Impact of fish oil supplement on brain lipids profile in ApoE-/- mice and C57BL/6 J mice treated with diets containing different dosage of vitamin E

IF 4.8 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Nutritional Biochemistry Pub Date : 2025-05-21 DOI:10.1016/j.jnutbio.2025.109964

Lu Liu , Xiaochen Huang , Jingjing Xu , Xixiang Wang , Yu Liu , Xiuwen Ren , Chi Zhang , Ying Wang , Yueyong Wang , Shaobo Zhou , Linhong Yuan

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Abstract

The study was designed to explore the impact of fish oil supplement on the brain lipids profile in ApoE-deficient (ApoE-/-) mice and wild-type C57BL/6 J (C57 wt) mice treated with diets containing varying dosage of vitamin E (VE). Compared to C57 wt mice, ApoE-/- mice exhibited increased cortical TC and LDL-C levels, but decreased HDL-C level (P<.05). The fish oil intervention, combined with low dietary VE intake resulted in increased cortical protein expression of CD36 and PPARγ in C57 wt mice. PI (36:5) was identified as a significantly different metabolite when compared to the control group in both C57 wt and ApoE-/- mice. The combination of fish oil and varying doses of VE had different effects on the expression of brain lipids and fatty acid transporters in ApoE-/- and C57 wt mice, indicating that ApoE status and dietary VE intake influence the responses of the cerebral lipids profile to fish oil supplementation.

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补充鱼油对添加不同剂量维生素E的ApoE-/-小鼠和C57BL/6J小鼠脑脂质谱的影响

该研究旨在探讨鱼油补充剂对ApoE缺乏（ApoE-/-）小鼠和野生型C57BL/6J （C57 wt）小鼠脑脂质谱的影响，这些小鼠在饮食中含有不同剂量的维生素E （VE）。与C57小鼠相比，ApoE-/-小鼠皮层TC和LDL-C水平升高，HDL-C水平降低（P < 0.05）。鱼油干预结合低VE饮食摄入导致C57 wt小鼠皮质蛋白CD36和PPARγ表达增加。在C57 wt和ApoE-/-小鼠中，与对照组相比，PI（36:5）被鉴定为显著不同的代谢物。鱼油和不同剂量VE联合使用对ApoE-/-和C57 wt小鼠脑脂质和脂肪酸转运蛋白的表达有不同的影响，表明ApoE状态和膳食VE摄入量影响了脑脂质谱对鱼油补充的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutritional Biochemistry 医学-生化与分子生物学

CiteScore

9.50

自引率

3.60%

发文量

237

审稿时长

68 days

期刊介绍： Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.