Journal of oral rehabilitation最新文献

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Patient Experiences With Temporomandibular Disorders: A Survey on the Pathways in Diagnosis and Treatment. 颞下颌疾患的临床经验:诊断和治疗途径的综述。
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.13993
Aurora Manfredini, Ovidiu Ionut Saracutu, Charles S Greene, Marco Ferrari, Daniele Manfredini
{"title":"Patient Experiences With Temporomandibular Disorders: A Survey on the Pathways in Diagnosis and Treatment.","authors":"Aurora Manfredini, Ovidiu Ionut Saracutu, Charles S Greene, Marco Ferrari, Daniele Manfredini","doi":"10.1111/joor.13993","DOIUrl":"https://doi.org/10.1111/joor.13993","url":null,"abstract":"<p><strong>Background: </strong>Despite the availability of evidence-based guidelines on temporomandibular disorders (TMD), some past theories of TMD aetiology, diagnosis and treatment are still diffused among clinical practitioners.</p><p><strong>Objective(s): </strong>The study aims to gather and analyse patient experiences and outcomes related to their seeking care for TMD symptoms.</p><p><strong>Methods: </strong>In November 2023, a survey to collect comprehensive data on patients' diagnostic journeys, treatment experiences, and outcomes was distributed through online platforms and TMD patient support groups in a variety of countries. Correlation between different variables was assessed and comparisons were made between patients with a different history of treatment-seeking experiences.</p><p><strong>Results: </strong>A total of 153 participants filled out the survey. Of them, 31.4% (N = 48) needed to consult two or three professionals, while some of them saw up to four or five (N = 27, 17.6%). Moreover, patients experienced a wide range of pain duration time before receiving a diagnosis. Almost one-third of patients were in pain for more than one year (N = 43, 28.1%), and a remarkable number never received appropriate care (N = 30, 19.6%). Additionally, those patients who saw one or more dentists who emphasised abnormalities of dental occlusion or jaw position ended up consulting significantly more health providers before receiving a diagnosis than those who did not have that experience (p = 0.0062).</p><p><strong>Conclusion: </strong>There is a need to better implement knowledge about TMDs among health-care providers, starting from improving the quality of education at the university course level and continuing into various post-graduate educational offerings.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posture Meets Function: How Cervical Alignment Shapes Tongue Strength. 姿势符合功能:颈椎对齐如何塑造舌头力量。
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.14033
Suriyaraj Shanmugasundaram Prema, Deepankumar Shanmugamprema
{"title":"Posture Meets Function: How Cervical Alignment Shapes Tongue Strength.","authors":"Suriyaraj Shanmugasundaram Prema, Deepankumar Shanmugamprema","doi":"10.1111/joor.14033","DOIUrl":"https://doi.org/10.1111/joor.14033","url":null,"abstract":"","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Orofacial Myofunctional Behaviour in Adults (OMA-) Project: Orofacial Myofunctional Behaviour, Orofacial Strength and Oral Health-Related Quality of Life in Healthy Adults With and Without a History of Orofacial Myofunctional Therapy. 成人口面肌功能行为(OMA-)项目:有或没有接受过口面肌功能治疗的健康成人的口面肌功能行为、口面力量和口腔健康相关生活质量。
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.13974
Charis Van der Straeten, Noor Ockier, Jolien Verbeke, Ineke Van Hecke, Kim Bettens, Kristiane Van Lierde
{"title":"The Orofacial Myofunctional Behaviour in Adults (OMA-) Project: Orofacial Myofunctional Behaviour, Orofacial Strength and Oral Health-Related Quality of Life in Healthy Adults With and Without a History of Orofacial Myofunctional Therapy.","authors":"Charis Van der Straeten, Noor Ockier, Jolien Verbeke, Ineke Van Hecke, Kim Bettens, Kristiane Van Lierde","doi":"10.1111/joor.13974","DOIUrl":"https://doi.org/10.1111/joor.13974","url":null,"abstract":"<p><strong>Background: </strong>Orofacial Myofunctional Therapy (OMT) is a widely adopted behavioural intervention for managing Orofacial Myofunctional Disorders (OMDs). Nevertheless, there is a lack of data on the long-term outcomes of OMT.</p><p><strong>Objectives: </strong>The aim of this study was to compare orofacial myofunctional status, orofacial strength, and Oral Health-Related Quality of Life (OHRQoL) in healthy adults with and without a history of OMT, and to explore person- and therapy-related factors influencing long-term outcomes of OMT.