Journal of Oral Pathology & Medicine最新文献

{"title":"No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non-Smokers and Non-Drinkers.","authors":"F J Mulder, T F B Gielgens, E J de Ruiter, R de Bree, M F C M van den Hout, B Kremer, S M Willems, E J M Speel","doi":"10.1111/jop.70120","DOIUrl":"10.1111/jop.70120","url":null,"abstract":"<p><strong>Introduction: </strong>While the prevalence of microsatellite instability (MSI) is low in the whole head and neck squamous cell carcinoma (HNSCC) population, it has been suggested to be more prominent in tumors of non-smokers. Therefore, the goal of this study was to determine the presence of MSI in a cohort of well-defined HNSCC of non-smokers and non-drinkers (NSND).</p><p><strong>Methods: </strong>Clinical characteristics and tumor tissue of 119 NSND with HNSCC were retrospectively collected and analyzed for MLH1, PMS2, MSH2, and MSH6 protein expression on tissue microarrays (TMA). In case of negative staining for one of these mismatch repair proteins in the TMA cores, immunohistochemistry (IHC) was repeated on a whole slide section and additional molecular analyses were performed using polymerase chain reaction (PCR) and quantitative PCR (qPCR).</p><p><strong>Results: </strong>Two cases showed dubious loss of MSH2 expression, one of these with concurrent dubious loss of MSH6 on the TMA. However, MSH2 and MSH6 expression was retained on whole slide sections and PCR and qPCR analyses did not show any mutations, compatible with a microsatellite stable result.</p><p><strong>Conclusion: </strong>This study shows no single case with MSI in the NSND subgroup of HNSCC. Although a deficient DNA mismatch repair system is a predictive biomarker for response to immune checkpoint inhibitors, we found no evidence to support routine analysis of MSI in HNSCC, also not in the subgroup of NSND.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"611-615"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Putative Role of Mast Cells in Oral Leukoplakia-A Systematic Review and Meta-Analysis.","authors":"Nikita Kashyap, Achla Bharti, Mala Kamboj, Anjali Narwal, Anju Devi, Adarsh Kumar, Gitika Sharma","doi":"10.1111/jop.70100","DOIUrl":"10.1111/jop.70100","url":null,"abstract":"<p><strong>Background: </strong>Mast cells are believed to contribute to inflammation-associated carcinogenesis, but their specific role in the development of oral leukoplakia (OLK) and its progression to oral squamous cell carcinoma (OSCC) remains uncertain. This systematic review and meta-analysis aimed to determine whether mast cell density differs among normal oral mucosa (NOM), OLK, and OSCC.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in PubMed, Scopus, Web of Science and Embase along with Google Scholar for studies that reported mast cell counts in OLK, OSCC, and NOM published up to September 30, 2025. Data were extracted, and the mean difference was calculated. Risk of bias was assessed using the JBI critical appraisal tool, and meta-analysis was performed using MetaAnalysisOnline.com.</p><p><strong>Results: </strong>Thirty-four studies were included for qualitative and 26 contributed to quantitative data synthesis. The studies opined that mast cells were highest in OSCC, followed by OLK and NOM. Mast cell density was higher in OSCC than in OLK; however, the difference was not significant. A random-effects model revealed a significant increase in mast cell density in OLK than NOM (p < 0.0001) and OSCC than NOM (p = 0.0055); however, when OLK was compared with OSCC, the difference was not significant (p = 0.2865).</p><p><strong>Conclusion: </strong>The existing data validate that mast cells were increased in oral leukoplakia, indicating their potential involvement in early oral carcinogenesis; however, future studies focusing on the prognostic value of mast cells in oral leukoplakia are warranted.</p><p><strong>Trial registration: </strong>PROSPERO number: CRD42024533723.