Journal of Nutrition最新文献

{"title":"Corrigendum to 'Compared with What?-The Illusion of Olive Oil as \"Heart-Healthy\"' [J. Nutr 154 (2024) 1480-1481].","authors":"Andi Olluri","doi":"10.1016/j.tjnut.2024.12.016","DOIUrl":"https://doi.org/10.1016/j.tjnut.2024.12.016","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Healthy Eating Index (HEI)-2015 total and component scores with measures of inflammation and immune activation in healthy adults.","authors":"Charles B Stephensen, Xiaowen Jiang, Barbara Gale, Janet M Peerson","doi":"10.1016/j.tjnut.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.005","url":null,"abstract":"<p><strong>Background: </strong>The Healthy Eating Index (HEI)-2015 measures diet quality and is associated with a lower risk of death from chronic disease. Dietary components may affect health via multiple mechanisms, including by decreasing inflammation and affecting immune activation.</p><p><strong>Objective: </strong>We hypothesized that the overall HEI-2015 score, or individual component scores, would be associated with altered inflammation and immune activation in healthy adults.</p><p><strong>Methods: </strong>The association of HEI-2015 scores with 88 inflammation and immune activation markers was examined in 346 adults without diagnosed disease using general linear models to adjust for covariates including visceral fat mass index (VFMI).</p><p><strong>Results: </strong>The overall HEI-2015 score was inversely associated with plasma CRP and leukocyte concentrations, which are markers of inflammation, but these associations lost statistical significance with adjustment for VFMI. However, even with VFMI adjustment, the total vegetables score was inversely associated with total lymphocyte concentration (β = -0.157 ± 0.052, p = 0.019) and with monocyte and neutrophil activation (e.g., classic monocyte CD11b β = -0.153 ± 0.055, p = 0.030; neutrophil CD11b β = -0.122 ± 0.051, p = 0.049). The refined grain score was inversely associated with percent NK-T cells (β = -0.171 ± 0.058, p = 0.037), IL-10 production by T cells (β = -0.204 ± 0.057, p = 0.0039) and positively associated with plasma soluble CD14 (β = 0.220 ± 0.059, p = 0.0041). The total dairy score was positively associated with production of multiple cytokines by lipopolysaccharide-stimulated peripheral blood mononuclear cells (e.g., IL-1β β = 0.182 ± 0.054, p = 0.0066).</p><p><strong>Conclusions: </strong>Adjustment for VFMI decreased the association of HEI-2015 with inflammation, consistent with the known role of adiposity in mediating effects of poor diet on inflammation. This study also identified component scores associated with various aspects of immune activation that bear further study to clarify possible health benefits.</p><p><strong>Clinical trial registry: </strong>ClinicalTrials.gov Identifier: NCT02367287.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The arcana of zinc.","authors":"Wolfgang Maret","doi":"10.1016/j.tjnut.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.004","url":null,"abstract":"<p><p>This perspective discusses that the essential micronutrient zinc has functions in over 3000 human proteins (the zinc proteome), and the implications of three aspects to ascertain an adequate zinc status for human health. First, the advent of highly sensitive fluorescent (bio)chemicals revealed cellular pools of zinc ions involved in signalling and secretion from cells for paracrine, autocrine, and possibly endocrine functions. Zinc signalling adds a yet unaccounted number of targeted proteins to the already impressive number of zinc proteins. Second, cellular zinc concentrations are remarkably high in the order of the concentrations of major metabolites and, therefore, at the cellular level zinc is not a trace element. Zinc is also not an antioxidant, because zinc ions are redox-inactive in biology. However, zinc can express indirect pro-oxidant or pro-antioxidant effects depending on how cellular zinc is buffered. Zinc sites in proteins and other biomolecules can become redox-active when zinc is bound to the redox-active sulfur donor atom of cysteine. This interaction links zinc and redox metabolism, confers mobility on tightly bound zinc, and has implications for treating zinc deficiency. Third, the concept of zinc deficiency in blood as the only measure of an inadequate zinc status needs to be extended to zinc dyshomeostasis in cells, because overwhelming the mechanisms controlling cellular zinc homeostasis can result in either not enough or too much available zinc. We need additional biomarkers of zinc status that determine cell-specific changes, perturbations of the system regulating cellular zinc, including functional deficits, and address the multiple genetic and environmental factors that can cause a conditioned zinc deficiency or overload. Considering the wider context of altered zinc availability in different organs, cells, and organelles impinges on whether zinc supplementation will be efficacious and adds another dimension to the already high health burden of zinc deficiency and its sequelae worldwide.