Journal of Nutrition最新文献

{"title":"Continuous exposure of non-obese adult male rats to a soft-textured, readily absorbable diet induces insulin resistance and derangements in hepatic glucose and lipid metabolism.","authors":"Fumitake Yamaguchi, Sayaka Akieda-Asai, Eriko Nakamura, Hinano Uchida, Atsushi Yamashita, Yukari Date","doi":"10.1016/j.tjnut.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.03.009","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes (T2D) is characterized by insulin resistance and defective insulin secretion. Previously, we found that rats fed soft pellets (SPs) on a 3-hour restricted schedule over 14 weeks demonstrated glucose intolerance and insulin resistance with disruption of insulin signaling.</p><p><strong>Objective: </strong>To determine (1) the time required for an SP diet to induce insulin resistance, and (2) whether the metabolic derangements in rats fed SPs can be reversed by changing to a standard control diet.</p><p><strong>Methods: </strong>We performed glucose tolerance tests and calculated the homeostasis model assessment of insulin resistance (HOMA-IR) to evaluate the insulinemic response to glucose and assess insulin resistance in non-obese male rats fed control pellets (CPs) or SPs on a 3-hour restricted schedule (10:00 to 13:00) for 4 and 9 weeks. At 11 weeks, we switched half of the insulin-resistant SP group to CPs (soft-to-control pellets [SCPs]) and after an additional 11 weeks, evaluated changes in glucose and lipid metabolism across the three groups.</p><p><strong>Results: </strong>The glucose tolerance test results in the SP and CP rats did not differ at 4 or 9 weeks. The insulin levels in the SP group were higher than in the CP group at both time points (P < 0.05). The HOMA-IR was significantly higher in the SP rats at 9 weeks compared with the controls (P < 0.05). At 22 weeks, the HOMA-IR, blood glucose levels at 30 minutes after initiating feeding, hepatic glucose metabolism, and lipid synthesis in the rats fed SPs continuously were significantly greater than in those fed CPs (P < 0.05); however, these values in the SCP rats did not differ from those in the CP rats.</p><p><strong>Conclusions: </strong>A continuous diet of soft textured, readily absorbable food may be an important and reversible underlying driver in T2D pathogenesis.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional associations between clinical biochemistry and nutritional biomarkers and sarcopenic indices of skeletal muscle in the Baltimore Longitudinal Study of Aging.","authors":"Jamie Scott, Max Yates, Toshiko Tanaka, Luigi Ferrucci, Donnie Cameron, Ailsa A Welch","doi":"10.1016/j.tjnut.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.03.006","url":null,"abstract":"<p><strong>Background: </strong>Investigating relationships between nutritional and clinical biochemistry biomarkers and skeletal muscle mass, strength and function (sarcopenic indices) may: (i) highlight micronutrients of interest for potential preventive or treatment strategies for sarcopenia, or (ii) highlight biomarkers that may be useful for identifying individuals at risk of sarcopenia.</p><p><strong>Objectives: </strong>Investigate associations between nutritional biomarkers (vitamin D, vitamin B12, folate, magnesium, potassium, calcium, iron), clinical biomarkers (haemoglobin, ferritin, albumin, creatinine, HbA1c) and sarcopenic indices (appendicular lean mass (ALM), height-adjusted ALM (ALM_ht), fat-free mass percentage of body weight (FFM%), extended short physical performance battery score (_extSPPB), and height-adjusted hand grip strength (HGS_ht) and knee extension concentric (KEC_ht) and isometric (KEI_ht) strength) in men and women.</p><p><strong>Design: </strong>Using multivariable linear regression analysis we investigated cross-sectional associations between biomarkers and sarcopenic indices in data collected from 1,761 participants (age 22-103 years) from the Baltimore Longitudinal Study of Aging (BLSA).</p><p><strong>Results: </strong>Haemoglobin was positively associated with ALM (β=0.20, p=0.021), HGS_ht (β=0.25, p=0.001) and _extSPPB (β=0.13, p=0.024) in men, and with _extSPPB in women (β=0.15, p=0.019). In men, serum iron was positively associated with ALM_ht (β=0.0021, p=0.038) and _extSPPB (β=0.0043, p=0.045). In women, ferritin was positively associated with knee-extension strength measurements. Serum creatinine was positively associated with lean mass measures in men and women, and with muscle strength and function measures in men with normal renal function (estimated glomerular filtration rate 60 mL/min/1.73m²). In men, high HbA1c was associated with lower ALM_ht (β=-0.21, p=0.023), _extSPPB (β=-0.40, p=0.027) and HGS_ht (β=-0.56, p=0.031). In men and women, magnesium was positively associated with _extSPPB, and potassium was positively associated with measures of knee-extension strength.