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"555-566"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duplicated, Translocated Upper Lip and Maxilla: An Extremely Rare Congenital Craniofacial Anomaly With Novel Genetic Findings.","authors":"Chen-Xi Li, Di-Shu Huang, Zhong-Cheng Gong","doi":"10.1111/jop.70117","DOIUrl":"10.1111/jop.70117","url":null,"abstract":"<p><strong>Importance: </strong>Diprosopus is an exceedingly rare craniomaxillofacial dysmorphosis that is considered a subgroup of conjoined twins. This phenotype encompasses a broad spectrum of duplications ranging from partial structures to complete dicephalus. The embryogenesis and mechanism of disease are not well understood. The objective of this investigation was to describe a case of partial dentofacial duplication and to discuss the possible etiology with novel genetic insights thereof.</p><p><strong>Observations: </strong>A newborn Kazakh boy was referred to the First Affiliated Hospital of Xinjiang Medical University because of a maxillary mass detected on prenatal imaging. Physical examination revealed a unilateral cleft lip and a soft lump around 2.5 cm in diameter with the appearance of an accessory upper lip. He underwent two surgical procedures at 11 months and 4 years of age for definitive treatment. He demonstrated favorable recovery outcomes, maintaining normal speech and oral intake capabilities during long-term follow-up.</p><p><strong>Conclusions and relevance: </strong>Our preliminary findings and comprehensive literature review suggest that mutations in the PAX7 gene could contribute to the pathogenesis of craniofacial duplication. This hypothesis establishes a previously unrecognized association between specific genetic alterations and the clinical manifestations of this condition, potentially offering a molecular foundation for prenatal diagnostic approaches. The present case provides more profound insights into the disease mechanisms compared to prior reports. Further validation through basic scientific investigations and clinical studies, incorporating comprehensive genetic analyses, will be essential to substantiate this proposed mechanism.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"605-610"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning for Predicting Malignant Transformation in Actinic Cheilitis: A Prognostic Support System Based on Demographic and Clinical Descriptors.","authors":"Ivan José Correia-Neto, Alex Franco da Costa, Anna Luíza Damaceno Araújo, Cristina Saldivia-Siracusa, Raísa Sales de Sá, Thiago Martini Pereira, Pablo Agustin Vargas, Alan Roger Santos-Silva, Luiz Paulo Kowalski, Matheus Cardoso Moraes, Marcio Ajudarte Lopes","doi":"10.1111/jop.70113","DOIUrl":"10.1111/jop.70113","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop and evaluate Machine Learning models to predict the malignant transformation (MT) in patients with actinic cheilitis (AC).</p><p><strong>Methods: </strong>Three hundred forty patients diagnosed with AC (322 in the no MT group, and 18 in the MT group) were carefully documented. The study used the Adaptive Synthetic Sampling to adaptively balance the dataset (322 in the no MT group and 319 in the MT group). Four supervised Machine Learning classifiers (Random Forest, Xtreme Gradient Boosting, Multilayer Perceptron, and Support Vector Machine) were trained and tested using 5-fold cross-validation to correlate inputs (clinical descriptors and demographic data) to outputs (MT). SHAP values were used to identify the most influential predictors of MT.</p><p><strong>Results: </strong>The Xtreme Gradient Boosting model stood out, achieving 96.72% accuracy, 96.87% sensitivity, 96.57% specificity, 96.61% precision, 96.73% of F1-Score, and 0.9498 AUC. Multilayer Perceptron showed the best sensitivity (98.44%), and Random Forest presented comparable results. In contrast, Support Vector Machine underperformed, with higher values of false negatives and false positives. Across models, ulceration, multifocality, and long-standing lesions were the strongest predictors of MT, while small, asymptomatic, or solitary lesions were associated with lower risk.</p><p><strong>Conclusion: </strong>The results revealed promising performance metrics for Xtreme Gradient Boosting and Multilayer Perceptron suggesting their potential value as tools in a support system for monitoring AC. Additionally, synthetic data proved constructive in training, enhancing the models' robustness and predictive capabilities.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"574-582"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Risk of Cardiometabolic Conditions Among Patients With Oral Candidiasis: A Global Large-Scale Population-Based Study.","authors":"Samer Kridin, Hala Karayanni Matanis, Idan Redenski, Mariam Abdelghaffar, Samer Srouji, Khalaf Kridin","doi":"10.1111/jop.70105","DOIUrl":"10.1111/jop.70105","url":null,"abstract":"<p><strong>Background: </strong>The cardiometabolic burden of oral candidiasis (OC) is yet to be thoroughly elucidated.