Journal of Nutritional Biochemistry最新文献_第3页

The roles and functions of ergothioneine in metabolic diseases 麦角硫因在代谢性疾病中的作用和功能。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-07 DOI: 10.1016/j.jnutbio.2025.109895

Tingting Wen (文婷婷) , Wanjing Chen (陈婉静) , Fengjing Wang (王枫婧) , Rui Zhang (张睿) , Cheng Chen (陈诚) , Mingliang Zhang (张明亮) , Teng Ma (马腾)

{"title":"The roles and functions of ergothioneine in metabolic diseases","authors":"Tingting Wen (文婷婷) , Wanjing Chen (陈婉静) , Fengjing Wang (王枫婧) , Rui Zhang (张睿) , Cheng Chen (陈诚) , Mingliang Zhang (张明亮) , Teng Ma (马腾)","doi":"10.1016/j.jnutbio.2025.109895","DOIUrl":"10.1016/j.jnutbio.2025.109895","url":null,"abstract":"<div><div>The global prevalence of metabolic diseases is on the increase, and it has become a significant threat to the health and lives of individuals. Ergothioneine (EGT) is a natural betaine amino acid found in various foods, particularly mushrooms. EGT cannot be synthesized by mammals; it is absorbed into small intestinal epithelial cells by a cationic protein, the novel organic cation transporter 1 (OCTN1), and transported to certain organs including liver, spleen, kidney, lung, heart, eyes and brain. EGT has been reported to exhibit antioxidant, anti-inflammatory, anti-apoptotic, anti-aging, and metal-chelating effects. The unique chemical properties and biological functions of EGT position it as a promising candidate for the research and treatment of metabolic diseases. This review summarizes EGT's capacities, potential therapeutic effects on multiple metabolic diseases, and their specific mechanisms. Finally, we outline challenges for future research on EGT and aspire to establish it as a prospective therapeutic agent for metabolic diseases.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"141 ","pages":"Article 109895"},"PeriodicalIF":4.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folic acid intervention ameliorates hepatic steatosis after long-term alcohol exposure by alleviating endoplasmic reticulum stress 叶酸干预通过减轻内质网应激改善长期酒精暴露后的肝脂肪变性。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-06 DOI: 10.1016/j.jnutbio.2025.109896

Huichao Zhao , Man Liu , Yiqing Ma , Ronghuan Du , Bin Wang , Tongtong Lan , Huaqi Zhang , Meilan Xue , Hui Liang

引用次数: 0

Iron metabolism and ferroptosis in health and diseases: The crucial role of mitochondria in metabolically active tissues 健康和疾病中的铁代谢和铁下垂：线粒体在代谢活性组织中的关键作用。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-06 DOI: 10.1016/j.jnutbio.2025.109888

Angela Catapano , Fabiano Cimmino , Lidia Petrella , Amelia Pizzella , Margherita D'Angelo , Katia Ambrosio , Francesca Marino , Annarita Sabbatini , Massimiliano Petrelli , Barbara Paolini , Lucio Lucchin , Gina Cavaliere , Luigia Cristino , Marianna Crispino , Giovanna Trinchese , Maria Pina Mollica

