nie ,&nbsp;Xianhui Qin","doi":"10.1016/j.tjnut.2025.02.005","DOIUrl":"10.1016/j.tjnut.2025.02.005","url":null,"abstract":"<div><h3>Background</h3><div>The association of protein from different food sources and different plasma amino acids with risk of chronic kidney disease (CKD) is unclear.</div></div><div><h3>Objectives</h3><div>We aimed to investigate longitudinal relationships of dietary protein intake from different sources and quantity of plasma amino acids with new-onset CKD in the general population.</div></div><div><h3>Methods</h3><div>Participants (mean age: 56 y) without CKD at baseline were included in the UK Biobank. A total of 176,980 were included in the analysis for protein intakes and 99,061 participants were included in the analysis for plasma amino acids. Information on dietary protein was collected based on a 24-h dietary recall from the previous day. Plasma amino acid concentrations were measured by a high-throughput nuclear magnetic resonance (NMR)-based metabolic biomarker profiling platform. The study outcome was new-onset CKD.</div></div><div><h3>Results</h3><div>During a median follow-up of 12 y (beginning between 2006 and 2010 and ending in 2021), 3542 participants (2,128,626 person-year) developed new-onset CKD. Higher intakes of dairy-derived and fish-derived protein were associated with lower incidence of CKD [per standard deviation, SD increment, adjusted hazard ratio, HR (95% confidence interval, 95% CI): 0.95 (0.91, 0.98) and 0.95 (0.92, 0.99), respectively], but protein intake from other foods was not (<em>P</em>-trend &gt; 0.1). Moreover, incident CKD was lower among those with higher plasma histidine (per SD increment; adjusted HR = 0.90; 95% CI: 0.86, 0.95), tyrosine (0.90; 0.87, 0.94), isoleucine (0.89; 0.85, 0.92), leucine (0.89; 0.85, 0.93), and valine (0.89; 0.85, 0.93).</div></div><div><h3>Conclusions</h3><div>The protein intake from dairy and fish, as well as the concentration of plasma histidine, tyrosine, isoleucine, leucine, and valine, was inversely associated with new-onset CKD.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 4","pages":"Pages 1165-1172"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}