Gastric Cancer and Obesity: Disease Occurrence and Perioperative Treatment.

Abstract

With the increasing prevalence of obesity worldwide, the association between obesity and gastric cancer (GC) has gained significant attention. This review examines current research on the effects of obesity on GC risk, surgical outcomes, and prognosis. Findings indicate that obesity significantly increases the risk of GC and substantially affects the perioperative treatment of patients with GC. Furthermore, the potential mechanisms by which obesity contributes to GC were explored, including insulin resistance, abnormal adipokine secretion, hormonal changes, reflux esophagitis, and Helicobacter pylori infection. In the context of perioperative treatment, obesity not only increases surgical complexity and prolongs operative duration but also elevates the incidence of postoperative complications. In conclusion, the relationship between obesity and GC is highly complex and requires further investigation to improve treatment strategies and prognostic evaluations in GC management.