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythrocyte fatty acid patterns are associated with skeletal muscle mass in Chinese children.","authors":"Qinwen Zhou, Lan Huang, Yulin Wu, Mengyang Su, Xuemei Liao, Quan Zhou, Guo Zheng, Jingjing Liang, Qinzhi Wei, Zheqing Zhang","doi":"10.1016/j.tjnut.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.001","url":null,"abstract":"<p><strong>Background: </strong>Nutritional factors are important for skeletal muscle mass and grip strength development in children.</p><p><strong>Objective: </strong>This study aimed to investigate the relationship between erythrocyte membrane fatty acid patterns and skeletal muscle mass and grip strength in children.</p><p><strong>Methods: </strong>A total of 452 children aged 6-9 years were included in this study. Appendicular skeletal muscle mass (ASM) was assessed by dual-energy X-ray absorptiometry. Hand grip strength (HGS) was determined by the Jamar® Plus+ hand dynamometer (Sammons Preston, Bolingbrook, IL, USA). Appendicular skeletal muscle mass index (ASMI) was calculated, and the relative concentrations of 20 fatty acids in erythrocyte membranes were measured by gas chromatography-mass spectrometry. Factor analysis was used to explore the relationship between fatty acids and skeletal muscle mass and grip strength.</p><p><strong>Results: </strong>Five fatty acid patterns (FAPs) were identified by factor analysis, and after adjusting for covariates, a multiple linear regression model showed that FAP2 (high C17:0, C20:5 n-3, C22:6 n-3) showed a negative correlation with ASM (β = -0.214; P<0.001), ASMI (β = -0.085; P<0.001) and left-hand grip strength (LHGS) (β = -0.235; P = 0.012). FAP3 (high C14:0, C15:0, C16:0, C16:1 n-7, low C20:4 n-6) scores were positively correlated with ASM (β = 0.134, P = 0.017). No other associations between fatty acid patterns and skeletal muscle mass were found.</p><p><strong>Conclusions: </strong>The relationship between different fatty acid patterns and skeletal muscle health in children aged 6-9 years may be different. The pattern characterized by higher concentrations of C17:0, C20:5 n-3, and C22:6 n-3 in erythrocyte membranes may be associated with lower skeletal muscle mass. The pattern featuring higher concentrations of C14:0, C15:0, C16:0, C16:1 n-7, and lower concentrations of C20:4 n-6 may be protective factors for muscle mass.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modelling vitamin D fortification scenarios for the Australian population.","authors":"Eleanor Dunlop, Anita S Lawrence, Belinda Neo, Mairead Kiely, Anna Rangan, Caryl Nowson, Paul Adorno, Paul Atyeo, Edoardo Tescari, Daniel Russo-Batterham, Kim Doyle, Lucinda J Black","doi":"10.1016/j.tjnut.2024.12.032","DOIUrl":"https://doi.org/10.1016/j.tjnut.2024.12.032","url":null,"abstract":"<p><strong>Background: </strong>Low vitamin D status (circulating 25-hydroxyvitamin D concentration <50 nmol/L) is prevalent in Australia, and 95% of Australians have been estimated to have low vitamin D intake (mean range 1.8-3.2 μg/day). Increasing the dietary supply of vitamin D could improve vitamin D status across the population.</p><p><strong>Objective: </strong>We modelled four vitamin D fortification scenarios to support useful and safe fortification strategies for Australia.