Journal of oral rehabilitation最新文献

{"title":"Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post-Traumatic Trigeminal Neuropathic Pain: A Real-World Evidence Study.","authors":"Ashley Lebel, Imen Stambouli, Yves Boucher","doi":"10.1111/joor.70209","DOIUrl":"https://doi.org/10.1111/joor.70209","url":null,"abstract":"<p><strong>Background: </strong>Post-traumatic trigeminal neuropathic pain (PTNP) is a debilitating orofacial pain disorder most commonly caused by trigeminal nerve injury after dental procedures or facial trauma. Available systemic therapies have modest and inconsistent efficacy, with substantial tolerability concerns limiting adherence.</p><p><strong>Objectives: </strong>To evaluate the real-world effectiveness and tolerability of a compounded intraoral mucoadhesive gel containing amitriptyline 10% plus lidocaine 2% in adults with PTNP.</p><p><strong>Methods: </strong>This retrospective real-world evidence study included adults with PTNP meeting ICHD-3/ICOP criteria who were treated at a tertiary orofacial pain clinic from May 1, 2023, to April 30, 2024. The primary outcome was the within-patient change in pain intensity on a 0-10 numerical rating scale (NRS) from baseline to week 8. Secondary outcomes included responder rates (≥ 50% and ≥ 30% pain reduction), patient global impression of improvement (PGI-I) and adverse events (AEs).</p><p><strong>Results: </strong>Of 94 patients identified, 40 were included in the complete-case initiator cohort. Mean pain intensity decreased from 6.3 ± 1.7 at baseline to 3.0 ± 2.7 at week 8, corresponding to a mean within-patient reduction of 3.30 points (95% CI, 2.51-4.09; p < 0.001). Twenty-two of 40 patients (55%; 95% CI, 40-69) achieved a ≥ 50% reduction in pain intensity, and 27 of 40 (68%; 95% CI, 52-80) achieved a ≥ 30% pain reduction. Seventy-five percent (30/40, 95% CI, 60-86) reported overall improvement on the PGI-I. Mild treatment-related AEs occurred in five of 40 patients (12%); no serious AEs or treatment discontinuations were reported.</p><p><strong>Conclusion: </strong>In this retrospective real-world study, topical amitriptyline-lidocaine mucoadhesive gel was associated with statistically significant and clinically meaningful pain improvement in adults with PTNP, together with favourable tolerability. These findings support targeted mucosal delivery as a promising local therapeutic option and potential medication-sparing strategy, particularly when systemic therapies are ineffective or poorly tolerated. Randomized controlled trials are now needed to confirm efficacy and clarify the role of topical amitriptyline in PTNP treatment pathways and routine clinical care.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Chewing Frequency and Self-Reported Mastication Satisfaction: A Cross-Sectional Study.","authors":"Carlo Ciotola, Mariam Hmeidan, Luca Contardo, Bachar Reda","doi":"10.1111/joor.70212","DOIUrl":"https://doi.org/10.1111/joor.70212","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the association between unilateral chewing frequency and self-reported mastication satisfaction while taking into account other demographic and psychological factors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between January 2018 and June 2020. Included participants were adult patients attending the Clinica di Chirurgia Maxillofacciale e Odontostomatologica di Trieste, Italy. Pearson chi-square and independent samples t-tests were used to determine the association between mastication satisfaction and unilateral chewing behaviour frequency, sex, depression and somatization scores. Afterwards, binary logistic regression was conducted to assess the relationship between self-reported mastication satisfaction and unilateral chewing behaviours while controlling for covariates.</p><p><strong>Results: </strong>A total of 1425 participants with a mean age of 49.7 ± 17.6 years were included. Overall, 58.5% of the participants were females and the majority (83.3%) reported mastication satisfaction. Pearson chi-square indicated a significant association between unilateral chewing frequency and mastication satisfaction (p < 0.001). Binary logistic regression indicated that frequent engagement in unilateral chewing behaviour was associated with a reduction in the odds of reporting satisfactory mastication. Study participants who reported unilateral chewing behaviour 'all of the time' showed the lowest likelihood of satisfaction (OR = 0.17). Female sex (OR = 0.69) and higher somatization scores (OR = 0.91) were associated with lower odds of mastication satisfaction, whereas higher depression scores were associated with slightly increased odds (OR = 1.04).</p><p><strong>Conclusion: </strong>Limited mastication satisfaction was associated with frequent unilateral chewing. These findings highlight the potential relevance of self-regulation strategies in managing habitual chewing patterns and supporting masticatory performance.