</p><p><strong>Objective: </strong>To assess the risk of long-term cardiovascular and metabolic outcomes in patients with OC relative to those with two other common oral conditions: herpes simplex virus (HSV) infections and recurrent aphthous stomatitis (RAS).</p><p><strong>Methods: </strong>A global retrospective cohort study comprised two analyses comparing patients with OC to those with HSV and RAS. The study groups were compared regarding the risk of 11 different cardiovascular and four metabolic outcomes. Propensity score matching was performed to optimize inter-group comparability.</p><p><strong>Results: </strong>Relative to those with HSV infections, patients with OC were found to experience a higher risk of stroke (HR, 1.78; 95% CI, 1.65-1.92), sudden cardiac death (HR, 2.46; 95% CI, 2.14-2.82), congestive heart failure (CHF; HR, 1.92; 95% CI, 1.80-2.06), hypertension (HR, 1.56; 95% CI, 1.50-1.62), hyperlipidemia (HR, 1.18; 95% CI, 1.13-1.24), type-2 diabetes mellitus (DM; HR, 1.72; 95% CI, 1.63-1.81), and obesity (HR, 1.32; 95% CI, 1.27-1.38). Compared to RAS, OC demonstrated an elevated risk of myocardial infarction (HR, 1.47; 95% CI, 1.40-1.54), stroke (HR, 1.30; 95% CI, 1.25-1.36), pulmonary embolism (HR, 2.23; 95% CI, 2.11-2.35), peripheral vascular disease (HR, 1.35; 95% CI, 1.29-1.41), atrial fibrillation (HR, 1.61; 95% CI, 1.55-1.68), CHF (HR, 1.79; 95% CI, 1.73-1.86), hyperlipidemia (HR, 1.36; 95% CI, 1.33-1.40), DM (HR, 1.44; 95% CI, 1.40-1.48), and obesity (HR, 1.30; 95% CI,1.27-1.34).</p><p><strong>Conclusion: </strong>OC is associated with an elevated risk of cardiometabolic outcomes. Physicians managing patients with OC should be aware of these associations.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"539-545"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papilliferous Keratoameloblastoma (PKA): Is It a Different Clinicopathological Entity or Histological Subtype of Conventional Ameloblastoma?","authors":"Yet Ching Goh, Ronell Bologna-Molina, Kelly Magliocca, Willie van Heerden, Liam Robinson, Elizabeth Ann Bilodeau, Haizal Mohd Hussaini, Merva Soluk-Tekkesin, Madhu Shrestha, Marilena Vered, Akinyele Olumuyiwa Adisa, Jiang Li, Ricardo Santiago Gomez, Keith David Hunter, Wanninayake Mudiyanselage Tilakaratne","doi":"10.1111/jop.70115","DOIUrl":"10.1111/jop.70115","url":null,"abstract":"<p><strong>Background: </strong>Papilliferous keratoameloblastoma (PKA) is an exceptionally rare variant of conventional ameloblastoma, marked by papilliferous epithelial projections and prominent keratinization within an ameloblastomatous framework. Because of its rarity and overlap with other keratinizing odontogenic tumours, PKA is often overlooked and is not recognised in the current WHO classification. Limited awareness and inconsistent terminology contribute to diagnostic uncertainty and may affect clinical management.</p><p><strong>Objectives: </strong>This review critically analysed all published PKA cases to describe their clinical, radiographic and histopathological features, evaluating whether PKA should be regarded as a distinct clinicopathological entity or a histological subtype of conventional ameloblastoma.</p><p><strong>Materials and methods: </strong>A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was performed to identify all English-language reports of PKA. Extracted data included demographics, clinical presentation, radiographic findings, histopathology, treatment and outcomes. The information was synthesised and descriptively analysed.</p><p><strong>Results: </strong>Seven cases of PKA were included. Patients ranged from 18 to 76 years (mean age: 50.4 years), with a male predominance. All lesions involved the right mandible. Clinically, most patients presented with slow-growing mandibular swellings, occasionally accompanied by pain or mucosal changes. Radiographs most often show multilocular radiolucencies with buccolingual expansion or cortical perforation. Histopathology consistently reveals classic ameloblastomatous epithelium with squamous metaplasia, keratin pearl formation, and distinctive papilliferous projections lining cystic spaces.