Journal of Nutritional Biochemistry最新文献

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EPA but not DHA prevents lipid metabolism disorders by regulating myogenic IL-6 in high-fat fed mice EPA而非DHA通过调节肌源性IL-6阻止高脂喂养小鼠脂质代谢紊乱。
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-12-09 DOI: 10.1016/j.jnutbio.2024.109815
Qunying Xie , Lianzhi Mao , Ning Xiong, Qiting Cheng, Wei Tang, Ci Li, Chongxiang Zeng, Zhilin Liu, Limei Mao
{"title":"EPA but not DHA prevents lipid metabolism disorders by regulating myogenic IL-6 in high-fat fed mice","authors":"Qunying Xie ,&nbsp;Lianzhi Mao ,&nbsp;Ning Xiong,&nbsp;Qiting Cheng,&nbsp;Wei Tang,&nbsp;Ci Li,&nbsp;Chongxiang Zeng,&nbsp;Zhilin Liu,&nbsp;Limei Mao","doi":"10.1016/j.jnutbio.2024.109815","DOIUrl":"10.1016/j.jnutbio.2024.109815","url":null,"abstract":"<div><div>Lipid metabolism disorder serve as a critical starting point for the development of chronic non-communicable diseases (NCDs). Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) are known for their lipid-lowering properties, but few studies have revealed their differences from the perspective of skeletal muscle endocrinology. Myogenic IL-6 has garnered significant attention for its role in energy distribution. The primary aim of this study was to investigate the effects and mechanisms of EPA and DHA on myogenic IL-6 and lipid metabolism disorders in mice, and to clarify the association between the alleviation of lipid metabolism disorders and myogenic IL-6 mediated by EPA/DHA. We found that EPA and DHA not only prevented high-fat diet-induced lipid metabolism disorders, but also up-regulated the expression of myogenic IL-6 by activating TRPV1/Ca<sup>2+</sup> signaling in skeletal muscle. However, the lipid metabolism prevention effect mediated by EPA was weakened after knockout gene of myogenic IL-6, with its body weight and body fat increased and a large amounts of lipid deposited in the blood, liver, and adipocytes. Meanwhile, there no significantly differences of AMPK/STAT3 signaling in adipose tissue between groups after knockout gene of myogenic IL-6. Based on the results above, we concluded that EPA and DHA can stimulate the production of myogenic IL-6 through TRPV1/Ca<sup>2+</sup> signaling in skeletal muscle. The prevention effect of lipid metabolism disorders by EPA, but not DHA, relies on myogenic IL-6, with the underlying mechanism may involving the enhancement of AMPK/STAT3 signaling mediated by myogenic IL-6 in adipose tissues.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"139 ","pages":"Article 109815"},"PeriodicalIF":4.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermogenic adipose tissues: Promising therapeutic targets for metabolic diseases 热源性脂肪组织:代谢疾病的治疗靶点:热源性脂肪和肥胖。
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-12-07 DOI: 10.1016/j.jnutbio.2024.109832
Mandana Pahlavani , Kenneth Pham , Nishan Sudheera Kalupahana , Ashti Morovati , Latha Ramalingam , Hussain Abidi , Vasana Kiridana , Naima Moustaid-Moussa
{"title":"Thermogenic adipose tissues: Promising therapeutic targets for metabolic diseases","authors":"Mandana Pahlavani ,&nbsp;Kenneth Pham ,&nbsp;Nishan Sudheera Kalupahana ,&nbsp;Ashti Morovati ,&nbsp;Latha Ramalingam ,&nbsp;Hussain Abidi ,&nbsp;Vasana Kiridana ,&nbsp;Naima Moustaid-Moussa","doi":"10.1016/j.jnutbio.2024.109832","DOIUrl":"10.1016/j.jnutbio.2024.109832","url":null,"abstract":"<div><div>The ongoing increase in the prevalence of obesity and its comorbidities such as cardiovascular disease, type 2 diabetes (T2D) and dyslipidemia warrants discovery of novel therapeutic options for these metabolic diseases. Obesity is characterized by white adipose tissue expansion due to chronic positive energy balance as a result of excessive energy intake and/or reduced energy expenditure. Despite various efforts to prevent or reduce obesity including lifestyle and behavioral interventions, surgical weight reduction approaches and pharmacological