Journal of Oral Pathology & Medicine最新文献

{"title":"Global Research Trends on the Links Between the Oral Microbiome and Cancer From 2014 to 2024: A Visualization Analysis.","authors":"Umar Pervaiz, Pervaiz Nabeel, Rui Zhao, Zhengbin Zhao, Yibao Zhang, Degui Wang","doi":"10.1111/jop.70000","DOIUrl":"https://doi.org/10.1111/jop.70000","url":null,"abstract":"<p><strong>Background: </strong>In recent years, noteworthy connections have been discovered between human wellness and microbiota. This study aims to outline the hotspots and trends in the links between the oral microbiome and cancer over the past 10 years from a bibliometric perspective.</p><p><strong>Methods: </strong>Reports on original research and literature reviews on the relationship between the oral microbiome and cancer from 2014 to 2024 were retrieved from the Web of Science Core Collection and PubMed databases. CiteSpace and VOSviewer were utilized to display the research patterns.</p><p><strong>Results: </strong>A bibliometric analysis was conducted on 4638 relevant publications, of which 3450 research articles and 1188 reviews were examined. China and the United States have contributed greatly to the research on the relationship between the oral microbiota and cancer, most of which were published in Frontiers in Microbiology, Frontiers in Cellular and Infection Microbiology, and International Journal of Molecular Sciences. The Chinese Academy of Sciences (107), Sichuan University (81), and Zhejiang University (79) are the most productive institutions. Zhou Xuedong, Hao Zhang, and Christian C. Abnet are the most recognized authors. Keyword co-occurrence revealed that the terms microbiome, oral microbiota, oral cancer, inflammatory diseases, probiotics, and dysbiosis are research hotspots in the past 10 years.</p><p><strong>Conclusions: </strong>The knowledge map provides a helpful visual representation of the main relevant topics in research conducted in the last 10 years on the relationship between the oral microbiome and cancer. The findings imply that oral squamous cell carcinoma, F. nucleatum, biomarkers, dysbiosis, and cancer treatment therapies have become popular topics in recent years.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TROP2 Expression in Salivary Gland Adenoid Cystic Carcinoma (ACC) According to Histologic Subtype: Therapeutic Implications.","authors":"Juliana Mota Siqueira, Yoshitsugu Mitani, Mario L Marques-Piubelli, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mutsumi Mitani, Giovanna Lopes Carvalho, Fabio Daumas Nunes, Leandro Luongo Matos, Shiaw-Yih Lin, Michael T Spiotto, Ehab Y Hanna, Daniel J McGrail, Adel K El-Naggar, Renata Ferrarotto","doi":"10.1111/jop.70008","DOIUrl":"https://doi.org/10.1111/jop.70008","url":null,"abstract":"<p><strong>Background: </strong>Adenoid cystic carcinoma (ACC) is a common salivary gland carcinoma with high recurrence and distant metastasis rates. Currently, there is no standard systemic treatment available. TROP2 is a transmembrane glycoprotein involved in the oncogenesis of several tumors that can be therapeutically targeted by a TROP2-antibody-drug conjugate (ADC). We aimed to characterize TROP2 expression in ACC and assess TROP2 as a potential therapeutic target.</p><p><strong>Methods: </strong>TROP2 immunohistochemistry was performed in a tissue microarray including 165 ACC of salivary gland. The tumors were grouped according to the histological pattern as non-solid, solid + non-solid, or solid. TROP2 protein expression in ACC cell lines was assessed and subjected to drug screening with TROP2-ADC.</p><p><strong>Results: </strong>TROP2 expression was high in 59%, moderate in 30%, weak in 8%, and negative in 3% of cases. TROP2 expression was significantly higher in non-solid compared with solid or solid + non-solid (p < 0.001). Notably, TROP2 expression was heterogenous among the dual cellular component, with TROP2 expression identified predominantly in the ductal and not in the myoepithelial cells. In vitro drug screening demonstrated that TROP2-ADC had selective anti-tumor effect in TROP2 expressing ACC cells.</p><p><strong>Conclusions: </strong>TROP2 expression is prevalent in ACC, particularly in the ductal cell component of the non-solid tumors. The pre-clinical drug screening findings provide a biological rationale for exploring TROP2 as a therapeutic target in TROP2-expressing ACC.</p><p><strong>Trial registration: </strong>clinicaltrials.gov: NCT05884320; NCI-2023-04260.