{"title":"Iron metabolism and ferroptosis in health and diseases: The crucial role of mitochondria in metabolically active tissues","authors":"Angela Catapano , Fabiano Cimmino , Lidia Petrella , Amelia Pizzella , Margherita D'Angelo , Katia Ambrosio , Francesca Marino , Annarita Sabbatini , Massimiliano Petrelli , Barbara Paolini , Lucio Lucchin , Gina Cavaliere , Luigia Cristino , Marianna Crispino , Giovanna Trinchese , Maria Pina Mollica","doi":"10.1016/j.jnutbio.2025.109888","DOIUrl":"10.1016/j.jnutbio.2025.109888","url":null,"abstract":"<div><div>Iron is essential in various physiological processes, but its accumulation leads to oxidative stress and cell damage, thus iron homeostasis has to be tightly regulated. Ferroptosis is an iron-dependent non-apoptotic regulated cell death characterized by iron overload and reactive oxygen species accumulation. Mitochondria are organelles playing a crucial role in iron metabolism and involved in ferroptosis. MitoNEET, a protein of mitochondrial outer membrane, is a key element in this process. Ferroptosis, altering iron levels in several metabolically active organs, is linked to several non-communicable diseases. For example, iron overload in the liver leads to hepatic fibrosis and cirrhosis, accelerating non-alcholic fatty liver diseases progression, in the muscle cells contributes to oxidative damage leading to sarcopenia, and in the brain is associated to neurodegeneration. The aim of this review is to investigate the intricate balance of iron regulation focusing on the role of mitochondria and oxidative stress, and analyzing the ferroptosis implications in health and disease.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"140 ","pages":"Article 109888"},"PeriodicalIF":4.8,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol improves gasdermin D-mediated pyroptosis of vascular endothelial cells induced by a high-fat diet and palmitic acid possibly via the SIRT1-p66Shc-NLRP3 pathway 白藜芦醇可能通过SIRT1-p66Shc-NLRP3途径改善高脂肪饮食和棕榈酸诱导的气皮素d介导的血管内皮细胞焦亡。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-05 DOI: 10.1016/j.jnutbio.2025.109890

Heng Zhou , Yueming Long , Fangmei Yu , Chenhui Ji , Li Gui , Yunxia Lu

{"title":"Resveratrol improves gasdermin D-mediated pyroptosis of vascular endothelial cells induced by a high-fat diet and palmitic acid possibly via the SIRT1-p66Shc-NLRP3 pathway","authors":"Heng Zhou , Yueming Long , Fangmei Yu , Chenhui Ji , Li Gui , Yunxia Lu","doi":"10.1016/j.jnutbio.2025.109890","DOIUrl":"10.1016/j.jnutbio.2025.109890","url":null,"abstract":"<div><div>Resveratrol (RSV) ameliorates endothelial dysfunction (ED) primarily through sirtuin 1 (SIRT1). Increasing evidence shows pyroptosis as a novel mechanism in palmitic acid (PA)-induced ED. p66Shc is an adaptor protein involved in oxidative stress. However, whether RSV attenuates the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome via p66Shc remains elusive. This study aims to evaluate whether the antipyroptotic effect of RSV and the SIRT1 inhibitor EX527 are related to p66Shc. High-fat diet (HFD) induced obesity in mice, and RSV was administered intragastrically with 400mg/kg/d for 22 successive weeks. The serum levels of interleukin-1β (IL-1β) and IL-18 were analyzed, and the expression of related proteins were assayed with immunohistochemistry in the thoracic aorta. human umbilical vein endothelial cells (HUVECs) were induced by PA, then treated with RSV and EX527 respectively, lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP) and expression of p66Shc, NLRP3, GSDMD and pyroptosis-related genes were assayed. RSV administration ameliorated endothelial cell pyroptosis by decreasing serum IL-1β and IL-18, the expression of NLRP3, p66Shc, and gasdermin D (GSDMD), and increasing the expression of SIRT1 in the HFD-treated thoracic aorta. PA promoted GSDMD-mediated endothelial cell pyroptosis by ROS production, LDH release, decreased MMP and SIRT1 expression, increased expression of p66Shc and activation of the NLRP3 inflammasome in a dose-dependent manner. RSV attenuated PA-induced pyroptosis, whereas EX527 reversed the antipyroptotic effect of RSV in PA-treated HUVECs. Our results suggested a new mechanism that RSV improves PA-induced pyroptosis in endothelial cells via the SIRT1-p66Shc-NLRP3 pathway.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"140 ","pages":"Article 109890"},"PeriodicalIF":4.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naringenin alleviates heat stress-induced liver injury in Ningdu yellow chickens by decreasing RIPK3 and PDC binding 柚皮素通过降低RIPK3和PDC结合减轻宁都黄鸡热应激性肝损伤。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-05 DOI: 10.1016/j.jnutbio.2025.109894

