Journal of Nutrition最新文献

{"title":"Erratum to 'Association between Adiposity and Iron Status in Women of Reproductive Age: Data from the UK National Diet and Nutrition Survey (NDNS) 2008-2019', [J Nutr 154 (2024) 3048-3059].","authors":"Sabrina P Demirdjian, Maeve A Kerr, Maria S Mulhern, Paul D Thompson, Mark Ledwidge, Mary T McCann","doi":"10.1016/j.tjnut.2025.01.026","DOIUrl":"10.1016/j.tjnut.2025.01.026","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P-Hydroxycinnamic Acids:Advancements in Synthetic Biology, Emerging Regulatory Targets in Gut Microbiota Interactions, and Implications for Animal Health.","authors":"Chunlai Ma, Ziqi Liang, Yuan Wang, Huiying Luo, Xiaojun Yang, Bin Yao, Tao Tu","doi":"10.1016/j.tjnut.2025.01.034","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.034","url":null,"abstract":"<p><p>P-hydroxycinnamic acids (p-HCAs), a class of natural phenolic acid compounds extracted from plant resources and widely distributed, feature a C6-C3 phenylpropanoid structure. Their antioxidant, anti-inflammatory, and antibacterial activities have shown great potential for applications in food and animal feed. The interactions between p-HCAs and the gut microbiota, as well as their subsequent effects on animal health, have increasingly attracted the attention of researchers. In the context of a greener and safer future, the progress and innovation in biosynthetic technology have occupied a central position in ensuring the safety of food and feed. This review emphasizes the complex mechanisms underlying the interactions between p-HCAs and the gut microbiota, providing a solid explanation for the remarkable bioactivities of p-HCAs and their subsequent impact on animal health. Furthermore, it explores the advancements in the synthetic biology of p-HCAs. This review could aid in a basis for better understanding the underlying interactions between p-HCAs, gut microbiota and animal health.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Premeal Pistachio Supplementation on Cardiometabolic Risk Factors among Asian Indian Adults with Prediabetes: A Randomized Controlled Trial.","authors":"Karthikeyan Ashwini, Kuzhandhaivelu Abirami, Rajagopal Gayathri, Sekar Sasikala, Vasudevan Sudha, Shanmugam Shobana, Raman Ganesh Jeevan, Kamala Krishnaswamy, Vadivelu Deepika, Marimuthu Rajalakshmi, Mookambika Ramya Bai R, Karthikeyan Parkavi, Soundararajan Padmavathi, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Frank B Hu, Walter C Willett, Jordi Salas-Salvadó, Shilpa N Bhupathiraju, Viswanathan Mohan","doi":"10.1016/j.tjnut.2024.12.005","DOIUrl":"10.1016/j.tjnut.2024.12.005","url":null,"abstract":"<p><strong>Background: </strong>Asian Indians are susceptible to developing type 2 diabetes at a lower age and often consume diets that are high in glycemic load and low in healthy fats.</p><p><strong>Objectives: </strong>This study aimed to evaluate the effect of 30 g prebreakfast and 30 g predinner supplementation of pistachios for 12 wk on glycated hemoglobin (HbA1c), other glycemic markers, anthropometry, and lipid profile of Asian Indians with prediabetes.</p><p><strong>Methods: </strong>In a 12-wk parallel arm, randomized controlled trial, we recruited 120 participants with prediabetes based on American Diabetes Association criteria. The intervention group (n = 60) consumed 60 g pistachios (30 g prebreakfast and predinner) whereas the control group (n = 60) followed a routine diet that excluded nuts. At baseline and 12 wk, we collected blood samples for biochemical analysis, anthropometrics, and 24-h recalls. Participants wore a continuous glucose monitoring (CGM) sensor during the trial's first and last 2 wk. Urinary N-methyl-trans-4-hydroxy-l-proline (MHP) was measured as a marker of pistachio consumption.</p><p><strong>Results: </strong>A total of 109 participants completed the study (follow-up rate = 90.8%). Compared with participants in the control group, those in the intervention group had significant reductions in HbA1c (mean between-group difference: -0.2; 95% confidence interval: -0.3, -0.1; P < 0.001] with no significant changes in fasting or 2-h post glucose load plasma glucose. Compared with the control group, the intervention group had significant reductions in serum triglyceride, waist circumference, lipid accumulation product, visceral adiposity index, and atherogenic index. Urinary MHP (mg/g creatinine) showed a 62% increase in the intervention compared with the control group (P < 0.05). CGM data revealed significant decreases in the incremental area under the curve, 2-h after breakfast (28%, p=0.01) and after dinner (17%, P = 0.002) in the intervention group compared to the control group.