Journal of Ophthalmic Inflammation and Infection最新文献

{"title":"Diagnostic riddle- case report of ocular syphilis.","authors":"Marta Bociąga-Kożuch, Aleksandra Raczyńska, Dorota Trela, Aleksander Garlicki, Tomasz Berus","doi":"10.1186/s12348-025-00488-4","DOIUrl":"10.1186/s12348-025-00488-4","url":null,"abstract":"<p><p>Syphilis is one of sexually transmitted infections (STIs). The incidence of Treponema pallidum infection has increased in the last 20 years. This rise is also evident in ophthalmological practice, with cases of ocular syphilis becoming more frequent.We present a case of a 29-year-old patient with blurred vision in his left eye. Patient showed no general symptoms, nor previous history of eye disorders. On ophthalmological examination, the best-corrected visual acuity (BCVA) was 20/20 in the right eye (OD) and 20/80 in the left eye (OS). The left eye presented high intraocular pressure (IOP) of 31 mmHg and symptoms of anterior uveitis with a linear branching corneal erosion. A B-scan ultrasound of the left eye revealed no vitritis. The preliminary diagnosis of herpetic infection was made, and antiviral therapy was introduced. Despite the initial improvement, symptoms of active anterior uveitis were found on follow-up visits. After approximately 4 weeks of ambulatory treatment, the patient was admitted to the hospital because of roseolae and lumps of the left iris, which appeared accompanied by a rash on patients' lower limbs. Laboratory tests confirmed syphilis and human immunodeficiency virus (HIV) coinfection. During hospitalization intravenous treatment with penicillin and antiretroviral drugs was introduced. Therapy with penicillin was continued to 21 days with improvement in examination. On a follow-up visit after 6 months BCVA in both eyes was 20/20.It is crucial to consider testing for STIs, especially Treponema pallidum infection, in the diagnostic process of patients with nontypical or nonresponsive to treatment ocular symptoms.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"33"},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of acute retinal pigmentepithelitis.","authors":"Daniel Ahmed-Balestra, Martin Stattin, Katharina Krepler, Siamak Ansari-Shahrezaei","doi":"10.1186/s12348-025-00491-9","DOIUrl":"10.1186/s12348-025-00491-9","url":null,"abstract":"<p><strong>Purpose: </strong>To present a pediatric case of acute retinal pigment epitheliitis (ARPE) and propose a classification based on imaging findings and prognosis.</p><p><strong>Methods: </strong>A case report with literature review.</p><p><strong>Results: </strong>The case demonstrated hallmark ARPE features alongside an atypical disease course, indicating a broader clinical spectrum. Multimodal imaging plays a crucial role in differentiating ARPE from mimicking retinal disorders.</p><p><strong>Conclusion: </strong>ARPE may represent a spectrum of subtypes with varying prognostic implications. A classification based on age, laterality and imaging biomarkers could improve diagnostic accuracy and patient management.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"32"},"PeriodicalIF":2.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveitis output in high-impact clinical ophthalmology journals: a bibliometric analysis.","authors":"Baotram V Nguyen, Priyanka Bhatnagar, Daniel C Lee, Meghan K Berkenstock","doi":"10.1186/s12348-025-00490-w","DOIUrl":"10.1186/s12348-025-00490-w","url":null,"abstract":"<p><strong>Background: </strong>Despite uveitis subspecialty workforce shortages, uveitis specialists remain engaged in research. This study examines the relationship between the proportions of uveitis-focused articles in high-impact ophthalmology journals and fellowship-trained uveitis specialists on their editorial boards.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted on articles published from 2014 to 2023 in the five highest-impact ophthalmology journals: Ophthalmology, JAMA Ophthalmology, British Journal of Ophthalmology (BJO), American Journal of Ophthalmology (AJO), and Investigative Ophthalmology and Visual Science (IOVS). Editorial board members with uveitis or ocular immunology fellowships were identified from public domain sources. Articles were screened using uveitis MeSH terms. Data analysis was performed using STATA to assess the relationship between the proportions of uveitis-focused articles and uveitis-trained editors.