Journal of Oral Pathology & Medicine最新文献

{"title":"Triptolide Treatment for Oral Squamous Cell Carcinoma by Regulating the LncRNA-MSTRG.24214.1/MiRNA-939-5p/LCN2 Axis","authors":"Siyan Chen,&nbsp;Zhengmiao Li,&nbsp;Menglin Hu,&nbsp;Yang Yu,&nbsp;Bing Liu,&nbsp;Wuliji Saiyin,&nbsp;Jichen Li","doi":"10.1111/jop.13625","DOIUrl":"10.1111/jop.13625","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although triptolide has demonstrated efficacy in treating oral squamous cell carcinoma (OSCC), its precise molecular mechanism remains unclear. This study investigated the mechanism underlying triptolide's action in lncRNA-mediated competing endogenous RNA (ceRNA) regulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The impact of triptolide on OSCC in vivo was validated using a xenograft tumor model. Whole-transcriptome sequencing and bioinformatics analysis were conducted to construct the lncRNA-miRNA-mRNA regulatory network. Relative gene and protein expression levels were confirmed using qRT-PCR and Western blot. Dual-luciferase assays were performed to assess target interactions, while cell proliferation was measured using CCK8 assays, and cell migration and invasion were evaluated via wound healing and transwell assays.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Triptolide markedly reduced proliferation, migration, and invasion in Cal27 and Tca8113 cells. After 22 days of triptolide treatment, the tumor volume of mice gradually shrank. This led to significant upregulation of cleaved Caspase-3 and Bax, alongside downregulation of Bcl-2. Transcriptome sequencing and bioinformatics analysis identified 266 differentially expressed mRNAs, 528 lncRNAs, and 85 miRNAs. Enhanced expression of lncRNA MSTRG.24214.1 and mRNA LCN2, along with reduced expression of miR-939-5p, was observed in the triptolide group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The lncRNA-miRNA-mRNA ceRNA network associated with triptolide's impact on OSCC was successfully established. Triptolide suppressed OSCC development and progression both in vitro and in vivo, potentially through modulation of the MSTRG.24214.1-miR-939-5p-LCN2 axis. These findings offer a solid foundation for future personalized triptolide-based therapeutic approaches.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 5","pages":"312-324"},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Royal Jelly as a Therapeutic Intervention in Medication-Related Osteonecrosis of the Jaw (MRONJ): An Animal Model Study","authors":"Cihan Topan,&nbsp;Suheyb Bilge,&nbsp;Ahmet Emin Demirbas,&nbsp;Gürkan Ağyüz,&nbsp;Ayça Kara","doi":"10.1111/jop.13627","DOIUrl":"10.1111/jop.13627","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To evaluate the efficacy of royal jelly in managing experimentally created MRONJ model in rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty rats were randomly allocated into control, bisphosphonate (BP), royal jelly (RJ), Treatment, and Preventive groups. A defect was created in the alveolar socket following tooth extraction in the mandible as a surgical procedure in all groups. Before surgery, RJ was administered orally to the RJ group. Zoledronic acid was administered intraperitoneally to induce osteonecrosis in BP, treatment, and preventive group rats. Treatment group rats received RJ orally post-surgery, while preventive group rats received it pre-surgery. Histological and radiographic evaluations were performed post-study completion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Micro-CT examinations demonstrated significantly improved values in RJ-received groups (RJ, treatment, and preventive) compared to BP and control groups (<i>p</i> &lt; 0.001). Immunohistochemical analysis revealed higher mean IL-1β and TNF-α levels in the BP group. The highest IL-1β difference was between BP and preventive groups (<i>p</i> &lt; 0.001). TNF-α expression levels in all RJ-received groups were comparatively close to those of the control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RJ enhances soft and hard tissue healing in MRONJ rat models, suggesting its potential as a therapeutic or preventive agent in osteonecrosis management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"232-240"},"PeriodicalIF":2.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Oral-Systemic Link: Controversies and Policy Implications","authors":"Nicola Cirillo","doi":"10.1111/jop.13619","DOIUrl":"10.1111/jop.13619","url":null,"abstract":"<div>\u0000 \u0000 <p>Oral health has never been more central to the political agenda than it is today, particularly in the context of broader health policy. However, there are important caveats to consider when assessing the oral-systemic nexus.</p>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"197-198"},"PeriodicalIF":2.