</p><p><strong>Conclusion: </strong>The associations found between measures of iron status and creatinine and sarcopenic indices, in men in particular, indicate potential importance for muscle health. Future longitudinal and intervention studies are warranted to confirm these findings.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folic acid-containing supplement use among females aged 15-55 in the Canadian Community Health Survey 2015-2018.","authors":"Kathryn E Hopperton, Lidia Loukine, The Minh Luong, Loan Nguyen, Jesse Bertinato, Yvette Bonvalot, Marcia Cooper, Wei Luo, Amanda J MacFarlane, Jennifer McCrea, Carley Nicholson, Huma Rana, Kelsey Vercammen, Jane Yuan, Shawn Brule, Hope A Weiler","doi":"10.1016/j.tjnut.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.03.004","url":null,"abstract":"<p><strong>Introduction: </strong>In Canada, those who are or who could become pregnant are recommended to consume a daily multivitamin containing 400 μg of folic acid to help prevent neural tube defects.</p><p><strong>Objectives: </strong>To report the prevalence and determinants of folic acid-containing supplement use among females of childbearing age in Canada.</p><p><strong>Methods: </strong>Data were combined from cycles 2015/16 and 2017/18 of the maternal experiences module of the cross-sectional Canadian Community Health Survey, which was completed by females aged 15-55 years. Representative weighted estimates (means/percentages, 95% CI) were generated for folic acid-containing supplement use among all pregnant, non-pregnant, and lactating respondents. For those who had given birth in the preceding 5 years, estimates were also generated for supplement use in the 3 months before and first 3 months of their most recent pregnancy, and pre-pregnancy awareness of the link between folic acid and some birth defects. We examined associations with sociodemographic factors using multivariable logistic regression.</p><p><strong>Results: </strong>Overall, 16.5% (15.9-17.0%) of non-pregnant, 80.3% (77.1-83.5%) of pregnant, and 58.4% (54.8-61.9%) of lactating females aged 15-55 reported using a folic acid-containing supplement. Among those who had given birth in the preceding 5 years, 63.7% (62.2-65.1%) consumed a folic acid-containing supplement in the 3 months prior to pregnancy, while 89.9% (88.8-90.9%) did so during the first trimester. Lower prevalence of supplement use before or during pregnancy was reported among the 23.7% (22.4-25.1%) of respondents unaware of the relationship between folic acid and birth defects. Younger age, single marital status, lower educational attainment, income below the median, and smoking were associated with lower odds of awareness or supplement use.</p><p><strong>Conclusion: </strong>While most females living in Canada reported using folic acid-containing supplements prior to and during pregnancy, use of these supplements among non-pregnant females of childbearing age is low, and sociodemographic inequalities exist.</p><p><strong>Clinical trial registry number: </strong>not applicable REGISTRY AND REGISTRY NUMBER FOR SYSTEMATIC REVIEWS OF META-ANALYSIS: not applicable.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of gut microbiota-hif1α axis effectively restores resistance to Aeromonas veronii caused by improper administration of AiiO-AIO6.","authors":"Hongwei Yang, Rui Xia, Tsegay Teame, Delong Meng, Shenghui Li, Tiantian Wang, Qianwen Ding, Yuanyuan Yao, Xiaoqing Xu, Yalin Yang, Chao Ran, Yaqing Zhang, Shengkang Li, Benjamin Niemann, Le Luo Guan, Zhen Zhang, Zhigang Zhou","doi":"10.1016/j.tjnut.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.03.007","url":null,"abstract":"<p><strong>Background: </strong>Feeding adult zebrafish a diet supplemented with quenching enzyme AiiO-AIO6 for 3 wk improved the growth performance and disease resistance. However, when the feeding period was extended to 8 wk, zebrafish's disease resistance to Aeromonas veronii decreased.</p><p><strong>Objective: </strong>We investigated the mechanisms of the reduced disease resistance of zebrafish induced by feeding on AiiO-AIO6 supplemented diet for a long-term (8 wk), and assessed the effectiveness of feed additives in restoring the low disease resistance.