The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs

Journal of oral tissue engineering Pub Date : 2015-01-01 DOI:10.11223/JARDE.13.57

Makiko Kagawa, S. Goda, N. Matsumoto

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引用次数: 2

Abstract

57 INTRODUCTION Drug-induced gingival overgrowth is a disfiguring side effect of anticovulsants, calcineurin inhibitors, and calcium channel blocking agents. Phenytoin is an antiepileptic drug that acts on sodium channels in mammal cells. Clinically detectable gingival overgrowth occurs as the principal side-effect of phenytoin therapy in approximately half of the treated patients. Although the number of patients being treated with this drug is increasing, not all patients on phenytoin medication develop gingival overgrowth. Chronic periodontitis exacerbates the diagnosis of gingival overgrowth associated with phenytoin. Gingival overgrowth presents major problems for the maintenance of oral hygiene. Increased swelling and disfiguration of gingiva also elevate the risk of infections and inflammatory complications in patients. Additional ramifications of gingival overgrowth occur difficult orthodontic treatment. Orthodontic treatment could contribute to the pathogenesis of this side effect. Tumor necrosis factor (TNF)-α is an inflammatory cytokine that induces celThe Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs

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苯妥英对hgf中基质金属蛋白酶-3生成的影响

药物诱导的牙龈过度生长是抗凝血剂、钙调磷酸酶抑制剂和钙通道阻滞剂的一种毁容副作用。苯妥英是一种抗癫痫药物，作用于哺乳动物细胞中的钠通道。临床上可检测到的牙龈过度生长是苯妥英治疗的主要副作用，在大约一半的治疗患者中发生。尽管接受这种药物治疗的患者数量正在增加，但并非所有接受苯妥英药物治疗的患者都会出现牙龈过度生长。慢性牙周炎加剧了与苯妥英相关的牙龈过度生长的诊断。牙龈过度生长是维持口腔卫生的主要问题。牙龈肿胀和变形的增加也增加了患者感染和炎症并发症的风险。牙龈过度生长的其他后果是难以进行正畸治疗。正畸治疗可能是这一副作用的发病机制之一。肿瘤坏死因子(TNF)-α是一种诱导细胞的炎性细胞因子。苯妥英对hgf中基质金属蛋白酶-3产生的影响

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of oral tissue engineering

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