Jiayue Tang , Cai Shen , Dan Yao , Jingwen Yu , Yanan Liu , Maolin Tu , Hong Zhang , Xuebing Xu , Oi-Ming Lai , Ling-Zhi Cheong
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引用次数: 0
Abstract
Human milk (HM) is regarded as the gold standard for infant nutrition. The metabolite profiles of mature human milk (MHM) have been reported to be affected by maternal physiological conditions, lactation stage, and maternal diets. We collected MHM (3–6 months postpartum) from 32 healthy mothers with different parities and delivery modes. Then, GC-MS and LC-MS were used to perform an untargeted metabolomic study. A clear distinction can be observed in terms of MHM metabolites of mothers with different delivery modes and parities with a 95% confidence interval. A total of 119 differentially expressed metabolites (DEMs) were identified in MHM of women with different delivery modes. Metabolic pathway analyses indicated that these DEMs were mainly associated with fatty acid biosynthesis. The higher abundances of these DEMs in MHM of cesarean women may be due to the differing levels of cortisol and oxytocin between mothers with different delivery modes. Meanwhile, 284 DEMs were identified in MHM of women with different parities. These DEMs were primarily related to ABC transporters, center carbon metabolism in cancer, and D-amino acid metabolism. These findings highlighted the impact of delivery mode and parity on HM metabolite composition. Further research is needed to explore the long-term health implications of these metabolic differences and optimize infant nutrition strategies.
期刊介绍:
Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology.
Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.