</p><p><strong>Methods: </strong>We used cross-sectional food consumption data from the 2011-2012 National Nutrition and Physical Activity Survey (n = 12,153 aged 2-85 y) and analytical food composition data. Scenario 1 modelled the systematic addition of the maximum permitted amount of vitamin D to all foods for which vitamin D fortification is mandated (edible oil spreads) or optional (dairy products/plant-based alternatives, formulated beverages, permitted ready-to-eat breakfast cereals (RTEBC)). Scenarios 2-4 modelled the addition of vitamin D to edible oil spreads and fluid milk/alternatives at higher concentrations than permitted, and addition of the maximum permitted amount to: Scenario 2) dairy products/alternatives other than fluid milk, formulated beverages; Scenario 3) Scenario 2 plus eligible RTEBC; Scenario 4) Scenario 3 plus bread (not permitted for vitamin D fortification in Australia). We used the National Cancer Institute method to model usual intake of vitamin D for each scenario by sex and age group. Dietary adequacy and safety were assessed using the North American Estimated Average Requirement (EAR, 10 μg/day) and the Australian Upper Level of Intake (UL, 80 μg/day).</p><p><strong>Results: </strong>Under Scenarios 1-4, respectively, the projected proportion of Australians with vitamin D intake <10 μg/day was 80, 84, 73 and 60%. No participant exceeded the UL under any scenario.</p><p><strong>Conclusions: </strong>A systematic fortification strategy could support a nutritionally meaningful improvement in vitamin D intake across the Australian population. An optimal strategy would require amendments to the Australia New Zealand Food Standards Code.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suboptimal refeeding compensates stunting in a mouse model of juvenile malnutrition.","authors":"Jean-Louis Thoumas, Amandine Cavaroc, Damien Sery, François Leulier, Filipe De Vadder","doi":"10.1016/j.tjnut.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.01.002","url":null,"abstract":"<p><strong>Background: </strong>Early postnatal life is a critical period of rapid growth in mammals, heavily reliant on adequate nutrition. Protein-energy malnutrition (PEM) during this window can lead to stunting and wasting, with lasting health consequences.</p><p><strong>Objective: </strong>This study developed a mouse model of juvenile PEM to assess the effects of refeeding with various diets and interventions on growth recovery, including probiotic supplementation and suboptimal refeeding diets. Outcomes included length and weight catch-up, organ weights, and glucose tolerance.</p><p><strong>Methods: </strong>Juvenile male and female C57Bl/6J mice (N = 8-11/group) were fed a low-protein diet (LPD, 5% kcal from protein) starting at postnatal day 14 (P14) to which the pups and dams had access. Following weaning, mice were refed an optimal diet (27% kcal from protein) at different times (P28 to P56). Male mice received additional interventions, including supplementation with Lactiplantibacillus plantarum WJL (Lp^WJL) during refeeding, or refeeding with a Western diet (WD, 15.3% kcal from protein) or a modified Western diet (MWD, 7.5% kcal from protein). Statistical analyses used ANOVA, ANCOVA, and PCA.</p><p><strong>Results: </strong>Optimal refeeding restored growth in females (body weight in optimal-fed: 20.5 ± 0.3 g vs 19.4 ± 0.6 g in P56-refed), but males showed persistent stunting (26.8 ± 0.7 g vs 21.9 ± 0.9 g; P < 0.05). In males, Lp^WJL did not enhance growth recovery and exacerbated glucose intolerance in suboptimal refeeding groups. Males refed WD or MWD restored body length but showed impaired glucose metabolism, particularly in mice refed WD, with glycemia 30 minutes after glucose challenge reaching 20.4 ± 4.0 mM vs 14.3 ± 3.0 mM in optimal-fed mice (P < 0.05).</p><p><strong>Conclusion: </strong>Sex-dependent differences in recovery from PEM were evident, with males showing incomplete growth recovery despite optimal refeeding. Suboptimal diets compensated for stunting but impaired glucose metabolism, and Lp^WJL did not improve growth outcomes.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mice born to mothers fed a diet high in omega-6 fatty acids and low in omega-3 fatty acids during pregnancy exhibit various behavioral changes including impaired social behaviors and enhanced recognition memory.","authors":"Nobuyuki Sakayori, Kazuki Fujii, Masanori Katakura, Mayumi Adachi, Yumie Koshidaka, Keizo Takao, Makoto Sugita","doi":"10.1016/j.tjnut.2024.12.031","DOIUrl":"https://doi.org/10.1016/j.tjnut.2024.12.031","url":null,"abstract":"<p><strong>Background: </strong>Modern dietary trends have led to an increase in foods that are relatively high in n-6 polyunsaturated fatty acids (PUFAs) and low in n-3 PUFAs. We previously reported that the offspring of mother mice that consumed a diet high in n-6 linoleic acid (LA) and low in n-3 α-linolenic acid (ALA), hereinafter called the LA^high/ALA^low diet, exhibit behavioral abnormalities related to anxiety and feeding.