Journal of Nutritional Biochemistry最新文献_第2页

Intake of Neutral core Human Milk Oligosaccharides (HMOs) during early life improves long-term bone quality. 在生命早期摄入中性核心人乳寡糖（HMOs）可改善长期骨质量。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-20 DOI: 10.1016/j.jnutbio.2025.109968

N Bonnet, F N Schmidt, M Baruchet, E Migliavacca, M Ramos-Nieves, L Favre, D Brassart, K Mletzko, B Busse, Koopmans Sietse-Jan, M N Horcajada

{"title":"Intake of Neutral core Human Milk Oligosaccharides (HMOs) during early life improves long-term bone quality.","authors":"N Bonnet, F N Schmidt, M Baruchet, E Migliavacca, M Ramos-Nieves, L Favre, D Brassart, K Mletzko, B Busse, Koopmans Sietse-Jan, M N Horcajada","doi":"10.1016/j.jnutbio.2025.109968","DOIUrl":"https://doi.org/10.1016/j.jnutbio.2025.109968","url":null,"abstract":"<p><p>Infancy is a key period for bone growth, determining bone strength later in life. Studies have provided early insights into the role that human milk oligosaccharides (HMOs) may play in growth, potentially through their effects on the microbiome. However, focus was on sialylated HMOs whereas neutral core HMOs represent the most abundant class in human breast milk. We explored impact on bone quantity, quality and strength in 1year old female minipigs exposed to neutral HMOs during preweaning. Milk formula led to significant lower bone mineral density and quality compared to sow-fed (positive control). Milk formula enriched in neutral HMOs led to higher tibia bone density, structure and matrix quality compared to milk formula, leading to similar bone strength as in naturally sow-fed, whereas sialylated HMOs was not able to significantly differentiate than milk formulae. We identify a specific correlation between neutral HMOs, bone and microbiome, with the novel taxonomies Turicibacter sanguinis and Paraprevotella clara associating with HMO-mediated bone strength. This study provides important insights on the role of different HMO subtypes on bone health and possible associated adaptations in microbiome taxa, providing perspectives for new nutritional solutions for bone growth in early life.</p>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":" ","pages":"109968"},"PeriodicalIF":4.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in mature human milk metabolic profiles based on delivery mode and parity. 基于分娩方式和胎次的成熟人乳代谢谱的差异。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-19 DOI: 10.1016/j.jnutbio.2025.109967

Jiayue Tang, Cai Shen, Dan Yao, Jingwen Yu, Yanan Liu, Maolin Tu, Hong Zhang, Xuebing Xu, Oi-Ming Lai, Ling-Zhi Cheong

{"title":"Differences in mature human milk metabolic profiles based on delivery mode and parity.","authors":"Jiayue Tang, Cai Shen, Dan Yao, Jingwen Yu, Yanan Liu, Maolin Tu, Hong Zhang, Xuebing Xu, Oi-Ming Lai, Ling-Zhi Cheong","doi":"10.1016/j.jnutbio.2025.109967","DOIUrl":"https://doi.org/10.1016/j.jnutbio.2025.109967","url":null,"abstract":"<p><p>Human milk (HM) is regarded as the gold standard for infant nutrition. The metabolite profiles of mature human milk (MHM) have been reported to be affected by maternal physiological conditions, lactation stage, and maternal diets. We collected MHM (3-6 months postpartum) from 32 healthy mothers with different parities and delivery modes. Then, GC-MS and LC-MS were used to perform an untargeted metabolomics study. A clear distinction can be observed in terms of MHM metabolites of mothers with different delivery modes and parities with a 95% confidence interval. A total of 119 differentially expressed metabolites (DEMs) were identified in MHM of women with different delivery modes. Metabolic pathway analyses indicated that these DEMs are mainly associated with fatty acid biosynthesis. The higher abundances of these DEMs in MHM of cesarean women may be due to the differing levels of cortisol and oxytocin between mothers with different delivery modes. Meanwhile, 284 DEMs were identified in MHM of women with different parities. These DEMs are primarily related to ABC transporters, center carbon metabolism in cancer, and D-amino acid metabolism. These findings highlighted the impact of delivery modes and parity on HM metabolite composition. Further research is needed to explore the long-term health implications of these metabolic differences and optimize infant nutrition strategies.</p>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":" ","pages":"109967"},"PeriodicalIF":4.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of dietary fiber intake with all-cause and cardiovascular mortality among maintenance hemodialysis patients: a retrospective cohort study. 维持性血液透析患者膳食纤维摄入量与全因死亡率和心血管死亡率的关系：一项回顾性队列研究

