Journal of oral rehabilitation最新文献

{"title":"Brief Diagnostic Criteria for Temporomandibular Disorders: Sensitivity and Specificity of Clinical Diagnoses (A Multi-Center Study).","authors":"Laura Nykänen, Kirsi Sipilä, Ilana Eli, Pessia Freidman-Rubin, Lihi Keren, Antti Kämppi, Ritva Näpänkangas, Shalev Antshel Tamar, Johanna Tanner, Tuija Teerijoki-Oksa, Ephraim Winocur, Alona Emodi-Perlman","doi":"10.1111/joor.13969","DOIUrl":"https://doi.org/10.1111/joor.13969","url":null,"abstract":"<p><strong>Background: </strong>The brief Diagnostic Criteria for Temporomandibular Disorders (bDC/TMD) was recently published to simplify the full Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol.</p><p><strong>Objective: </strong>To measure the inter-examiner reliability, sensitivity and specificity of bDC/TMD Axis I diagnoses against DC/TMD Axis I diagnoses in primary and tertiary clinic TMD patient populations.</p><p><strong>Methods: </strong>A multi-center (Finland, Israel) retrospective study on 334 patients' records was conducted. A full DC/TMD clinical examination data was reduced to bDC/TMD items. Five Level 3 calibrated examiners independently determined a bDC/TMD diagnosis. Inter-examiner reliability, sensitivity and specificity were calculated for individual diagnoses, using DC/TMD diagnosis as the reference standard.</p><p><strong>Results: </strong>Inter-examiner reliability showed excellent to good reliability in all diagnoses except headache attributed to TMD, in which it was fair. Apart from headache attributed to TMD, the sensitivity of individual pain diagnoses was high. The sensitivity was lower in joint diagnoses. The specificity was high in all diagnoses.</p><p><strong>Conclusion: </strong>The bDC/TMD is a reliable instrument for general practitioner use.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the Oral Frailty Index-8 With the Diagnosis and Results of Oral Hypofunction Testing.","authors":"Tomohiro Tabata, Yukiko Hatanaka, Masatsugu Teraoka, Mana Hirayama, Housei Suzuki, Junichi Furuya","doi":"10.1111/joor.13966","DOIUrl":"https://doi.org/10.1111/joor.13966","url":null,"abstract":"<p><strong>Background: </strong>Oral frailty is associated with physical frailty and the risk of requiring nursing care and death in older people. The Oral Frailty Index-8 (OFI-8) was developed for self-assessment of oral frailty, assuming that high-risk patients will visit a dentist for oral hypofunction tests. However, the screening utility of the OFI-8 for oral hypofunction and the relationship between them remain unclear.</p><p><strong>Objective: </strong>In this study, we aimed to elucidate the relationship between the OFI-8 and the diagnosis and results of oral hypofunction tests through a cross-sectional survey of older outpatients visiting dental clinics.</p><p><strong>Methods: </strong>Outpatients (n = 120) who underwent diagnostic tests for oral hypofunction were enrolled. The survey items encompassed age, sex, oral hypofunction test results and the OFI-8 score. The relationships between oral hypofunction diagnosis and the OFI-8 score and between the oral hypofunction test and OFI-8 scores were analysed.</p><p><strong>Results: </strong>Binomial logistic regression analysis showed that the higher the total OFI-8 score was, the more likely the diagnosis of oral hypofunction (odds ratio = 1.76) was. Receiver operating characteristic curve analysis identified a cut-off OFI-8 score of 3 for detecting oral hypofunction (area under the curve = 0.77). Multiple regression analysis showed that oral dryness, occlusal force, number of teeth, masticatory function, swallowing function and number of items with functional decline were significantly associated with high OFI-8 scores. Oral hygiene, tongue-lip motor function and tongue pressure were less sensitive to the OFI-8.</p><p><strong>Conclusion: </strong>The OFI-8 is useful for screening oral hypofunction, exhibiting considerable potential effectiveness in detecting oral dryness, occlusal, masticatory and swallowing dysfunctions.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimentation Without Randomised Controls.","authors":"Stephen D Simon","doi":"10.1111/joor.13960","DOIUrl":"https://doi.org/10.1111/joor.13960","url":null,"abstract":"<p><strong>Background: </strong>In an experimental study, researchers often have the ability to assign different treatments. This is often done with randomisation. There are many settings; however, where it is not desirable to use randomisation. It is unclear how to best design an experimental study without randomisation while still providing persuasive evidence.</p><p><strong>Objectives: </strong>The aim of this study was to outline several approaches, broadly classified as quasiexperimental studies, where researchers can use methodologically sound alternatives to randomisation.</p><p><strong>Results: </strong>The interrupted time series, phased inventions, withdrawal design, waiting list control group, stepped wedge design and regression discontinuity all represent approaches where careful nonrandom allocation to treatment groups can produce high-quality research findings.