Journal of oral rehabilitation最新文献

{"title":"Effectiveness of Resistance Training of Masticatory Muscles for Patients With Temporomandibular Disorders: A Systematic Review.","authors":"Giacomo Asquini, Giulia Pisacane, Filippo Maselli, Firas Mourad, Paolo Bizzarri, Edoardo Balli, Cecilia Bagnoli, Anna Manzari, Marco Pernici, Andrea Giusti, Deborah Falla","doi":"10.1111/joor.14021","DOIUrl":"https://doi.org/10.1111/joor.14021","url":null,"abstract":"<p><strong>Background: </strong>Evidence supports the use of exercise for patients with temporomandibular disorders (TMDs). However, previous studies have mainly focused on combined treatment strategies or undefined exercise modalities.</p><p><strong>Objective: </strong>This systematic review aims to evaluate the effectiveness of Resistance Training (RT) as a standalone treatment for managing pain and improving neuromuscular performance in individuals with TMDs.</p><p><strong>Methods: </strong>This systematic review followed a pre-established and published protocol, which was registered with PROSPERO (CRD42023476269). The literature search was conducted from March 1st 2024 to March 31st 2024 via the following electronic databases: MEDLINE (OVID interface), EMBASE (OVID interface), SCOPUS, Web of Science, PubMed, and Cochrane Central Register of Controlled Trials (CENTRAL). Randomised controlled trials or nonrandomised studies of interventions were included when they compared the effect of RT targeting masticatory muscles on pain, neuromuscular performance, and maximum mouth opening in patients with TMDs versus other treatment modalities. Two independent reviewers screened articles for inclusion, extracted data, assessed the risk of bias using the revised Cochrane risk of bias tool for randomised trials and evaluated the overall quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach.</p><p><strong>Results: </strong>From an initial 2177 articles, only three met the inclusion criteria and involved 108 participants. All the included studies demonstrated a decrease in pain intensity and an improvement in neuromuscular performance following RT, even if the superiority of RT over other interventions remains uncertain. However, the combination of moderate risk of bias, significant heterogeneity and small sample sizes resulted in a very low quality of evidence.</p><p><strong>Conclusions: </strong>Clinicians managing patients with TMDs should consider RT as an effective, conservative option in conjunction with other treatment modalities. Future methodologically robust studies with large sample sizes and clearly defined exercise protocols are needed to investigate the role of RT for reducing TMD-related pain by increasing load tolerance and addressing potential bruxism-related muscle overload.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masticatory Movement With Whey Peptide Supplementation Inhibits the Decrease of Masseter Weight in Protein Malnourished Rats.","authors":"Tomohiro Kagawa, Ippei Yamaoka","doi":"10.1111/joor.14040","DOIUrl":"https://doi.org/10.1111/joor.14040","url":null,"abstract":"<p><strong>Background: </strong>The importance of continued mastication to maintain oral function has been suggested, but whether atrophy of the masseter muscle can be inhibited with a combination of mastication and protein intake is not known.</p><p><strong>Objective: </strong>This study aimed to clarify the molecular mechanism for inhibiting masseter atrophy, and the effects of mastication and protein intake were examined in a rat model of masseter muscle atrophy.</p><p><strong>Methods: </strong>Male Wistar rats were divided into a group given a solid purified diet with normal (20%) protein content and administered a sugar solution and groups given solid or powdered purified diets with low (2.5%) protein content, each of which was given a whey peptide solution or a sugar solution for 3 weeks. On the final day, the animals were sacrificed 1 h after being administered each of the solutions, and blood and masseter muscles were collected.</p><p><strong>Results: </strong>Masseter weight decreased in all of the groups given the low-protein diet compared with the normal protein content diet, but that decrease was inhibited the most in groups fed a solid diet and administered whey peptide. When animals were given a solid diet and administered whey peptide, the expression levels of ULK1 (Unc-51-like kinase 1) and phosphorylated ULK1 (Ser757) proteins, which are associated with protein degradation, were markedly elevated compared with other conditions.</p><p><strong>Conclusion: </strong>The decrease in masseter weight was inhibited in protein malnourished rats in which mastication was encouraged and whey peptide was administered. The results suggest that the molecular mechanism for this is attributable to the control of autophagy.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of the CALHM1 Gene Alleviates Allodynia in Rats With Trigeminal Neuralgia.","authors":"Xiaolei Zhu, Zhang Yi, Xuelian Li, Kaiming Duan, Dong Huang, Xuebin Yan","doi":"10.1111/joor.13980","DOIUrl":"https://doi.org/10.1111/joor.13980","url":null,"abstract":"<p><strong>Objective: </strong>The sudden onset of trigeminal neuralgia is very similar to epilepsy. CALHM1 is associated with the development of temporal lobe epilepsy. Therefore, does CALHM1 play an important role in the pathogenesis of trigeminal neuralgia? In this study, we explored the effects of pain behaviour in rats with trigeminal neuralgia by knocking down the Calcium homeostasis modulator 1 gene.