Zhenni Liu , Ruoyun Tang , Qiurong Qi, Siting Lin, Ping Liu, Gaofeng Cai, Zhanhong Zheng, Xiaoquan Guo, Xiaona Gao

{"title":"Naringenin alleviates heat stress-induced liver injury in Ningdu yellow chickens by decreasing RIPK3 and PDC binding","authors":"Zhenni Liu , Ruoyun Tang , Qiurong Qi, Siting Lin, Ping Liu, Gaofeng Cai, Zhanhong Zheng, Xiaoquan Guo, Xiaona Gao","doi":"10.1016/j.jnutbio.2025.109894","DOIUrl":"10.1016/j.jnutbio.2025.109894","url":null,"abstract":"<div><div>Naringenin, a flavonoid extract, possesses anti-inflammatory, antioxidant, hepatoprotective, antitumor, and antineurotoxic properties. This study investigated the antiheat stress effects in broilers by adding 200mg/kg naringenin to the diet of Ningdu yellow chicken under heat stress conditions. Heat stress conditions was controlled at 37±2°C (7:00 a.m.–7:00 p.m.) and 24±2°C (7:00 p.m.–7:00 a.m.) at humidity maintained at 60–65%. The results suggest that naringenin elevated the body weight and the ratio of liver mass to weight of Ningdu yellow chicken significantly. Additionally, naringenin significantly reduces heat stress level, improves liver function and antioxidant capacity. Meanwhile, the levels of necroptosis indexes (CYLD, RIPK1, RIPK3 and MLKL) and oxidative stress indexes (PDC, PYGL, GLUL and GLUD1) are downregulated by naringenin. Naringenin mitigated liver damage by decreasing inflammatory indexes caused by heat stress, including NF-κB, IL-1β, IL-18 and HMGB1. This anti-inflammatory effect arose through the downlink binding of the necroptosis index (RIPK3) and the oxidative stress index (PDC) as shown in results of fluorescence co-localization and co-immunoprecipitation. The use of naringenin in poultry may be a possible feed additive to address clinical heat stress.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"140 ","pages":"Article 109894"},"PeriodicalIF":4.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21 限时喂养可通过提高FGF21的敏感性来减轻hfd诱导的衰老小鼠肌少性肥胖。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-05 DOI: 10.1016/j.jnutbio.2025.109893

Ting Wang , Hongkun Lin , Yan Deng , Wenwen Chen , Yangliu Xu , Li Wang , Aojia Zhou , Yidan Zhang , Ziping Wang , Xin Jin , Li Zhang , Xin Wang , Yang Zhou , Ruhan Wang , Shuang Rong