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Cytological Methods in Early Detection of Oral Squamous Cell Carcinoma and Potentially Malignant Disorders: A Systematic Review and Meta-Analysis.","authors":"Hoda Tayebi-Hillali, Alejandro I Lorenzo-Pouso, Xabier Marichalar-Mendía, Pilar Gándara-Vila, Dolores Reboiras-López, Andrés Blanco-Carrión, Martina Coppini, Vito Carlo Alberto Caponio, Mario Pérez-Sayáns","doi":"10.1111/jop.70010","DOIUrl":"https://doi.org/10.1111/jop.70010","url":null,"abstract":"<p><strong>Introduction: </strong>Oral squamous cell carcinoma (OSCC) carries significant global mortality rates. Brush cytology presents a potential adjunctive tool for early detection and monitoring of OSCC and oral potentially malignant disorders (OPMDs). This study aims to systematically evaluate the diagnostic accuracy of cytology for detecting OSCC and OPMDs compared to histopathology as the reference standard. We conducted a systematic review and meta-analysis following PRISMA-DTA guidelines.</p><p><strong>Material and methods: </strong>We searched PubMed, Embase, Scopus, Cochrane Library, and Web of Science from inception to January 2023 (updated in March 2025). Eligible studies included cohort studies evaluating cytology versus histopathological diagnosis. Two reviewers independently screened studies, extracted data, and assessed risk of bias using QUADAS-2. We used the Hierarchical Summary Receiver Operating Characteristic model for meta-analysis.</p><p><strong>Results: </strong>Of 2603 identified studies, 53 met inclusion criteria, comprising 13,249 patients. Cytology demonstrated a pooled sensitivity of 0.914 (95% CI: 0.878-0.941) and specificity of 0.960 (95% CI: 0.937-0.975). The diagnostic odds ratio was 137.502 (95% CI: 79.733-237.127), with a positive likelihood ratio of 11.970 (95% CI: 9.005-15.912) and negative likelihood ratio of 0.096 (95% CI: 0.059-0.158). Subgroup analysis showed improved performance when exfoliative cytology was combined with DNA analysis or when using a metal spatula. Both conventional and liquid-based cytology were effective, with the latter showing modest advantages. Heterogeneity was substantial across studies (I² = 86.26%).</p><p><strong>Conclusion: </strong>Cytology demonstrates good diagnostic accuracy for detecting OSCC and OPMDs and may serve as a valuable adjunctive screening tool. However, it does not replace histopathological examination as the diagnostic gold standard. Further research should focus on standardizing collection techniques and interpretation criteria.</p><p><strong>Registration: </strong>PROSPERO CRD42023438610.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on Regulating OSCC Cell Function by Blocking Integrin αvβ3 With Cilengitide.","authors":"Liujun Zeng, Huanquan Nie, Haofeng Xiong, Zhimin Yang, Xin Hu, Tong Su","doi":"10.1111/jop.70004","DOIUrl":"https://doi.org/10.1111/jop.70004","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is the most important histologic type of oral tumor. Integrin- and integrin-dependent processes are involved in almost every step of cancer progression. Integrin αvβ3 was initially considered an integrin associated with tumor angiogenesis. With the gradual deepening of research, it was found that αvβ3 also plays a role in tumor cells. This study aimed to explore the function of tumor cell integrin αvβ3 in the progression of OSCC.</p><p><strong>Methods: </strong>Immunohistochemical methods in OSCC tissues explored the expression of integrin αvβ3. CCK-8, EdU, Cell cycle assay, Scratch test, Transwell, Cell adhesion assay, Colony formation assay, Apoptosis assay, and in vivo experiment were performed to investigate the effects of integrin αvβ3 on the biological behaviors of OSCC cells such as proliferation, adhesion, migration, and invasion.</p><p><strong>Results: </strong>In this study, we found that integrin αvβ3 expression was upregulated in OSCC. The inhibition of integrin αvβ3 expression by cilengitide resulted in the inhibition of proliferation, adhesion, migration, and invasion of OSCC cells.</p><p><strong>Conclusion: </strong>Integrin αvβ3 regulates cell proliferation by affecting the cell cycle. Furthermore, inhibition of integrin αvβ3 expression significantly suppresses migration and invasion of OSCC cells in vitro and in vivo.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-134-3p Deficiency-Induced Methionine Metabolism Promotes Fibrosis via SLC25A33 in OSF.","authors":"Mian-Feng Yao, Meng-Ying Shao, Qiu-Lan Li, Tian-Ru Yang, Zi-Ran Zheng, Xin-Le Zhang, Jia-Jun Huang, Yuan-Xin Sun, Jing He, Jiang Li, Chang-Yun Fang","doi":"10.1111/jop.70003","DOIUrl":"https://doi.org/10.1111/jop.70003","url":null,"abstract":"<p><strong>Background: </strong>Fibrosis is a disease characterized by excessive collagen deposition by fibroblasts, leading to tissue and organ dysfunction. Fibroblasts are the primary effector cells, and their functional phenotype is regulated by various factors, with metabolic reprogramming being a crucial one. Previous studies have shown that microRNAs induce hypoxia, abnormal energy metabolism, and promote fibrosis. Our research aimed to identify the miRNA associated with oral submucous fibrosis (OSF) pathogenesis and to preliminarily explore its role in the phenotypic transformation of fibroblasts.