Journal of Oral Pathology & Medicine最新文献

{"title":"Fragmented Thresholds, Unified Vision: Advancing Salivary Diagnostics for OSCC and OPMD","authors":"Hichem Moulahoum,&nbsp;Faezeh Ghorbanizamani","doi":"10.1111/jop.70141","DOIUrl":"10.1111/jop.70141","url":null,"abstract":"<div>\u0000 \u0000 <p>Salivary diagnostics for oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) have advanced significantly, yet clinical translation remains limited. A key barrier is the lack of harmonized thresholds for candidate biomarkers, ranging from cytokines to genetic and epigenetic markers, across studies. This variability undermines biosensor calibration, impedes algorithmic integration, and restricts the scalability of AI and eHealth tools. Paradoxically, saliva is well-established in systemic disease diagnostics but remains undervalued in oral oncology. Recent initiatives, such as COST Action CA21140—INTERCEPTOR, are working to intercept oral carcinogenesis through collaborative innovation in molecular diagnostics and surveillance technologies. This letter calls for standardized protocols, multicenter validation, and digital integration to unlock saliva's full potential as a frontline diagnostic fluid. By addressing biomarker variability and embracing cross-sector collaboration, the field can move toward clinically actionable, digitally enabled solutions for early detection and monitoring of OSCC and OPMD.</p>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"729-731"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Malignant Transformation in Patients With Oral Lichen Planus or Lichenoid Lesions: A Retrospective Study of 323 Patients With a Minimum of 5-Year Follow-Up","authors":"Mari Vehviläinen,&nbsp;Tuomas Selander,&nbsp;Tuula Salo,&nbsp;Maria Siponen","doi":"10.1111/jop.70139","DOIUrl":"10.1111/jop.70139","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To estimate the risk for oral squamous cell carcinoma (OSCC) among patients with oral lichen planus (OLP) or lichenoid lesions (OLL) and the possible risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Two hundred thirty-nine OLP and 84 OLL patients diagnosed between years 1982 and 2017 were followed up to December 2023, diagnosis of an OSCC, or death. Potential demographic and clinical risk factors were compared, and a Cox proportional-hazards model was used to investigate associations between time to OSCC onset and variables of interest.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Six OLP patients (2.5%; three females), in a mean follow-up of 17.5 years, and six OLL patients (7.1%; three females), in a mean follow-up of 13.8 years, developed OSCC. The annual MT rate was 0.14% for OLP and 0.5% for OLL. The mean time for OSCC development from OLP diagnosis was 11.4 years and from OLL diagnosis 12 years. Four OLP patients (67%; two females) developed OSCC in the mobile tongue, while in OLL patients OSCCs occurred at various sites. A potential association was observed between floor-of-mouth lesions in OLP and gingival or extraoral LP involvement in OLL and increased OSCC risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study confirms that both OLP and OLL patients are at a long-term risk of OSCC, and the risk is higher for OLL patients. Site-specific lesions in OLP and OLL were linked to increased OSCC risk, warranting confirmation in larger studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"784-792"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Career Prospects in Oral and Maxillofacial Pathology and Oral Medicine Among Final-Year Brazilian Dental Students: A Multi-institutional Study","authors":"Hélen Kaline Farias Bezerra,&nbsp;Fabrício Emanuel Soares de Oliveira,&nbsp;Daniella Reis Barbosa Martelli,&nbsp;Renato Assis Machado,&nbsp;Zêus Araújo Cunha,&nbsp;Fábio Ramoa Pires,&nbsp;Danyele Cambraia Franco de Souza,&nbsp;Silvia Regina de Almeida Reis,&nbsp;Giovanna Ribeiro Souto,&nbsp;Paulo Rogério Ferreti Bonan,&nbsp;Danyel Elias da Cruz Perez,&nbsp;Alan Roger dos Santos-Silva,&nbsp;Luiz Evaristo Ricci Volpato,&nbsp;Janete Dias Almeida,&nbsp;Hercílio Martelli-Júnior","doi":"10.1111/jop.70152","DOIUrl":"10.1111/jop.70152","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral and maxillofacial pathology (OP) and oral medicine (OM) are