</p><p><strong>Methods: </strong>Thirty-one healthy adults (mean age 23.9 years old, SD 3.99 years) who underwent OMT as a child or adolescent were included in this cross-sectional study (OMT group), as well as 31 age and gender matched control participants without a history of OMT (non-OMT group). For perceptual assessment of orofacial functions, the Orofacial Myofunctional Evaluation with Scores (OMES) was used, with higher scores indicative of better performance. Maximum isometric pressure and endurance measurements were obtained using the Iowa Oral Performance Instrument (IOPI). The Oral Health Impact Profile questionnaire (OHIP-NL14) was used to assess OHRQoL.</p><p><strong>Results: </strong>The OMT group did not show significant differences in orofacial appearance/posture, mobility, strength, endurance, or OHRQoL compared to those who did not undergo therapy. The OMT group did demonstrate a significantly higher OMES function sub score (p = 0.046) and exhibited a typical swallowing pattern significantly more frequently (p = 0.045) than the non-OMT group. No demographic or therapy-related factors significantly influencing long-term OMT intervention outcomes were identified.</p><p><strong>Conclusions: </strong>These results suggest that OMT may have a lasting positive impact in the treatment of OMDs, indicating its effectiveness over the long term.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Haematologic Data Improves Long-Term Prediction Accuracy of Artificial Intelligence Models for Temporomandibular Disorders. 血液学数据提高颞下颌疾病人工智能模型的长期预测准确性。
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.14030
Moon Jong Kim, Taegun An, Il-San Cho, Changhee Joo, Ji Woon Park
{"title":"Haematologic Data Improves Long-Term Prediction Accuracy of Artificial Intelligence Models for Temporomandibular Disorders.","authors":"Moon Jong Kim, Taegun An, Il-San Cho, Changhee Joo, Ji Woon Park","doi":"10.1111/joor.14030","DOIUrl":"https://doi.org/10.1111/joor.14030","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to develop and evaluate an artificial intelligence (AI) model to predict long-term treatment outcomes in temporomandibular disorder (TMD) patients using clinical data and verify the value of adding haematologic data in enhancing predictive accuracy.</p><p><strong>Methods: </strong>The medical records of 132 TMD patients who visited the clinic and underwent 6 months of non-invasive conservative treatment between 2013 and 2019 were included in this study. The clinical data and haematologic features were collected from medical records. A decision tree algorithm was employed for feature selection, followed by a deep neural network (DNN) to build the prediction model. The performance of the models based on the decision tree algorithm and DNN was evaluated.</p><p><strong>Results: </strong>The decision tree model achieved an accuracy of 90.6% and an F1-score of 0.800. The subjective pain-related features, along with haematologic markers associated with systemic inflammation, were proven to be important features in the decision tree model. The predictive performance of the DNN model improved as haematologic features were added, with the final model achieving an accuracy of 90.6% and an F1-score of 0.769.</p><p><strong>Conclusions: </strong>This study showed the potential of machine learning models in predicting long-term TMD prognosis using clinical and haematological features. In addition, these findings highlight the importance of including both subjective pain assessments and systemic haematologic markers for the development of aetiology-based diagnostic systems for TMD to enhance clinical decision-making and prognosis prediction accuracy.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporomandibular Disorder in Domestic Waste Collectors: Cross-Sectional Study. 生活垃圾收集者颞下颌紊乱:横断面研究。
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.13975
Patricia Ramos Cury, Nara Santos Araujo, Marcel Jhonnata Ferreira Carvalho, Mariana Carvalho Andrade, Daniel Araki Ribeiro, Jean Nunes Dos Santos
{"title":"Temporomandibular Disorder in Domestic Waste Collectors: Cross-Sectional Study.","authors":"Patricia Ramos Cury, Nara Santos Araujo, Marcel Jhonnata Ferreira Carvalho, Mariana Carvalho Andrade, Daniel Araki Ribeiro, Jean Nunes Dos Santos","doi":"10.1111/joor.13975","DOIUrl":"https://doi.org/10.1111/joor.13975","url":null,"abstract":"<p><strong>Background: </strong>Musculoskeletal disorders are prevalent among waste collectors, yet the temporomandibular disorder (TMD) assessment within this group remains overlooked.</p><p><strong>Objective: </strong>This cross-sectional study examined TMD in domestic waste collectors and its association with their work.