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Combined Transcranial Direct Current Stimulation and Oral Capsaicinoids on Swallowing Function: A Randomized Controlled Trial.","authors":"Ivy Cheng, Sonja Suntrup-Krüger","doi":"10.1111/joor.70214","DOIUrl":"https://doi.org/10.1111/joor.70214","url":null,"abstract":"<p><strong>Background: </strong>The swallowing biomechanics may be modulated by cortical stimulation through transcranial direct current stimulation (tDCS) or sensory stimulation through oral capsaicinoids. However, the effects of combining these techniques remain relatively unexplored.</p><p><strong>Objective: </strong>This pilot study investigated the effects of tDCS combined with oral capsaicinoids on swallowing function.</p><p><strong>Methods: </strong>Twenty-one healthy individuals (mean age = 25.8 ± 9.9 years; 7 males, 14 females) received two experimental conditions: (1) anodal tDCS and oral capsaicinoids, and (2) sham tDCS and oral capsaicinoids. The experimental conditions were randomized in order and conducted at least 1 week apart. Anodal and sham tDCS were applied over the right pharyngeal motor cortex at 1 mA for 20 min and 30 s respectively. A 15-min break was given after tDCS, after which participants drank 150 mL of 10 μM capsaicinoid-containing solution. Swallowing function was assessed using the timed water swallow test (TWST) before, immediately after and 15 min after each experimental condition.</p><p><strong>Results: </strong>The baseline volume per swallow, duration per swallow and swallowing capacity, as assessed by TWST, were comparable between the two conditions. Combined anodal tDCS and oral capsaicinoids significantly increased the volume per swallow compared with combined sham tDCS and oral capsaicinoids (p = 0.003). There were no significant effects of intervention on duration per swallow or swallowing capacity between the two conditions.</p><p><strong>Conclusions: </strong>We found that combined anodal tDCS and oral capsaicinoids increased the volume per swallow, suggesting potential changes in swallowing biomechanics. The findings imply that cortical stimulation may enhance the effects of peripheral sensory stimulation on the swallowing system.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occlusal Splint Therapy in the Management of Temporomandibular Disorders-Evidence from Systematic Reviews.","authors":"Daniela Del Sorbo, Tessa Bijelic, Birgitta Häggman-Henrikson, Thomas List, Ambrosina Michelotti, Rosaria Bucci","doi":"10.1111/joor.70208","DOIUrl":"https://doi.org/10.1111/joor.70208","url":null,"abstract":"<p><strong>Background and aim: </strong>Occlusal splints are commonly used to manage temporomandibular disorders (TMDs), yet their efficacy remains controversial. This study aimed to summarise and assess the methodological quality of available systematic reviews (SRs) regarding occlusal splint therapy in TMD patients.</p><p><strong>Materials and methods: </strong>Following a PROSPERO-registered protocol (CRD42021276856), a comprehensive search was conducted across PubMed, Scopus, Lilacs, and Cochrane. SRs focused on TMD management with occlusal splints were included. Two independent operators performed the review process, and the risk of bias was assessed using AMSTAR-2. Primary outcomes were pain intensity and maximum mouth opening (MMO).</p><p><strong>Results: </strong>After screening of 1740 abstracts followed by full text assessment, 21 SRs were included with diverse methodological quality ranging from critically low (5 SRs) to high (4 SRs). The majority of the included SRs (12) compared occlusal splint with other conservative treatments, with four of these reporting effective reduction in pain intensity, while three SRs did not. Furthermore, five SRs concluded that there was insufficient evidence for or against occlusal splint therapy over other active interventions for TMD treatment. Only one SR compared the effect of occlusal splint versus no treatment, supporting no differences in pain reduction in the jaw joint area. One SR compared the effects of different occlusal splint designs. Three SRs assessed the effects of occlusal splint in specific treatment settings or populations (in adolescents, compared to arthrocentesis, compared to jaw exercises).</p><p><strong>Conclusion: </strong>The majority of findings from the existing SRs report small beneficial or neutral effects following OS therapy in TMD patients.