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Need to Improve the Medical Subject Headings (MeSH) and the Excerpta Medica Tree (EMTREE) Thesauri to Perform Systematic Review on Oral Potentially Malignant Disorders","authors":"Vito Carlo Alberto Caponio,&nbsp;Gennaro Musella,&nbsp;Mario Pérez-Sayáns,&nbsp;Lorenzo Lo Muzio,&nbsp;Rui Amaral Mendes,&nbsp;Rosa María López-Pintor","doi":"10.1111/jop.13616","DOIUrl":"10.1111/jop.13616","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite recent advancements in the understanding and classification of oral potentially malignant disorders (OPMD), their terminology remains inconsistent and heterogeneous throughout the scientific literature, thus affecting evidence-based decision-making relevant for clinical management of these disorders. Updating this classification represents a necessity to improve the indexing and retrieval of OPMD publications, in particular for systematic reviews and meta-analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Through a critical appraisal of the Medical Subject Headings (MeSH) and Excerpta Medica Tree (EMTREE) thesauri, we assessed gaps in the indexing for OPMD literature and propose improvements for enhanced categorisation and retrieval.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The present study identifies inconsistencies and limitations in the classification of these disorders across the major medical databases, which may be summarized in the following findings: a) The MeSH database lacks a dedicated subject heading for “oral potentially malignant disorders”; b) EMTREE indexing is incomplete, with only 5 out of 11 recognised OPMD having corresponding terms; c) Incoherent controlled vocabulary mappings hinder systematic literature retrieval.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>To ensure accurate evidence synthesis, the authors recommend searching both PubMed and Embase for OPMD studies. Moreover, the use of Embase’s PubMed query translator and Large Language Models, such as ChatGPT, may lead to retrieval biases due to indexing discrepancies, posing challenges for early-career researchers and students. We recommend introducing “oral potentially malignant disorders” as a standardised subject heading. Evidence-based medicine underpins clinical decision support systems, which rely on standardised clinical coding for reliable health information. Enhanced medical ontologies will facilitate structured clinical coding, ensuring interoperability and improving clinical decision support systems.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"241-247"},"PeriodicalIF":2.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Dysplasia the Sole Determinant of the Prognosis in Oral Potentially Malignant Disorders?","authors":"Pelin Güneri,&nbsp;Betul İlhan,&nbsp;Gaye Bolukbasi,&nbsp;Ali Veral,&nbsp;Joel B. Epstein","doi":"10.1111/jop.13617","DOIUrl":"10.1111/jop.13617","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The dynamic nature of oral epithelial dysplasia, involving both progression and regression over time, complicates prognostic predictions for the lesion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This paper addresses the intricacies of this challenge and advocates for a nuanced strategy. It proposes a comprehensive assessment, tailored to individual patients, incorporating genetic, behavioral, and medical factors to enhance the precision of lesion evaluation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"248-250"},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic Cigarettes Versus Combustible Cigarettes in Oral Squamous Cell Cancer Patients: A Systematic Review","authors":"Martín Pérez-Leal,&nbsp;Bouchra El Helou,&nbsp;Inés Roger","doi":"10.1111/jop.13618","DOIUrl":"10.1111/jop.13618","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Oral squamous cell carcinoma (OSCC) is associated with tobacco. In order to reduce the burden of smoking, e-cigarettes emerge as devices to aid cessation of tobacco addiction. However, growing evidence shows that e-cigarettes can lead to harmful effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objetives</h3>\u0000 \u0000 <p>The aim is to analyze the prevalence of combustible or electronic cigarette smoking in patients with a diagnosis of OSCC, analyze the prevalence of precancerous lesions in smokers of combustible or electronic cigarettes, and describe the location and differentiation of OSCC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methodology</h3>\u0000 \u0000 <p>PRISMA guidelines were followed. PubMed, Web of Science, and Scopus were used, introducing specific algorithms related to electronic and combustible cigarettes associated with OSCC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 400 potentially eligible articles, 15 met the inclusion criteria: 13 studies on combustible and 2 on e-cigarettes. Regarding combustible, the mean smoking prevalence in patients was 56.38% with a prevalence of precancerous lesions of 2.50%, among other parameters. For the e-cigarette group, the mean prevalence was 4.26% with a prevalence of precancerous lesions of 2.20%. Tongue and lower lip are common and frequent locations in both cigarettes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite certain limitations, developing OSCC is mostly associated with combustible cigarettes and to a lesser extent with e-cigarettes. Both cigarettes show a similar prevalence of precancerous lesions, with the tongue as a common and frequent location.