</p><p><strong>Methods: </strong>The study involved 288 adult men from a waste collection corporation, with 130 working in domestic solid waste collection (operational workers) and 158 in other roles (controls). TMD severity was assessed through inquiries about signs and symptoms. Missing teeth were clinically evaluated. Socio-demographic data, employment history, psychosocial factors, and severity of TMD were collected using a questionnaire.</p><p><strong>Results: </strong>TMD was diagnosed in 47% of the operational workers, and the most reported TMD factors were self-perception of being a tense person (52.3%) and parafunctional habits (40.0%). In the whole sample, moderate/severe TMD was associated with alcohol dependence (OR = 3.51, 95% CI = 1.10-11.25, p = 0.03), and mild TMD was associated with parafunctional habits (OR = 3.36, 95% CI = 1.99-5.67, p < 0.001) and psychosocial factors (OR = 3.68, 95% CI = 2.17-6.25, p < 0.001). In operational workers, moderate/severe TMD was associated with alcohol dependence (OR = 4.84, 95% CI = 1.00-23.81, p = 0.05), and mild TMD was associated with age (OR = 2.60, 95% CI = 1.02-6.70, p = 0.05), psychosocial (OR = 4.41, 95% CI = 1.76-11.05, p = 0.002) and parafunctional (OR = 5.14, 95% CI = 2.17-12.19, p < 0.001) factors.</p><p><strong>Conclusion: </strong>In this sample of domestic waste collectors, moderate to severe TMD correlated with alcohol dependence, whereas mild TMD showed associations with age, psychosocial factors, and parafunctional habits. However, TMD did not exhibit a direct association with domestic waste-collecting work. Thus, addressing physical and mental health concerns within this occupational cohort may enhance overall well-being.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between Work-Related Stress and Temporomandibular Disorders-Related Symptoms in Japanese Working Population. 日本工作人群中工作压力与颞下颌疾病相关症状的关系
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.14006
Fares Moustafa, Akira Nishiyama, Hiroyuki Ishiyama, Kenji Fueki
{"title":"The Relationship Between Work-Related Stress and Temporomandibular Disorders-Related Symptoms in Japanese Working Population.","authors":"Fares Moustafa, Akira Nishiyama, Hiroyuki Ishiyama, Kenji Fueki","doi":"10.1111/joor.14006","DOIUrl":"https://doi.org/10.1111/joor.14006","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular disorders (TMD) aetiological factors have multidimensional, biomechanical, neuromuscular, biopsychosocial and neurobiological aspects. The relationship between work environment factors or occupational stress and TMD is not sufficiently investigated and is still poorly understood.</p><p><strong>Objective: </strong>To investigate work-related stress and the effect of personal computer (PC) use on TMD.</p><p><strong>Methods: </strong>A questionnaire-based survey that was conducted among 5619 employees of three companies. The questionnaire was used to screen TMD-related symptoms (TRS), habitual behaviours, psychosocial status, awake and sleep bruxism and time spent using a PC at work. After excluding missing data values, 4776 individuals were included in the analysis. Structural equation modelling (SEM) was used to test the hypothesised models that correlated TRS with the other factors of the questionnaire, and to examine the effect of the time spent using the PC on men and women in our sample. Statistical significance was set at p < 0.05.</p><p><strong>Results: </strong>SEM revealed that psychosocial factors affected TRS indirectly through their direct effect on sleep bruxism and other behavioural factors which had a direct effect on TRS. The effect of PC usage time was greater for women than for men.</p><p><strong>Conclusions: </strong>Behavioural factors, including SB, may have a direct effect on TRS, while psychosocial factors may have an indirect effect on TRS. In addition, the results suggest that prolonged PC use influences behavioural and psychosocial factors, and this was especially true for women.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General and Health Anxiety in Temporomandibular Disorders: Correlates With Depression, Pain Intensity, Sleep Propensity, Oral Behaviours, Jaw Function, and Oral Health-Related Quality of Life. 颞下颌疾病患者的一般焦虑和健康焦虑:与抑郁、疼痛强度、睡眠倾向、口腔行为、颌功能和口腔健康相关生活质量相关
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.14023
Adrian Ujin Yap, Yunhao Zheng, Tiqian Liu, Yijun Li, Yi Liu, Xueman Zhou, Jun Wang, Xin Xiong