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Limitations and the Necessity of Objective Biomarkers in Linking Oral Frailty to Subjective Sleep Quality.","authors":"Takahiko Nagamine","doi":"10.1111/joor.70210","DOIUrl":"https://doi.org/10.1111/joor.70210","url":null,"abstract":"<p><p>Although Lin et al. highlighted the importance of oral frailty and sleep quality as key research areas, their methodologies still rely too heavily on subjective reporting. Incorporating objective indicators such as polysomnography and tongue pressure measurement is essential to verifying these findings.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding 'Research Waste in Temporomandibular Disorders Among Registered Randomised Controlled Trials: A Meta-Epidemiologic Study'.","authors":"Yue Gao, Xinxing Fei","doi":"10.1111/joor.70211","DOIUrl":"https://doi.org/10.1111/joor.70211","url":null,"abstract":"","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporomandibular Joint Involvement in Paediatric Patients Affected by Juvenile Idiopathic Arthritis.","authors":"Giulia Vallogini, Ambra Michelotti, Silvia Magni Manzoni, Paola Festa, Alessandra Putrino, Roberto Uomo, Lorenzo Maria Gregori, Simone Piga, De Benedetti Fabrizio, Angela Galeotti","doi":"10.1111/joor.70200","DOIUrl":"https://doi.org/10.1111/joor.70200","url":null,"abstract":"<p><strong>Background: </strong>Juvenile idiopathic arthritis (JIA) is an autoimmune disease that can involve the temporomandibular joint (TMJ).</p><p><strong>Objectives: </strong>To investigate the association between clinical signs and symptoms of temporomandibular disorders (TMD) and TMJ inflammation, as detected by magnetic resonance imaging (MRI) in children and adolescents with JIA.</p><p><strong>Methods: </strong>Monocentric cross-sectional observational study. Consecutive JIA patients underwent clinical dental examination following the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and performed MRI examination when the presence of signs and/or symptoms was detected. TMJ involvement was assessed using MRI parameters. Data were analysed with descriptive statistics, using parametric statistical tests for normally distributed data and non-parametric statistical tests for other variables. Associations between TMD signs/symptoms and MRI findings were investigated using appropriate statistical tests. Adjustment for multiple comparisons was performed using a false discovery rate approach. A p-value < 0.05 after correction was considered statistically significant.</p><p><strong>Results: </strong>Seventy-six JIA patients were included. In unadjusted analyses, multiple associations emerged between clinical findings and MRI signs of TMJ involvement. After correction for multiple comparisons, TMJ sounds remained significantly associated with protrusion limitation, and mandibular deviation patterns were significantly associated with inflammatory MRI findings, particularly synovial thickening and bone marrow edema. Other associations did not retain statistical significance after adjustment and should be considered exploratory.</p><p><strong>Conclusions: </strong>Dental and TMD evaluations revealed correlations with MRI findings of TMJ involvement. Application of TMD screening at JIA onset might make it possible to detect TMJ-related early signs of arthritis in patients with JIA.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KDM2B-PP1 Promotes Remyelination and Functional Recovery After Facial Nerve Injury.","authors":"Huiyue Xu, Haoqing Yang, Yangyang Cao, Zhipeng Fan","doi":"10.1111/joor.70203","DOIUrl":"https://doi.org/10.1111/joor.70203","url":null,"abstract":"<p><strong>Background: </strong>Peripheral nerve injury (PNI) often causes persistent sensory and motor deficits because of incomplete axonal regeneration and insufficient remyelination. Schwann cells (SCs) are essential for peripheral nerve repair, but effective recovery depends on their timely transition from a repair state to a myelinating phenotype.</p><p><strong>Objective(s): </strong>To investigate whether KDM2B-PP1, a bioactive peptide designed to disrupt the interaction between lysine-specific demethylase 2B (KDM2B) and enhancer of zeste homologue 2 (EZH2), promotes SC redifferentiation, remyelination, and functional recovery after PNI.</p><p><strong>Methods: </strong>Primary rat SCs were treated with KDM2B-PP1 in vitro. Myelin-related gene and protein expression were assessed by PCR array, qPCR, Western blotting, and ELISA. The effects of KDM2B-PP1 on SC proliferation, apoptosis, and migration were also examined. A rat facial nerve transection model was used to evaluate the effects of local KDM2B-PP1 administration on remyelination, nerve structure, and functional recovery in vivo.</p><p><strong>Results: </strong>KDM2B-PP1 disrupted the KDM2B-EZH2 interaction and relieved EZH2-mediated repression of myelin-related genes. In SCs, KDM2B-PP1 increased the expression of myelin-associated transcripts and proteins, including Olig1, and promoted redifferentiation toward a myelinating phenotype. In vivo, local administration of KDM2B-PP1 enhanced myelin sheath formation, improved nerve architecture, and promoted late-stage functional recovery after facial nerve injury. KDM2B-PP1 did not significantly affect SC proliferation, apoptosis, or migration.