Journal of Oral Pathology & Medicine最新文献

{"title":"The Need to Improve the Medical Subject Headings (MeSH) and the Excerpta Medica Tree (EMTREE) Thesauri to Perform Systematic Review on Oral Potentially Malignant Disorders.","authors":"Vito Carlo Alberto Caponio, Gennaro Musella, Mario Pérez-Sayáns, Lorenzo Lo Muzio, Rui Amaral Mendes, Rosa María López-Pintor","doi":"10.1111/jop.13616","DOIUrl":"https://doi.org/10.1111/jop.13616","url":null,"abstract":"<p><strong>Background: </strong>Despite recent advancements in the understanding and classification of oral potentially malignant disorders (OPMD), their terminology remains inconsistent and heterogeneous throughout the scientific literature, thus affecting evidence-based decision-making relevant for clinical management of these disorders. Updating this classification represents a necessity to improve the indexing and retrieval of OPMD publications, in particular for systematic reviews and meta-analysis.</p><p><strong>Methods: </strong>Through a critical appraisal of the Medical Subject Headings (MeSH) and Excerpta Medica Tree (EMTREE) thesauri, we assessed gaps in the indexing for OPMD literature and propose improvements for enhanced categorisation and retrieval.</p><p><strong>Results: </strong>The present study identifies inconsistencies and limitations in the classification of these disorders across the major medical databases, which may be summarized in the following findings: a) The MeSH database lacks a dedicated subject heading for \"oral potentially malignant disorders\"; b) EMTREE indexing is incomplete, with only 5 out of 11 recognised OPMD having corresponding terms; c) Incoherent controlled vocabulary mappings hinder systematic literature retrieval.</p><p><strong>Conclusion: </strong>To ensure accurate evidence synthesis, the authors recommend searching both PubMed and Embase for OPMD studies. Moreover, the use of Embase's PubMed query translator and Large Language Models, such as ChatGPT, may lead to retrieval biases due to indexing discrepancies, posing challenges for early-career researchers and students. We recommend introducing \"oral potentially malignant disorders\" as a standardised subject heading. Evidence-based medicine underpins clinical decision support systems, which rely on standardised clinical coding for reliable health information. Enhanced medical ontologies will facilitate structured clinical coding, ensuring interoperability and improving clinical decision support systems.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Dysplasia the Sole Determinant of the Prognosis in Oral Potentially Malignant Disorders?","authors":"Pelin Güneri, Betul İlhan, Gaye Bolukbasi, Ali Veral, Joel B Epstein","doi":"10.1111/jop.13617","DOIUrl":"https://doi.org/10.1111/jop.13617","url":null,"abstract":"<p><strong>Background: </strong>The dynamic nature of oral epithelial dysplasia, involving both progression and regression over time, complicates prognostic predictions for the lesion.</p><p><strong>Objective: </strong>This paper addresses the intricacies of this challenge and advocates for a nuanced strategy. It proposes a comprehensive assessment, tailored to individual patients, incorporating genetic, behavioral, and medical factors to enhance the precision of lesion evaluation.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic Cigarettes Versus Combustible Cigarettes in Oral Squamous Cell Cancer Patients: A Systematic Review.","authors":"Martín Pérez-Leal, Bouchra El Helou, Inés Roger","doi":"10.1111/jop.13618","DOIUrl":"https://doi.org/10.1111/jop.13618","url":null,"abstract":"<p><strong>Introduction: </strong>Oral squamous cell carcinoma (OSCC) is associated with tobacco. In order to reduce the burden of smoking, e-cigarettes emerge as devices to aid cessation of tobacco addiction. However, growing evidence shows that e-cigarettes can lead to harmful effects.</p><p><strong>Objetives: </strong>The aim is to analyze the prevalence of combustible or electronic cigarette smoking in patients with a diagnosis of OSCC, analyze the prevalence of precancerous lesions in smokers of combustible or electronic cigarettes, and describe the location and differentiation of OSCC.</p><p><strong>Methodology: </strong>PRISMA guidelines were followed. PubMed, Web of Science, and Scopus were used, introducing specific algorithms related to electronic and combustible cigarettes associated with OSCC.