</p><p><strong>Methods: </strong>One-month-old (adult) zebrafish were fed with a basal diet and the basal diet supplemented with AiiO-AIO6 (10 U/g) for 8 wk (Expt. 1). Furthermore, zebrafish larvae model (Expt. 2) was developed and used to study the mechanisms how AiiO-AIO6 affected the disease resistance (Expt. 3). We also investigated the effectiveness of selected prebiotic tributyrin, β-glucan or mannan in activating gut microbiota-hif1α to restore the low disease resistance of adult zebrafish fed with AiiO-AIO6 for 8 wk (Expt. 4). Lastly, the effects of Bacillus subtilis in activating the gut microbiota-hif1α and improving the low disease resistance of zebrafish larvae induced by AiiO-AIO6 was examined (Expt. 5).</p><p><strong>Results: </strong>Feeding adult zebrafish with AiiO-AIO6 for 8 wk promoted the growth but disordered the gut microbiota and reduced disease resistance. Zebrafish larvae model confirmed that feeding AiiO-AIO6 for 2 d increased disease resistance, while 7 d decreased the resistance by suppressing hif1α. Using a germ-free zebrafish larvae model, we also demonstrated that AiiO-AIO6-induced gut microbiota mediated inhibition of hif1α. Furthermore, zebrafish fed on the AiiO-AIO6 containing diet supplement with tributyrin, β-glucan, mannan, or B. subtilis activated the gut microbiota-hif1α axis to reverse the low resistance caused by AiiO-AIO6.</p><p><strong>Conclusion: </strong>Activating the gut microbiota-hif1α axis has vital role in improving intestinal health and restores the low resistance to A. veronii caused by improper administration of dietary AiiO-AIO6 in zebrafish.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles from Lactobacillus fermentum enhance intestinal barrier integrity and restore gut microbial homeostasis in experimental murine colitis.","authors":"Yanwei Wang, Tiantian Li, Zhuo Dong, Qiyue Zhang, Jingqiu Mi, Qingfeng Wang, Gang Lin, Qiugang Ma, Ru Jia, Shimeng Huang","doi":"10.1016/j.tjnut.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.03.001","url":null,"abstract":"<p><strong>Background: </strong>Lactobacillus fermentum (L. fermentum) has been shown to improve intestinal health and treat colitis; however, its precise efficacy and mechanisms in inflammatory bowel disease (IBD) remain unclear.</p><p><strong>Objectives: </strong>This study aimed to evaluate whether L. fermentum and its metabolites, extracellular vesicles, and other components could modulate intestinal barrier function and gut microbiota to alleviate dextran sulfate sodium (DSS)-induced colitis in mice.</p><p><strong>Methods: </strong>Forty-eight mice were randomly assigned to six groups: Control (CON), DSS, L. fermentum + DSS group (LF + DSS), heat-inactivated L. fermentum + DSS group (LHF + DSS), L. fermentum supernatant solution + DSS group (LSF + DSS), and L. fermentum extracellular vesicles + DSS group (LEV + DSS). After a one-week acclimation, mice were gavaged daily for three weeks. Fresh cultures, including live (LF + DSS), heat-inactivated (LHF + DSS), supernatant (LSF + DSS), and extracellular vesicles (LEV + DSS), were prepared daily. During the final seven days, the control group received normal water, while the other groups received 3% DSS. Data were collected daily, followed by sample collection from the mice.</p><p><strong>Results: </strong>Herein, significant reductions (P < 0.05) in body weight changes, disease activity index (DAI), intestinal damage, and histology scores were observed in the treatment groups, especially LEV + DSS and LF + DSS. Additionally, compared with the DSS group, colonic mucus secretion, as well as claudin-1 and occludin expression, increased significantly (P < 0.05) in the LEV + DSS and LF + DSS groups, while proinflammatory cytokines interleukin (IL) -1β and tumor necrosis factor-α (TNF-α) decreased (P < 0.05) and IL-10 increased (P < 0.05) in the LEV + DSS group. L. fermentum and its components significantly regulated gut microbiota α-diversity and β-diversity, affecting overall composition. LEfSe analysis revealed an enrichment of beneficial bacteria including Prevotellaceae_UCG-001, Romboutsia, and Ruminococcus in the LF + DSS group, and Akkermansia, Odoribacter, and Marvinbryantia in the LEV + DSS group. Both L. fermentum and its extracellular vesicles significantly downregulated the gene expression of TNF-α and IL-1β, while upregulating the expression of IL-10, thereby contributing to the alleviation of colitis symptoms.</p><p><strong>Conclusions: </strong>This study reveals that L. fermentum alleviates colitis through modulation of the gut microbiota and reinforcement of the intestinal mucosal barrier, with its extracellular vesicles potentially playing a key role in this regulatory process.