</p><p><strong>Methods: </strong>Rats were randomly divided into the Control group, Sham group and dION-CCI group. Animal models of trigeminal neuralgia were constructed by ligating the distal infraorbital nerve of rats with a chromic gut wire; mechanical pain thresholds and spontaneous pain behaviour were measured in rats. The trigeminal spinal subnucleus caudalis was taken on day 15 postoperatively, and expression of CALHM1 was detected by qRT-PCR and western blot. The shCALHM1 group used adeno-associated viral transfection to downregulate CALHM1 expression and detected the effect of CALHM1 knockdown by immunohistochemistry. Then the dION-CCI model was established after 3 weeks. The alterations in CALHM1 expression were identified using western blot, and the modifications in pain response in rats were observed.</p><p><strong>Results: </strong>The mRNA and protein expression of CALHM1 were significantly increased in the dION-CCI group. Knockdown of the CALHM1 gene attenuated the nociceptive allodynia in rats with trigeminal neuralgia.</p><p><strong>Conclusion: </strong>This experiment demonstrated that the occurrence of trigeminal neuralgia may be associated with increased expression of CALHM1.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Clinical Features on Radiographic Progression of Degenerative Joint Disease: A Retrospective Cone Beam Computed Tomography Study.","authors":"Chu-Qiao Xiao, Yi-Chun Yang, Grace Paka Lubamba, Xiao-Yi Wang, Chun-Jie Li, Xin Xiong","doi":"10.1111/joor.14026","DOIUrl":"https://doi.org/10.1111/joor.14026","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively evaluate the association between clinical features and long-term radiographic progression in temporomandibular joint (TMJ) degenerative joint disease (DJD).</p><p><strong>Methods: </strong>We included 198 TMJs from 104 patients diagnosed with DJD (119 TMJs) or indeterminate DJD (79 TMJs). These patients underwent an initial cone beam computed tomography (CBCT) scan and at least one follow-up CBCT scan at least 1 year later. Demographic information, oral behaviours, chief complaints and clinical examination findings were collected.</p><p><strong>Results: </strong>Radiographic progression was observed in 33% of DJD and 24% of indeterminate DJD cases during a median follow-up period of 680 days. Teeth clenching (HR = 3.58), disc displacement without reduction (HR = 2.49), limited mouth opening > 3 months (HR = 1.87), and maximum incisal opening < 35 mm (HR = 4.98) appeared to be significant risk factors for DJD progression. Angle Class II malocclusion (HR = 0.49) might be a protective factor for progression of DJD. Time-dependent receiver operating characteristic (ROC) analysis showed area under the curve (AUC) values ranging from 0.74 to 0.88 over 3 years, with a survival tree model predicting DJD progression with 72% accuracy.</p><p><strong>Conclusion: </strong>Clinical features significantly correlate with DJD progression. The multivariate and survival tree analyses provide moderate predictive accuracy, which could contribute to early identification and management of patients at risk. Further multicentre validation is still required.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Healthy Aging on Tongue-Jaw Kinematics During Feeding.","authors":"Shreyas Punacha, Kevin Huang, Fritzie I Arce-McShane","doi":"10.1111/joor.14035","DOIUrl":"10.1111/joor.14035","url":null,"abstract":"<p><strong>Background: </strong>Several age-related oral health problems have been associated with neurodegenerative diseases such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). However, the distinction between oromotor dysfunctions in healthy aging and pathological aging remains unclear. This is partly because changes in the cortical and biomechanical (\"neuromechanical\") control of oromotor behaviour in healthy aging are poorly understood.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate age-related changes in tongue and jaw kinematics during natural feeding behaviour in non-human primates.</p><p><strong>Methods: </strong>We captured three-dimensional tongue and jaw movements in young and aged rhesus macaques (Macaca mulatta) using high-resolution biplanar videoradiography combined with X-ray Reconstruction of Moving Morphology (XROMM). This approach allowed precise tracking of tongue and jaw kinematics during natural feeding behaviour. Tongue stereotypy and velocity were quantitatively assessed, along with the temporal coordination between tongue and jaw movements. Feeding performance was measured using frequency and duration of food manipulation, chewing, and swallowing.</p><p><strong>Results: </strong>Older subjects exhibited reduced stereotypy in tongue movements during chews and greater lags in tongue movements relative to jaw movements compared to younger subjects.