体外实验银银合金胚胎干细胞试验及全胚培养的研究

Journal of oral tissue engineering Pub Date : 2015-01-01 DOI:10.11223/JARDE.12.127

K. Imai, H. Takashima

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引用次数: 3

摘要

使用胚胎干细胞试验(EST)方案，对小鼠ES-D3细胞进行胚胎毒性试验，注意到几种铟化合物的胚胎毒性。EST方案已在欧洲得到验证，证明其与人类致畸性有很强的相关性。虽然各种含铟合金已被用于牙科合金，但尚未发表关于其胚胎毒性风险的报告。体外用Ag-20% In和Ag-Pd-Au-Cu制备实验Ag-In合金的胚胎干细胞试验方案和全胚培养研究

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In Vitro Study of Experimental Ag-In Alloys with Embryo Stem Cell Test Protocol and Whole Embryo Culture

127 INTRODUCTION Using the Embryo Stem Cell Test (EST) protocol , a embryotoxicity test with mouse ES-D3 cells, embryotoxicity was noted for several indium compounds . The EST protocol has already been validated in Europe, demonstrating a strong correlation with human teratogenicity . Although various indiumcontaining alloys have already been used for dental alloys , no report has been published on their embryotoxicity risk. Using Ag-20% In and Ag-Pd-Au-Cu In Vitro Study of Experimental Ag-In Alloys with Embryo Stem Cell Test Protocol and Whole Embryo Culture

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Journal of oral tissue engineering

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