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case-Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.","authors":"Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Tomoko Tanaka, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara","doi":"10.1016/j.tjnut.2025.02.024","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.02.024","url":null,"abstract":"<p><strong>Background: </strong>Adiposity rebound (AR) is the point when the body mass index (BMI) begins to rise again during early childhood. Early AR (before age 5) is associated with a higher risk of lifelong obesity and metabolic disorders and may be influenced by breastfeeding. Although human milk oligosaccharides (HMOs) in breast milk are crucial for child growth, their association with AR status has not been studied.</p><p><strong>Objective: </strong>To explore breast milk HMO compositions and molecules associated with AR status in children.</p><p><strong>Methods: </strong>In this case-control study, we included 184 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study (93 AR cases, 91 controls). Breast milk was collected 1 month postpartum, and the concentration of 15 HMO molecules and alpha-diversity index (Inverse Simpson index) were quantified. Wilcoxon's rank-sum test and partial least squares-discriminant analysis (PLS-DA) identified candidate HMOs, and multivariable logistic regression analysis evaluated associations between candidate HMOs and AR status. Analyses were stratified by maternal secretor status (secretor or non-secretor).</p><p><strong>Results: </strong>In secretor mothers, multivariable logistic regression showed that the Inverse Simpson index (OR, 0.54 [95% CI, 0.36-0.82]), sum of sialic acid-bound HMOs (0.61 [0.41-0.91]), and 3'-sialyllactose (0.67 [0.46-0.98]) were inversely associated with early AR in a fully adjusted model. A trend of interaction between sialyl-lacto-N-tetraose a (LSTa) and maternal secretor status on AR was observed in a fully adjusted model (P-value for interaction = 0.051).</p><p><strong>Conclusions: </strong>Alpha diversity, sialic acid-bound HMOs, and 3'SL may be involved in inhibiting AR in children of secretor mothers, and a trend of interactive effect of LSTa among maternal secretor status on AR was indicated. These findings offer novel perspectives on the associations between breastfeeding and a child's adiposity as well as potential metabolic disorders later in life. REGISTRY NUMBER/WEBSITE: https://www.umin.ac.jp/ (trial registration number: UMIN000047160).</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary gluten intake and cardiovascular disease mortality in Japanese adults in the Takayama study.","authors":"Michiko Tsuji, Keiko Wada, Michiyo Yamakawa, Masaaki Sugino, Tomoka Mori, Chisato Nagata","doi":"10.1016/j.tjnut.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.03.005","url":null,"abstract":"<p><strong>Background: </strong>There is growing attention toward the gluten-free diet in Japan, in spite of a low prevalence of celiac disease and high consumption of rice.</p><p><strong>Objectives: </strong>The present study examined whether gluten intake is associated with an increased risk of cardiovascular disease (CVD) mortality in Japanese adults.</p><p><strong>Methods: </strong>In 1992, 13,355 men and 15,724 women, 35 years of age and older, in the Takayama study completed a self-administered questionnaire. Gluten intake was estimated using a food-frequency questionnaire as the baseline. Mortality was ascertained during 16 years of follow-up. Hazard ratios (HRs) and 95% CIs for CVD mortality according to gluten intake quartiles were calculated.</p><p><strong>Results: </strong>During 16.1 years of follow-up, 775 CVD deaths in men and 903 CVD deaths in women occurred. As compared with the lowest quartile of intake, the highest quartile of gluten intake was significantly associated with a decreased risk of CVD mortality after controlling for age, sex and other covariates (HR = 0.73; 95% CI: 0.62-0.86, P-trend = 0.0003).</p><p><strong>Conclusions: </strong>Our data showed a significant inverse association between gluten intake and CVD mortality. The present study does not support the notion that gluten avoidance should have a beneficial effect on CVD mortality.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habitual dietary collagen intake is lower in women and older Irish adults compared to younger men.","authors":"Christopher D Nulty, Janette Walton, Robert M Erskine","doi":"10.1016/j.tjnut.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.03.002","url":null,"abstract":"<p><strong>Background: </strong>Collagen ingestion is purported to benefit connective tissues, such as skin, bone, muscle, tendon, and ligament. However, the quantity of collagen intake in the diet of European adults is unknown.