</p><p><strong>Conclusions: </strong>KDM2B-PP1 is a novel epigenetic modulator that selectively promotes SC-mediated remyelination and functional recovery after peripheral nerve injury. These findings provide new insight into the epigenetic regulation of peripheral nerve regeneration and support KDM2B-PP1 as a potential therapeutic candidate for PNI.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Similar Stressors Different Expression: Ethnic Disparities in Temporomandibular Disorders and Bruxism During Wartime.","authors":"Alona Emodi-Perlman, Khalil Masarwe, Nour Mahajne, Lihi Keren, Ilana Eli","doi":"10.1111/joor.70205","DOIUrl":"https://doi.org/10.1111/joor.70205","url":null,"abstract":"<p><strong>Background: </strong>War, an intense and enduring source of stress, exerts wide-ranging impacts on psychological well-being, provoking significant stress and anxiety reactions even in individuals not directly exposed to combat.</p><p><strong>Objective: </strong>To examine how ethnicity influences bruxism and temporomandibular disorders (TMD) during an armed conflict.</p><p><strong>Methods: </strong>In a cross-sectional design, 895 subjects from two ethnic origins (595 Jews and 301 Arabs) were evaluated through an online survey. The assessment tools covered demographic data, TMD screening, subject-based sleep bruxism (SB), subject-based awake bruxism (AB) including grinding, clenching, teeth contact, and bracing behaviours, along with measures of psychological distress (Patient Health Questionnaire-4), perceived stress (Perceived Stress Scale), and resilient coping (Brief Resilient Coping Scale).</p><p><strong>Results: </strong>Arab participants reported the greatest psychological distress and perceived stress, yet they also displayed the strongest resilient coping. Regression analyses identified a distinct pattern in the Arab group regarding TMD and bruxism. Compared with a Jewish reference group, Arabs had markedly higher odds of TMD (OR = 2.58) and higher odds of grinding (OR = 1.81). In contrast, they showed lower odds for sleep bruxism (OR = 0.55) and awake bruxism behaviours of teeth contact (OR = 0.44) and bracing (OR = 0.55).</p><p><strong>Conclusion: </strong>The elevated TMD risk among Arab participants (more than double that of Jewish participants) suggests combined effects of chronic psychosocial stress and potential barriers to accessing health care. These findings highlight the need for culturally informed approaches to diagnosing and treating TMD and bruxism, particularly during periods of widespread societal stress.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Habitual Tongue Posture on Tongue Pressure During Swallowing.","authors":"Liqin Wang, Kentaro Okuno, Ayako Masago, Ryuichiro Kobuchi, Kazuhiro Murakami, Kazuhiro Hori, Kazuya Takahashi","doi":"10.1111/joor.70206","DOIUrl":"https://doi.org/10.1111/joor.70206","url":null,"abstract":"<p><strong>Background: </strong>Tongue pressure is essential for bolus transport and oral stability during swallowing and serves as a clinical marker of tongue function. Habitual tongue posture, defined as the resting position of the tongue, is associated with swallowing efficiency and craniofacial development.</p><p><strong>Objective: </strong>This study investigated the association between habitual tongue posture and regional tongue pressure amplitudes.</p><p><strong>Methods: </strong>We enrolled 52 healthy adult participants (26.0 [24.0-27.0] years). Habitual tongue posture was evaluated using standardised lateral cephalometric radiographs, measuring tongue-palate (T-P) and mandible-hyoid distances. Based on the mean T-P value, participants were divided into long-distance (LD) and short-distance (SD) groups. Tongue pressure during 5 mL water swallowing was measured using a tactile sensor system with five sensor points (Ch1-5).</p><p><strong>Results: </strong>Intra-group analysis revealed significantly lower pressure at Ch3 (2.1 [0.7-4.5] kPa) than at Ch4 (5.6 [2.0-9.9] kPa, p = 0.0286) and Ch5 (8.1 [3.8-15.7] kPa, p < 0.0001) in the LD group. Inter-group comparisons showed that the LD group had significantly lower tongue pressure than the SD group at Ch2 (3.2 [1.5-6.5] kPa vs. 6.8 [4.6-14.7] kPa, p = 0.0018), Ch3 (2.1 [0.7-4.5] kPa vs. 10.6 [6.0-21.2] kPa, p < 0.0001), and Ch4 (5.6 [2.0-9.9] kPa vs. 9.8 [5.5-11.8] kPa, p = 0.0203).</p><p><strong>Conclusion: </strong>Our findings suggest that habitual low tongue posture impairs swallowing efficiency by reducing tongue pressure in certain areas, posing a risk for age-related dysphagia and swallowing difficulties.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}