recognized specialties in Brazil and worldwide. Identifying dental students' intentions to pursue these fields and understanding the factors influencing their career choices may provide insights into the future of the specialties. Therefore, this study aimed to determine the intention of Brazilian final-year dental students to pursue the professional career in OP and OM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Final-year undergraduate dental students, from various public and private institutions in Brazil, were invited to voluntarily complete a self-administered and anonymous virtual questionnaire. The questionnaire consisted of 11 questions. The statistical analysis consisted of describing the absolute and relative numbers, and performing analytical statistics using Pearson's chi-squared test for categorical variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 358 students participated of the study. The majority were female (75.1%), with a mean age of 25.27 years, mainly from public universities (52%). The main careers pursued were restorative dentistry (39.1%), dental implantology (37.7%), prosthodontics (33%), and orofacial harmonization (31.3%). The main reasons for choosing specialization were to stand out in the profession and to perform better in the profession with better clinical outcomes. OM was reported as a career choice by 17% of students and OP by 7.5%. The motivations for such choice were vocation and influence from professors, colleagues, or family members.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results revealed a surprising and concerning finding: interest in the fields of OP and OM, which are fundamental for diagnosing and treating complex conditions of the oral cavity, was relatively low.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"848-855"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemidesmosomal Proteins in Oral Cancer Progression: An Immunohistochemical Study of Human and Mouse","authors":"Nikhil Mongia,&nbsp;Ali Ibrahim Mohammed,&nbsp;Michael McCullough,&nbsp;Rita Paolini,&nbsp;James A. Rickard,&nbsp;Massimo Mascolo,&nbsp;Silvia Varricchio,&nbsp;Lorraine A. O'Reilly,&nbsp;John Silke,&nbsp;Nicola Cirillo,&nbsp;Antonio Celentano","doi":"10.1111/jop.70145","DOIUrl":"10.1111/jop.70145","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease pathogenesis remains limited. This study evaluated the expression of key yet overlooked hemidesmosomal subunits, plectin isoform Ia (PIa), dystonin, and CD151 antigen, from normal tissue as well as tissue from hyperplasia, dysplasia, and OSCC in the human and murine oral cavity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Immunohistochemistry was performed on custom-built human tissue microarrays and 4-Nitroquinoline 1-oxide (4-NQO)-induced murine OSCC covering the spectrum of histological changes from normal to cancer. Quantitative image analysis of subunit expression was conducted using QuPath, with distinct analytical approaches applied to human tissues, including a refined method focusing on the basement membrane zone (BMZ) and adjacent basal epithelial layers, key sites of hemidesmosomal protein localization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant increase in expression of all three proteins was observed comparing normal tissue with hyperplasia, dysplasia, and OSCC in murine tissues, but not in humans. The expression of hemidesmosomal proteins increased across this spectrum, suggesting their potential as progression biomarkers in mice. A focused analysis of the basement membrane zone and adjacent basal epithelial layers in human tissues revealed a sustained baseline expression and a significant reduction in CD151 antigen in OSCC compared with control and high-grade dysplasia groups, as well as a significant reduction in dystonin expression in OSCC compared to high-grade dysplasia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings highlight the importance of biologically targeted region-of-interest selection when assessing hemidesmosomal protein expression in OSCC while demonstrating that BMZ-focused digital analysis provides a more informative approach for exploratory evaluation of heterogeneous human tissues alongside progression-associated patterns observed in a murine model.