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"199-206"},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Antisense Transcript-Mediated Regulation of HOXA10-AS in Oral Squamous Cell Carcinoma","authors":"Kanaka Sai Ram Padam,&nbsp;Satyajit Dey Pereira,&nbsp;Naveena A. N. Kumar,&nbsp;Raghu Radhakrishnan","doi":"10.1111/jop.13613","DOIUrl":"10.1111/jop.13613","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The oncogenic role of <i>HOXA10</i>-<i>AS</i> and <i>HOXA10</i> in cancer has been well documented. However, the epigenetic role of <i>HOXA10</i> and the natural antisense-mediated regulation of <i>HOXA10-AS</i> in oral squamous cell carcinoma progression is not understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 35 oral squamous cell carcinoma specimens and 35 adjacent normal clinical specimens were collected and categorized on the basis of their lymph node status. <i>HOXA10-AS</i> and <i>HOXA10</i> expression were analyzed using RT-qPCR. Methyl-capture sequencing was performed using lymph node-negative (<i>n</i> = 6) and lymph node-positive (<i>n</i> = 5) matched cases. The promoter activity of <i>HOXA10</i> was determined using a luciferase assay. ChIP-qPCR was performed to determine histone mark localization in the distal promoter region of <i>HOXA10</i>. A protein–protein interaction network of genome-wide antisense targets was constructed using StringDB, and functional enrichment was performed using the R package ClusterProfiler. Transient siRNA-mediated transfection was performed to target specific exons of the <i>HOXA10-AS</i> gene, followed by subsequent cell proliferation, cell cycle, and cell migration assays and validation of cancer signaling pathways through western blotting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>\u0000 <i>HOXA10-AS</i> and its antisense target <i>HOXA10</i> were significantly overexpressed in the lymph node-positive samples. The transcriptionally active distal promoter of <i>HOXA10</i> consists of a constitutively unmethylated CpG island region (CUR). H3K4me3, H3K27ac, and H3K27me3 histone mark deposition at the adjacent methylated loci of the distal promoter suggest the nature of euchromatin-driven regulation. Genome-wide mapping revealed 11 potential targets of <i>HOXA10</i>-<i>AS</i>. Targeted specific knockdown of <i>HOXA10</i>-<i>AS</i> exons significantly reduced the expression of <i>HOXA10</i> and deregulated its downstream targets, contributing to decreased cell cycle progression and epithelial-to-mesenchymal transition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>\u0000 <i>HOXA10</i>-<i>AS</i> regulates the expression of <i>HOXA10</i> through a natural antisense-mediated mechanism and is epigenetically regulated by constitutively unmethylated marks in the distally enhancing promoter of <i>HOXA10</i>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"217-231"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Diseases With Oral Malignant Potential: Need for Change to Inform Research, Policy, and Practice”","authors":"Rajiv S. Desai,&nbsp;Fareha Rashid,&nbsp;Madhura Patil,&nbsp;Shivani Singh","doi":"10.1111/jop.13615","DOIUrl":"10.1111/jop.13615","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"195-196"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Prognostic Features in Salivary Gland Adenoid Cystic Carcinoma: Critical Appraisal and Methodological Considerations","authors":"Carlos M. Ardila,&nbsp;Pradeep Kumar Yadalam","doi":"10.1111/jop.13614","DOIUrl":"10.1111/jop.13614","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"193-194"},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Y-27632 Suppresses the Growth and Migration of Oral Squamous Cell Carcinoma, but Upregulates Autophagy by Suppressing mTOR Effectors","authors":"Jie Wen,&nbsp;Yunhan Sun,&nbsp;Li Ma,&nbsp;Tingjian Zu,&nbsp;Na Wang,&nbsp;Tianqi Zhang,&nbsp;Jin Liang,&nbsp;Yulei Zhang,&nbsp;Haoyang Lu,&nbsp;Yihua Wu,&nbsp;Shizhou Zhang","doi":"10.1111/jop.13603","DOIUrl":"10.1111/jop.13603","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Rho-associated protein kinase (ROCK) inhibitor Y-27632 is a potential immunotherapeutic agent for cancer treatment. Y-27632 blocks the growth and migration of oral squamous cell carcinoma (OSCC) CAL-27 cells. However, detailed studies on the underlying mechanisms have not yet been reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We investigated the effects of Y-27632 on the proliferation, migration, and invasion of OSCC cells (CAL-27, SCC-4, and SCC-9) using the Cell Counting Kit-8 assay, ethynyl-2′-deoxyuridine staining, cell scratch, and transwell assay in vitro. Next, ROCK1/2 was knocked down using siRNA to confirm that the effects of Y-27632 were mediated by the inhibition of ROCK activity. A xenograft mouse model was used to verify the effects of Y-27632 in vivo. The mechanisms underlying Y-27632-induced tumor suppression were detected using western blotting and qRT-PCR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our data demonstrated that Y-27632 potently inhibited OSCC cells (CAL-27, SCC-4, and SCC-9) by inhibiting ROCK activity. In vivo assays confirmed that Y-27632 suppressed OSCC growth by reducing cell proliferation. Biochemical assays demonstrated that Y-27632 inactivated the AKT pathway, and treatment with SC79, an AKT activator, rescued the cell growth and migration inhibition elicited by Y-27632. Further investigation revealed that Y-27632 enhanced autophagy by suppressing the AKT/mTOR pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study demonstrated that Y-27632 significantly suppressed the growth and migration of OSCC cells and upregulated autophagy via the AKT/mTOR pathway, thus providing a potential therapeutic drug for patients with OSCC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 4","pages":"207-216"},"PeriodicalIF":2.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}