</p><p><strong>Conclusion: </strong>The uniform histopathological pattern observed across reported cases supports recognising PKA as a distinct histopathological subtype of conventional ameloblastoma. Its formal inclusion in odontogenic tumour classification appears justified, although further molecular and clinicopathological studies are needed to better define its biological behaviour.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"511-519"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of p16 ^INK4A Methylation With Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review and Meta-Analysis.","authors":"Rairam Fernandes de Aguiar, Denis Francisco Gonçalves de Oliveira, Lucas Moreira de Araújo, Khalil Fernandes Viana, Douglas Matheus Lima Farias, Joyce Magalhães de Barros, Filipe Nobre Chaves, Alexia Nathália Brígido Assef, Thâmara Manoela Marinho Bezerra, Sthefane Gomes Feitosa, Karuza Maria Alves Pereira","doi":"10.1111/jop.70119","DOIUrl":"10.1111/jop.70119","url":null,"abstract":"<p><strong>Introduction: </strong>Methylation of tumor-suppressor gene promoters, particularly p16 ^INK4A , is implicated in oral carcinogenesis. Although associations with oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) have been reported, no systematic review has examined these conditions while assessing evidence certainty. This review evaluated whether p16 ^INK4A promoter methylation is associated with OSCC and OPMD.</p><p><strong>Materials and methods: </strong>PubMed, Embase, Web of Science, Scopus, Livivo, and Google Scholar were searched. Studies were selected by title/abstract and then full-text review. Eligible studies investigated p16 ^INK4A methylation in OSCC or OPMD with comparator groups. Data were meta-analyzed using random-effects models to obtain pooled odds ratios (OR). Heterogeneity, publication bias, sensitivity analyses, and prediction intervals were assessed. Evidence certainty was rated using GRADE.</p><p><strong>Results: </strong>Twenty-four studies were included, comprising 1330 OSCC patients, 606 OPMD patients, and 681 healthy controls. Meta-analyses demonstrated a strong association between p16 ^INK4A methylation and OSCC when compared with healthy controls (OR = 11.59; 95% CI = 6.01-22.37; p < 0.0001), with surgical margins (OR = 3.24; 95% CI = 1.86-5.65; p < 0.0001) and with OPMD (OR = 3.72; 95% CI = 2.47-5.59; p < 0.0001). OPMD also showed increased methylation versus healthy controls (OR = 24.8; 95% CI = 7.4-83.14; p < 0.0001).</p><p><strong>Conclusions: </strong>p16 ^INK4A methylation is strongly associated with OSCC and OPMD; however, due to heterogeneity and low certainty of evidence, these findings should be interpreted cautiously. Further standardized, well-designed studies are needed to clarify the role of p16 ^INK4A methylation in oral carcinogenesis.</p><p><strong>Trial registration: </strong>International Prospective Register of Systematic Reviews (PROSPERO): CRD42023410477.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"591-600"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sjögren's Disease and Cancer: Key Predictors From the Spanish Multicenter SjögrenSER-TRANS Cohort.","authors":"Olga Rusinovich-Lovgach, Zulema Plaza, Mónica Fernández Castro, Carlos Sánchez-Piedra, José Rosas, Victor Martínez-Taboada, Alejandro Olivé, Raul Menor Almagro, Beatriz Rodrígez-Lozano, Angel Garcia-Aparicio, Francisco Javier Lopez Longo, Sara Manrique-Arija, Jesús Alberto Garcia-Vadillo, Susana Gil Barato, Ruth Lopez-Gonzalez, Javier Narvaez García, Carlos Galisteo Lencastre, Jorge Gonzalez-Martin, Fernando Alonso, Jose Luis Andreu","doi":"10.1111/jop.70123","DOIUrl":"10.1111/jop.70123","url":null,"abstract":"<p><strong>Objective: </strong>To identify key clinical and therapeutic predictors of malignancy in a well-characterized, multicenter Spanish cohort of patients with Sjögren's disease (SjD).</p><p><strong>Methods: </strong>A retrospective, cross-sectional study was conducted using data from the SjögrenSER-TRANS registry, a national cohort of 437 SjD patients from 33 Spanish hospitals who fulfilled the 2002 AECG classification criteria. Clinical, serological, and treatment-related variables were systematically collected. Descriptive statistics were used to summarize demographic and clinical characteristics. Bivariate analysis (chi-squared for categorical variables and t-tests for continuous variables) was performed to identify associations with malignancy (p < 0.05), followed by multivariate logistic regression to determine independent predictors.