Giovanna D'Abbronzo, Giuseppe Scidà, Cinzia Quaglia, Angela A Rivellese, Lutgarda Bozzetto, Giovanni Annuzzi, Marilena Vitale
{"title":"App-based bioelectrical impedance analysis provides accurate body composition parameters in a more cost-efficient and time-efficient way.","authors":"Giovanna D'Abbronzo, Giuseppe Scidà, Cinzia Quaglia, Angela A Rivellese, Lutgarda Bozzetto, Giovanni Annuzzi, Marilena Vitale","doi":"10.1016/j.tjnut.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.013","url":null,"abstract":"<p><strong>Background: </strong>In clinical practice, there is an increasing demand for methods that provide accurate, precise, and real-time body composition measurements while reducing costs and data collection time.</p><p><strong>Objective: </strong>This study aimed to evaluate the validity of an app-based bioelectric impedance analysis (BIA) system for determining body composition compared to a standard BIA method.</p><p><strong>Methods: </strong>A total of 109 individuals with type 1 diabetes (56 men and 53 women), aged 18 to 70 years, with a BMI of 25.0-35.0 kg/m<sup>2</sup> and glycated hemoglobin levels of 7.0-9.0%, were recruited. Participants were randomly assigned to start with either the app-based BIA system or the standard method (A-Wave BIA Quantum-V) and then switched to the other method. Anthropometric parameters, blood pressure, and metabolic profiles were also assessed.</p><p><strong>Results: </strong>The comparison between the two methods showed a negligible difference in resistance but a significant difference in reactance (-4.9%). The degree of consistency was excellent for both resistance (ICC=0.990, p<0.001) and reactance (ICC=0.903, p<0.001), with individual differences falling within acceptable ranges. Furthermore, body composition parameters, including fat-free mass, fat mass, skeletal muscle mass, total body water, and extracellular water, showed only minor and non-significant differences between the two methods.</p><p><strong>Conclusions: </strong>These findings suggest that the app-based BIA system is a valid and reliable tool for assessing body composition, offering healthcare professionals, including dietitians and nutritionists, a cost-effective and time-efficient alternative to standard BIA methods.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pascal Gloor, Isabelle Haeberling, Katharina Spanaus, Gerd A Kullak-Ublick, Gregor Berger, Michele Visentin
{"title":"The Role of Folate Receptor α Autoantibodies in Folate Deficiency, Disease Severity, and Treatment Response in Adolescents with Major Depressive Disorder.","authors":"Pascal Gloor, Isabelle Haeberling, Katharina Spanaus, Gerd A Kullak-Ublick, Gregor Berger, Michele Visentin","doi":"10.1016/j.tjnut.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.012","url":null,"abstract":"<p><strong>Background: </strong>Low levels of systemic folates have been associated with a higher risk of major depressive disorder (MDD) and more severe symptoms. Moreover, folate supplementation has been shown to increase the response to selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs). Folates reach the brain through the choroid plexus via transcytosis mediated by the folate receptor alpha (FRα). FRα also represents the main mechanism of folate retrieval from the nascent urine. Autoantibodies against the FRα (FRAA) have been found in the serum of individuals with cerebral folate deficiency.</p><p><strong>Objective: </strong>To assess the role of serum FRAA titer on serum folate level, disease severity and response to the SSRI/SNRI treatment in adolescents with MDD.</p><p><strong>Methods: </strong>Serum samples at baseline obtained from the participants of a large multi-center intervention trial in moderately to severely depressed youth were analyzed. Quantification of FRAA was performed by enzyme-linked immunosorbent assay (ELISA). Serum folate concentration was determined by radioligand binding assay.