methods, there has been limited success in significantly reducing obesity prevalence. Recent research has shown that thermogenic adipocyte (brown and beige) activation or formation, respectively, could potentially act as a therapeutic strategy to ameliorate obesity and its related disorders. This can be achieved through the ability of these thermogenic cells to enhance energy expenditure and regulate circulating levels of glucose and lipids. Thus, unraveling the molecular mechanisms behind the formation and activation of brown and beige adipocytes holds the potential for probable therapeutic paths to combat obesity. In this review, we provide a comprehensive update on the development and regulation of different adipose tissue types. We also emphasize recent interventions in harnessing therapeutic potential of thermogenic adipocytes by bioactive compounds and new pharmacological anti-obesity agents.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"137 ","pages":"Article 109832"},"PeriodicalIF":4.8,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the protective mechanism of paeoniflorin against hyperlipidemia by an integrated metabolomics and gut microbiota strategy 通过代谢组学和肠道微生物群综合策略研究芍药苷对高脂血症的保护机制
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-12-07 DOI: 10.1016/j.jnutbio.2024.109831
Youwei Zhao , Shijie Sun , Jiawen Liu , Mingzhu Zheng , Meihong Liu , Jingsheng Liu , Huimin Liu
{"title":"Investigation of the protective mechanism of paeoniflorin against hyperlipidemia by an integrated metabolomics and gut microbiota strategy","authors":"Youwei Zhao ,&nbsp;Shijie Sun ,&nbsp;Jiawen Liu ,&nbsp;Mingzhu Zheng ,&nbsp;Meihong Liu ,&nbsp;Jingsheng Liu ,&nbsp;Huimin Liu","doi":"10.1016/j.jnutbio.2024.109831","DOIUrl":"10.1016/j.jnutbio.2024.109831","url":null,"abstract":"<div><div>The prevalence of hyperlipidemia is gradually increasing globally, posing a serious threat to public health. Previous studies have shown that paeoniflorin (PF) effectively improved abnormal lipid metabolism in atherosclerotic mice. However, the anti-hyperlipidemia effect and potential mechanism of paeoniflorin remain unclear. The gut microbiota (GM) is closely related to hyperlipidemia. This study was aimed to investigate effects of PF on improving the health of high-fat diet (HFD)-induced hyperlipidemic mice by modulating GM. A hyperlipidemic mouse model was established using an HFD, and the hypolipidemic effect of PF was detected in vivo. Besides16S ribosomal RNA sequencing and SCFAs metabolic analysis were performed to explore the lipid-lowering mechanism of PF. Importantly, fecal microbiota transplantation (FMT) experiments were conducted to verify the lipid-lowering mechanism of PF. The results showed that PF significantly inhibited the development of hyperlipidemia, reduced serum lipid and inflammatory cytokine levels, and improved liver steatosis. In addition, 16S rRNA sequencing revealed that PF treatment significantly increased the relative abundance of <em>Lactobacillus, Coprococcus, Blautia, Roseburia</em>, and <em>Bacteroides</em> while reducing the relative abundance of <em>Prevotella</em>. Meanwhile, the results of targeted metabolomics indicate that PF therapy can effectively restore butyric acid and propionic acid levels in the intestine. The FMT experiments further demonstrated that PF improved hyperlipidemia by regulating GM and its metabolites. The above results provide a valuable theoretical basis for the development and application of PF as a functional food for hyperlipidemia.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"137 ","pages":"Article 109831"},"PeriodicalIF":4.8,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal exercise programs placental miR-495-5p-mediated Snx7 expression and kynurenic acid metabolic pathway induced by prenatal high-fat diet: Based on miRNA-seq, transcriptomics, and metabolomics 基于miRNA-seq、转录组学和代谢组学的产前高脂饮食诱导的胎盘mir -495-5p介导的Snx7表达和尿酸代谢途径
