{"title":"下颌推进装置对OSA兔舌下神经功能的改善。","authors":"Xing Qiao, Dechao Zhu, Xiaoyi Wang, Chunyan Liu, Zuo Zhang, Peipei Zhang, Haiyan Lu","doi":"10.1111/joor.70060","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study investigates the interaction between the motor endplate of the genioglossus and the hypoglossal nerve in an obstructive sleep apnea (OSA) model and explores the mechanism of mandibular advancement devices (MAD) in treating OSA.</p><p><strong>Methods: </strong>18 male New Zealand white rabbits were randomly divided into three groups-control, OSA and MAD (n = 6 each). OSA was induced in the OSA and MAD groups by injecting gel into the soft palate. The MAD group received MAD treatment. Cone-beam computed tomography (CBCT) and polysomnography (PSG) confirmed MAD efficacy. Rabbits underwent 2 h of sleep induction daily for 8 weeks. Electrophysiological signals of the genioglossus and hypoglossal nerve were recorded. Morphological assessments of nerve fibres and motor endplates used gold chloride, acetylcholine and haematoxylin-Eosin (HE) staining. Immunofluorescence and acetylcholinesterase (AChE) staining evaluated nerve conduction.</p><p><strong>Results: </strong>OSA symptoms were successfully induced and reversed by MAD. Structural and functional impairments of the hypoglossal nerve and motor endplates in the OSA group were alleviated by MAD, improving nerve impulse conduction and muscle function.</p><p><strong>Conclusions: </strong>MAD treatment mitigates OSA-induced damage to the hypoglossal nerve and genioglossus motor endplates, enhancing structure and function.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mandibular Advancement Device Improves the Function of Hypoglossal Nerve in OSA Rabbits.\",\"authors\":\"Xing Qiao, Dechao Zhu, Xiaoyi Wang, Chunyan Liu, Zuo Zhang, Peipei Zhang, Haiyan Lu\",\"doi\":\"10.1111/joor.70060\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study investigates the interaction between the motor endplate of the genioglossus and the hypoglossal nerve in an obstructive sleep apnea (OSA) model and explores the mechanism of mandibular advancement devices (MAD) in treating OSA.</p><p><strong>Methods: </strong>18 male New Zealand white rabbits were randomly divided into three groups-control, OSA and MAD (n = 6 each). OSA was induced in the OSA and MAD groups by injecting gel into the soft palate. The MAD group received MAD treatment. Cone-beam computed tomography (CBCT) and polysomnography (PSG) confirmed MAD efficacy. Rabbits underwent 2 h of sleep induction daily for 8 weeks. Electrophysiological signals of the genioglossus and hypoglossal nerve were recorded. Morphological assessments of nerve fibres and motor endplates used gold chloride, acetylcholine and haematoxylin-Eosin (HE) staining. Immunofluorescence and acetylcholinesterase (AChE) staining evaluated nerve conduction.</p><p><strong>Results: </strong>OSA symptoms were successfully induced and reversed by MAD. Structural and functional impairments of the hypoglossal nerve and motor endplates in the OSA group were alleviated by MAD, improving nerve impulse conduction and muscle function.</p><p><strong>Conclusions: </strong>MAD treatment mitigates OSA-induced damage to the hypoglossal nerve and genioglossus motor endplates, enhancing structure and function.</p>\",\"PeriodicalId\":16605,\"journal\":{\"name\":\"Journal of oral rehabilitation\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-10-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of oral rehabilitation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/joor.70060\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral rehabilitation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/joor.70060","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Mandibular Advancement Device Improves the Function of Hypoglossal Nerve in OSA Rabbits.
Background: This study investigates the interaction between the motor endplate of the genioglossus and the hypoglossal nerve in an obstructive sleep apnea (OSA) model and explores the mechanism of mandibular advancement devices (MAD) in treating OSA.
Methods: 18 male New Zealand white rabbits were randomly divided into three groups-control, OSA and MAD (n = 6 each). OSA was induced in the OSA and MAD groups by injecting gel into the soft palate. The MAD group received MAD treatment. Cone-beam computed tomography (CBCT) and polysomnography (PSG) confirmed MAD efficacy. Rabbits underwent 2 h of sleep induction daily for 8 weeks. Electrophysiological signals of the genioglossus and hypoglossal nerve were recorded. Morphological assessments of nerve fibres and motor endplates used gold chloride, acetylcholine and haematoxylin-Eosin (HE) staining. Immunofluorescence and acetylcholinesterase (AChE) staining evaluated nerve conduction.
Results: OSA symptoms were successfully induced and reversed by MAD. Structural and functional impairments of the hypoglossal nerve and motor endplates in the OSA group were alleviated by MAD, improving nerve impulse conduction and muscle function.
Conclusions: MAD treatment mitigates OSA-induced damage to the hypoglossal nerve and genioglossus motor endplates, enhancing structure and function.
期刊介绍：
Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function.
Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology.
The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.
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