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"822-836"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Implementation of a Three-Year Postgraduate Curriculum for Oral Medicine Specialist Training in Australasia: A Framework From the Oral Medicine Academy of Australasia","authors":"Sue-Ching Yeoh,&nbsp;Michael McCullough,&nbsp;Ajith Polonowita,&nbsp;Maryam Jessri,&nbsp;Ramesh Balasubramaniam","doi":"10.1111/jop.70171","DOIUrl":"10.1111/jop.70171","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Oral Medicine is that specialist branch of dentistry concerned with the diagnosis, prevention, and predominantly non-surgical management of medically-related disorders and conditions affecting the oral and maxillofacial region, in particular oral mucosal disease and orofacial pain, as well as the oral health care of medically complex patients. Published national curricula for postgraduate Oral Medicine training exist in the United Kingdom (UK General Dental Council, 2010; revised 2023) and the United States (American Academy of Oral Medicine competency framework, 2015), and an international competency consensus was established by the Sixth World Workshop on Oral Medicine (2015). Despite this international momentum, no equivalent nationally published, competency-aligned postgraduate curriculum has been established for the Australasian region. This manuscript describes the development and structure of a contemporary 3-year Doctor of Clinical Dentistry (DClinDent) curriculum for Oral Medicine specialist training, developed by the Oral Medicine Academy of Australasia (OMAA) and aligned with the OMAA Essential Competencies (2026).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The curriculum was developed through a joint collaboration of all program convenors and heads of training of DClinDent (Oral Medicine) programs in Australia and New Zealand, together with the OMAA Curriculum Working Group, informed by the OMAA Essential Competencies (2026), benchmarked against the UK GDC Oral Medicine Specialty Training Curriculum (2023) and the internationally validated competencies from the Sixth World Workshop on Oral Medicine (2015), and structured according to a spiral learning framework. The curriculum was endorsed by the OMAA Credentialing and Peer Review Subcommittee in 2026. The program is divided into three progressive phases: Foundations (Year 1), Development (Year 2), and Consolidation (Year 3).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The curriculum encompasses five competency domains—Professionalism; Communication and Social Skills; Critical Thinking; Scientific and Clinical Knowledge; and Patient Care—mapped across all 3 years. The integration of cultural awareness and safety is an important feature across all phases of the curriculum. Year 1 establishes core scientific, clinical, and professional foundations. Year 2 develops clinical expertise across all Oral Medicine domains with increasing diagnostic independence. Year 3 prepares trainees for autonomous specialist practice, including complex case management, research thesis completion, and professional leadership. Minimum clinical case targets, portfoli","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"732-746"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Sjögren's Disease and Cancer: Key Predictors From the Spanish Multicenter SjögrenSER-TRANS Cohort”","authors":"","doi":"10.1111/jop.70169","DOIUrl":"10.1111/jop.70169","url":null,"abstract":"&lt;p&gt;\u0000 \u0000 &lt;span&gt;O. Rusinovich-Lovgach&lt;/span&gt;, &lt;span&gt;Z. Plaza&lt;/span&gt;, &lt;span&gt;M. F. Castro&lt;/span&gt;, et al., “ &lt;span&gt;Sjögren's Disease and Cancer: Key Predictors From the Spanish Multicenter SjögrenSER-TRANS Cohort&lt;/span&gt;,” &lt;i&gt;Journal of Oral Pathology &amp; Medicine 55&lt;/i&gt;, &lt;span&gt;no. 5&lt;/span&gt; (&lt;span&gt;2026&lt;/span&gt;): &lt;span&gt;583&lt;/span&gt;–&lt;span&gt;590&lt;/span&gt;, https://doi.org/10.1111/jop.70123.\u0000 &lt;/p&gt;&lt;p&gt;The authors wish to acknowledge the investigators and collaborating centers of the SjögrenSER Group who participated in and contributed to the multicenter cohort study. Owing to an inadvertent error during the final publication process, their names and affiliations were omitted from the Acknowledgements section.