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-12-06 DOI: 10.1016/j.jnutbio.2024.109830
Shunhua Li , Liyuan Zhou , Jing Ren , Qian Zhang , Xinhua Xiao
{"title":"Maternal exercise programs placental miR-495-5p-mediated Snx7 expression and kynurenic acid metabolic pathway induced by prenatal high-fat diet: Based on miRNA-seq, transcriptomics, and metabolomics","authors":"Shunhua Li ,&nbsp;Liyuan Zhou ,&nbsp;Jing Ren ,&nbsp;Qian Zhang ,&nbsp;Xinhua Xiao","doi":"10.1016/j.jnutbio.2024.109830","DOIUrl":"10.1016/j.jnutbio.2024.109830","url":null,"abstract":"<div><div>Poor intrauterine environments increase the prevalence of chronic metabolic diseases in offspring, whereas maternal exercise is an effective measure to break this vicious intergenerational cycle. Placenta is increasingly being studied to explore its role in maternal-fetal metabolic cross-talk. The association between placental miRNA and offspring development trajectories has been established, yet the specific role and mechanism thereof in maternal exercise-induced metabolic protection remain elusive. Here, C57BL/6 female mice were subjected to either a normal control or a high-fat diet (HFD), half of the HFD-fed dams were housed with voluntary wheel running for 3 weeks before and during gestation. At embryonic day 18.5, we sacrificed parturient mice and then conducted miRNA-seq, transcriptomic, and metabolomic profiling of the placenta. Our data revealed that maternal HFD resulted in significant alterations in both miRNA and gene expressions, as well as metabolic pathways of the placenta, whereas prenatal exercise negated these perturbations. The common differentially expressed transcripts among three groups were enriched in multiple critical pathways involving energy expenditure, signal transduction, and fetal development. Through integrated analysis of multiomics data, we speculated that maternal exercise reversed the suppression of miR-495-5p induced by HFD, thereby inhibiting miR-495-5p-targeted <em>Snx7</em> and modulating kynurenic acid production. These datasets provided novel mechanistic insight into how maternal exercise positively affects the metabolic homeostasis of offspring. The discovered important miRNAs, mRNAs, and metabolites could be promising predictive and therapeutic targets for protecting offspring metabolic health.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"137 ","pages":"Article 109830"},"PeriodicalIF":4.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ameliorative effect of phenolic compound-pterostilbene on corticosterone-induced hepatic lipid metabolic disorder in broilers 酚类化合物-紫檀芪对皮质酮诱导的肉鸡肝脏脂质代谢紊乱的改善作用。
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-12-05 DOI: 10.1016/j.jnutbio.2024.109822
Ruoshi Zhang , Jing Sun , Yingjie Wang , Hao Yu , Shenao Wang , Xingjun Feng
{"title":"Ameliorative effect of phenolic compound-pterostilbene on corticosterone-induced hepatic lipid metabolic disorder in broilers","authors":"Ruoshi Zhang ,&nbsp;Jing Sun ,&nbsp;Yingjie Wang ,&nbsp;Hao Yu ,&nbsp;Shenao Wang ,&nbsp;Xingjun Feng","doi":"10.1016/j.jnutbio.2024.109822","DOIUrl":"10.1016/j.jnutbio.2024.109822","url":null,"abstract":"<div><div>The aim of this study was to investigate the ameliorative effects of pterostilbene (PTE), a polyphenolic compound, on stress-induced lipid metabolic disorders in the liver of broiler chickens. Six hundred healthy, 1-day-old Arbor Acres with similar weight were randomly assigned to five groups, each consisting of eight replicates with 15 broilers per replicate. The groups included: a control group (fed a basal diet), and four groups treated with corticosterone (CORT) at varying dietary levels of PTE supplementation: CORT (0 mg/kg PTE), CORT-PT200 (200 mg/kg PTE), CORT-PT400 (400 mg/kg PTE), and CORT-PT600 (600 mg/kg PTE). The results indicated that PTE administration to corticosterone (CORT)-injected broilers significantly improved weight gain, reduced liver index, and lowered the elevation of serum aspartate aminotransferase, gamma-glutamyl transferase, glucose, total cholesterol, triglycerides, and lipoprotein cholesterol concentrations induced by CORT injection (<em>P&lt;.