</p><p><strong>Conclusion: </strong>Quasiexperimental studies can produce rigorous research findings. The allocation to treatment groups and the times of evaluation need to be carefully designed. Proper use of these quasiexperimental approaches can enhance research options in settings where the research team has control of allocation but finds randomisation to be problematic.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Depression: The Role of Antidepressants in Managing Chronic Temporomandibular Disorders. A Systematic Review.","authors":"Takara Dei, Kennedy Galloway, Nathalia Carolina Fernandes Fagundes, Janice Y Kung, Nathan P Beahm, Reid Friesen","doi":"10.1111/joor.13971","DOIUrl":"https://doi.org/10.1111/joor.13971","url":null,"abstract":"<p><strong>Background: </strong>Chronic temporomandibular disorder (TMD) pain significantly impairs quality of life and lacks universally effective treatments. Antidepressants, traditionally used for mood disorders, have shown potential in managing chronic pain conditions. This systematic review evaluates the efficacy and safety of antidepressants for chronic TMD pain management.</p><p><strong>Methods: </strong>Eligibility criteria: Included randomised controlled trials (RCTs) assessing antidepressants for chronic TMD pain in adults, reporting pain reduction or functional improvement as outcomes.</p><p><strong>Information sources: </strong>Searches were conducted in MEDLINE, Embase, CINAHL, Scopus, Web of Science, and Cochrane Library through April 2024. Risk of bias: The Cochrane Risk of Bias 2 tool was used to assess study quality.</p><p><strong>Synthesis of results: </strong>Narrative synthesis was performed due to heterogeneity in interventions and outcomes.</p><p><strong>Results: </strong>Included studies: Seven RCTs with sample sizes ranging from 12 to 80 participants. Studies evaluated various antidepressants, including amitriptyline, duloxetine, nortriptyline, and citalopram, alone or combined with non-pharmacological treatments.</p><p><strong>Synthesis of results: </strong>Amitriptyline and duloxetine demonstrated significant reductions in pain intensity when used in combination therapies. Functional improvements, such as increased mouth opening, were observed in some studies. Side effects, particularly with duloxetine, were more frequent than with placebo. Variability in study designs, populations, and outcome measures limited comparability. Small sample sizes, short follow-up durations, and heterogeneity in interventions and outcomes reduced the strength of evidence.</p><p><strong>Conclusion: </strong>Antidepressants, particularly when combined with non-pharmacological treatments, may enhance pain relief and functional outcomes for chronic TMD pain. However, high-quality, long-term studies are needed.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Four-Dimensional Impact of Pain-Related and/or Intra-Articular Temporomandibular Disorder Symptoms on Oral Health-Related Quality of Life Among Young Adults.","authors":"Adrian Ujin Yap, Yinghao Xiong, Carolina Marpaung, May Chun Mei Wong","doi":"10.1111/joor.13965","DOIUrl":"https://doi.org/10.1111/joor.13965","url":null,"abstract":"<p><strong>Objectives: </strong>A four-dimensional structure for oral health-related quality of life (OHRQoL) was recently proposed, comprising oral function (OF), orofacial pain (OP), orofacial appearance (OA) and psychosocial impact (PI). This study examined the impact of different temporomandibular disorder (TMD) symptoms on the four OHRQoL dimensions in young adults. It also correlated the four dimensions with the seven Oral Health Impact Profile (OHIP) domains.</p><p><strong>Methods: </strong>Young adults were recruited from a large university. The quintessential five TMD symptoms (5Ts) and OHIP-14 were used to assess TMD symptoms and OHRQoL. Participants were categorised into no (NT), pain-related (PT), intra-articular (IT) and combined (CT) TMD groups, and total, dimension and domain OHIP scores were computed. Data were evaluated using the chi-square test and non-parametric analyses (α = 0.05).</p><p><strong>Results: </strong>Among the 1097 eligible participants (mean age 19.9 years [SD = 1.3]; 69.7% women), 47.2% reported no TMD symptoms, while 20.5%, 14.9% and 17.4% had PT, IT and CT TMD symptoms, respectively. Significant differences in OHIP scores were noted between individuals with and without TMD symptoms across all dimensions and domains (CT, PT, IT > NT). Additionally, notable distinctions in normalised dimension scores were evident in all participant groups (OP, OA > OF, PI). Moderate to strong correlations were discerned between OHIP dimensions and domain, except for OA with functional limitation (r_s = 0.35).</p><p><strong>Conclusions: </strong>Adopting the four dimensions as the standard metric for assessing OHRQoL can improve study comparability and enhance understanding of TMD impacts.