</p><p><strong>Conclusions: </strong>A 12-wk, premeal load of 60 g pistachios lowers HbA1c and improves cardiometabolic profile among Asian Indians with prediabetes. This is among the first studies to investigate these effects in this ethnic group. This study was registered in the Clinical Trial Registry of India as CTRI/2020/11/029340.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance and Evaluation of Vitamin D Nutrition and its Health Impact in Chinese Older Adults.","authors":"Wenxuan Wu, Ji-Chang Zhou, Licheng Yang","doi":"10.1016/j.tjnut.2025.01.030","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.030","url":null,"abstract":"<p><p>Vitamin D is an essential fat-soluble vitamin for humans and vitamin D deficiency (VDD) affects all age groups, with older adults being at high risk of VDD. A deficiency in Vitamin D has been associated with a range of health concerns in older adults, including osteomalacia and osteoporosis. Additionally, there is limited evidence suggesting that VDD may be associated with an increased risk of developing cognitive impairment, muscle wasting disorders, cardiovascular disease, type 2 diabetes mellitus, and mortality. This review synthesizes the latest research advances in China and abroad to provide detailed information on the current status of vitamin D nutritional monitoring, causes of deficiency, health risks, and proposed intake for reducing the risk of diet-related non-communicable diseases (PI-NCD) in the Chinese older adults.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness of protein supplementation combined with resistance training on body composition and physical function in healthy elderly adults: A systematic review and network meta-analysis.","authors":"Haiping Tian, Wanwan Qiao, Xianxiu Wen","doi":"10.1016/j.tjnut.2025.01.017","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.017","url":null,"abstract":"<p><strong>Background: </strong>The global population of individuals over 65 is expected to reach 426 million by 2050. Aging is associated with a progressive loss of muscle mass, strength, and function, leading to sarcopenia and adverse outcomes such as physical disability and increased mortality. Interventions such as resistance training and protein supplementation have shown promise in mitigating these effects.</p><p><strong>Objective: </strong>To determine the comparative effectiveness of protein supplementation, resistance training, and their combination on body composition and physical function in healthy older adults through a network meta-analysis.</p><p><strong>Methods: </strong>We conducted a systematic review and network meta-analysis following PRISMA guidelines and registered in PROSPERO (CRD42021226561). We included randomized controlled trials comparing protein supplementation, resistance training, and their combination in participants aged 50 years or older. Data were extracted from PubMed, Web of Science, Embase, and Cochrane Library. The risk of bias was assessed using the Cochrane Collaboration Risk of Bias Tool.</p><p><strong>Results: </strong>A total of 38 randomized controlled trials involving 2,610 participants were included. The combined intervention of protein supplementation and resistance training significantly improved lean body mass (SMD, 0.44; 95% CI, 0.05 to 0.95) compared to protein supplementation alone. The combined intervention also showed significant improvements in muscle mass (SMD, 1.49; 95% CI, 0.11 to 2.67). The combined intervention (SMD, 2.74, 95% CI 0.76 to 4.74) and resistance training alone (SMD, 2.53, 95% CI 0.29 to 4.84) significantly improved muscle strength compared to controls. The combined intervention (SMD, 4.98, 95% CI 2.72 to 7.17) and resistance training alone (SMD, 4.52, 95% CI 2.30 to 6.64) significantly improved physical function compared to protein supplementation alone.</p><p><strong>Conclusion: </strong>Combining exercise and protein supplementation is the most effective for improving muscle mass, strength, and physical function in older adults. This approach should be considered for enhancing physical health in this population. Future large-scale trials are necessary to confirm these findings.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Odd-chain fatty acids-enriched fats improved the growth and intestinal morphology and function in milk replacers-fed piglets.","authors":"Geyan Duan, Mengmeng Li, Changbing Zheng, Mengliao Wan, Jiayi Yu, Bo Cao, Yulong Yin, Yehui Duan, Fang Cong","doi":"10.1016/j.tjnut.2025.01.021","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.021","url":null,"abstract":"<p><strong>Background: </strong>The intestinal development and nutritional needs of piglets after birth are similar to those of human infants.