</em>05), but had no significant effect on serum CORT concentration (<em>P&gt;.</em>05). PTE also significantly reduced the increased rate of abdominal fat deposition induced by CORT, decreased the average size of adipocytes, and downregulated the expression of the FAS gene (<em>P&lt;.</em>05). It reversed the increase in liver total cholesterol, triglycerides, lipoprotein cholesterol, and non-esterified fatty acids content induced by CORT (<em>P&lt;.</em>05). PTE had no significant effect on the expression of the glucocorticoid receptor (<em>P&gt;.</em>05), but significantly upregulated the protein expression of Sirt1 and p-AMPK (<em>P&lt;.</em>05), promoted the expression of lipid autophagy genes MAP1LC3B and lipolytic genes LPL, but inhibited the expression of fatty acid synthesis genes SREBP-1c, ACC, and SCD (<em>P&lt;.</em>05). The addition of PTE to the diet alleviated CORT-induced oxidative stress and inflammation by enhancing T-SOD and GSH-Px activities, reducing MDA content, inhibiting p-NF-κB p65 and NLRP3 expression and the release of TNF-α and IL-1β in the serum, and increasing IL-4 content (<em>P&lt;.</em>05). Overall, dietary PTE effectively regulates lipid metabolism and antioxidant status, offering a potential strategy to mitigate stress-induced metabolic disruptions in broilers.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"137 ","pages":"Article 109822"},"PeriodicalIF":4.8,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary pentadecanoic acid supplementation at weaning in essential fatty acid-deficient rats shed light on the new family of odd-chain n-8 PUFAs 断奶时必需脂肪酸缺乏大鼠的饮食补充五酸揭示了奇链n-8 PUFAs新家族。
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-11-29 DOI: 10.1016/j.jnutbio.2024.109814
Vincent Ciesielski , Thomas Guerbette , Léa Fret , Mélodie Succar , Youenn Launay , Patrice Dahirel , Philippe Legrand , Manuel Vlach , Sophie Blat , Vincent Rioux
{"title":"Dietary pentadecanoic acid supplementation at weaning in essential fatty acid-deficient rats shed light on the new family of odd-chain n-8 PUFAs","authors":"Vincent Ciesielski ,&nbsp;Thomas Guerbette ,&nbsp;Léa Fret ,&nbsp;Mélodie Succar ,&nbsp;Youenn Launay ,&nbsp;Patrice Dahirel ,&nbsp;Philippe Legrand ,&nbsp;Manuel Vlach ,&nbsp;Sophie Blat ,&nbsp;Vincent Rioux","doi":"10.1016/j.jnutbio.2024.109814","DOIUrl":"10.1016/j.jnutbio.2024.109814","url":null,"abstract":"<div><div>Pentadecanoic acid (C15:0) is a saturated odd-chain fatty acid (OCFA), mainly found in dairy products. Its physiological and nutritional effects are still unknown, yet some recent evidences suggest it might be beneficial to human health. Moreover, pentadecanoic acid has recently been suspected of having essential roles in humans, although the mechanisms are not described. We therefore questioned the potential essentiality of this fatty acid (FA). We investigated <em>in vivo</em> the effect of a C15:0 supplementation on essential fatty acid (EFA) deficient Wistar rats. Female rats were fed an EFA-deficient diet 2 weeks before mating, during pregnancy and lactation. Weaned pups were fed the EFA-deficient diet or were switched to a diet supplemented with C15:0 or linoleic acid (LA) for 11 weeks. A control group was fed with EFA during the whole study. Since linoleic acid deficiency is known to induce growth delay, weights were measured throughout the experiment and FA content in collected tissues were analyzed to evaluate biochemical markers of the deficiency. As expected, EFA-deficient rats showed growth retardation, compared to control rats. Supplementation of C15:0 at weaning increased early growth rate compared to deficient animals, as also did the supplementation of C18:2 n-6. Furthermore, the supplementation of C15:0 in the diet of EFA-deficient animals induced the previously undescribed synthesis of odd-chain PUFAs of the n-8 family (C19:3, C21:3 and C21:4 n-8). These results suggest dietary C15:0 might counteract EFA induced growth retardation, possibly through the synthesis of odd-chain n-8 PUFAs, yet mechanisms are to be deciphered for further validation.