{"title":"General and Health Anxiety in Temporomandibular Disorders: Correlates With Depression, Pain Intensity, Sleep Propensity, Oral Behaviours, Jaw Function, and Oral Health-Related Quality of Life.","authors":"Adrian Ujin Yap, Yunhao Zheng, Tiqian Liu, Yijun Li, Yi Liu, Xueman Zhou, Jun Wang, Xin Xiong","doi":"10.1111/joor.14023","DOIUrl":"https://doi.org/10.1111/joor.14023","url":null,"abstract":"<p><strong>Background: </strong>Health anxiety (HA) has been underexplored in temporomandibular disorders (TMDs). This study compared general anxiety (GA) and HA across TMD subtypes, examining correlations with depression, pain intensity, sleep propensity, oral behaviours, jaw function, and oral health-related quality of life (OHRQoL).</p><p><strong>Methods: </strong>Participants recruited from TMD patients completed a survey with the General Anxiety Disorder-7 Scale, Whitely Index-8, relevant DC/TMD Axis II measures, Epworth Sleepiness Scale, and Oral Health Impact Profile for TMDs, followed by a physical examination. They were subsequently categorised into Intra-Articular (IT), Pain-Related (PT), and Combined (CT) TMD groups based on DC/TMD algorithms. Data were analysed using the Chi-square Test, non-parametric tests, and logistic regression (α = 0.05).</p><p><strong>Results: </strong>Among the 371 participants (mean age 29.8 years; 79.5% female), moderate-to-severe GA and depression were found in 15.1%, and high HA was noted in 19.7%. Significant differences were observed across the three TMD subtypes in the proportion of females (CT > PT/IT), age, GA, HA, depression, pain intensity, jaw functional limitation (PT/CT > IT), and OHRQoL (CT ≥ PT > IT). GA was strongly correlated with HA and depression and moderately correlated with OHRQoL, while HA was moderately correlated with both depression and OHRQoL (r<sub>s</sub> = 0.60-0.77). The multivariate model indicated that CT (OR 2.86), GA (OR 1.35), HA (OR 1.13), pain intensity (OR 1.03), and jaw functional limitation (OR 1.04) significantly increased the odds of low OHRQoL.</p><p><strong>Conclusions: </strong>One-fifth of TMD patients exhibited HA, which was moderate to strongly correlated with GA and depression. GA and HA appear to have a greater impact on OHRQoL than depression.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-Specific Clinical and Brain Features of Masticatory and Swallowing Performance. 咀嚼和吞咽行为的年龄特异性临床和脑特征。
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.13998
Chia-Shu Lin, Wei-Chieh Kao
{"title":"Age-Specific Clinical and Brain Features of Masticatory and Swallowing Performance.","authors":"Chia-Shu Lin, Wei-Chieh Kao","doi":"10.1111/joor.13998","DOIUrl":"https://doi.org/10.1111/joor.13998","url":null,"abstract":"<p><strong>Background: </strong>Mastication and swallowing are the fundamental processes for food intake and the primary functions of living. The clinical and neurological features associated with individual differences in masticatory performance and swallowing performance have remained unexplored.</p><p><strong>Objectives: </strong>The study focuses on the age-specific association between masticatory/swallowing performance and oral/systemic/nutritional factors and their association with functional brain connectivity.</p><p><strong>Methods: </strong>One-hundred and eighteen healthy adults (48 older age, 27 middle-aged and 43 younger age) were recruited for food-mixing and repetitive saliva swallowing tests, respectively, indexed for masticatory and swallowing performance, as well as oral, systemic and nutritional factors, including mid-upper arm and calf circumferences. Structural and resting-state (rs) functional magnetic resonance imaging was acquired. Seed-based connectivity analyses were conducted to investigate the association between swallowing performance and rs-functional connectivity (rs-FC) of the sensorimotor network.</p><p><strong>Results: </strong>(a) In contrast to mastication, individual swallowing performance was not associated with oral or systemic factors. (b) In older adults, higher mid-upper arm and calf circumferences were associated with both higher masticatory and swallowing performance (a statistically significant interaction, p = 0.018). (c) In older adults, higher swallowing performance was associated with stronger rs-FC between the cerebellum and basal ganglia (p = 0.008, corrected for small volume), whilst higher masticatory performance was associated with stronger rs-FC between the cerebellum and primary sensorimotor cortices (p = 0.045, corrected for small volume).</p><p><strong>Conclusion: </strong>Our findings reveal age-specific associations between swallowing, mastication, nutritional factors and brain functional connectivity. The findings highlight the association between the brain and individual differences in masticatory and swallowing performance.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Canonical Wnt Pathway Enhanced Dental Pulp Mesenchymal Stem Cells-Mediated Cementum Regeneration. 典型Wnt通路增强牙髓间充质干细胞介导的牙骨质再生。
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.14001
Dongmei Cheng, Xin Yuan, Zhiyu Ma, Xiaoyu Lin, Zhao Zhu, Jinsong Wang, Chunmei Zhang, Yuji Wang, Jian Zhou, Songlin Wang, Lei Hu