</p><p><strong>Objectives: </strong>This study aimed to investigate the effect of odd chain fatty acids (OCFAs) with different forms on the growth and intestinal morphology and function in milk replacers-fed piglets, as a model for human infants.</p><p><strong>Methods: </strong>Forty 7-day-old piglets from 8 sows were randomly assigned into 5 groups (n = 8, each of them was from different litters) and fed sow milk or milk replacers supplemented with different kinds of fats (namely, the control fats, and the DHA algal oil-, OCFA algal oil-, and OCFA-enriched fats) for 21 days. The statistical analysis about the data from milk replacers-fed piglet groups was conducted on the one-way ANOVA. And the data between sow milk- and milk replacers-fed piglets were analyzed by unpaired t-test.</p><p><strong>Results: </strong>Milk replacers supplemented with OCFA-enriched fats increased the average daily gain (ADG) and the ratio of villus height to crypt depth, increased the protein expression of Ki67, p-mTOR, p-p70S6k, Occludin, Claudin, and ZO-1 in selected intestines, and decreased the protein expression of p-ULK1, Parkin, and PINK1 to levels similar to the sow milk group (P < 0.05).</p><p><strong>Conclusion: </strong>Overall, milk replacers supplemented with OCFA-enriched fats improved the ADG and intestinal morphology and function of piglets to levels comparable to the sow milk-fed piglets.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Vitamin K Intake Impairs Cognition, Neurogenesis, and Elevates Neuroinflammation in C57BL/6 Mice.","authors":"Tong Zheng, Shannon Marschall, Jasper Weinberg, Xueyan Fu, Andrew Tarr, Barbara Shukitt-Hale, Sarah L Booth","doi":"10.1016/j.tjnut.2025.01.023","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.023","url":null,"abstract":"<p><strong>Background: </strong>In addition to its important roles in blood coagulation and bone formation, vitamin K (VK) contributes to brain function. Low dietary VK intake, which is common among older adults, is associated with age-related cognitive impairment.</p><p><strong>Objective: </strong>To elucidate the biological mechanisms underlying VK's effects on cognition, we investigated the effects of low VK (LVK) intake on cognition in C57BL/6 mice.</p><p><strong>Methods: </strong>Male and female 9-month old C57BL/6 mice (n=60) were fed a LVK diet or a control diet for 6 months. Behavioral tests were performed on a subset of animals (n=26) at 15 months and brain tissues were collected for follow-up analyses.</p><p><strong>Results: </strong>Menaquinone-4 (MK4), the predominant VK form in the brain, was significantly lower in LVK animals compared to controls (15.6±13.3 vs 189±186 pmol/g, respectively, p<0.01). LVK animals showed reduced recognition memory in the novel object test by spending a lower percentage of time exploring the novel object compared to controls (47.45%± 4.17 vs. 58.08%±3.03, p=0.04). They also spent a significantly longer time learning the task of locating the platform in the Morris water maze test. Within the hippocampal dentate gyrus, LVK animals had a significantly lower number of proliferating cells, and fewer newly generated immature neurons compared to control animals. Additionally, more activated microglia cells were identified in the LVK animals.</p><p><strong>Conclusion: </strong>Our data indicate that LVK intake reduced MK4 levels in brain tissues and impaired learning- and memory-related cognitive function. This impairment may be related to the observed reduced hippocampal neurogenesis and elevated neural inflammation.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative Artificial Intelligence in Nutrition: A Revolution in Accessibility and Personalization.","authors":"Nicola Pugliese, Federico Ravaioli","doi":"10.1016/j.tjnut.2025.01.025","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.025","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intimate Partner Violence and Women's Dietary Diversity: A Population-Based Investigation in Eight Low- and Middle-Income Countries.","authors":"Luissa Vahedi, Manuela Orjuela-Grimm, Pui Man Pamela Chan, Sarah R Meyer","doi":"10.1016/j.tjnut.2025.01.024","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.024","url":null,"abstract":"<p><strong>Background: </strong>Intimate partner violence (IPV) poses a significant threat to the well-being of women and girls and is a highly prevalent form of gender-based violence. Evidence regarding the nutritional implications of IPV has focused primarily on intergenerational relationships with child nutrition and growth. There remains a knowledge gap regarding the association with women's own dietary intake.