{"title":"Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21","authors":"Ting Wang , Hongkun Lin , Yan Deng , Wenwen Chen , Yangliu Xu , Li Wang , Aojia Zhou , Yidan Zhang , Ziping Wang , Xin Jin , Li Zhang , Xin Wang , Yang Zhou , Ruhan Wang , Shuang Rong","doi":"10.1016/j.jnutbio.2025.109893","DOIUrl":"10.1016/j.jnutbio.2025.109893","url":null,"abstract":"<div><div>Time-restricted feeding (TRF) is a dietary intervention that has been shown to have numerous health benefits. However, it is important to further investigate the potential effectiveness of TRF in addressing sarcopenic obesity (SO), which is characterized by a combination of age-related obesity and sarcopenia. In this study, 14-month-old C57BL/6J male mice were fed either regular chow diet or high-fat diet (HFD), and had either ad libitum or restricted access to food for 8 hours daily (Intervention for 7 months). For the human trial (ChiCTR2100052876), obese individuals (<em>n</em>=21) with a Body Mass Index ≥28 were recruited and instructed to adopt an 8-hour eating window and a 16-hour fasting period. Here, we found that the TRF intervention significantly reduced global fat mass (<em>P</em> < .001) and volume (<em>P</em> < .05), and increase lean mass compared to mice fed with HFD. Furthermore, TRF improved overall metabolic mobility (8h TRF+HFD vs. AL+HFD). This intervention also enhanced liver FGF21 protein levels (<em>P</em> < .01) and the expression of FGFR1 and FGF21 target genes in adipose and muscle tissues, thus improving mitochondrial quality control in these tissues. Notably, TRF interventions led to a significant decrease in serum FGF21 levels (<em>P</em> < .05). In the human trial, TRF intervention resulted in a significant reduction in weight (<em>P</em> < .001) and body fat levels (<em>P</em> < .001) among obese individuals, as well as a decrease in serum GLU (<em>P</em> < .001), insulin (<em>P</em> < .001), and TC levels (<em>P</em> < .05). Overall, the findings indicate that TRF intervention improves SO by regulating liver FGF21 expression, thereby enhancing FGF21 sensitivity in adipose and muscle tissues.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"140 ","pages":"Article 109893"},"PeriodicalIF":4.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased circulating apolipoprotein Cs are implicated in the association between elevated serum retinol and retinol-binding protein 4 and adverse progression of metabolic syndrome in adults: A prospective study 成人血清视黄醇和视黄醇结合蛋白4升高与代谢综合征不良进展之间的关联：一项前瞻性研究

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-05 DOI: 10.1016/j.jnutbio.2025.109892

Danyu Chen , Keliang Xie , Chang Gao , Yingdi Yang , Ying Xu , Bang-yan Li , Yue Xi , Ju-Sheng Zheng , Yu-ming Chen

{"title":"Increased circulating apolipoprotein Cs are implicated in the association between elevated serum retinol and retinol-binding protein 4 and adverse progression of metabolic syndrome in adults: A prospective study","authors":"Danyu Chen , Keliang Xie , Chang Gao , Yingdi Yang , Ying Xu , Bang-yan Li , Yue Xi , Ju-Sheng Zheng , Yu-ming Chen","doi":"10.1016/j.jnutbio.2025.109892","DOIUrl":"10.1016/j.jnutbio.2025.109892","url":null,"abstract":"<div><div>Prior research has highlighted the significant roles of circulating retinol, retinol-binding protein 4 (RBP4), and apolipoprotein C (ApoC) in metabolic health. This study investigates the joint association of retinol and RBP4 with metabolic syndrome (MetS) and examines the potential mediating role of ApoCs in these relationships. This prospective study included 3,009 and 2,724 participants with baseline serum retinol and RBP4 data, respectively. Over a 9-year follow-up among 2,621 participants, 1,136, 127, 696, and 662 were categorized into MetS-free, recovered, incident MetS, and persistent MetS groups, respectively. Midway through the study, ApoC1-4 levels were measured in 2316 participants. Adjusted odds ratios (95% CIs) for the highest (vs. lowest) tertile of retinol and RBP4 levels were 3.63 (2.69–4.92) and 5.64 (4.05–7.92) for 9-year persistent MetS, respectively. The corresponding hazard ratios (95% CIs) were 1.67 (1.39–2.01) and 1.67(1.38, 2.03) for incident MetS, and 0.65 (0.41–1.03) and 0.44 (0.28, 0.70) for recovered MetS (all <em>P</em>-trends<.05). A synergistic association of retinol and RBP4 with MetS risk was observed for persistent MetS. Higher levels of retinol or RBP4 were associated with increased concentrations of ApoC1-4, which were linked to a greater risk of incident and persistent MetS. A newly developed composite score (ApoCS), derived from ApoC1-4 levels, explained 30.5% and 24.5% of the association between retinol or RBP4 and MetS, with ApoC2 and ApoC3 contributing predominantly to this connection. Our study identified notable positive correlations between serum retinol and RBP4 levels and MetS progression, explained by increases in circulating ApoC2 and ApoC3 within a Chinese cohort.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"140 ","pages":"Article 109892"},"PeriodicalIF":4.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal omega-3 polyunsaturated fatty acids improved levels of DHA-enriched phosphatidylethanolamines and enriched lipid clustering in the neuronal membranes of C57BL/6 mice fetal brains during gestation 母体omega-3多不饱和脂肪酸提高了妊娠期C57BL/6小鼠胎儿大脑神经元膜中dha富集的磷脂酰乙醇胺水平，并增强了脂质聚集。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-04 DOI: 10.1016/j.jnutbio.2025.109891