</p><p><strong>Results: </strong>FRAA titer in the patients with folate deficiency (≤ 3.0 ng/mL) was significantly higher than that in the patients with a normal folate level, and a low FRAA titer was associated with a reduced risk of folate deficiency. No correlation was found between the Children's Depression Rating Scale - Revised (CDRS-R) score and the serum folate level or the FRAA titer. In regression analysis, the effect size of the serum folate concentration on the response to SSRI/SNRI was larger than that of the FRAA titer. The response rate to the treatment in the high folate group was approximately 4 times that in the low folate group (28.5% vs. 6.7%).</p><p><strong>Conclusions: </strong>In conclusion, patients with high FRAA titers carry a higher risk of folate deficiency. Moreover, the response to SSRI/SNRI treatment is less likely in patients with folate deficiency.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing One Health.","authors":"Naïma Moustaïd-Moussa, Ismahane Elouafi, Ron Cook","doi":"10.1016/j.tjnut.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.001","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coffee Consumption and Mortality Among U.S. Adults: A Prospective Cohort Study.","authors":"Bingjie Zhou, Mengyuan Ruan, Yongyi Pan, Lu Wang, Fang Fang Zhang","doi":"10.1016/j.tjnut.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.004","url":null,"abstract":"<p><strong>Background: </strong>While coffee consumption has been associated with a variety of health benefits, it remains unclear whether the addition of sugar and saturated fat modifies these effects.</p><p><strong>Objective: </strong>To examine the relationship between coffee intake, including the amount of added sugar and saturated fat, and mortality among U.S. adults.</p><p><strong>Methods: </strong>We conducted a prospective cohort study using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, linked to National Death Index Mortality Data. The study included 46,332 adults aged 20 years and older who completed valid first-day 24-hour dietary recalls. Coffee consumption was categorized by type (caffeinated or decaffeinated) and by sugar (<2.5g per 8-oz), and saturated fat content (<1g per 8-oz). Mortality outcomes included all-cause, cancer, and cardiovascular disease (CVD) mortality. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality risk based on type, intake levels (non-drinkers, <1 cup/day, 1 to <2 cups/day, 2 to <3 cups/day, and ≥3 cups/day) and the amount of added sugar and saturated fat.</p><p><strong>Results: </strong>Over a median follow-up of 9.3 to 11.3 years, a total of 7,074 deaths occurred, including 1,176 cancer-specific and 1,089 CVD-specific deaths. Higher coffee consumption was associated with lower all-cause mortality (HR [95% CI]: 0.89 [0.78, 1.02] for < 1 cup/d; 0.84 [0.77, 0.92] for 1 to <2 cups/d; 0.83 [0.75,0.93] for 2 to < 3 cups/d; and 0.85 [0.77, 0.95] for ≥3 cups/day; P-trend= 0.004). However, the mortality benefits were restricted to black coffee (HR [95% CI]: 0.86 [0.77, 0.97]) and coffee with low added sugar and saturated fat content (HR [95% CI]: 0.86 [0.75,0.99]).</p><p><strong>Conclusion: </strong>The health benefits of coffee consumption may be diminished when sugar and saturated fat are added.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saija Tarro, Jussi Vahtera, Jaana Pentti, Harri Niinikoski, Olli Raitakari, Tapani Rönnemaa, Jorma Viikari, Katja Pahkala, Hanna Lagström
{"title":"Diet quality trajectories from infancy to young adulthood: The STRIP Study.","authors":"Saija Tarro, Jussi Vahtera, Jaana Pentti, Harri Niinikoski, Olli Raitakari, Tapani Rönnemaa, Jorma Viikari, Katja Pahkala, Hanna Lagström","doi":"10.1016/j.tjnut.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.005","url":null,"abstract":"<p><strong>Background: </strong>Stability in dietary habits has been observed during childhood and adolescence, but their stability from infancy to adulthood is less known.</p><p><strong>Objectives: </strong>Our aim was to identify latent diet quality trajectories from age 1 to 18 years and to examine their association with diet quality at age 26.