</p><p><strong>Methods: </strong>RNA-seq was used to analyze the differential expression of miRNA in OSF and normal tissues, followed by validation in clinical samples (n = 14), saliva (n = 65), and animal models (n = 16). The effect of hsa-miR-134-3p on collagen synthesis was detected by qPCR. Bioinformatic, immunoblot, and Elisa methods were used to analyze the correlation between hsa-miR-134-3p and methionine metabolism, as well as the mTOR pathway. Finally, the luciferase reporter gene assay was used to identify the target gene of hsa-miR-134-3p.</p><p><strong>Results: </strong>Hsa-miR-134-3p is underexpressed in fibrotic tissues. Arecoline can promote collagen synthesis by reducing hsa-miR-134-3p. Bioinformatic analysis indicated that hsa-miR-134-3p is associated with methionine metabolism and mTOR signaling, and immunoblot and ELISA methods revealed that hsa-miR-134-3p regulates methionine metabolism via the mTOR pathway. Ultimately, hsa-miR-134-3p was identified to directly target SLC25A33 in fibroblasts using the luciferase reporter gene assay.</p><p><strong>Conclusion: </strong>In summary, the findings suggested that miR-134-3p is underexpressed in fibroblasts, which directly binds to SLC25A33, leading to degradation of SLC25A33 mRNAs. SLC25A33 induces methionine metabolism reprogramming to promote collagen synthesis through the mTOR pathway in OSF.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation of Oral Spindle Cell and Pleomorphic Lipomas From Their Mimics via Retinoblastoma Status Through Immunohistochemistry and Fluorescence In Situ Hybridization.","authors":"Hiromasa Hasegawa, Yoshihiko Sugita, Takanaga Ochiai, Rita Rani Roy, Katsumitsu Shimada, Motohiko Nagayama, Hatsuhiko Maeda","doi":"10.1111/jop.70007","DOIUrl":"https://doi.org/10.1111/jop.70007","url":null,"abstract":"<p><strong>Background: </strong>The incidence of spindle cell/pleomorphic lipomas ranges from 2.2% to 47.2%. Its diagnosis is impeded by its diverse histological features, including adipocytes and myxo-collagenous stroma. Accordingly, we aimed to reexamine oral adipocytic tumors, focusing on RB1-deficient tumors, to reveal the diversity of oral spindle cell lipomas.</p><p><strong>Methods: </strong>We selected 30 cases of spindle cell/pleomorphic lipomas and their mimics from 111 oral adipocytic tumors. Subsequently, we performed analysis using immunohistochemistry for CD34 and RB protein (pRB) and RB1 fluorescence in situ hybridization (FISH) in limited cases.</p><p><strong>Results: </strong>Among the included cases, 16 were CD34-positive with pRB and/or the RB1 loss. Among them, 15 were spindle cell lipomas (SCLs) with 27% of them being confirmed through FISH in cases where pRB status was mosaic. These included five low-fat SPLs (including one low-fat pleomorphic lipoma), four conventional SCLs, three fibrous SCLs, two myxoid, and one fat-rich SCL. The remaining case was an atypical spindle cell lipomatous tumor. Only prominent spindle cell and myxoid changes showed significant differences between SCL and fibrous lipoma. Two cases, initially identified as spindle cell lipomas, were reclassified as fibrolipoma and lipoma.</p><p><strong>Conclusion: </strong>Oral spindle cell/pleomorphic lipomas frequently exhibit prominent collagenous stroma, which results in low-fat and fibrous variants that require careful differentiation from fibrous lipomas or non-adipocytic tumors. Given the diverse histological findings, meticulous diagnosis of rare spindle cell lipoma variants and other lipomas in daily surgical pathology is essential. Specifically, it should apply CD34 and retinoblastoma protein immunohistochemistry, as well as RB1 FISH when necessary.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Transfection With Anti-Fibrotic microRNAs for Treating Oral Submucous Fibrosis.","authors":"Chih-Yuan Fang, Yin-Ju Chen, Kuan-Chou Lin, Yueh-Hsin Chen, Kai-Chiang Yang","doi":"10.1111/jop.70009","DOIUrl":"https://doi.org/10.1111/jop.70009","url":null,"abstract":"<p><strong>Background: </strong>Oral submucous fibrosis is characterized by excessive collagen deposition and is highly associated with a patient's betel nut chewing habit. Arecoline initiates the transforming growth factor-beta (TGF-β)/Smads signaling pathway and activates downstream fibrotic genes. Dysregulation of microRNA (miR) expression is involved in the OSF progression, and miR modulation is a promising treatment. As one miR can target multiple mRNAs, and one mRNA has multiple binding sites to different miRs, we thus propose that simultaneous co-transfection of anti-fibrotic miRs may have a better therapeutic effect than single miR transfection.