</p><p><strong>Results: </strong>From 2014 to 2023, 3.57% (575/16,093) of articles published in the five journals were uveitis-focused. The proportion of uveitis-focused articles ranged from 1.74% in IOVS to 5.89% in AJO. On average, fellowship-trained uveitis specialists comprised 5.28% of editorial board members annually. There were positive correlations between the proportions of uveitis-focused articles and uveitis-trained editors annually (r = 0.6799, p < 0.00005) and over the 10-year period (r = 0.2675, p < 0.00005). No significant correlation was observed within individual journals.</p><p><strong>Conclusions: </strong>Uveitis research remains underrepresented in high-impact ophthalmology journals despite research productivity in the field. While a positive correlation between uveitis-trained editors and uveitis-focused articles was found across all journals, this trend did not hold within individual journals. Enhancing uveitis research visibility in high-impact journals is essential to advancing clinical knowledge, improving patient outcomes, and inspiring ophthalmologists to enter this underserved subspecialty.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"31"},"PeriodicalIF":2.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive bony destructive orbital aspergillosis in an immunocompetent child: a case report.","authors":"Seyed Mohsen Rafizadeh, Amir Mousavi, Mohammad Taher Rajabi, Amirhossein Aghajani, Zohreh Nozarian, Amin Zand","doi":"10.1186/s12348-025-00485-7","DOIUrl":"10.1186/s12348-025-00485-7","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of invasive sino-orbital aspergillosis, a rare condition in a healthy child. The patient presented with orbital involvement and bone destruction, an exceedingly uncommon occurrence that mimics other invasive inflammatory or neoplastic orbital lesions.</p><p><strong>Case presentation: </strong>A 4-year-old female presented with an ill-defined, irregular, erythematous mass-like lesion measuring 8 × 10 mm on the left upper eyelid. Orbital computed tomography (CT) revealed an infiltrative soft tissue mass with bone erosions and destruction on the medial side of the frontal bone, extending toward the fronto-maxillary suture in the anterior orbit. Except for the left anterior ethmoidal sinus, the other paranasal sinuses were nearly clear. Magnetic resonance imaging (MRI) showed enhancement of the adjacent dura mater near the site of bony erosion and lesion expansion. The lesion was surgically excised, with drainage of mucopurulent discharge. Pathological examination revealed necrotizing granulomatous inflammation and fungal hyphae, with Aspergillus fumigatus growth confirmed by culture. The patient was diagnosed with invasive orbital aspergillosis. She was treated with intravenous and then oral voriconazole, and there was no recurrence of the disease.</p><p><strong>Conclusions: </strong>Invasive orbital aspergillosis with bone destruction of the orbital walls can occur in immunocompetent individuals, including children, without any predisposing factors. It can mimic other invasive orbital diseases, leading to delayed diagnosis and treatment, which may result in life-threatening outcomes if intracranial spread occurs. Therefore, timely orbital biopsy of the lesions is crucial.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"30"},"PeriodicalIF":2.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular complications in psoriatic patients: a systematic review and meta-analysis.","authors":"Adriano Cypriano Faneli, Dillan Cunha Amaral, Isabelle Rodrigues Menezes, Guilherme Nunes Marques, Jaime Guedes, Rodrigo Brazuna, Ricardo Danilo Chagas Oliveira, Cristina Muccioli","doi":"10.1186/s12348-025-00486-6","DOIUrl":"10.1186/s12348-025-00486-6","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the prevalence of ocular findings in patients with psoriasis and compare the odds of developing these conditions between the psoriatic and control population through a systematic review and meta-analysis.