</p><p><strong>Conclusions: </strong>Our findings reveal age-related changes in tongue and jaw kinematics, which may indicate impaired tongue-jaw coordination. These results have important implications for the discovery of potential neuromechanical biomarkers for early diagnosis of AD.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction Between Age and Task Demand on Brain Connectivity Associated With Mastication.","authors":"Chia-Shu Lin, Wei-Chieh Kao","doi":"10.1111/joor.14036","DOIUrl":"https://doi.org/10.1111/joor.14036","url":null,"abstract":"<p><strong>Background: </strong>Sensorimotor processing is critical to the ageing brain and geriatric health. Masticatory performance (MP) is key to the systemic health of older individuals. Neuroimaging research has revealed a potential link between brain functional connectivity (FC) and MP. Using the masticatory perturbation task (MPT), we investigated the FC associated with MP under different conditions of task demand and age groups.</p><p><strong>Methods: </strong>Thirty-four older-age (OA, ≥ 65 years), 26 middle-aged (MA, between 40 and 64 years) and 42 younger-age (YA, < 40 years) participants were recruited for assessment of the MPT, and structural and resting-state (rs) functional magnetic resonance imaging (MRI). Analyses of seed-based connectivity and FC networks were conducted to investigate the rs-FC associated with MP in the baseline condition (without perturbation) and the perturbation condition (with perturbation) of MPT.</p><p><strong>Results: </strong>(A) In the baseline condition, OA participants with better MP showed higher rs-FC between the cerebellum and primary sensorimotor cortices. (B) In the perturbation condition, OA participants with better MP showed higher rs-FC between the middle frontal gyrus and the primary somatosensory cortex, and MA participants with better MP showed higher rs-FC between the supplementary motor area and the caudate nucleus. (C) The network analysis revealed that the pattern of rs-FC related to MP differed between age groups and task conditions. In the perturbation condition, YA participants with better MP showed higher rs-FC outside the sensorimotor network.</p><p><strong>Conclusion: </strong>The findings provide novel evidence demonstrating an interaction between age and task demand on rs-FC associated with MP.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effect of Training on the Anterior Belly of the Digastric Muscle Using Ultrasound Elastography.","authors":"Ryosuke Fuma, Mai Ohkubo, Keina Miura, Tetsuya Sugiyama, Ryo Ishida","doi":"10.1111/joor.13988","DOIUrl":"https://doi.org/10.1111/joor.13988","url":null,"abstract":"<p><strong>Background: </strong>Neuromuscular electrical stimulation (NMES) strengthens muscles and is used to treat dysphagia. Assessing NMES training at rest is preferable because patients may experience difficulty following instructions.</p><p><strong>Objectives: </strong>To determine whether muscle hardness, circumference and area changes can be measured using ultrasound real-time tissue elastography (RTE) after NMES of the anterior belly of the digastric muscle and whether these measurements can be an index for muscle activity during NMES.</p><p><strong>Methods: </strong>Overall, 21 healthy adults were included in this study. Baseline hardness, circumference and area of the anterior belly of the digastric muscle at rest and with the mouth open, as well as the muscle activity of the submandibular surface layer when the mouth was open, were measured using RTE and surface electromyography. NMES was performed for 30 min weekly for 4 weeks, and similar measurements were taken at 2 and 4 weeks after the start of stimulation.</p><p><strong>Results: </strong>Muscle hardness at rest and with the mouth open differed significantly between baseline and Week 4 (resting: p = 0.0048; mouth open: p = 0.034). The strain ratio at Weeks 2 and 4 correlated negatively with the maximum voluntary contraction (Week 2: r = -0.77, p < 0.01; Week 4: r = -0.564, p < 0.05). A positive correlation was found between muscle hardness at rest and with the mouth open at Week 4 (r = 0.544, p < 0.05).</p><p><strong>Conclusion: </strong>Our results indicate that muscle hardness at rest determined using RTE may be utilised to assess the influence of NMES. This measurement could serve as an objective indicator for implementing NMES.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Cyberchondria to Temporomandibular Disorders: How Somatic Symptoms and Anxiety Bridge the Gap.","authors":"Zhiwei Cao, Yanyu Sun, Houpeng Li, Chen Lin, Hui Loon Wong, Hongyu Ming, Po-Kam Wo, Jun Wang, Xin Xiong","doi":"10.1111/joor.14041","DOIUrl":"https://doi.org/10.1111/joor.14041","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to explore the potential association among cyberchondria, self-reported temporomandibular disorders (TMDs), somatic symptoms and anxiety, and verify the chain mediating effect of somatic symptoms and anxiety between cyberchondria and self-reported TMDs.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among community dwellers. A total of 531 participants, ranging in age from 18 to 50 years, were included. They all completed self-report measures of demographic information, the quintessential five TMDs symptoms (5Ts), the somatic symptom scale-8 (SSS-8), the 7-item Generalised Anxiety Disorder Questionnaire (GAD-7) and the short-form version of the cyberchondria severity scale (CSS-12). Statistical analyses were conducted using SPSS, Origin 2021 and Mplus.