</p><p><strong>Results: </strong>Of 400 potentially eligible articles, 15 met the inclusion criteria: 13 studies on combustible and 2 on e-cigarettes. Regarding combustible, the mean smoking prevalence in patients was 56.38% with a prevalence of precancerous lesions of 2.50%, among other parameters. For the e-cigarette group, the mean prevalence was 4.26% with a prevalence of precancerous lesions of 2.20%. Tongue and lower lip are common and frequent locations in both cigarettes.</p><p><strong>Conclusions: </strong>Despite certain limitations, developing OSCC is mostly associated with combustible cigarettes and to a lesser extent with e-cigarettes. Both cigarettes show a similar prevalence of precancerous lesions, with the tongue as a common and frequent location.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Antisense Transcript-Mediated Regulation of HOXA10-AS in Oral Squamous Cell Carcinoma.","authors":"Kanaka Sai Ram Padam, Satyajit Dey Pereira, Naveena A N Kumar, Raghu Radhakrishnan","doi":"10.1111/jop.13613","DOIUrl":"https://doi.org/10.1111/jop.13613","url":null,"abstract":"<p><strong>Background: </strong>The oncogenic role of HOXA10-AS and HOXA10 in cancer has been well documented. However, the epigenetic role of HOXA10 and the natural antisense-mediated regulation of HOXA10-AS in oral squamous cell carcinoma progression is not understood.</p><p><strong>Methods: </strong>A total of 35 oral squamous cell carcinoma specimens and 35 adjacent normal clinical specimens were collected and categorized on the basis of their lymph node status. HOXA10-AS and HOXA10 expression were analyzed using RT-qPCR. Methyl-capture sequencing was performed using lymph node-negative (n = 6) and lymph node-positive (n = 5) matched cases. The promoter activity of HOXA10 was determined using a luciferase assay. ChIP-qPCR was performed to determine histone mark localization in the distal promoter region of HOXA10. A protein-protein interaction network of genome-wide antisense targets was constructed using StringDB, and functional enrichment was performed using the R package ClusterProfiler. Transient siRNA-mediated transfection was performed to target specific exons of the HOXA10-AS gene, followed by subsequent cell proliferation, cell cycle, and cell migration assays and validation of cancer signaling pathways through western blotting.</p><p><strong>Results: </strong>HOXA10-AS and its antisense target HOXA10 were significantly overexpressed in the lymph node-positive samples. The transcriptionally active distal promoter of HOXA10 consists of a constitutively unmethylated CpG island region (CUR). H3K4me3, H3K27ac, and H3K27me3 histone mark deposition at the adjacent methylated loci of the distal promoter suggest the nature of euchromatin-driven regulation. Genome-wide mapping revealed 11 potential targets of HOXA10-AS. Targeted specific knockdown of HOXA10-AS exons significantly reduced the expression of HOXA10 and deregulated its downstream targets, contributing to decreased cell cycle progression and epithelial-to-mesenchymal transition.</p><p><strong>Conclusion: </strong>HOXA10-AS regulates the expression of HOXA10 through a natural antisense-mediated mechanism and is epigenetically regulated by constitutively unmethylated marks in the distally enhancing promoter of HOXA10.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Diseases With Oral Malignant Potential: Need for Change to Inform Research, Policy, and Practice\".","authors":"Rajiv S Desai, Fareha Rashid, Madhura Patil, Shivani Singh","doi":"10.1111/jop.13615","DOIUrl":"https://doi.org/10.1111/jop.13615","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Prognostic Features in Salivary Gland Adenoid Cystic Carcinoma: Critical Appraisal and Methodological Considerations.","authors":"Carlos M Ardila, Pradeep Kumar Yadalam","doi":"10.1111/jop.13614","DOIUrl":"https://doi.org/10.1111/jop.13614","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Y-27632 Suppresses the Growth and Migration of Oral Squamous Cell Carcinoma, but Upregulates Autophagy by Suppressing mTOR Effectors.","authors":"Jie Wen, Yunhan Sun, Li Ma, Tingjian Zu, Na Wang, Tianqi Zhang, Jin Liang, Yulei Zhang, Haoyang Lu, Yihua Wu, Shizhou Zhang","doi":"10.1111/jop.13603","DOIUrl":"https://doi.org/10.1111/jop.13603","url":null,"abstract":"<p><strong>Background: </strong>The Rho-associated protein kinase (ROCK) inhibitor Y-27632 is a potential immunotherapeutic agent for cancer treatment. Y-27632 blocks the growth and migration of oral squamous cell carcinoma (OSCC) CAL-27 cells. However, detailed studies on the underlying mechanisms have not yet been reported.