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Stress in Burning Mouth Syndrome Triggered by Dental Treatments: A Two-Step Hypothesis.","authors":"Ashley Lebel, Géraldine Lescaille, Iva Alajbeg, Ivan Alajbeg, Yves Boucher","doi":"10.1111/joor.13964","DOIUrl":"https://doi.org/10.1111/joor.13964","url":null,"abstract":"<p><strong>Objectives: </strong>Burning mouth syndrome (BMS) is a complex and debilitating orofacial pain disorder, defined as a persistent burning sensation in the oral mucosa without any identifiable causative lesion. Its prevalence increases with age, and women are disproportionately more affected. Onset typically occurs around menopause, sometimes associated with triggers such as stressful life events. Interestingly, some patients report dental treatments (DTs) as a precipitating event, yet evidence supporting the association between DTs and BMS onset remains scarce in the literature.</p><p><strong>Patients and methods: </strong>In this retrospective study based on electronic medical records, we identified BMS patients from the ABCD cohort of Chronic Orofacial Pain Department (COFPD) of the Pitié-Salpêtrière hospital in Paris, France, between January 2020 and December 2023. Patients fulfilling the International Classification of Orofacial Pain (ICOP) and International Classification of Headache Disorders (ICHD-3) criteria for BMS, who reported burning tongue pain following DTs and had a well-documented clinical history, were included.</p><p><strong>Results: </strong>Among 78 identified BMS patients (70 women, 8 men), seven cases (all women, mean age 51.0 ± 3.8 years) of unilateral or bilateral burning tongue pain with a well-documented dental history were included. Detailed demographic, medical and pain characteristics are thoroughly reported. Pathophysiological hypotheses focusing on neurobiological mechanisms, the significant role of stress and neuronal sensitization are discussed.</p><p><strong>Conclusion: </strong>The diagnosis of BMS should be considered cautiously in cases of unilateral symptoms to avoid misdiagnosis with other orofacial pain conditions, such as painful trigeminal neuropathy. A two-step hypothesis is proposed to explain the development of BMS, emphasising the interplay between stress and dental treatments in its onset.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Clinical and Patient-Reported Outcomes Between Single- and Two-Implant Mandibular Overdenture-An Umbrella Review.","authors":"Aleksandra Milić Lemić, Stefan Vulović, Aleksandar Jakovljević, Jelena Jaćimović, Frauke Müller, Sabrina Maniewicz, Marija S Milić, Aleksandra Popovac","doi":"10.1111/joor.13962","DOIUrl":"https://doi.org/10.1111/joor.13962","url":null,"abstract":"<p><strong>Background: </strong>A two-implant mandibular overdenture (TIMO) is considered a viable approach for the rehabilitation of the edentulous mandible, enhancing retention, stability, overall function and patient-reported outcome. Recently, the minimalist strategy of single-implant mandibular overdenture (SIMO) was proposed as an alternative treatment for mandibular edentulism.</p><p><strong>Objectives: </strong>To analyse systematic reviews (SRs) and provide a comprehensive overview of clinical and patient-reported outcomes, including implant failure, peri-implant marginal bone loss, overall prosthetic complications and maintenance, patient satisfaction and oral health-related quality of life, in SIMO compared with TIMO.</p><p><strong>Methods: </strong>The umbrella review was designed and reported following the PRISMA guidelines, and the protocol was registered in the PROSPERO database (CRD42024599304). Included SRs evaluated the clinical and/or patient-reported outcomes in edentulous patients rehabilitated with SIMO and TIMO. A literature search was conducted without restrictions on the language in Web of Science, ProQuest, SCIELO, KCI, Grants Index, Scopus, PubMed/MEDLINE and the Cochrane Library databases. Critical evaluation of the included SRs was conducted using AMSTAR 2.</p><p><strong>Results: </strong>Out of 243 papers suitable for title/abstract screening, 7 SRs were selected. One SR favoured SIMO over TIMO for both implant failure and peri-implant marginal bone loss, whereas in another SR it was shown that TIMO revealed significantly more implant failures after 1 and 5 years, significantly more prosthetic failures after 1 year, and significantly more O-ring replacements after 5 years, compared to SIMO. Regarding the quality assessment of included SRs, two were categorised as 'critically low', two as 'low' and three as 'moderate'.</p><p><strong>Conclusions: </strong>SIMO corresponds with the conventional TIMO as a potentially effective treatment for the rehabilitation of the edentulous mandible. Additional studies are warranted to obtain more robust patient evidence and refine clinical guidelines.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Masticatory Dysfunction and Salivary Microbiota.","authors":"Tsunglin Liu, Mu-Heng Wu, Po-Hsiang Hu, Yu-Ching Chuang, Pei-Fang Tsai, Nai-Ying Ko, Wen-Chien Ko, Yen-Chin Chen, Jiun-Ling Wang","doi":"10.1111/joor.13963","DOIUrl":"https://doi.org/10.1111/joor.13963","url":null,"abstract":"<p><strong>Backgrounds: </strong>Oral health predicts adverse systemic health-related outcomes, including future physical frailty. This study aimed to determine whether the salivary microbiome is associated with specific oral health indicators.