&lt;/p&gt;&lt;p&gt;\u0000 &lt;b&gt;\"SJÖGRENSER Project Collaborative Group:&lt;/b&gt; The members of the SJÖGRENSER Project Collaborative Group include: Raúl Menor (Hospital General Jerez de la Frontera, Jerez de la Frontera), Beatriz Rodríguez (Hospital Universitario de Canarias, Santa Cruz de Tenerife), Ángel García Aparicio (Hospital Virgen de la Salud, Toledo), Francisco Javier López Longo (Hospital Gregorio Marañón, Madrid), Sara Manrique-Arija (Hospital Carlos Haya, Málaga), Jesús Alberto García Vadillo (Hospital de la Princesa, Madrid), Susana Gil Barato (Hospital General de Alicante, Alicante), Ruth López-González (Hospital Virgen de la Concha, Zamora), Francisco Javier Narváez (Hospital de Bellvitge, Barcelona), Carlos Galisteo (Hospital Parc-Taulí, Sabadell), Jorge González Martín (Hospital Madrid Norte Sanchinarro, Madrid), Esther Ruiz Lucea (Hospital de Basurto, Basurto), Antonio Naranjo, Celia Erausquin, Iñigo Rúa-Figueroa (Hospital Doctor Negrín, Las Palmas de Gran Canaria), Mónica Fernández Castro, Óscar Illera (Hospital Infanta Sofía, Madrid), Lurdes Romani (Hospital Virgen de las Nieves, Granada), Sheila Melchor (Hospital Doce de Octubre, Madrid), Begoña Moreira (Hospital de Sierrallana, Torrelavega), Enrique Raya (Hospital Clínico San Cecilio, Granada), Marina Rodríguez López, Coral Mouriño, José María Pego (Hospital de Meixoeiro, Vigo), Natalia Cid (Hospital de Valme, Sevilla), Enrique Júdez (Hospital de Albacete, Albacete), Clara Moriano (Hospital de León, León), Vicente Torrente (Hospital de L’Hospitalet, Hospitalet de Llobregat), Hèctor Corominas (Hospital Sant Joan Despí Moisès Broggi, Barcelona), Blanca García Magallón (Hospital Miguel Servet, Zaragoza), Carlos Guillén Astete (Hospital Ramón y Cajal, Madrid), Ivan Castellvi (Hospital San Pau y Santa Creu, Barcelona), Cristina Bohórquez (Hospital Príncipe de Asturias, Alcalá de Henares), Víctor Martínez-Taboada, Javier Loricera (Hospital Marqués de Valdecilla, Santander), Joaquín Belzunegui (Hospital de Donostia, Guipúzcoa), Alejandro Olivé (Hospital Germans Trias i Pujol, Badalona), José Rosas (Hospital Marina Baixa, Villajoyosa), José Luis Andreu (Hospital Universitario Puerta de Hierro Majadahonda, Madrid).\"&lt;/p&gt;&lt;p&gt;The authors apologize for this omission and thank al","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Prevalence of Oral Potentially Malignant Disorders: An Updated Systematic Review and Meta-Analysis","authors":"Nicole Lonni,&nbsp;Tulio Silva Rosa,&nbsp;Camilla Kammer Pereira,&nbsp;Gilberto Melo,&nbsp;Saman Warnakulasuriya,&nbsp;Eliete Neves Silva Guerra,&nbsp;Elena Riet Correa Rivero","doi":"10.1111/jop.70146","DOIUrl":"10.1111/jop.70146","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral potentially malignant disorders (OPMDs) represent a diverse group of mucosal disorders with varying risks of progression to oral cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This updated systematic review (SR) and meta-analysis (MA) estimated the global prevalence of histopathologically confirmed OPMDs, excluding oral lichen planus and lichenoid lesions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted using predefined eligibility criteria. A total of 108 studies were included, comprising 86 additional studies and 22 from a previous SR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall pooled prevalence of OPMDs was 4.67% (95% CI: 3.62–5.84). Prevalence of OPMDs was as follows: Asia (5.44%), followed by South America/Caribbean (5.21%), and Europe (4.89%). Considering OPMD cases, the proportion was higher among males (62.87%) and individuals aged ≥ 50 years (68.1%). Histopathological evidence of epithelial dysplasia was present in 46.21% of cases. Oral leukoplakia (OL), oral submucous fibrosis (OSMF), and actinic cheilitis (AC) emerged as the most prevalent lesions, with relevant differences considering the geographic regions. OL and OSMF were the most common OPMDs in Asia, while OL and AC predominated in South America/Caribbean, and in Europe OL remains the most frequently encountered OPMD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The global prevalence of OPMDs, estimated at approximately 5%, should be interpreted as a broad summary measure, given the substantial heterogeneity driven by regional variations possibly related to behavioral, biological, and/or environmental risk factors. Future preventive efforts should focus on the type of OPMD prevalent in the region/country. The heterogeneity across studies highlights the need for standardized, population-based studies using WHO nomenclature to better define the global burden.