</p><p><strong>Results: </strong>The CSS-12 score was higher in participants with self-reported TMDs (p < 0.05). Having systemic diseases, a higher education level, somatic symptoms burden, anxiety and a high level of cyberchondria were significantly linked to self-reported TMDs (p < 0.05). Mediation analysis revealed that cyberchondria has a direct effect on self-reported TMDs (β = 0.129; 95% CI 0.026-0.232). Somatic symptoms burden (β = 0.073; 95% CI 0.031-0.115) and anxiety (β = 0.041; 95% CI 0.010-0.071) respectively mediated the association between cyberchondria and self-reported TMDs. Additionally, somatic symptoms burden and anxiety collectively exhibit a chain mediation effect (β = 0.031; 95% CI 0.005-0.058).</p><p><strong>Conclusions: </strong>Cyberchondria is associated with self-reported TMDs, mediated by somatic symptoms burden and anxiety. Cyberchondria can both directly and indirectly affect self-reported TMDs. Preventing cyberchondria may be beneficial for reducing the somatic symptoms burden and anxiety associated with self-reported TMDs.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Instruction of Chewing Well Affects Masticatory Activity and Bolus Flow During Rice Chewing in Healthy Humans.","authors":"Akira Okubo, Takanori Tsujimura, Rumi Ueha, Taku Suzuki, Eri Takei, Anna Sasa, Yuhei Tsutsui, Yuta Nakajima, Jin Magara, Makoto Inoue","doi":"10.1111/joor.14034","DOIUrl":"https://doi.org/10.1111/joor.14034","url":null,"abstract":"<p><strong>Background: </strong>Chewing well (CW) is widely recommended for general health.</p><p><strong>Objective: </strong>The study aimed to consider what healthy participants associated with the instruction of 'CW' and to investigate the effects of CW on masticatory activity and bolus flow during rice chewing.</p><p><strong>Methods: </strong>Twenty-six healthy participants ate 8, 12 and 16 g of steamed rice with barium sulphate under the following two instructions: chewing freely and CW. We investigated the masticatory muscle activity by electromyography (EMG) and the bolus flow by videofluoroscopy. A paired t-test or Wilcoxon signed-rank test was used to analyse data.</p><p><strong>Results: </strong>All participants associated the 'CW' instruction with 'chewing for a long time'. CW shortened the masseter (Mas) EMG burst duration per chewing cycle (p < 0.001). At 8 and 12 g, CW decreased the suprahyoid (Shy) EMG activity per chewing cycle (p < 0.05) and increased the ratio of valleculae and hypopharyngeal time (VHT) to chewing time (p < 0.01). CW increased the chewing rate in the VHT for 8 and 12 g (p < 0.05) and in the processing time for 16 g (p < 0.05) in the participants who reached the food bolus in the valleculae area during chewing.</p><p><strong>Conclusion: </strong>CW decreased the Mas activity during chewing at all volumes, while its effects on the Shy activity and bolus flow during chewing depended on the mouthful volume. CW increased the chewing rate in the final stage for the small and medium volumes, and in the early stage for the large volume.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Number of Teeth Present With Nutrient Intake and Food Group Consumption.","authors":"Mayuka Asaeda, Rumi Nishimura, Shino Suma, Mineko Tsukamoto, Yuka Kadomatsu, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Chiho Goto, Nahomi Imaeda, Kenji Wakai, Nishiki Arimoto, Tomoko Maehara, Mariko Naito","doi":"10.1111/joor.14011","DOIUrl":"https://doi.org/10.1111/joor.14011","url":null,"abstract":"<p><strong>Background: </strong>Several studies have examined the impact of tooth loss on nutrient intake, yielding mixed results.</p><p><strong>Objectives: </strong>This cross-sectional study aimed to investigate the association among the number of teeth present, nutrient intake and food group consumption in Japanese adults with no history of the four major diseases (diabetes, cancer, heart disease and stroke).</p><p><strong>Methods: </strong>Data were obtained from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study conducted in the Shizuoka and Daiko areas. Participants completed a self-administered questionnaire on their number of teeth, medical history (diabetes, cancer, heart disease and stroke), education level, employment status and lifestyle factors, such as diet, smoking history and exercise habits. The number of teeth was classified into four groups: 0 teeth, 1-19 teeth, 20-27 teeth and 28-32 teeth.</p><p><strong>Results: </strong>A total of 8912 individuals included in the analysis had a mean age ± SD of 51.7 ± 9.5 years, with women accounting for 53.6% of the total. In adult men, the number of teeth was negatively associated with the intake of vitamin D, n-3 highly unsaturated fatty acid intake and seafood, while in women, bread consumption was positively associated with the number of teeth.</p><p><strong>Conclusions: </strong>These findings suggest that the number of teeth is independently associated with poor nutritional status in Japanese adults with no history of the four major diseases.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}