</p><p><strong>Objective: </strong>To investigate collagen intake in the habitual diets of Irish adults, and whether it differed according to sex and/or age.</p><p><strong>Methods: </strong>We conducted secondary analysis of the Irish National Adult Nutrition Survey, which assessed typical dietary intake using a four-day food diary in 1,500 adults, aged 18-90 years. We categorized participants into three age groups: young (18-39 years, n=630), middle-aged (40-64 years, n=644), and older (≥65 years, n=226) adults. Collagen composition of each individual food item in the database was determined by applying a percentage collagen value from analytical sources, allowing computation of collagen mean daily intake (MDI), collagen MDI relative to body mass, and collagen/total protein MDI. Differences in intakes between age groups and sexes were evaluated using physical activity level as a covariate.</p><p><strong>Results: </strong>Collagen MDI for the entire population was 3.2±2.0 g∙day^-1, representing 3.6±1.9% total protein intake. Men had higher absolute and relative collagen MDI than women, regardless of age (4.0±2.1 g∙day^-1 vs. 2.3±1.4 g∙day^-1, p<0.001), while older adults had lower absolute collagen MDI than middle-aged adults (2.9±1.8 g∙day^-1 vs. 3.3±2.0g∙day^-1, p=0.021).</p><p><strong>Conclusions: </strong>Collagen intake in the Irish adult population was considered low (relative to total protein intake and to dose-response studies), particularly in women and older individuals. Increasing daily collagen intake may therefore be warranted to optimise the health of collagen-rich tissues.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation. J Nutr 148 (2018); 3:316-325.","authors":"Yun Hu, Qinwei Sun, Yan Hu, Zhen Hou, Yibo Zong, Nagmeldin A Omer, Halima Abobaker, Ruqian Zhao","doi":"10.1016/j.tjnut.2025.02.014","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.02.014","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effectiveness of Protein Supplementation Combined with Resistance Training on Body Composition and Physical Function in Healthy Elderly Adults","authors":"Haiping Tian ,&nbsp;Wanwan Qiao ,&nbsp;Xianxiu Wen","doi":"10.1016/j.tjnut.2025.01.017","DOIUrl":"10.1016/j.tjnut.2025.01.017","url":null,"abstract":"<div><h3>Background</h3><div>The global population of individuals over 65 y is expected to reach 426 million by 2050. Aging is associated with a progressive loss of muscle mass, strength, and function, leading to sarcopenia and adverse outcomes such as physical disability and increased mortality. Interventions such as resistance training and protein supplementation have shown promise in mitigating these effects.</div></div><div><h3>Objectives</h3><div>To determine the comparative effectiveness of protein supplementation, resistance training, and their combination on body composition and physical function in healthy older adults through a network meta-analysis.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and network meta-analysis following PRISMA guidelines and registered it in PROSPERO (CRD42021226561). We included randomized controlled trials comparing protein supplementation, resistance training, and their combination in participants aged ≥50 y. Data were extracted from PubMed, Web of Science, Embase, and Cochrane Library. The risk of bias was assessed using the Cochrane Collaboration Risk of Bias Tool.</div></div><div><h3>Results</h3><div>A total of 38 randomized controlled trials involving 2610 participants were included. The combined intervention of protein supplementation and resistance training significantly improved lean body mass (standardized mean difference [SMD]: 0.44; 95% confidence interval [CI]: 0.05, 0.95) compared with protein supplementation alone. The combined intervention also showed significant improvements in muscle mass (SMD: 1.49; 95% CI: 0.11, 2.67). The combined intervention (SMD: 2.74; 95% CI: 0.76, 4.74) and resistance training alone (SMD: 2.53, 95% CI: 0.29, 4.84) significantly improved muscle strength compared with controls. The combined intervention (SMD: 4.98; 95% CI: 2.72, 7.17) and resistance training alone (SMD: 4.52; 95% CI: 2.30, 6.64) significantly improved physical function compared with protein supplementation alone.</div></div><div><h3>Conclusions</h3><div>Combining exercise and protein supplementation is the most effective method for improving muscle mass, strength, and physical function in older adults. This approach should be considered to enhance physical health in this population. Future large-scale trials are necessary to confirm these findings.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 3","pages":"Pages 764-774"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}