</p><p><strong>Results: </strong>Malignancy was identified in 30 patients (6.86%), with gynecological cancers (30%) and lymphomas (23.3%) being the most common types. Independent predictors of malignancy included older age (OR 1.042, 95% CI 1.007-1.079), glandular inflammation (OR 2.888, 95% CI 1.281-6.512), and rituximab use (OR 3.959, 95% CI 1.461-10.730).</p><p><strong>Conclusion: </strong>This study underscores the role of older age, glandular inflammation, and rituximab use as key risk factors for malignancy in SjD. However, the association with rituximab should be interpreted with caution, as indication bias cannot be ruled out. These findings emphasize the need for improved risk stratification and targeted surveillance strategies to facilitate early detection and enhance malignancy management in clinical practice. Prospective studies are warranted to refine monitoring protocols and optimize patient outcomes.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"583-590"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imbalance of Free Radicals and Antioxidants in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma: A Review.","authors":"Toniya Raut, Namrata G R Raut, Neetu Jain, Shashi Keshwar, Sunil Shrestha","doi":"10.1111/jop.70109","DOIUrl":"10.1111/jop.70109","url":null,"abstract":"<p><strong>Background: </strong>The dynamic interplay between reactive free radicals (FR) and antioxidants (AO) can lead to either redox homeostasis or oxidative stress. Disruption of redox balance contributes to oxidative stress, a key factor in the pathogenesis of various conditions, notably oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC). At low to moderate levels, FRs trigger adaptive mutations that initiate carcinogenesis and support neoplastic cell survival. In contrast, high concentrations of FRs exert cytotoxic effects, a mechanism exploited in radiotherapy and chemotherapy. Antioxidants counteract FRs, mitigating cellular damage-a benefit demonstrated in several clinical trials involving OPMDs. However, their efficacy in OSCC remains contentious.</p><p><strong>Methods and finding: </strong>This review explores the multifaceted roles of FRs and AOs in OPMD and OSCC, with emphasis on their contributions to carcinogenesis and therapeutic strategies. Tracking the FR-AO ratio during treatment may offer predictive insights into malignant transformation and facilitate early OSCC detection.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"520-531"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Molecular Insights of Human Papillomavirus in Dentigerous Cysts and Odontogenic Keratocysts: A Comparative Study.","authors":"Nelli Agbulut, Mualla Özcan","doi":"10.1111/jop.70118","DOIUrl":"10.1111/jop.70118","url":null,"abstract":"<p><strong>Background: </strong>No studies to date have examined human papillomavirus (HPV) positivity in both odontogenic keratocysts (OKCs) and dentigerous cysts (DCs) or performed HPV genotyping in these lesions. This research aims to compare HPV expression rates in DCs and OKCs to provide insight into the molecular behavior of OKCs.</p><p><strong>Methods: </strong>Forty DC and forty OKC cases were randomly selected and analyzed for HPV-DNA expression. Positive cases underwent HPV genotyping. Additionally an immunohistochemical staining for p16 was performed for each case.</p><p><strong>Results: </strong>Due to epithelial integrity loss or inflammation, 18 samples were excluded, leaving 32 DCs and 30 OKCs for evaluation. HPV was detected in five DC cases but absent in all OKC samples. The difference between DC and OKC groups was not statistically significant (p = 0.053). Genotyping identified HPV-16 in four cases and HPV-66 in one.</p><p><strong>Discussion: </strong>Despite OKCs' aggressive behavior, this study found no significant association between HPV and their pathogenesis. These findings suggest HPV is unlikely to contribute to OKC proliferation or recurrence, underscoring the need for larger studies to clarify its role in odontogenic cysts.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":"567-573"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}