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-19 DOI: 10.1016/j.jnutbio.2025.109966

Shuang Zhang, Qi-Jun Wu, Yu-Lin Wu, Ping Xiao, Zhi-Hong Wang, Hong Liu, Yan Lu, Shu-Xin Liu

{"title":"Associations of dietary fiber intake with all-cause and cardiovascular mortality among maintenance hemodialysis patients: a retrospective cohort study.","authors":"Shuang Zhang, Qi-Jun Wu, Yu-Lin Wu, Ping Xiao, Zhi-Hong Wang, Hong Liu, Yan Lu, Shu-Xin Liu","doi":"10.1016/j.jnutbio.2025.109966","DOIUrl":"https://doi.org/10.1016/j.jnutbio.2025.109966","url":null,"abstract":"<p><strong>Objective: </strong>To determine the association between dietary fiber intake (DFI) and all-cause mortality and cardiovascular mortality in Chinese maintenance hemodialysis (MHD) patients, considering fiber type and source.</p><p><strong>Methods: </strong>Adjusted Cox regression analyses were utilized to assess the correlation between quartiles of DFI and mortality. Restricted cubic spline (RCS) regression was employed to investigate the non-linear relationship between the total cereal fiber and mortality. Subgroup and sensitivity analysis was performed to examine the robustness.</p><p><strong>Results: </strong>Among 742 patients (median follow-up: 30.47 months), 210 deaths (28.30%) occurred, including 149 (20.08%) cardiovascular-related deaths. Higher total cereal fiber intake correlated with reduced all-cause mortality [HR (hazard ratio) <sub>quartile 4 (Q4) vs. quartile 1 (Q1)</sub> = 0.58, 95% CI: 0.36-0.93] and cardiovascular mortality (HR <sub>Q4 vs. Q1</sub> = 0.53, 95% CI = 0.30-0.95). Apart from fruit fiber as well as bean fiber for all-cause mortality and soluble fruit fiber for cardiovascular mortality, a similar association was observed for fiber from other dietary sources, albeit without statistical significance. Furthermore, each standard deviation increase in total cereal fiber intake lowered all-cause mortality risk (HR = 0.82, 95% CI: 0.69-0.98). The findings were robust in all the subgroup and sensitivity analyses. Additionally, the RCS regression model indicated linear inverse associations between total cereal fiber and mortality risks (all p<sub>non-linear</sub> > 0.05).</p><p><strong>Conclusions: </strong>Total cereal fiber intake was inversely associated with reduced all-cause and cardiovascular mortality in MHD patients. Our data suggest that cereal fiber is a potentially protective component and may enhance overall longevity in MHD patients.</p>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":" ","pages":"109966"},"PeriodicalIF":4.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the crosstalk between gut microbiota and stool metabolome in omnivorous, vegetarian, and vegan diets: a pilot study. 探索杂食、素食和纯素饮食中肠道微生物群和粪便代谢组之间的串扰：一项试点研究。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-19 DOI: 10.1016/j.jnutbio.2025.109965

Andrea Massaro, Arianna Peruzzo, Carmela Zacometti, Mirella Zancato, Roberto Piro, Carmen Losasso, Alessandra Tata, Gregorio Peron

