Chiho Mashimo, O. Tsuzukibashi, Satoshi Uchibori, T. Nambu
{"title":"Variations of Nitrate-reducing Activity in Oral Rothia mucilaginosa","authors":"Chiho Mashimo, O. Tsuzukibashi, Satoshi Uchibori, T. Nambu","doi":"10.11223/JARDE.13.18","DOIUrl":"https://doi.org/10.11223/JARDE.13.18","url":null,"abstract":"18 INTRODUCTION Nitric oxide (NO) is a signaling molecule with the ability to affect various biological functions including vascular homeostasis, neurotransmission, gastric physiology, mitochondrial function, and, through its antibacterial effects, host defense. Several recent reports have shown that the prominent role of NO lies in its beneficial effects on blood pressure and vascular health . In human physiology, there are two major NO generation pathways; the first of these is the endogenous L-arginin–NO synthase (NOSs) pathway, in which NOS catalyzes L-arginin and molecular oxygen to Variations of Nitrate-reducing Activity in Oral Rothia mucilaginosa","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91434415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Imai, T. Nishikawa, Tomoharu Okamura, A. Tanaka, Tatsuro Miyake, I. Tamura, Hiroki Ishikawa, T. Iseki, S. Morita, H. Sawai, T. Ohkubo, M. Shida, K. Suese
{"title":"Study of the Mutagenicity of Prototype Ag-In, Porcelain Bonding and Au-Ag-Pd Alloys Containing Indium using the Umu-test","authors":"K. Imai, T. Nishikawa, Tomoharu Okamura, A. Tanaka, Tatsuro Miyake, I. Tamura, Hiroki Ishikawa, T. Iseki, S. Morita, H. Sawai, T. Ohkubo, M. Shida, K. Suese","doi":"10.11223/JARDE.13.27","DOIUrl":"https://doi.org/10.11223/JARDE.13.27","url":null,"abstract":"27 INTRODUCTION There are many mutagens which increase the frequency of mutation in DNA and chromosomal genetic information of biologics. Of carcinogens, most of the initiators that produce an abnormality in genetic information and a cause of cancer are mutagens . Many dental alloys are covered by national health insurance and clinically used, such as Ag-In and gold-silver-palladium alloys . However, the toxicity of indium and its compounds has been reported , and the WHO stated the possibility of the Study of the Mutagenicity of Prototype Ag-In, Porcelain Bonding and Au-Ag-Pd Alloys Containing Indium using the Umu-test","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74273236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kawaguchi, K. Mori, H. Kajiya, T. Ikebe, T. Fukushima
{"title":"In Vivo Evaluation of Bone Regeneration by DNA/protamine Complex Treatment with Photothermal Stress Stimulation in an Aged Rat Calvarial Defect Model","authors":"M. Kawaguchi, K. Mori, H. Kajiya, T. Ikebe, T. Fukushima","doi":"10.11223/JARDE.13.67","DOIUrl":"https://doi.org/10.11223/JARDE.13.67","url":null,"abstract":"SYNOPSIS DNA/protamine (D/P) complex was prepared and evaluated for new bone formation ability using a calvarial defect model in rats over 40 weeks old. Photothermal stress (42°C, 15 min) was repeated every day for up to 3 months to assess the effects of thermal stress on bone healing. Photothermal stress stimulation was carried out using a photothermal device, composed of an alginate gel containing carbon nanotubes and an irradiator supplying near-infrared light. Bone regeneration with the D/P complex was accelerated by photothermal stimulation compared with D/P complex implantation without thermal stimulation. There were no significant differences in Knoop hardness values between the newly formed bone, with or without photothermal stimulation, and peripheral bone. Microhardness measurement revealed that the regenerated bones were sufficiently mature. The results of this study suggested that photothermal stress stimulation upregulated bone regeneration induced by expression of heat shock-related","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80549360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs","authors":"Makiko Kagawa, S. Goda, N. Matsumoto","doi":"10.11223/JARDE.13.57","DOIUrl":"https://doi.org/10.11223/JARDE.13.57","url":null,"abstract":"57 INTRODUCTION Drug-induced gingival overgrowth is a disfiguring side effect of anticovulsants, calcineurin inhibitors, and calcium channel blocking agents. Phenytoin is an antiepileptic drug that acts on sodium channels in mammal cells. Clinically detectable gingival overgrowth occurs as the principal side-effect of phenytoin therapy in approximately half of the treated patients. Although the number of patients being treated with this drug is increasing, not all patients on phenytoin medication develop gingival overgrowth. Chronic periodontitis exacerbates the diagnosis of gingival overgrowth associated with phenytoin. Gingival overgrowth presents major problems for the maintenance of oral hygiene. Increased swelling and disfiguration of gingiva also elevate the risk of infections and inflammatory complications in patients. Additional ramifications of gingival overgrowth occur difficult orthodontic treatment. Orthodontic treatment could contribute to the pathogenesis of this side effect. Tumor necrosis factor (TNF)-α is an inflammatory cytokine that induces celThe Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77404854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Imai, Tsubasa Shirai, Y. Honda, T. Nishikawa, Tomoharu Okamura, A. Tanaka, Fumiya Ogawa, H. Sawai, M. Shida, K. Suese