</p><p><strong>Methods: </strong>The study included 620 participants from the Special Turku Coronary Risk Factor Intervention Project (STRIP), initiated in infancy. Food and nutrient intake were assessed annually from age one to age 18, and again at age 26 using food records. A food-based diet score (range 0-33) was calculated to indicate diet quality. Group-based modelling was used to model trajectories of diet quality between the ages of 1 and 18 years. Logistic regression analysis examined associations of childhood sociodemographic characteristics with diet trajectories. Linear regression analyses investigated associations between the observed developmental diet quality trajectory groups and diet quality at age 26 years, adjusted for adulthood sociodemographic characteristics.</p><p><strong>Results: </strong>From age 1 to 18 years, five diet quality trajectory groups were identified: low (19% of participants), decreasing (25%), increasing (15%), intermediate (31%) and high (10%). Throughout the follow-up period, the diet score remained at 20-22 in the high group, and at 11-13 in the low diet quality trajectory group. The diet quality trajectory groups predicted diet quality at age 26 (p <0.001). The adjusted mean difference in adulthood diet score between the low and high trajectory groups was 3.6 (1.5-5.7). Notably, participants in the intervention group had higher scores than controls across all trajectories and throughout the entire follow-up period.</p><p><strong>Conclusions: </strong>The study identified five distinct diet quality trajectory groups from infancy to adulthood, highlighting a clear difference between the highest and lowest diet quality groups. The findings suggest that dietary habits established in early childhood remain moderately stable into early adulthood.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shreya Verma, Tori A Holthaus, Shelby Martell, Hannah D Holscher, Ruoqing Zhu, Naiman A Khan
{"title":"Predicting Cognitive Outcome Through Nutrition and Health Markers Using Supervised Machine Learning.","authors":"Shreya Verma, Tori A Holthaus, Shelby Martell, Hannah D Holscher, Ruoqing Zhu, Naiman A Khan","doi":"10.1016/j.tjnut.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.003","url":null,"abstract":"<p><strong>Background: </strong>Machine learning (ML) use in health research is growing, yet its application to predict cognitive outcomes using diverse health indicators is under-investigated.</p><p><strong>Objective: </strong>We utilized ML models to predict cognitive performance based on a set of health and behavioral factors, aiming to identify key contributors to cognitive function for insights into potential personalized interventions.</p><p><strong>Methods: </strong>Data from 374 adults aged 19-82 years (227 females) were used to develop ML models predicting cognitive performance (reaction time in milliseconds [ms]) on a modified Eriksen flanker task. Features included demographics, anthropometric measures, dietary indices (healthy eating index [HEI], Dietary Approaches to Stop Hypertension [DASH], Mediterranean, and Mediterranean-DASH Intervention for Neurodegenerative Delay [MIND]), self-reported physical activity, systolic (SBP) and diastolic blood pressure (DBP). The dataset was split (80:20) for training and testing. Predictive models (Decision Trees, Random Forest, AdaBoost, XGBoost, Gradient Boosting, Linear, Ridge, and Lasso Regression) were used with hyperparameter tuning and cross-validation. Feature importance was calculated using Permutation Importance, while Performance using Mean Absolute Error (MAE) and Mean Squared Error (MSE).</p><p><strong>Results: </strong>Random Forest Regressor exhibited the best performance, with the lowest MAE (ms) (training: 0.66, testing: 0.78) and MSE (ms<sup>2</sup>) (training: 0.70, testing:1.05). Age was the most significant feature (score: 0.208), followed by DBP (0.169), BMI (0.079), SBP (0.069), and HEI (0.048). Ethnicity (0.005) and sex (0.003) had minimal predictive effect.</p><p><strong>Conclusion: </strong>Age, blood pressure, and BMI showed strong associations with cognitive performance, while diet quality had a subtler effect. These findings highlight the potential of ML models for developing personalized interventions and preventive strategies for cognitive decline.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaowen Wang, Caifang Xu, Hualin Wang, Bowen Du, Qianchuo Wang, Zhuoyan Li, Zhikang Xu, Zhi Wang, Bo Wang, Fengxiu Ouyang, Jian Wang, Kun Sun