{"title":"Exploring the crosstalk between gut microbiota and stool metabolome in omnivorous, vegetarian, and vegan diets: a pilot study.","authors":"Andrea Massaro, Arianna Peruzzo, Carmela Zacometti, Mirella Zancato, Roberto Piro, Carmen Losasso, Alessandra Tata, Gregorio Peron","doi":"10.1016/j.jnutbio.2025.109965","DOIUrl":"https://doi.org/10.1016/j.jnutbio.2025.109965","url":null,"abstract":"<p><p>Gut microbiota (GM) and fecal metabolome are shaped by different dietary regimens. Nevertheless, outlining generalized patterns is challenging, due to the intrinsic heterogeneity of individual dietary choices. In this work, the fecal metabolome of adult volunteers consuming omnivorous (n = 44), vegetarian (n = 29), and vegan diets (n = 25) for at least 12 months was characterized. The crosstalk among diet, GM and fecal metabolome was also investigated correlating metabolomics and metataxonomics data. Untargeted metabolomic profiles were correlated with metataxonomics data previously acquired on the same stool samples. The sphingomyelin SM(d18:2/18:1-2OH) and phosphoethanolamines from animal-based food were associated to the omnivorous diet and were negatively correlated to beneficial Bacteroides ovatus and Odoribacter genus. Plant glycerides, sterols, triterpenes, and oleic-linoleic acid were associated with the vegan diet. Oleic-linoleic acid was positively correlated with Alistipes putredinis. Chenodeoxycholic acid, a primary bile acid, was identified as a marker of vegan diet, while ketolithocholic acid, a secondary bile acid, was associated to the omnivorous diet. This latter was also negatively correlated to B.ovatus. Overall, results confirm that assessing markers of dietary regimens instead of specific food categories is challenging, especially if volunteers' diet is not strictly monitored. However, the integration of metabolomics and metataxonomic data allows to better understand the effects of specific food components on the GM and represents a suitable approach for further molecular investigation in nutrition.</p>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":" ","pages":"109965"},"PeriodicalIF":4.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenethyl Isothiocyanate (PEITC) interaction with Keap1 activates the Nrf2 pathway and inhibits lipid accumulation in adipocytes. 异硫氰酸苯乙酯（PEITC）与Keap1相互作用激活Nrf2通路，抑制脂肪细胞中的脂质积累。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-16 DOI: 10.1016/j.jnutbio.2025.109963

Hae-Sun Ko, Kwonyoung Kim, Yu-Ran Na, Chang-Hwan Yeom, Chu Won Nho, Yoon Shin Cho, Jihoe Kim, Kye Won Park

{"title":"Phenethyl Isothiocyanate (PEITC) interaction with Keap1 activates the Nrf2 pathway and inhibits lipid accumulation in adipocytes.","authors":"Hae-Sun Ko, Kwonyoung Kim, Yu-Ran Na, Chang-Hwan Yeom, Chu Won Nho, Yoon Shin Cho, Jihoe Kim, Kye Won Park","doi":"10.1016/j.jnutbio.2025.109963","DOIUrl":"https://doi.org/10.1016/j.jnutbio.2025.109963","url":null,"abstract":"<p><p>Phenethyl isothiocyanate (PEITC) has been recognized for its potential effects in various human diseases. However, the impact of PEITC on adipocyte differentiation and its underlying molecular mechanisms is not well understood. This study investigates the effects of PEITC on adipocyte differentiation and elucidates the molecular mechanisms involved in Nrf2 activation. The effects of PEITC on adipocyte differentiation were assessed in C3H10T1/2 and 3T3-L1 cells. Nrf2-induced effects by PEITC were examined in Nrf2 knockout (KO) MEF and Keap1 KO H1299 cells. The interaction between PEITC and Keap1 was evaluated using thermal shift assays and Co-immunoprecipitation experiments. Reconstitution of cysteine mutants of Keap1 in Keap1 KO cells was used to elucidate a critical amino acid for the PEITC-induced Nrf2 stabilization. The initial stages of adipogenesis were crucial for PEITC's anti-adipogenic effects in C3H10T1/2 and 3T3-L1 cells. PEITC increased Nrf2 protein expression, but this induction was absent in Keap1 KO cells. Thermal shift assays with the purified BTB domain of Keap1 confirmed a direct interaction with PEITC. Re-expression of Keap1 in Keap1 KO cells showed that the cysteine residue at position 151 is essential for PEITC-induced Nrf2 expression and the disruption of the Nrf2-Keap1 complex. PEITC was found to activate Nrf2-mediated gene expression and inhibit adipocyte differentiation, at least partially, through Nrf2-dependent mechanisms. This study confirms the anti-adipogenic effects of PEITC. Mechanistic investigations demonstrate that PEITC interacts with Keap1 and that the cysteine residue (C151) of Keap1 is critical for PEITC's effects on Nrf2 activation.</p>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":" ","pages":"109963"},"PeriodicalIF":4.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low butyrate concentrations exert anti-inflammatory and high concentrations exert pro-inflammatory effects on macrophages. 低丁酸盐浓度对巨噬细胞有抗炎作用，高浓度对巨噬细胞有促炎作用。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-15 DOI: 10.1016/j.jnutbio.2025.109962