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"747-754"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Models of Oral Epithelial Dysplasia: A Systematic Review and Temporal Analysis","authors":"Zilefac Brian Ngokwe,&nbsp;Satutya Wicaksono,&nbsp;Michael McCullough,&nbsp;Antonio Celentano,&nbsp;Tami Yap","doi":"10.1111/jop.70149","DOIUrl":"10.1111/jop.70149","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck, associated with substantial morbidity and mortality worldwide. Oral epithelial dysplasia (OED) can precede OSCC, offering a critical window for preventive and therapeutic intervention. This review maps the historical and current landscape of in vitro and in vivo models of OED, providing insight into their strengths, limitations, and translational relevance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review and temporal analysis were conducted following PRISMA guidelines, with literature searches performed across Medline, EMBASE, EBM Reviews, and Web of Science.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 4009 records, 292 studies from 26 countries were included, yielding 307 models of OED. Only a minority of studies (17.4%) focused primarily on dysplasia as a precancerous condition. In vivo models predominated (88.9%), while in vitro systems were comparatively scarce and largely limited to 2D cultures. Organoid-based approaches were rarely reported, highlighting a gap in advanced model development. Reproducibility data were available for 125 studies (45.8%). The hamster emerged as the most frequently used animal [<i>n</i> = 96, 35%], and 4-nitroquinoline-1-oxide (4-NQO) remained the most common carcinogen, particularly in murine models. A strong sex bias was observed, with male animals heavily over-represented.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, models of OED remain under-represented and under-developed, particularly in comparison to innovations in other fields of cancer research. Despite the central role of OED in oral carcinogenesis, current models do not adequately reflect clinical diversity or exploit modern 3D and patient-derived technologies. This review provides a critical reference point to guide future studies toward more accurate, reproducible, and clinically relevant models, with the potential to advance prevention, early detection, and targeted therapies for OSCC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"755-773"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of miR-214-3p on Cisplatin Resistance in Oral Squamous Cell Carcinoma by Regulating Ferroptosis Through Targeting GPX4","authors":"Rongxia Zhang,&nbsp;Jing Zhang,&nbsp;Yongle Qiu,&nbsp;Alin Tian,&nbsp;Weiwei Yin,&nbsp;Nan Zhang,&nbsp;Yang Liu,&nbsp;Yunfang Bai","doi":"10.1111/jop.70138","DOIUrl":"10.1111/jop.70138","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Emerging evidence underscores the potential of ferroptosis as a promising therapeutic target in cancer. However, the role of microRNAs (miRNAs) in modulating ferroptosis sensitivity remains largely unexplored, particularly in the context of oral squamous cell carcinoma (OSCC) chemoresistance. This study was designed to investigate the role of miR-214-3p in regulating ferroptosis by targeting glutathione peroxidase 4 (GPX4) and its influence on cisplatin (DDP) resistance in OSCC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients diagnosed with OSCC and receiving DDP-based chemotherapy between February 2022 and February 2024 at our institution were included in this study. Expression levels of miR-214-3p and GPX4 were quantitatively assessed in DDP-sensitive versus DDP-resistant OSCC tissues and cell lines using qRT-PCR and Western blot. Cell viability, IC50 values, and apoptosis were evaluated using the CCK-8 assay and flow cytometry. Intracellular reactive oxygen species (ROS) and Fe&lt;sup&gt;2+&lt;/sup&gt; levels were measured to determine the status of ferroptosis. Bioinformatics prediction and dual-luciferase reporter assays confirmed the interaction between miR-214-3p and GPX4. In vivo xenograft models were utilized to investigate the impact of miR-214-3p on OSCC tumor growth.