{"title":"Association of Maternal Whole Blood Selenium with Cardiac Structure at 4 years of Age:a prospective birth cohort study.","authors":"Xiaowen Wang, Caifang Xu, Hualin Wang, Bowen Du, Qianchuo Wang, Zhuoyan Li, Zhikang Xu, Zhi Wang, Bo Wang, Fengxiu Ouyang, Jian Wang, Kun Sun","doi":"10.1016/j.tjnut.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.002","url":null,"abstract":"<p><strong>Background: </strong>Currently, little is known about the relationship between maternal blood selenium levels and offspring cardiac structure.</p><p><strong>Objectives: </strong>This study aimed to evaluate the association of maternal whole blood selenium levels during early pregnancy with children's cardiac structure at 4 years of age.</p><p><strong>Methods: </strong>Using data from the Shanghai Birth Cohort, this study analyzed the data from 956 mother-child pairs. Multiple linear or logistic regressions and restricted cubic spline were used to explore the association of maternal whole blood selenium levels with offspring cardiac structure.</p><p><strong>Results: </strong>Low maternal selenium levels were associated with increased left ventricular posterior wall thickness at systole (LVPWs) (β = 0.29, 95%CI: 0.06, 0.53), left ventricular posterior wall thickness at diastole (LVPWd) (β = 0.17, 95%CI: 0.01, 0.31), and relative wall thickness (RWT) (β = 0.011, 95%CI: 0.003, 0.019) in male offspring. Moreover, maternal selenium showed a U-shape curve with left ventricular mass index (LVMI) (P for nonlinearity = 0.002), LVPWd (P for nonlinearity = 0.035), IVSd (P for nonlinearity = 0.006) and RWT (P for nonlinearity = 0.013) in male offspring. However, no significant association of structural changes was found in female offspring. Compared with offspring with medium maternal selenium levels, the increased risk of left ventricular hypertrophy (LVH) (OR = 4.14; 95% CI: 1.81, 9.45) was only found in male offspring with lower maternal selenium levels.</p><p><strong>Conclusions: </strong>Low maternal selenium levels were associated with cardiac structural changes and higher LVH risk in preschool male offspring, while no correlation was found in female offspring.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bile Acids Modulate Hepatic Glycolipid Metabolism via the Microbiota-Gut-Liver Axis in Lambs.","authors":"Hailong Zhao, Daiwei Zhu, Yuyang Gao, Bing Wang","doi":"10.1016/j.tjnut.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.008","url":null,"abstract":"<p><strong>Background: </strong>Bile acids are essential molecules that facilitate lipid emulsification and function as signaling molecules mediating host-microbiota interactions. They shape the gut microbial structure and function, playing a critical role in metabolic regulation via the gut-liver axis.</p><p><strong>Objectives: </strong>This study aimed to investigate the effects of exogenous bile acids, primarily hyocholic acid (HCA), on the microbiota-gut-liver metabolism in male Tan-lambs fed a high-grain diet.</p><p><strong>Method: </strong>Thirty six-month-old male Tan lambs (Ovis aries) were randomly allocated into either a control (CON) group or an HCA-supplemented group (n = 15 per group). The trial lasted 84 days, including a 14-day adaptation period. On day 70, six lambs from each group were randomly selected for slaughter. Rumen and ileal contents were collected for microbial profiling via 16S rRNA sequencing, and liver tissue samples were harvested for transcriptomic and metabolomic analyses.</p><p><strong>Results: </strong>The HCA intervention significant altered the composition and structure of ruminal and ileal bacteria. Notable increases were observed in Turicibacter (linear discriminant analysis (LDA) score = 2.48; P < 0.05) and Muribaculaceae (LDA score = 3.75; P < 0.05) in the rumen, and Eubacterium fissicatena group (LDA score = 2.50; P < 0.05) in the ileum. Key hepatic genes and metabolites targeted by HCA were identified, including ENPP3, RFK, Ifi203, LIPG, CYP1A1, CYP4A11, nordeoxycholic acid (log-fold change = 6.30, P < 0.005), α-muricholic acid (log-fold change = 5.60, P < 0.001), β-muricholic acid (log-fold change = 5.60, P < 0.001).