Muwei Jiang, Danny Incarnato, Rutger Modderman, Aina Altimira Lazaro, Iris H Jonkers, Frans Bianchi, Geert van den Bogaart

{"title":"Low butyrate concentrations exert anti-inflammatory and high concentrations exert pro-inflammatory effects on macrophages.","authors":"Muwei Jiang, Danny Incarnato, Rutger Modderman, Aina Altimira Lazaro, Iris H Jonkers, Frans Bianchi, Geert van den Bogaart","doi":"10.1016/j.jnutbio.2025.109962","DOIUrl":"https://doi.org/10.1016/j.jnutbio.2025.109962","url":null,"abstract":"<p><p>Butyrate is a four-carbon short-chain fatty acid produced from microbial fermentation of dietary fibers present at high millimolar concentrations in the colonic lumen. However, in an intact epithelium, macrophages residing in the lamina propria are exposed to only micromolar butyrate concentrations. Current studies show anti-inflammatory properties of butyrate and suggest that it might have therapeutic applications in inflammatory bowel disease and colonic cancer. We now show that the effect of butyrate on human macrophages is strongly concentration dependent: 0.1 mM butyrate suppresses LPS-induced production of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α. Experiments with siRNA knockdown and small molecule inhibitors suggest that this is mediated by a mechanism involving PPAR-γ signaling, whereas we observed no or only a minor effect of histone acetylation. In contrast, 10 mM butyrate promotes macrophage cell death, does not inhibit LPS-induced production of TNF-α, and promotes production of IL-1β, while production of anti-inflammatory IL-10 is reduced in a mechanism involving G protein-coupled receptors, the lipid transporter CD36, and the kinase SRC. We propose that butyrate is a signaling molecule for intestinal integrity, since intestinal disruption exposes macrophages to high butyrate concentrations.</p>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":" ","pages":"109962"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cell membranes undergo biochemical and biophysical changes in response to hydroxycinnamic acid derivatives: ferulic acid and caffeic acid 在羟基肉桂酸衍生物阿魏酸和咖啡酸的作用下，细胞膜发生生化和生物物理变化。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-14 DOI: 10.1016/j.jnutbio.2025.109956

Anna Barbasz, Barbara Dyba, Elżbieta Rudolphi-Szydło, Wiktoria Omachel, Barbara Kreczmer

{"title":"The cell membranes undergo biochemical and biophysical changes in response to hydroxycinnamic acid derivatives: ferulic acid and caffeic acid","authors":"Anna Barbasz, Barbara Dyba, Elżbieta Rudolphi-Szydło, Wiktoria Omachel, Barbara Kreczmer","doi":"10.1016/j.jnutbio.2025.109956","DOIUrl":"10.1016/j.jnutbio.2025.109956","url":null,"abstract":"<div><div>Ferulic acid (FA) and caffeic acid (CA), due to their strong antioxidant properties, are widely used both in dietary supplements and as ingredients in cosmetics. However, despite the undoubtedly beneficial properties of these molecules, they can also exhibit toxic effects. This study aimed to investigate which concentrations of the compounds are toxic for different types of cells and which are beneficial. Detailed analyses were performed on human cells (U937, HL-60, SK-N-SH) and mouse cells (B16-F0), as well as on cell membrane models created using the Langmuir technique. Based on biochemical studies, it was shown that both compounds can act cytotoxically, although FA is significantly more cytotoxic than CA. This difference in toxicity levels is attributed to the presence of different substituents, which affect the molecules' hydrophobicity and, consequently, their localization in membranes. Based on model membranes, it was demonstrated that the polar parts of membranes are decisive in determining the degree of this interaction. While cinnamic acid derivatives offer localized health benefits, they can also have toxic effects on different types of cells.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"144 ","pages":"Article 109956"},"PeriodicalIF":4.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota regulation by Lactiplantibacillus plantarum SG5 enhances mitochondrial function in Parkinson's disease mice via the GLP-1/PGC-1α pathway 植物乳杆菌SG5通过GLP-1/PGC-1α途径调节帕金森病小鼠肠道微生物群，增强线粒体功能。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-12 DOI: 10.1016/j.jnutbio.2025.109954