{"title":"Study of Hybrid Culture Technique using Human Hepatocytes and Mouse ES Cells by Three-dimensional Culture Scaffolds","authors":"K. Imai, Tsubasa Shirai, Y. Honda, T. Nishikawa, Tomoharu Okamura, A. Tanaka, Fumiya Ogawa, H. Sawai, M. Shida, K. Suese","doi":"10.11223/JARDE.12.121","DOIUrl":"https://doi.org/10.11223/JARDE.12.121","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77074530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Vitro Study of Experimental Ag-In Alloys with Embryo Stem Cell Test Protocol and Whole Embryo Culture","authors":"K. Imai, H. Takashima","doi":"10.11223/JARDE.12.127","DOIUrl":"https://doi.org/10.11223/JARDE.12.127","url":null,"abstract":"127 INTRODUCTION Using the Embryo Stem Cell Test (EST) protocol , a embryotoxicity test with mouse ES-D3 cells, embryotoxicity was noted for several indium compounds . The EST protocol has already been validated in Europe, demonstrating a strong correlation with human teratogenicity . Although various indiumcontaining alloys have already been used for dental alloys , no report has been published on their embryotoxicity risk. Using Ag-20% In and Ag-Pd-Au-Cu In Vitro Study of Experimental Ag-In Alloys with Embryo Stem Cell Test Protocol and Whole Embryo Culture","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79063481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomohiro Hoshika, Y. Nishitani, Kei Takahashi, Haruka Ogata, N. Ohara, Takehiro Kajihara, M. Yoshiyama
{"title":"Mineralization of Resin Using Experimental Adhesives Containing Hydroxyapatite in Long Term","authors":"Tomohiro Hoshika, Y. Nishitani, Kei Takahashi, Haruka Ogata, N. Ohara, Takehiro Kajihara, M. Yoshiyama","doi":"10.11223/JARDE.13.85","DOIUrl":"https://doi.org/10.11223/JARDE.13.85","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79078264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Imai, T. Nishikawa, S. Morita, T. Iseki, H. Yoshida, Kazuhiro Matsumoto, M. Shida, Fumiya Ogawa, K. Suese
{"title":"Influence on the Long-term Differentiation Culture of ES-D3 Cells with String-like Collagen Scaffolds Derived from Tilapia Scales","authors":"K. Imai, T. Nishikawa, S. Morita, T. Iseki, H. Yoshida, Kazuhiro Matsumoto, M. Shida, Fumiya Ogawa, K. Suese","doi":"10.11223/JARDE.13.125","DOIUrl":"https://doi.org/10.11223/JARDE.13.125","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75030163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Embryotoxicity Test of Restoration Materials using ES Cells Enclosed with Collagen Gel","authors":"K. Imai, H. Takashima","doi":"10.11223/JARDE.13.136","DOIUrl":"https://doi.org/10.11223/JARDE.13.136","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73561233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasuko Takahashi, Yuichi Ito, Y. Kimura, N. Hashiguchi, Y. Nakajima, N. Fukui, Yoshifumi Suwa, Shin Kasuya, Akihiro Sunano, M. Kanou, T. Ueno
{"title":"The Influence of the Usage of a Trephine Bar for Dental Implant Placement","authors":"Yasuko Takahashi, Yuichi Ito, Y. Kimura, N. Hashiguchi, Y. Nakajima, N. Fukui, Yoshifumi Suwa, Shin Kasuya, Akihiro Sunano, M. Kanou, T. Ueno","doi":"10.11223/JARDE.13.5","DOIUrl":"https://doi.org/10.11223/JARDE.13.5","url":null,"abstract":"5 INTRODUCTION The sufficient integration of bone and the dental implant surface, or osseointegration, is critical in dental implant treatment. The use of the appropriate drill is important for achieving clinically sufficient osseointegration. Recently, we tried to use a trephine bar for the first drilling in dental implant placement. However, no previous report has evaluated the influence of the usage of a trephine bar for dental implant placement. The usage of a trephine bar for drilling enables the histological diagnosis of bone quality and the addition of the removed bone to cover deficient bone around the implant. In the present study, we evaluated the clinical results for dental implants placed with a trephine bar compared with those for dental implants placed with a regular drill.","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80408213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}