</p><p><strong>Conclusions: </strong>Exogenous bile acids regulate the microbiota-gut-liver axis, influencing hepatic glycolipid metabolism in sheep. Specifically, nordeoxycholic acid, demonstrates potential as a dietary intervention to promote metabolic homeostasis in ruminants. These findings highlight the potential of HCA and norDCA as functional feed additives or prebiotic agents for improving metabolic health in ruminants and potentially other species.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zenaida Vázquez-Ruiz, Alvaro Alonso, Ángel Alonso-Gómez, Dora Romaguera, Miguel Ángel Martínez-González, Linzi Li, Itziar Berrade, Lucas Tojal-Sierra, Marta Noris, Rosa M Lamuela-Raventós, Vicente Martín, Jordi Salas-Salvadó, Montserrat Fito, Estefanía Toledo
{"title":"Associations between Dietary Phenolic Compounds and Biomarkers of Atrial Fibrillation Risk in Adults with Metabolic Syndrome: A Longitudinal Analysis.","authors":"Zenaida Vázquez-Ruiz, Alvaro Alonso, Ángel Alonso-Gómez, Dora Romaguera, Miguel Ángel Martínez-González, Linzi Li, Itziar Berrade, Lucas Tojal-Sierra, Marta Noris, Rosa M Lamuela-Raventós, Vicente Martín, Jordi Salas-Salvadó, Montserrat Fito, Estefanía Toledo","doi":"10.1016/j.tjnut.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.007","url":null,"abstract":"<p><strong>Introduction: </strong>Phenolic compounds (PC) may reduce the risk of cardiovascular disease due to their anti-inflammatory and antioxidant effects. Examining relationships between dietary intake of total PC and atrial fibrillation (AF) risk biomarkers in a Mediterranean population with metabolic syndrome may offer new insights about AF physiopathology.</p><p><strong>Objective: </strong>This observational study aims to analyze the relationship between total PC intake and serum levels of five AF-related biomarkers over 5 years in 566 participants from the PREDIMED-Plus trial.</p><p><strong>Methods: </strong>In participants with metabolic syndrome (mean age: 65.1 years, 40.4% women), blood biomarkers were measured at baseline, 3, and 5 years: N-terminal pro B-type natriuretic peptide (NT-proBNP) (atrial stretch), high-sensitivity Troponin T (hs-TnT) (myocardial damage), high-sensitivity C-reactive protein (hs-CRP) (inflammation), procollagen type 1 carboxy-terminal propeptide (PICP) (fibrosis), and 3-nitrotyrosine (3-NT) (oxidative stress). PC intake was assessed using a validated 143-item food frequency questionnaire and the Phenol-Explorer database. Changes in log-transformed biomarkers levels were evaluated with multivariable-adjusted mixed linear models. Sources of between-person variability in total PC intake were also evaluated.</p><p><strong>Results: </strong>Over 5-year, participants with moderate-high baseline PC intake (quartiles 2-4) showed a 39.5% (95%CI 27.4%;52.6%; p<0.001) increase in NT-proBNP concentrations compared to a 20.5% (95%CI% 3.4%,40.3%; p=0.03) increase in the lowest quartile, (ptime*categories =0.04). When PC intake was updated over follow-up, moderate-high intake showed a 32.2% (95%CI 19.5%;46.2%, p<0.001) increase in NT-proBNP vs. a 27.3% (95%CI 6.5%;52.1%, p=0.004) in the lowest quartile, (ptime*categories =0.02). Participants with moderate-high PC intake undergoing intensive lifestyle intervention (ILI) showed smaller increases in hs-TnT than those with lower intake. Chocolate was the main contributor to between-person variability in PC intake.</p><p><strong>Conclusion: </strong>Our results shows that higher PC intake was associated with larger increases in NT-proBNP concentrations. In participants undergoing an ILI and higher PC intake, a lower increase in hs-TnT levels was found. Future research is warranted to better understand the role of dietary intake of PC in AF-related pathways.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fiber for Thought: How Fiber-Based Microbiota-Modulation Can Impact Pediatric Brain Health.","authors":"N M Frerichs, T G J de Meij, H J Niemarkt","doi":"10.1016/j.tjnut.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.tjnut.2025.05.011","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}