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"137 ","pages":"Article 109814"},"PeriodicalIF":4.8,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated metabolome and microbiome strategy reveals the therapeutic effect of nervonic acid on Alzheimer's disease rats 综合代谢组和微生物组策略揭示了神经酸对阿尔茨海默病大鼠的治疗效果。
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-11-26 DOI: 10.1016/j.jnutbio.2024.109813
Ziyi Chen , Shu Liu , Fengrui Song , Zong Hou , Hui Zhou , Yuting Fan , Rongjin Wang , Zhongying Liu
{"title":"Integrated metabolome and microbiome strategy reveals the therapeutic effect of nervonic acid on Alzheimer's disease rats","authors":"Ziyi Chen ,&nbsp;Shu Liu ,&nbsp;Fengrui Song ,&nbsp;Zong Hou ,&nbsp;Hui Zhou ,&nbsp;Yuting Fan ,&nbsp;Rongjin Wang ,&nbsp;Zhongying Liu","doi":"10.1016/j.jnutbio.2024.109813","DOIUrl":"10.1016/j.jnutbio.2024.109813","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a complex neurodegenerative disease. Nervonic acid is a component of breast milk and is also found in fish oil and specific vegetable oils. Studies have shown that nervonic acid is essential for the development of the human nervous system. In this study, Morris water maze (MWM) test and pathological analysis showed that nervonic acid could improve cognitive deficits and brain nerve damage in AD rats. Then, through sequencing, we found that nervonic acid increased the abundance of beneficial bacteria such as <em>Lactobacillus</em> and <em>Bacteroides</em>, and decreased the abundance of <em>Pseudomonadaceae_Pseudomonas</em>. Not only that, nervonic acid also regulates the production of short-chain fatty acids (SCFA) and the levels of 29 fecal metabolites, and affects the metabolism of linoleic acid, α-linolenic acid, arachidonic acid, and sphingolipid. Finally, we verified the regulatory effect of nervonic acid on metabolic enzyme activity.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"137 ","pages":"Article 109813"},"PeriodicalIF":4.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term iodine deficiency and excess inhibit β-casein and α-lactalbumin secretion of milk in lactating rats 长期缺碘和碘过量都会抑制哺乳期大鼠乳汁中β-酪蛋白和α-乳白蛋白的分泌。
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-11-26 DOI: 10.1016/j.jnutbio.2024.109812
Ying Zhang , Xin Zhao , Na Zhao , Yan Song , Zixuan Zhang , Xinbao Zhang , Haohao Meng , Xiru Wang , Le Shan , Wanqi Zhang , Zhongna Sang
{"title":"Long-term iodine deficiency and excess inhibit β-casein and α-lactalbumin secretion of milk in lactating rats","authors":"Ying Zhang ,&nbsp;Xin Zhao ,&nbsp;Na Zhao ,&nbsp;Yan Song ,&nbsp;Zixuan Zhang ,&nbsp;Xinbao Zhang ,&nbsp;Haohao Meng ,&nbsp;Xiru Wang ,&nbsp;Le Shan ,&nbsp;Wanqi Zhang ,&nbsp;Zhongna Sang","doi":"10.1016/j.jnutbio.2024.109812","DOIUrl":"10.1016/j.jnutbio.2024.109812","url":null,"abstract":"<div><div>Iodine is critical for thyroid hormone synthesis and developmental programming in the first 1,000 days of life. The effect of maternal iodine on milk protein secretion remains unknown. We aimed to explore the effect of long-term maternal iodine deficiency and excess on milk protein secretion in lactating rats and its mechanisms preliminarily. Animal models of iodine deficiency and excess were generated by treating Wistar rats a low-iodine diet and deionized water with different potassium iodide concentrations from reproductive age to lactation. Under iodine deficiency, CSN2 and α-LA secretion of milk was inhibited in early and mid-lactation, respectively, and the inhibition of milk CSN2 and α-LA secretion weakened in late lactation. Under iodine excess, milk CSN2 secretion was inhibited in early lactation, and the inhibition of milk CSN2 and α-LA secretion was more pronounced in late lactation. Under iodine deficiency and excess, the concentrations of CSN2 and α-LA and protein expression levels of THRα1, THRβ1, and PRLR in the mammary gland decreased. These results demonstrate the negative impact of long-term maternal iodine malnutrition on milk protein secretion.