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using PubMed, Embase, Cochrane, and Web of Science databases to identify studies reporting ocular findings in psoriasis patients. Inclusion criteria encompassed cross-sectional, case-control, cohort studies, case series, and case studies. Data extraction and quality assessment followed PRISMA guidelines. The Newcastle-Ottawa Scale evaluated the risk of bias. Heterogeneity was assessed using Cochran's Q-test and I² statistics, with a random-effects model applied where significant heterogeneity was present.</p><p><strong>Results: </strong>30 studies comprising 131,687 patients (13,788 with psoriasis and 117,899 controls) were included. The relative likelihood of ocular findings in psoriasis patients showed to be increased in conjunctival hyperemia (OR = 7.38; 95% CI: 2.47-22.04), conjunctivitis (OR = 4.63; 95% CI: 1.42-15.08), dry eye (OR = 3.47; 95% CI: 2.06-5.83), and meibomian gland dysfunction (OR = 7.13; 95% CI: 2.14-23.72) compared to controls. In contrast, blepharitis, cataracts, episcleritis, glaucoma, pinguecula, pterygium, and uveitis did not differ significantly between the two groups.</p><p><strong>Conclusions: </strong>Psoriasis patients are at increased risk for certain ocular conditions, particularly conjunctival hyperemia, conjunctivitis, dry eye, and meibomian gland dysfunction. Further research is needed to understand the underlying mechanisms and to develop targeted management strategies.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"29"},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies in the management of endophthalmitis: a 5-year retrospective cohort study.","authors":"Ohisa Harley, Yufilia Suci Amelia, Elsa Gustianty, Nanny N M Soetedjo, Arief S Kartasasmita","doi":"10.1186/s12348-025-00468-8","DOIUrl":"10.1186/s12348-025-00468-8","url":null,"abstract":"<p><strong>Background and purpose: </strong>Post-operative endophthalmitis has a risk of vision loss if the treatment is delayed. Managing endophthalmitis based on visual outcome has become controversial. This study primarily aimed to evaluate the effectiveness of early pars plana vitrectomy (PPV) combined with intravitreal antibiotics in improving visual acuity and reducing complications in patients with post-operative endophthalmitis. Secondary objectives included identifying prognostic factors influencing visual outcomes after PPV, assessing the effectiveness of different intravitreal antibiotic regimens on visual recovery, and evaluating the role of steroid as adjunctive therapy in influencing visual outcome and controlling inflammation.</p><p><strong>Methods: </strong>A 5-year retrospective cohort study was conducted, reviewing medical records of patients diagnosed with post-operative endophthalmitis between 2019 and 2023. Data collected included patient demographics, medical and surgical history, culture results, treatments administered, baseline best-corrected visual acuity (BCVA), and BCVA outcomes within three months after vitrectomy.</p><p><strong>Results: </strong>40 eyes of 40 patients with acute post-operative endophthalmitis underwent early PPV followed by intravitreal antibiotics. Median logMAR BCVA improved from 2.0 at presentation to 0.4 three months post-vitrectomy (p < 0.05), with a mean final logMAR BCVA of 0.94 ± 1.13. No significant difference was observed in visual outcomes or complication rates between patients treated with intravitreal vancomycin and ceftazidime versus moxifloxacin monotherapy. Univariate analysis identified high intraocular pressure (p = 0.004, β = 2.42), hypopyon (p = 0.01, β = 1.79), and a history of surgery more than seven days prior (p = 0.032, β = 1.74) as significant predictive of visual outcomes. Multivariate analysis confirmed intraocular pressure (p = 0.008, β = 2.55) and surgical history (p = 0.045, β = 1.84) as independent predictors. Baseline BCVA, fibrin, retinal findings, and symptom onset were not significantly associated with outcomes. Neither antibiotics regimen nor steroid use significantly influenced treatment results.</p><p><strong>Conclusion: </strong>This study supports performing early PPV combined with intravitreal antibiotics as an effective primary treatment to improve visual outcomes in post-operative endophthalmitis. Negative prognostic factors included hypopyon, elevated intraocular pressure, and a surgical history of more than seven days. Management should prioritize clinical signs over microbiological culture results to prevent delays in treatment.