</p><p><strong>Methods: </strong>We investigated the effects of Y-27632 on the proliferation, migration, and invasion of OSCC cells (CAL-27, SCC-4, and SCC-9) using the Cell Counting Kit-8 assay, ethynyl-2'-deoxyuridine staining, cell scratch, and transwell assay in vitro. Next, ROCK1/2 was knocked down using siRNA to confirm that the effects of Y-27632 were mediated by the inhibition of ROCK activity. A xenograft mouse model was used to verify the effects of Y-27632 in vivo. The mechanisms underlying Y-27632-induced tumor suppression were detected using western blotting and qRT-PCR.</p><p><strong>Results: </strong>Our data demonstrated that Y-27632 potently inhibited OSCC cells (CAL-27, SCC-4, and SCC-9) by inhibiting ROCK activity. In vivo assays confirmed that Y-27632 suppressed OSCC growth by reducing cell proliferation. Biochemical assays demonstrated that Y-27632 inactivated the AKT pathway, and treatment with SC79, an AKT activator, rescued the cell growth and migration inhibition elicited by Y-27632. Further investigation revealed that Y-27632 enhanced autophagy by suppressing the AKT/mTOR pathway.</p><p><strong>Conclusion: </strong>Our study demonstrated that Y-27632 significantly suppressed the growth and migration of OSCC cells and upregulated autophagy via the AKT/mTOR pathway, thus providing a potential therapeutic drug for patients with OSCC.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The FUS/COL11A1/ZEB1 Axis Contributes to the Development of Oral Squamous Cell Carcinoma","authors":"Tianyuan Zhou,&nbsp;Shuang Liu,&nbsp;Lixin Shi,&nbsp;Lei Zhang","doi":"10.1111/jop.13610","DOIUrl":"10.1111/jop.13610","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Oral squamous cell carcinoma (OSCC) is a common type of head and neck cancer with high metastasis rate and poor prognosis. This study aimed to explore the role of collagen type XI alpha 1 (<i>COL11A1</i>) and its detailed mechanisms in OSCC progression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Quantitative reverse transcription polymerase chain reaction (RT-qPCR) analysis was used to measure the level of <i>COL11A1</i>, fused in sarcoma/translocated in liposarcoma (<i>FUS</i>) and zinc finger E-box binding homeobox 1 (<i>ZEB1</i>). The protein expression of COL11A1, E-cadherin, N-cadherin, FUS, and ZEB1 were detected using Western blot. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) and 5-Ethynyl-2′-deoxyuridine (EdU) staining assays were conducted to measure cell proliferation. Cell migration and invasion were evaluated via wound-healing assay and transwell migration and invasion assays, respectively. Moreover, epithelial mesenchymal transition (EMT) was determined via detecting the expression of EMT-related proteins, including E-cadherin and N-cadherin. RNA immunoprecipitation assay was conducted to evaluate the relationship between <i>ZEB1</i> and <i>COL11A1</i>. In vivo animal experiments were carried out to explore the role of <i>COL11A1</i> in OSCC mice, and immunohistochemistry assay was performed to detect the level of <i>ZEB1</i> and EMT-related proteins in tumor tissues from mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>\u0000 <i>COL11A1</i> was augmented in OSCC tissues and cells. <i>COL11A1</i> knockdown significantly inhibited cell proliferation, migration, invasion, and EMT in OSCC cells. <i>FUS</i> was increased in OSCC tissues. <i>FUS</i> stabilized the mRNA level of <i>COL11A1</i> and positively regulated the protein expression of COL11A1. <i>ZEB1</i> was highly expressed in OSCC tissues, and <i>COL11A1</i>directly targeted <i>ZEB1</i>. The inhibition effects of <i>COL11A1</i> knockdown on cell proliferation, invasion, migration, and EMT were reversed by <i>ZEB1</i> overexpression in OSCC cells. Additionally, <i>COL11A1</i> depletion markedly repressed tumor growth through decreasing <i>ZEB1</i> expression in vivo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>\u0000 <i>FUS</i> stabilized <i>COL11A1</i> to promote the malignant progression of OSCC via regulating <i>ZEB1</i> expression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 3","pages":"182-191"},"PeriodicalIF":2.