</p><p><strong>Objective: </strong>We investigated relationships between past year IPV (physical, emotional, sexual) and women's dietary habits, using the minimal dietary diversity tool (MDD-W).</p><p><strong>Methods: </strong>The data sources analyzed were the cross-sectional Demographic and Health Surveys conducted in Cambodia (2021, N=5,618), Nepal (2022, N=4,155), Sierra Leone (2019, N=3,808), Nigeria (2018, N=8,313), Tajikistan (2017, N=4,792), Cote D'Ivoire (2022, N=3,654), Kenya (2022, N=10,717), and the Philippines (2022, N=12,240). Utilizing multivariable generalized linear models, we assessed the overall relationship between women's exposure to IPV and (i) the number of food groups consumed and (ii) minimum dietary diversity.</p><p><strong>Results: </strong>Our results reveal heterogeneous relationship patterns between IPV and women's diet. Although none of the pooled estimates were significant and there were large number of non-significant associations, IPV was associated with consuming a lower number of total food groups and reduced consumption of a diverse diet in Nigeria and the Philippines. There is evidence that in Tajikistan, physical violence relates to an increased number of food groups consumed.</p><p><strong>Conclusions: </strong>IPV is associated with altered dietary intake patterns within certain LMICs. The directionality of associations may depend on local food environments and food access. Further research is needed to clarify the pathways underlying these findings. These pathways may involve impacts of IPV that influence diet and food access, for example, mental health symptoms and disorders and related coping mechanisms.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Alkylresorcinols is an objective biomarker for gluten intake in young children.","authors":"Elin M Hård Af Segerstad, Emelie Ericson-Hallström, Anna Bokström, Marina Armeni, Otto Savolainen, Carin Andrén Aronsson","doi":"10.1016/j.tjnut.2025.01.020","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.020","url":null,"abstract":"<p><strong>Background: </strong>Alkylresorcinols are a well-established biomarker for whole grain intake. There is evidence suggesting that total plasma alkylresorcinol concentration may also be used as a biomarker for gluten intake in adults.</p><p><strong>Objective: </strong>The aim of the study was to evaluate if total alkylresorcinol concentration is a valid biomarker for gluten intake in young children.</p><p><strong>Methods: </strong>Non-fasting plasma alkylresorcinol concentrations were analyzed by normal-phase ultra-high pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in 65 children aged 18 months included in a randomized controlled trial. The intervention group was following a gluten-free diet (n=21, 31.3%), while the diet was unrestricted in the control group (n=44, 65.7%). Alkylresorcinol concentrations in the 65 children were validated against simultaneously collected 3-day food records estimating total gluten intake.</p><p><strong>Results: </strong>Gluten intake in controls was median 5.8 grams (g)/day (inter quartile range [IQR] 2.8-9.4, max 17.1) compared to 0.0 g/day (IQR 0.0-0.0, max 0.7, p<0.001) in the intervention group. In the control group, wheat accounted for mean 85% (standard deviations [SD] 0.1) of the gluten intake. The intervention group had lower alkylresorcinol levels (median 7.2 nmol/L, IQR 4.0-10.5) compared to controls (median 269, IQR 116-505 nmol/L, p<0.001). The correlation between alkylresorcinol concentrations and gluten intake was rho=0.68 (p<0.001). Alkylresorcinol concentrations increased by 35.7% (95% confidence interval [CI] 25.9, 46.2, p<0.001) for every g/day increase of gluten intake. The Cohen's weighted kappa between quartiles of alkylresorcinol and gluten intake was 0.73 (95% CI 0.59, 0.86).</p><p><strong>Conclusions: </strong>Alkylresorcinol concentrations increased with gluten intake in young non-fasting children. The findings suggest that alkylresorcinol concentrations may be a useful biomarker for gluten intake in young children.</p><p><strong>Clinical trial registry: </strong>ClinicalTrials.gov Identifier NCT03562221.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}