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;As an initial assessment of clinical relevance, miR-214-3p was significantly downregulated in DDP-resistant OSCC tissues and cells, whereas GPX4 expression was markedly upregulated. Overexpression of miR-214-3p substantially decreased cell viability, reduced the IC&lt;sub&gt;50&lt;/sub&gt; values of DDP, and promoted apoptosis in resistant cells. In comparison to parental cells, resistant cells demonstrated lower levels of ROS and Fe&lt;sup&gt;2+&lt;/sup&gt;. Overexpression of miR-214-3p or treatment with a ferroptosis inducer (Erastin) increased ROS and Fe&lt;sup&gt;2+&lt;/sup&gt; levels, an effect that was effectively reversed by a ferroptosis inhibitor (Ferrostatin-1). Bioinformatics analysis combined with luciferase reporter assays confirmed the direct binding of miR-214-3p to the 3′ untranslated region (UTR) of GPX4. The overexpression of miR-214-3p resulted in the downregulation of GPX4, whereas overexpression of GPX4 reversed the effects mediated by miR-214-3p. Additionally, the overexpression of miR-214-3p in xenograft models inhibited tumor growth, which was correlated with decreased GPX4 expression and increased sensitivity to DDP.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Our findings reveal a novel miR-214-3p/GPX4/ferroptosis axis in OSCC DDP resistance. miR-214-3p suppresses GPX4 to promote","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"793-804"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Significance of Tertiary Lymphoid Structures in Head and Neck Cancers: A Systematic Review and Meta-Analysis","authors":"Everton Freitas de Morais,&nbsp;Bruno Cesar da Costa,&nbsp;Antti Mäkitie,&nbsp;Ricardo D. Coletta,&nbsp;Alhadi Almangush","doi":"10.1111/jop.70151","DOIUrl":"10.1111/jop.70151","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Head and neck squamous cell carcinoma (HNSCC), particularly oral squamous cell carcinoma (OSCC), is associated with poor survival despite therapeutic advances. Tertiary lymphoid structures (TLSs) are emerging components of the tumor microenvironment, but their prognostic significance in HNSCC remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To systematically review and meta-analyze the prognostic impact of TLSs in HNSCC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed/MEDLINE, Scopus, ScienceDirect, and Embase were searched through August 2025. Eligible studies evaluated TLS presence, density, maturity, or spatial distribution in histologically confirmed HNSCC. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using fixed-effects models. Risk of bias and certainty of evidence were assessed using QUIPS and GRADE, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventeen studies involving more than 2309 patients were included. TLS-positive tumors were significantly associated with improved overall and disease-free survival (DFS) (<i>p</i> &lt; 0.001). Absence of TLSs was associated with worse overall survival (HR: 2.20, 95% CI: 1.74–2.78, <i>I</i>\u0000 ² = 26%) and poorer DFS (HR: 2.21, 95% CI: 1.49–3.28, <i>I</i>\u0000 ² = 0%). This adverse prognostic effect persisted in the OSCC subgroup (HR: 1.97, 95% CI: 1.42–2.73, <i>I</i>\u0000 ² = 28%). Beyond quantitative presence, TLS maturation and spatial distribution influenced prognosis, with mature intratumoral TLSs associated with more favorable outcomes. Moreover, emerging evidence suggests that TLSs may also predict response to immunotherapy, particularly immune checkpoint blockade.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TLSs are strong prognostic biomarkers in HNSCC. Their presence, maturity, and spatial context significantly influence survival, supporting their role in prognostic stratification and future therapeutic strategies. TLS maturity emerges as a promising feature for standardized scoring systems and should be further explored in future studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 7","pages":"774-783"},"PeriodicalIF":2.3,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}