</p><p><strong>Objective: </strong>We currently lack a comprehensive overview of the behavioral abnormalities in these offspring, which was investigated in this study.</p><p><strong>Methods: </strong>C57BL/6J virgin female mice at 11 weeks of age were fed either a control diet or the LA^high/ALA^low diet, mated at 13 weeks of age, and maintained on their respective diet throughout gestation. At birth, the lactating mothers' diet was replaced with standard lab chow. After weaning, the offspring continued to receive standard lab chow, and both male and female offspring at 1-63 weeks of age were analyzed using a comprehensive behavioral test battery (n = 6-14 offspring/group and offspring in each group were derived from at least 3 independent litters).</p><p><strong>Results: </strong>Both male and female offspring exposed in utero to the LA^high/ALA^low diet exhibited impaired social behaviors including the lower number of contacts with novel mice in the social interaction test (diet, F_(1,15) = 9.807, P = 0.007, two-way analysis of variance (ANOVA)) and also showed enhanced recognition memory in the object location test (diet, F_(1,36) = 6.779, P = 0.013, two-way ANOVA) compared to offspring exposed in utero to the control diet. In addition, compared to sex-matched controls, female offspring displayed hyperactivity in the open field test (F_(1,36) = 6.097, P = 0.018, simple main effect analysis).</p><p><strong>Conclusions: </strong>The maternal balance between dietary n-6 and n-3 PUFAs during pregnancy can have significant effects on the offspring's behaviors, lasting well into adulthood.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between daily sesame consumption and the risk of sarcopenia in elderly adults: the TCLSIH cohort study.","authors":"Sizhen Lai, Xinzhe Xu, Liyuan Fu, Yeqing Gu, Ge Meng, Xuehui Wu, Dandan Zhu, Yinxiao Chen, Dongli Wang, Yaxiao Wang, Lirui Jiao, Hao Geng, Jinjin Zhang, Di Wang, Hao Yu, Hongmei Wu, Kaijun Niu","doi":"10.1016/j.tjnut.2024.12.033","DOIUrl":"https://doi.org/10.1016/j.tjnut.2024.12.033","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is an age-related, progressive, and systemic skeletal muscle disorder that can lead to numerous adverse outcomes. Animal studies have shown that sesame can enhance skeletal muscle blood flow and improve physical performance. However, no studies have yet explored the association between sesame consumption and the incidence of sarcopenia in the general population.</p><p><strong>Objective: </strong>This study aimed to clarify the association between daily sesame consumption and risk of sarcopenia in a cohort of Chinese elderly aged 60 years and over.</p><p><strong>Methods: </strong>This cohort study was conducted in Tianjin, China, involving 3,017 elderly participants (1,270 men). Sesame consumption frequency was assessed using a validated self-administered food frequency questionnaire. Sarcopenia was defined according to the consensus of the Asian Working Group (AWGS) for Sarcopenia. Multivariable Cox proportional hazards regression models were used to evaluate the association between daily sesame consumption and the risk of sarcopenia.</p><p><strong>Results: </strong>After adjusting for potential confounders [age, body mass index (BMI), smoking status, alcohol consumption, physical activity, marital status, educational level, personal history of diseases, depressive state, total energy intake, and dietary patterns], the multivariable hazard ratios (HRs) and 95% confidence interval (CIs) for sarcopenia among the elderly with different levels of daily sesame consumption were as follows: almost never consuming sesame (reference value), ≤1 time per week: 1.06 (0.81, 1.39), and ≥2-3 times per week: 0.62 (0.46, 0.84), respectively (P values <0.01).</p><p><strong>Conclusion: </strong>This study indicates that daily sesame consumption in the elderly aged 60 years and over is associated with a reduced risk of sarcopenia. Further research is needed to explore the causal mechanisms underlying this association.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and infant predictors of human milk macronutrient and energy concentrations in rural Bangladesh: an observational cohort study.","authors":"Krysten North, Chloe Andrews, Sophie Driker, Salahuddin Ahmed, Nabidul H Chowdhury, Rasheda Khanam, Tarik Hasan, Sayedur Rahman, Mandy Belfort, Sara Cherkerzian, Melanie Gao, Abdullah Baqui, Sarbattama Sen, Anne Cc Lee","doi":"10.1016/j.tjnut.2024.12.027","DOIUrl":"https://doi.org/10.1016/j.tjnut.2024.12.027","url":null,"abstract":"<p><strong>Background: </strong>Human milk macronutrient (protein, fat, and carbohydrate) and energy concentrations vary based on maternal and infant factors and time postpartum.