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"137 ","pages":"Article 109812"},"PeriodicalIF":4.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing wound healing via modulation of autophagy-induced apoptosis: the role of nicotinamide riboside and resveratrol in streptozotocin-treated diabetic rat 通过调节自噬诱导的细胞凋亡促进伤口愈合:烟酰胺核苷和白藜芦醇对链脲佐菌素治疗糖尿病大鼠的作用
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-11-20 DOI: 10.1016/j.jnutbio.2024.109811
Morvarid Siri , Mohammad Hasan Maleki , Seyed Mohammadmahdi Meybodi , Seyed Amirhossein Mazhari , Fatemeh Ghaderi Saviri , Amirreza Dehghanian , Maryam Naseh , Nafiseh Esmaeili , Sanaz Dastghaib , Zeinab Aryanian
{"title":"Enhancing wound healing via modulation of autophagy-induced apoptosis: the role of nicotinamide riboside and resveratrol in streptozotocin-treated diabetic rat","authors":"Morvarid Siri ,&nbsp;Mohammad Hasan Maleki ,&nbsp;Seyed Mohammadmahdi Meybodi ,&nbsp;Seyed Amirhossein Mazhari ,&nbsp;Fatemeh Ghaderi Saviri ,&nbsp;Amirreza Dehghanian ,&nbsp;Maryam Naseh ,&nbsp;Nafiseh Esmaeili ,&nbsp;Sanaz Dastghaib ,&nbsp;Zeinab Aryanian","doi":"10.1016/j.jnutbio.2024.109811","DOIUrl":"10.1016/j.jnutbio.2024.109811","url":null,"abstract":"<div><div>Impaired wound healing from diabetes mellitus (DM) causes lower limb amputations, posing clinical, social, and economic issues. Hypoxia and advanced glycation end products cause autophagy and apoptosis dysregulation, which delays wound healing. The study will test systemic and topical Nicotinamide Riboside (NR) and Resveratrol (RSV) for the capacity to modulate autophagy and apoptosis via the SIRT-1-FOXO1 pathway and improve diabetic wound healing. About 54 male Sprague-Dawley rats were separated into control, diabetic (T1D), T1D-Gel-Base, T1D-NR, T1D-RSV, and T1D-NR+RSV groups. Rats were gavaged with 50 mg/kg/day RSV and 300 mg/kg/day NR for 5 weeks before having their wounds topically treated with 5% NR and RSV gel for 15 days after diabetes induction. Biochemical, histomorphometric, and stereological assays were conducted. The mRNA expressions of <em>SIRT-1, FOXO1, VEGF, BAX, Cas3, Bcl-2, Beclin1, LC3IIβ, P62</em>, and <em>ATG5</em> were examined by qRT-PCR. NR and RSV improved diabetic rat wound closure. Diabetic rats treated with NR and RSV had significantly higher <em>LC3IIβ, VEGEF, Bcl-2</em>, and <em>SIRT-1</em> mRNA levels. <em>Bcl-2, p62</em>, and <em>ATG5</em> were regulated whereas <em>BAX</em> and <em>Cas 3</em> were reduced. Stereological investigations showed epidermal, dermal, collagen bundle, vascular, and fibroblast density enhancements. This study highlights the potential of NR and RSV, acting as SIRT-1 activators, in improving diabetic wound healing by regulating SIRT-1-FOXO1-mediated autophagy and apoptosis. These findings offer valuable insights for developing targeted strategies to enhance diabetic wound healing. The combination of NR and RSV showed promising effects, suggesting a potential therapeutic approach for improving diabetic wound healing.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"137 ","pages":"Article 109811"},"PeriodicalIF":4.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between blood DNA methylation, diet quality indices and metabolic health: Data from Obekit study 血液 DNA 甲基化、饮食质量指数和代谢健康之间的关系:来自 Obekit 研究的数据。
IF 4.8 2区 医学
Journal of Nutritional Biochemistry Pub Date : 2024-11-19 DOI: 10.1016/j.jnutbio.2024.109805
Aline Rosignoli da Conceição , Josefina Bressan , Marta Cuervo , Maria Luisa Mansego , J. Alfredo Martínez , José Ignacio Riezu-Boj , Fermín I. Milagro
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