Yueyan Qi , Siyou Xie , Jinhu Chen , Cancan Zhang , Xin Ma , Yang Yu , Xueping Yu , Yanqin Wang

{"title":"Gut microbiota regulation by Lactiplantibacillus plantarum SG5 enhances mitochondrial function in Parkinson's disease mice via the GLP-1/PGC-1α pathway","authors":"Yueyan Qi , Siyou Xie , Jinhu Chen , Cancan Zhang , Xin Ma , Yang Yu , Xueping Yu , Yanqin Wang","doi":"10.1016/j.jnutbio.2025.109954","DOIUrl":"10.1016/j.jnutbio.2025.109954","url":null,"abstract":"<div><div>Motor dysfunction constitutes a prominent characteristic of Parkinson's disease (PD), a neurodegenerative disorder associated with compromised mitochondrial activity, perturbed gut microbial composition, and neuronal loss. In this study, we examined the regulatory mechanisms of <em>Lactiplantibacillus plantarum</em> SG5 (<em>L. plantarum</em> SG5) on mitochondrial function in PD mouse models, with a particular emphasis on its interaction with the GLP-1/PGC-1α pathway. Findings revealed that MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP) induced (male 6-8 weeks C57BL/6 mice) motor impairments and damage to dopaminergic (DA) neurons in PD mice, resulting in mitochondrial dysfunction, decreased mitochondrial biogenesis, disrupted dynamics, and autophagy, while promoting fission and apoptosis. Additionally, MPTP modified gut microbial diversity and community structure. Nevertheless, supplementation with SG5 alleviated motor deficits and DA neurons damage in PD mice, enhancing mitochondrial quality by elevating PGC-1α expression and restoring biogenesis, dynamics, and autophagy levels. Mechanistic investigations demonstrated that SG5 increased colonic GLP-1 expression, suggesting that GLP-1 might regulate mitochondrial function via the GLP-1R-mediated PGC-1α. Furthermore, SG5 counteracted MPTP-induced gut dysbiosis. Notably, both GLP-1R antagonists and PGC-1α inhibitors attenuated the protective effects of SG5 in PD mice. In conclusion, <em>L. plantarum</em> SG5 may enhance mitochondrial function in the substantia nigra (SN) of PD mice through the GLP-1/PGC-1α pathway, potentially delaying neurodegeneration. Its mechanism is closely related to the regulation of the gut microenvironment and GLP-1 levels, presenting novel microbiota-based therapeutic targets for PD.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"143 ","pages":"Article 109954"},"PeriodicalIF":4.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network pharmacology and transcriptomics reveal Complanatoside A regulates lipid metabolism in hyperlipidemia and non-alcoholic fatty liver disease via the AMPK pathway. 网络药理学和转录组学研究表明，planatoside A通过AMPK通路调节高脂血症和非酒精性脂肪肝的脂质代谢。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-10 DOI: 10.1016/j.jnutbio.2025.109960

Sijia Jiang, Zhengting Liang, Jian Hua, Yajin Li, Xiaoxu Fan, Zhiyuan Qiao, Zhen Wang, Yiwei Shen, Le Fan, Jingxia Wang