</p><p><strong>Objective: </strong>To determine the change in milk macronutrient and energy concentrations from approximately 2 to 5 months postpartum and identify factors associated with this variation among a lactation cohort in Bangladesh.</p><p><strong>Methods: </strong>In this prospective observational lactation cohort in rural Sylhet, Bangladesh, we collected hand-expressed mid-feed human milk samples and analyzed macronutrient concentrations using mid-infrared spectroscopy. We used the Wilcoxon rank-sum test to compare macronutrient and energy concentrations between time points and mixed linear regression to determine associations between predictors (maternal body mass index [BMI], maternal mid-upper arm circumference, infant gestational age, and infant small-for-gestational age (SGA) status) and repeated measures of milk macronutrient and energy concentrations in models adjusted for parity, nicotine, and wealth index.</p><p><strong>Results: </strong>We enrolled 99 participants. From visit 1 (∼2 mos) to visit 2 (∼5mos), median milk protein concentration decreased from 1.4 g/dL (IQR 1.1, 1.6) to 0.8 g/dL (IQR 0.6, 1.1), median fat concentration decreased from 4.6 g/dL (interquartile range [IQR] 3.8, 5.5) to 2.8 g/dL (IQR 2.1, 3.7) and median energy concentration decreased from 22.7 kcal/oz (IQR 20.6, 25.1) to 17.5 kcal/oz (IQR 15.6, 19.9). Maternal overweight status was associated with a lower carbohydrate concentration (2 months: mean difference [MD] -0.16 g/dL [95% confidence interval [CI] -0.28, -0.03]; 5 months: MD -0.14 g/dL [95% CI -0.26, -0.02]; ref = normal BMI).</p><p><strong>Conclusions: </strong>The decline of protein, fat, and energy concentrations over time is a potential concern for Bangladesh's vulnerable population of human milk-fed infants, as these nutrients have implications for infant growth and neurodevelopment.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the EAT-Lancet Diet, Incidence of Cardiovascular Events, and All-cause Mortality: Results from a Swiss Cohort.","authors":"Laís Bhering Martins, Magda Gamba, Anna Stubbendorff, Nathalie Gasser, Laura Löbl, Florian Stern, Ulrika Ericson, Pedro Marques-Vidal, Séverine Vuilleumier, Angeline Chatelan","doi":"10.1016/j.tjnut.2024.12.012","DOIUrl":"https://doi.org/10.1016/j.tjnut.2024.12.012","url":null,"abstract":"<p><strong>Background: </strong>An unhealthy diet is a major contributor to several noncommunicable diseases, including cardiovascular diseases (CVD), the leading cause of death worldwide. Additionally, our food system has significant impacts on the environment. The EAT-Lancet Commission has recommended a healthy diet that preserves global environmental resources.</p><p><strong>Objective: </strong>This prospective study evaluated the associations between adherence to the EAT-Lancet diet and the incidence of cardiovascular events and all-cause mortality in a Swiss cohort.</p><p><strong>Methods: </strong>We analyzed data from the CoLaus|PsyCoLaus cohort study (n = 3,866). Dietary intake was assessed using a semiquantitative food frequency questionnaire. The EAT-Lancet adherence score was calculated based on the recommended intake and reference intervals of 12 food components, ranging from 0 to 39 points. Participants were categorized into low-, medium-, and high-adherence groups according to score tertiles. We used Cox Proportional Hazards regressions to assess the association between diet adherence, incident cardiovascular events and all-cause mortality.</p><p><strong>Results: </strong>During a mean follow-up of 7.9 years (SD, ±2.0), 294 individuals (7.6%) from our initial sample experienced a first cardiovascular event, and 264 (6.8%) died. Compared with the low-adherence group, the adjusted hazard ratios for all-cause mortality were 0.88 (95% CI: 0.66-1.17) and 0.70 (95% CI: 0.49-0.98) for the medium- and high-adherence groups, respectively (p for trend = 0.04). We observed no association between adherence groups and cardiovascular events.</p><p><strong>Conclusions: </strong>In a Swiss cohort, high adherence to the EAT-Lancet diet was associated with a potential 30% lower risk of overall mortality. However, no association was found between the EAT-Lancet diet and cardiovascular events.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}