Innocent Uzochukwu Okagu , Olatunji Anthony Akerele , Tiffany Fillier , Thu Huong Pham , Raymond Thomas , Katie A. Wilson , Sukhinder Kaur Cheema

{"title":"Maternal omega-3 polyunsaturated fatty acids improved levels of DHA-enriched phosphatidylethanolamines and enriched lipid clustering in the neuronal membranes of C57BL/6 mice fetal brains during gestation","authors":"Innocent Uzochukwu Okagu , Olatunji Anthony Akerele , Tiffany Fillier , Thu Huong Pham , Raymond Thomas , Katie A. Wilson , Sukhinder Kaur Cheema","doi":"10.1016/j.jnutbio.2025.109891","DOIUrl":"10.1016/j.jnutbio.2025.109891","url":null,"abstract":"<div><div>The composition of brain lipids is crucial for neurodevelopment and brain function. Diets enriched in omega (n)-3 polyunsaturated fatty acids (PUFA) can modulate brain lipid composition. However, the influence of maternal n-3 PUFA intake on fetal brain lipidome and neuronal membrane structure during gestation is not well studied. Eight-week-old female C57BL/6 mice were fed low or high n-3 PUFA semi-purified diets for two weeks before mating and during gestation. Fetal brain lipidome and neuronal membrane structure were studied at gestation day (GD) 12.5 (mid) and 18.5 (late) using liquid chromatography high-resolution accurate mass tandem mass spectrometry and computational techniques. Maternal diets high in n-3 PUFA increased fetal brain total phosphoethanolamine, phosphoinositol, phosphoglycerol, and phosphoserine glycerophospholipids, compared to the low n-3 PUFA diet. Docosahexaenoic acid (DHA, 22:6n-3)-enriched phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and lyso-PC (LPC) fatty acyl species increased as gestation progressed in the high n-3 PUFA group, compared to low n-3 PUFA. These fatty acyl species and phospholipids promote neurotransmission, memory, and cognition. A high n-3 PUFA diet increased the area per lipid in fetal neuronal membranes as gestation progressed, indicating improved membrane fluidity. Furthermore, a high n-3 PUFA diet increased the clustering of membrane lipids associated with neurotransmission, memory, and cognition (ceramide, PE, and cholesteryl ester) as gestation progressed. Our findings show for the first time that maternal diets high in n-3 PUFA before and during gestation improve fetal brain lipidome and membrane area per lipid that may enhance brain development and function.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"140 ","pages":"Article 109891"},"PeriodicalIF":4.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspartame consumption linked to delayed puberty and mitochondrial Dysfunction: Evidence from human and animal studies 食用阿斯巴甜与青春期延迟和线粒体功能障碍有关：来自人类和动物研究的证据。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-03-04 DOI: 10.1016/j.jnutbio.2025.109889

Yang-Ching Chen , Zih Ling Wang , Yu-Fang Lin , Chia-Yuan Lin , Shih-Yuan Hsu , Jacus S. Nacis , Rong-Hong Hsieh