{"title":"Network pharmacology and transcriptomics reveal Complanatoside A regulates lipid metabolism in hyperlipidemia and non-alcoholic fatty liver disease via the AMPK pathway.","authors":"Sijia Jiang, Zhengting Liang, Jian Hua, Yajin Li, Xiaoxu Fan, Zhiyuan Qiao, Zhen Wang, Yiwei Shen, Le Fan, Jingxia Wang","doi":"10.1016/j.jnutbio.2025.109960","DOIUrl":"https://doi.org/10.1016/j.jnutbio.2025.109960","url":null,"abstract":"<p><p>Non-alcoholic fatty liver disease (NAFLD) and hyperlipidemia belong to the metabolic disorder syndromes of metabolic syndrome. They share a common pathological basis and are often complicated. Complanatoside A (CA), a flavonoid abundant in Astragali complanati semen, helps to prevent NAFLD and hyperlipidemia. However, the exact molecular mechanism is uncertain. Therefore, this study aims to explore the core mechanism. Network pharmacology was used to analyze the preventive mechanism of CA against NAFLD and hyperlipidemia. The efficacy of CA was proven in a high-fat diet-fed mouse model and a steatogenic hepatocyte model. Transcriptomic analysis, Western blot validation, and molecular docking methods were used to explore the common mechanism of CA in preventing NAFLD and hyperlipidemia. Network pharmacology revealed that the AMP-activated protein kinase (AMPK) pathway is a common mechanism leading to NAFLD and hyperlipidemia. It is also a potential pathway by which CA exerts its protective effect, which was confirmed in transcriptomics in vivo. Both in vitro and in vivo experiments showed that CA could inhibit lipid synthesis and promote fatty acid oxidation by activating the AMPK, alleviating lipid accumulation, and lipotoxic liver injury. This was demonstrated by the use of an AMPK inhibitor in vitro. Furthermore, molecular docking results showed that CA could directly interact with AMPK to regulate downstream lipid-related proteins. In conclusion, the AMPK pathway is key in developing NAFLD and hyperlipidemia. CA plays a dual preventive role in NAFLD and hyperlipidemia by activating AMPK to regulate lipid metabolism.</p>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":" ","pages":"109960"},"PeriodicalIF":4.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction between nutritional factors and the enteric nervous system in inflammatory bowel diseases 炎症性肠病中营养因子与肠神经系统的相互作用。

IF 4.8 2区医学

Journal of Nutritional Biochemistry Pub Date : 2025-05-10 DOI: 10.1016/j.jnutbio.2025.109959

Aleksandra Tarasiuk-Zawadzka, Jakub Fichna

{"title":"Interaction between nutritional factors and the enteric nervous system in inflammatory bowel diseases","authors":"Aleksandra Tarasiuk-Zawadzka, Jakub Fichna","doi":"10.1016/j.jnutbio.2025.109959","DOIUrl":"10.1016/j.jnutbio.2025.109959","url":null,"abstract":"<div><div>The enteric nervous system (ENS) is a highly conserved, yet complicated network of neurons and glial cells located throughout the gut wall that controls digestive processes and gastrointestinal (GI) homeostasis. The intestinal epithelium, the immune system, and the gut microbiota are just a few examples of the cellular networks that the ENS interacts with on a variety of levels to maintain GI function. The presence or absence of nutrients in the intestinal lumen may cause short- and/or long-term changes in neurotransmitter expression, excitability, and neuronal survival, which ultimately affect gut motility, secretion, and permeability. Hence, the ENS should be identified as a key factor in initiating coordinated responses to nutrients. In this review we summarize current knowledge on nutrient-dependent ENS activity and how ENS secondary to nutrition may affect likelihood of developing inflammatory bowel disease. Our findings highlight that nutrients interact with enteroendocrine cells in the gut, triggering hormone secretion that plays a crucial role in signaling food-related information to the brain and regulating metabolic processes such as feeding behavior, insulin secretion, and energy balance; however, the complex interactions between nutrients, the ENS, and the immune system require further research to understand their contributions to GI disorders and potential therapeutic applications in treating obesity and metabolic diseases.</div><div>Lay Summary: The enteric nervous system (ENS) controls digestion and interacts with nutrients in the gut to regulate processes like gut movement and hormone release, affecting metabolism and overall gut health. This review highlights the need for further research on how nutrient-ENS interactions contribute to conditions like inflammatory bowel disease, obesity, and metabolic disorders.</div></div>","PeriodicalId":16618,"journal":{"name":"Journal of Nutritional Biochemistry","volume":"144 ","pages":"Article 109959"},"PeriodicalIF":4.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0