</p><p><strong>Methods: </strong>We collected oral gargle samples from 97 patients admitted to medical wards (mean age, 65 years) and assessed their oral health status. The saliva microbiota was examined via sequencing 16S rRNA genes.</p><p><strong>Results: </strong>Among the oral health indicators, only chewing ability was associated with saliva microbiota. The alpha diversities of bacterial communities decreased as chewing ability declined. Furthermore, patients with normal and abnormal chewing ability exhibited distinct microbial compositions. The relative abundances of Lactobacillus and Limosilactobacillus were higher in the impaired chewing group, whereas Lautropia was more abundant in the normal chewing group.</p><p><strong>Conclusions: </strong>Severe chewing disability might lead to an altered saliva microbiota. This emphasises the importance of restoring chewing function when the disability occurs.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysphagia Prevention Strategies for Community-Dwelling Older Adults: A Scoping Review.","authors":"Kristamuliana Kristamuliana, Eri Yanuar Achmad Budi Sunaryo, Miaofen Yen, Huan-Fang Lee","doi":"10.1111/joor.13961","DOIUrl":"https://doi.org/10.1111/joor.13961","url":null,"abstract":"<p><strong>Background: </strong>Swallowing difficulty, or dysphagia, is a common issue in aging populations, including those living in the community, due to age-related changes in sensory and motor functions. Effective prevention strategies are essential to avoid complications and improve well-being in this population.</p><p><strong>Objective: </strong>The objectives of this scoping review were to identify and summarise interventions for preventing dysphagia in community-dwelling older adults.</p><p><strong>Design: </strong>Following Arksey and O'Malley's framework, studies were retrieved from six databases: Embase, Ovid-Medline, Cochrane Library, CINAHL, Web of Science, and Scopus. The search was completed in July 2024, with two independent reviewers selecting and evaluating the studies.</p><p><strong>Result: </strong>Nine studies conducted between 2005 and 2023 were identified, including seven randomised controlled trials and two quasi-experimental studies. Three categories of dysphagia prevention were identified, including exercise, electrical stimulation, and educational programmes, and three studies used more than one intervention (combined intervention).</p><p><strong>Conclusion: </strong>Exercise-based interventions are the most studied strategies for preventing dysphagia in community-dwelling older adults, with combined approaches also showing promise. However, geographic bias, unclear sample size determination, and a lack of long-term follow-up limit the reliability and applicability of all interventions. Future research should address these gaps to strengthen evidence and improve dysphagia prevention efforts.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Dietary Caffeine Intake for Alleviating Symptoms of Burning Mouth Syndrome: A Randomised Controlled Comparison With Alpha-Lipoic Acid.","authors":"Chuanji Wu, Peiyang Yuan, Xuemei Qiu, Dan Liu, Yiming Xu, Yanxuan Xiao, Shuting Zhou, Zhenyu Zhang, Shuning Cai, Wei Ding, Xiaoping Xu, Feifei Hou, Lu Jiang","doi":"10.1111/joor.13957","DOIUrl":"https://doi.org/10.1111/joor.13957","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates whether daily supplementation of 120-150 mg of caffeine can relieve symptoms of Burning Mouth Syndrome (BMS) compared to alpha-lipoic acid (ALA) and a control group.</p><p><strong>Methods: </strong>In this randomised controlled trial, 118 BMS patients were divided into three groups: caffeine, ALA, and control. The caffeine group received 120-150 mg of caffeine daily, the ALA group received 200 mg of ALA three times daily, and the control group received no interventions. Symptom relief was assessed over 2 weeks using the Visual Analog Scale (VAS), with subgroup analyses based on symptom subtypes, disease duration, symptom sites, and characteristics.</p><p><strong>Results: </strong>The VAS of BMS patients in the caffeine and ALA groups exhibited significant reductions (p < 0.0005). The caffeine group exhibited a 65.1% symptom relief rate compared to 46.5% in the ALA group and 12.5% in the control group. Significant differences in symptom relief were noted between the caffeine and control groups (p < 0.0005) and between the ALA and control groups (p = 0.0032). No significant difference was observed between the caffeine and ALA groups (p = 0.084). Type I BMS patients in the caffeine group showed greater symptom relief than those in the ALA group (p = 0.026).</p><p><strong>Conclusions: </strong>Both caffeine and ALA effectively treated BMS, with caffeine showing higher efficacy in Type I patients. Treatments were well-tolerated with minimal adverse effects, suggesting caffeine and ALA as promising treatments for BMS, warranting further research on their long-term effects and mechanisms of action. [The study was registered on ClinicalTrials.gov (Identification No. NCT06195137).].</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}