{"title":"Canonical Wnt Pathway Enhanced Dental Pulp Mesenchymal Stem Cells-Mediated Cementum Regeneration.","authors":"Dongmei Cheng, Xin Yuan, Zhiyu Ma, Xiaoyu Lin, Zhao Zhu, Jinsong Wang, Chunmei Zhang, Yuji Wang, Jian Zhou, Songlin Wang, Lei Hu","doi":"10.1111/joor.14001","DOIUrl":"https://doi.org/10.1111/joor.14001","url":null,"abstract":"<p><strong>Background: </strong>Cementum is a mineralised tissue that is essential for maintaining periodontal tissue homeostasis. Our previous research has shown that dental pulp mesenchymal stem cells (DPSCs) can regenerate periodontal tissues. However, the regeneration efficiency and the specific molecular mechanism remain unclear.</p><p><strong>Objective: </strong>This study aimed to clarify the expression differences of the Wnt signalling pathway in cementum, dental pulp and periodontal ligament and illustrate the function of Wnt3a in promoting cementum regeneration of DPSCs.</p><p><strong>Methods: </strong>RNA Smart transcriptome sequencing was performed to illustrate the differential gene expression of the Wnt pathway among cementum, dental pulp and periodontal tissues. Biological function experiments of Wnt3a were conducted to demonstrate the capacity of Wnt3a to enhance cementum regeneration of DPSCs. The specific mechanism of Wnt3a function was clarified through single-cell sequencing and western blotting.</p><p><strong>Results: </strong>The expression of the canonical Wnt signalling pathway, especially Wnt3a, was significantly higher in cementum, while DPSCs mainly express the non-canonical Wnt signalling pathway. Furthermore, Wnt3a could enhance the cementum regeneration of DPSCs in vitro and in vivo. Single-cell RNA-seq analysis showed that Wnt3a promoted the cementogenic differentiation of DPSCs via the classical Wnt signalling pathway.</p><p><strong>Conclusions: </strong>The results unveiled that the non-classical Wnt signalling pathway of DPSCs would limit the efficiency of cementum regeneration. Wnt3a could improve the efficacy of DPSCs-mediated cementum regeneration through activating the canonical Wnt pathway, which may offer a promising therapeutic approach to tooth regeneration.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tongue Cleaning Enhances Activity of Suprahyoid Muscles During Exhalation in Healthy Young Adults: A Randomised Controlled Intervention Study. 清洁舌头增强健康年轻人呼气时舌骨上肌的活动:一项随机对照干预研究。
IF 3.1 3区 医学
Journal of oral rehabilitation Pub Date : 2025-05-14 DOI: 10.1111/joor.13990
Maya Izumi, Sumio Akifusa
{"title":"Tongue Cleaning Enhances Activity of Suprahyoid Muscles During Exhalation in Healthy Young Adults: A Randomised Controlled Intervention Study.","authors":"Maya Izumi, Sumio Akifusa","doi":"10.1111/joor.13990","DOIUrl":"https://doi.org/10.1111/joor.13990","url":null,"abstract":"<p><strong>Objective: </strong>Our previous study demonstrated that tongue cleaning can improve respiratory function, and this study seeks to understand the specific muscular mechanism for this improvement. The tongue and respiratory muscles are connected through the endothoracic fascia via the suprahyoid muscles. This study aimed to examine whether tongue cleaning activates suprahyoid muscle activity in healthy young adults, using surface electromyography (sEMG).</p><p><strong>Methods: </strong>A 4-week randomised controlled trial was conducted with 30 participants aged 21-22. The participants were divided into two groups: an intervention group that practised tongue cleaning in addition to routine oral hygiene, and a control group that practised only routine oral hygiene. sEMG was used to assess the myoelectric activity of the suprahyoid muscles during various actions, including inhalation, exhalation, head lifting, tongue pressure and tongue cleaning. The sEMG data were presented as microvolt root mean squares (RMS). An examination was conducted at baseline and after the 4-week intervention period.</p><p><strong>Results: </strong>The RMS of the suprahyoid muscles during various actions, except inhalation, had increased significantly by the end of the follow-up period in the intervention group but not in the control group. The degree of change to the RMS during exhalation in the intervention group was significantly larger than that in the control group [11.9 (-7.7 to 58.9) vs. 0 (-36.2 to 12.5), p = 0.013].</p><p><strong>Conclusion: </strong>Practicing tongue cleaning for 4 weeks increased the activity of the suprahyoid muscles during exhalation in healthy young adults, and it could be used to improve respiratory function in individuals with weakened suprahyoid muscles.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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