{"title":"Aspartame consumption linked to delayed puberty and mitochondrial Dysfunction: Evidence from human and animal studies","authors":"Yang-Ching Chen , Zih Ling Wang , Yu-Fang Lin , Chia-Yuan Lin , Shih-Yuan Hsu , Jacus S. Nacis , Rong-Hong Hsieh","doi":"10.1016/j.jnutbio.2025.109889","DOIUrl":"10.1016/j.jnutbio.2025.109889","url":null,"abstract":"<div><div>This study investigates the impact of aspartame consumption on pubertal timing in females. The research employs both human and rat models to explore underlying mechanisms. In the Taiwan Pubertal Longitudinal Study (2018–2022), 858 girls aged 6–12 were assessed for aspartame intake and puberty outcomes. Concurrently, female Sprague Dawley rats were exposed to low (30 mg/kg) or high (60 mg/kg) doses of aspartame from prenatal to postnatal stages. Results demonstrate that aspartame disrupts the hypothalamic–pituitary–gonadal (HPG) axis in rats, causing mitochondrial dysfunction and reduced ovarian mitochondrial biogenesis, leading to delayed puberty. Human data indicates higher aspartame consumption correlates with a decreased risk of precocious puberty (odds ratio = 0.63, 95% confidence interval = 0.42–0.96; <em>p</em> for trend = 0.03). These findings suggest long-term aspartame consumption may delay puberty, necessitating further research to inform dietary guidelines, especially for vulnerable populations such as prepubertal girls.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"140 ","pages":"Article 109889"},"PeriodicalIF":4.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to bisphenol A and sodium nitrate found in processed meat induces endocrine disruption and dyslipidemia through PI3K/AKT/SREBP pathway in zebrafish larvae 加工肉制品中的双酚A和硝酸钠通过PI3K/AKT/SREBP通路诱导斑马鱼幼鱼内分泌紊乱和血脂异常。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-02-27 DOI: 10.1016/j.jnutbio.2025.109887

Santosh Pushpa Ramya Ranjan Nayak , Anamika Das , Karthikeyan Ramamurthy , Mukesh Pasupuleti , Rajakrishnan Rajagopal , Jesu Arockiaraj

{"title":"Exposure to bisphenol A and sodium nitrate found in processed meat induces endocrine disruption and dyslipidemia through PI3K/AKT/SREBP pathway in zebrafish larvae","authors":"Santosh Pushpa Ramya Ranjan Nayak , Anamika Das , Karthikeyan Ramamurthy , Mukesh Pasupuleti , Rajakrishnan Rajagopal , Jesu Arockiaraj","doi":"10.1016/j.jnutbio.2025.109887","DOIUrl":"10.1016/j.jnutbio.2025.109887","url":null,"abstract":"<div><div>Meat is a staple in many cultural diets, and the consumption of processed meats has increased significantly worldwide. The widespread use of sodium nitrate (NaNO<sub>3</sub>) as a preservative and the unintentional leaching of bisphenol A (BPA) from packaging into meats have raised health concerns. This study evaluates the combined toxicity of BPA and NaNO<sub>3</sub> despite their individual safety assessments. Our findings reveal that coexposure to BPA and NaNO<sub>3</sub> at levels found in processed meats induces mortality and malformations in zebrafish larvae. The combined exposure triggers oxidative stress, lipid peroxidation, dyslipidemia, inflammation, and apoptosis. Network toxicology analysis elucidates the molecular mechanisms underlying metabolic dysfunction caused by these substances. Dysregulation of genes related to thyroid function (<em>tsh-β, dio-1, thr-b</em>) and inflammation (<em>tnf-α, il-1β, il-6, nfκb</em>) was observed in the co-exposure group. Additionally, this group exhibited increased lipid accumulation, elevated cholesterol and triglyceride levels, and dysregulation of essential lipid metabolism genes (<em>srebp2, pcsk9</em>). Co-exposure also impaired larval motility and behavior, evidenced by hypolocomotion and reduced acetylcholinesterase levels. Further gene expression analysis showed increased levels of <em>pi3k</em> and <em>akt,</em> two major signaling molecules. Ultimately, the simultaneous exposure to BPA and NaNO<sub>3</sub> leads to disruptions in the endocrine system and abnormal lipid levels via activating the PI3K/AKT/SREBP pathway.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"140 ","pages":"Article 109887"},"PeriodicalIF":4.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0