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Ki-67 in the Invasive Zone of Oral Squamous Cell Carcinoma","authors":"Ke Li,&nbsp;Shuai Wang,&nbsp;Zihui Li,&nbsp;Qiuya Yu,&nbsp;Lingyun Liu,&nbsp;Fuyan Li,&nbsp;Lei Zhang,&nbsp;Guowen Sun,&nbsp;Yanhong Ni","doi":"10.1111/jop.13608","DOIUrl":"10.1111/jop.13608","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The molecular profile of cells within the tumor invasive zone, where tumor cells interact with surrounding non-tumor cells, plays a crucial role in defining tumor malignant characteristics, such as the pattern of invasion (POI). Therefore, evaluating the diagnostic value of the proliferation index molecule, Ki-67, in both tumor cells and adjacent non-tumor cells at the invasive zone with different POIs, holds significant clinical importance for oral squamous cell carcinoma (OSCC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 133 primary OSCC samples, and the spatial pattern of Ki-67 in the tumor invasive zone was analyzed by immunohistochemistry (IHC). The prognostic value of tumor cells and stroma proliferative capacity in different POIs were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ki-67 was widely expressed in tumor cells and stroma cells within the invasive zone, and cells in high-invasiveness POIs exhibit higher proliferation. Elevated Ki-67 expression in tumor cells was associated with poor overall survival (OS) and disease-free survival (DFS) in patients, which is independent of POIs. In our study, we identified the expression level of Ki-67 in tumor cells across high-invasiveness POIs as an independent risk factor for OS and DFS in OSCC patiens. Additionally, Ki-67 expression in surrounding non-tumor cells did not significantly correlate with patient survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The remarkable proliferation characteristic of tumor cells in high-invasiveness POIs of OSCC tumors plays a crucial role in the prognosis of patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 3","pages":"173-181"},"PeriodicalIF":2.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiologic Specific Growth Rate of Ameloblastomas: A Clinicopathological Correlation","authors":"Chané Smit,&nbsp;Liam Robinson,&nbsp;Marlene B. van Heerden,&nbsp;Pieter W. Meyer,&nbsp;Felipe P. Fonseca,&nbsp;Willie F. P. van Heerden,&nbsp;André Uys","doi":"10.1111/jop.13611","DOIUrl":"10.1111/jop.13611","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The study aimed to assess the radiologic-specific growth rate of ameloblastomas, evaluating potential associations with demographics, radiologic features, histopathologic variants and proliferation indices. The results of this study will hopefully establish if any clinical or histopathologic features can elude fast-growing ameloblastomas.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients presenting with multiple radiographs before surgical intervention due to various healthcare constraints or patient factors were included in the study. The measurements from each radiograph included the lesion's length, height, width and amount of expansion in these dimensions. Furthermore, the circumference of the lesion was measured in sagittal, coronal and axial planes. The radiologic-specific growth rate was assessed by calculating the difference in measurements from the initial to follow-up radiographs divided by the duration between the visits to calculate the growth rate per year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The specific growth rate was analysed between age groups, histopathologic variants and Ki-67 values, with no statistically significant correlations found in all dimensions measured. A statistically significant faster growth (<i>p</i> = 0.04) was seen in females when measuring the mesial-distal length. When comparing radiologic features, ameloblastomas with loss of border demarcation, severe cortical destruction and tooth displacement demonstrated statistically significant faster growth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study found significant correlations with the growth rate of ameloblastomas, specifically in coronal dimensions, supporting the notion of buccal-lingual growth/expansion for which ameloblastomas are known.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 3","pages":"161-172"},"PeriodicalIF":2.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13611","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}