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"28"},"PeriodicalIF":2.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A complicated Vogt-Koyanagi-Harada presenting with bilateral papillitis in a 5-year-old- case report.","authors":"Salem Almerri, Raed Behbehani","doi":"10.1186/s12348-025-00481-x","DOIUrl":"10.1186/s12348-025-00481-x","url":null,"abstract":"<p><strong>Purpose: </strong>We report a case of a 5-year-old patient with Vogt-Koyanagi-Harada presenting atypically with bilateral papillitis and refractory inflammation, leading to uveitic glaucoma and necessitating an escalation of adalimumab to 40 mg biweekly.</p><p><strong>Observations: </strong>A 5-year-old girl presented with a 3-week history of eye redness, excessive lacrimation, and photophobia. Her medical history was unremarkable. On examination, her best-corrected visual acuity (BCVA) were 20/80 and 20/100 in right and left eye, respectively, with normal intraocular pressure (IOP). Anterior segment examination revealed fine keratic precipitates, anterior chamber inflammation (+ 4 cells and flare), and semi-dilated pupils with posterior synechiae. Posterior segment evaluation was limited by severe vitritis. Laboratory investigations were unremarkable except for HLA-DR4, DR52, and DR53 positivity. Optical coherence tomography (OCT) of the optic nerve showed increased retinal nerve thickness. Initial treatment with corticosteroids and methotrexate failed to achieve remission. Attempts to taper corticosteroids resulted in recurrence of anterior chamber flare, prompting the introduction of adalimumab at 20 mg/biweekly. Despite relative stability, persistent anterior chamber inflammation and subsequent corticosteroid tapering led to the development of uncontrolled uveitic glaucoma requiring surgical peripheral iridectomy. Postoperatively, adalimumab was escalated to 40 mg/biweekly, enabling successful tapering of corticosteroids. Over a 9-month follow-up period, the patient remained flare-free, with BCVA improving to 20/20 in both eyes.</p><p><strong>Conclusions and importance: </strong>This case highlights an atypical presentation of VKH in a preschool-aged child, characterized by bilateral papillitis without exudative retinal detachment. Escalation of adalimumab to 40 mg biweekly effectively controlled inflammation, facilitated corticosteroid tapering, and preserved visual acuity.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"27"},"PeriodicalIF":2.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent uveitic macular edema managed with intravitreal faricimab injection.","authors":"Negin Yavari, Dalia El Feky, Frances A Anover, Khiem Nguyen, Azadeh Mobasserian, Quan Dong Nguyen, Christopher Or","doi":"10.1186/s12348-025-00478-6","DOIUrl":"10.1186/s12348-025-00478-6","url":null,"abstract":"<p><strong>Purpose: </strong>To present a case of recurrent uveitic macular edema (UME) treated with intravitreal faricimab injection.</p><p><strong>Methods: </strong>Single case report from a tertiary referral center.</p><p><strong>Observations: </strong>A 63-year-old Caucasian female presenting with recurrent UME due to birdshot chorioretinopathy (BSCR) in both eyes. UME had been treated with multiple agents including intravenous methylprednisone, posterior subtenons and intravitreal triamcinolone acetonide injection, dexamethasone implant, mycophenolate mofetil, and adalimumab with limited improvement and development of intolerance. Moreover, optical coherence tomography also revealed recurrence of UME with subretinal fluid in both eyes. After treatment with one dose of intravitreal faricimab injection, complete resolution of UME was achieved and maintained for three months.</p><p><strong>Conclusion: </strong>The findings of this case hint towards the potential simultaneous effect of angiopoietin-2 blockade along with vascular endothelia growth factor A inhibition by faricimab in managing treatment-resistant UME. Nonetheless, more studies focusing on the role of intravitreal faricimab in UME are required.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"25"},"PeriodicalIF":2.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presumed granulomatosis with polyangiitis presenting with anterior scleritis and inflammatory ciliary body granuloma.","authors":"Negin Yavari, Hashem Ghoraba, S Saeed Mohammadi, Dalia El Feky, Irmak Karaca, Quan Dong Nguyen, Christopher Or","doi":"10.1186/s12348-025-00475-9","DOIUrl":"10.1186/s12348-025-00475-9","url":null,"abstract":"<p><strong>Purpose: </strong>To present a case of presumed limited granulomatosis with polyangiitis (GPA) associated with anterior scleritis and ciliary body inflammatory granuloma which was treated with systemic rituximab (RTX), oral mycophenolate mofetil, and intravitreal (IVT) dexamethasone implant.</p><p><strong>Observations: </strong>We report a patient presenting with sectoral scleritis and ciliary body granuloma in the left eye. The patient also had a nasal sinus granuloma which was biopsied three times with negative results for malignancy and fungal infections. The patient underwent a diagnostic vitrectomy, which was also negative for lymphoma, bacterial and fungal infections. Subsequently, intravenous methylprednisolone and oral methotrexate were started, but significant improvement was achieved only following initiation of intravenous RTX, oral mycophenolate mofetil, and IVT dexamethasone implant.</p><p><strong>Conclusion: </strong>Therapeutic management of scleritis associated with limited GPA can be very challenging; early diagnosis can help to eliminate potential complications. Our result showed that RTX, mycophenolate mofetil, and IVT dexamethasone implant can be beneficial in treatment-resistant cases.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"26"},"PeriodicalIF":2.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do people with diabetes have a higher risk of developing postoperative endophthalmitis after cataract surgery? A systematic review and meta-analysis.","authors":"Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan","doi":"10.1186/s12348-025-00483-9","DOIUrl":"10.1186/s12348-025-00483-9","url":null,"abstract":"<p><strong>Purpose: </strong>Postoperative endophthalmitis (POE) is a rare but severe complication of cataract surgery. While diabetes mellitus may increase the risk of POE, the relationship remains unclear.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, Scopus, Medline, Embase, and Google Scholar were searched for relevant studies up to September 10, 2024. The study included both randomized controlled trials and observational studies that evaluated POE outcomes in cataract surgery patients, comparing people with and without diabetes. Random-effects models were used to calculate pooled odds ratios (OR) with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Nine studies were included in the systematic review, with seven analyzed in the meta-analysis. The review on POE in people with diabetes undergoing cataract surgery revealed a higher incidence in this group, with a pooled odds ratio (OR) of 1.174 (95% CI: 1.109 to 1.242; p = 0.000) and an incidence rate of 0.261%, compared to 0.242% in people without diabetes. Males with diabetes had a 1.634 times higher risk of POE (p = 0.048), while diabetes and hypertension together increased risk by 3.961 times (p < 0.001). Posterior capsule rupture (PCR) was associated with a significantly higher risk of developing POE, which was also more common in people with diabetes, with an OR of 3.434 (95% CI: 1.789 to 6.591; p = 0.0001). The use of postoperative intracameral and topical antibiotics significantly reduced the risk of POE in both people with and without diabetes (OR: 0.231; p = 0.00).</p><p><strong>Conclusions: </strong>This meta-analysis shows that people with diabetes undergoing cataract surgery have a significantly higher risk of POE and PCR compared to those without diabetes, with odds ratios of 1.174 and 3.434, respectively. The administration of intracameral and topical antibiotics significantly reduces the risk of POE in both groups. Our study highlights the importance of maintaining well-controlled blood sugar and blood pressure before surgery. Additionally, extra caution should be taken during surgery to prevent PCR, and appropriate antibiotic use should be considered to minimize the risk of POE.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"24"},"PeriodicalIF":2.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}