</p><p><strong>Methods: </strong>Human oral fibroblasts were first subjected to arecoline stimulation and then transfected with 16 miRs individually. Based on the ability to downregulate TGFB1 and actin alpha 2, smooth muscle (ACTA2) mRNA levels, the miR-29a-3p mimic, miR-196a-3p mimic, and miR-509-5p mimic were selected for co-transfection.</p><p><strong>Results: </strong>In addition to downregulation of collagen type I alpha 1 chain (COL1A1), COL3A1, COL5A1, matrix metalloproteinase-1 (MMP1), MMP7, tissue inhibitor of metalloproteinase-1 (TIMP1), and TIMP2 mRNA expressions, co-transfection with the three miRs led to a more significant downregulation of COL1A1 and MMP1 expressions. A Western blot analysis revealed that co-transfection of the miRs efficiently suppressed the TGF-β/Smads pathway and extracellular matrix component productions. Furthermore, co-transfection with miRs more effectively inhibited wound closure and collagen gel contraction compared to single miR transfection.</p><p><strong>Conclusions: </strong>Co-transfection of anti-fibrotic miRs can be a promising treatment for oral submucous fibrosis.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoral Basal Cell Carcinoma: Controversies and Insights From a Systematic Review.","authors":"Antonia Taiane Lopes de Moraes, Lauren Frenzel Schuch, Pablo Agustin Vargas, Vivian Petersen Wagner","doi":"10.1111/jop.70005","DOIUrl":"https://doi.org/10.1111/jop.70005","url":null,"abstract":"<p><strong>Background: </strong>The existence of intraoral basal cell carcinoma (IOBCC) remains controversial, despite reported cases in the literature.</p><p><strong>Materials and methods: </strong>A systematic search of four electronic databases and grey literature was conducted. Strict inclusion criteria were established to define a true case of IOBCC, including Ber-EP4 positivity to distinguish it from peripheral ameloblastoma and the absence of a history of skin lesions-either nearby, which could indicate direct infiltration, or at distant sites, which could suggest metastasis rather than a true primary IOBCC.</p><p><strong>Results: </strong>A total of 9 cases met the inclusion criteria. IOBCC lesions were located on the palate, buccal mucosa and gingiva, with no cases involving the tongue or floor of the mouth-common sites for squamous cell carcinoma. Histologically, islands of basaloid cells with peripheral palisading and stromal retraction were the predominant findings. All cases were Ber-EP4 positive. Six patients remained disease-free during follow-up, one experienced multiple recurrences, and two had no follow-up data.</p><p><strong>Conclusion: </strong>IOBCC is extremely rare, with few documented cases. While previous studies suggested the gingiva as a common site, this review found no clear predilection, and some previously reported cases may have been misdiagnosed as peripheral ameloblastoma. Ber-EP4 positivity in IHC is valuable for distinguishing between these entities. Additionally, by excluding cases with potential infiltration from skin lesions, this review underscores the importance of a thorough dermatological evaluation to rule out cutaneous extension or metastasis.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Described Radiographic Characteristics of Bone Lesions Should Reflect Recent Technological Advances in Oral Radiology.","authors":"Eduardo Murad Villoria, Thaiza Gonçalves Rocha, Felipe Rodrigues Tosto, Lara Piê Ventura Mendonça, Maria Augusta Visconti","doi":"10.1111/jop.70006","DOIUrl":"https://doi.org/10.1111/jop.70006","url":null,"abstract":"<p><strong>Objective: </strong>To alert the scientific community about the emergence of new characteristics of bone lesions of the maxillomandibular complex visualized in newer cone-beam computed tomography (CBCT) technologies, as well as in current quantitative methods of image analysis.</p><p><strong>Methods: </strong>This Letter to the Editor was based on the authors' professional experience, supported by scientific articles that described the characteristics of bone lesions of the maxillomandibular complex visualized in two-dimensional (2D) and three-dimensional (3D) imaging methods.</p><p><strong>Results: </strong>Bone lesion patterns present in the maxillomandibular complex can vary between 2D and 3D exams, as well as between different protocols and generations of CBCT devices. Additionally, the radiomic analysis in CBCT allows a quantitative characterization of bone lesions, presenting potential to be a non-invasive method for differential diagnosis.</p><p><strong>Conclusion: </strong>Oral radiology undergoes constant technological modernization, resulting in improvements in image quality and revealing new behavior patterns of the bone lesions visualized in 3D images, especially in CBCT. Authors responsible for upcoming publications in oral pathology and radiology should be willing to research and describe possible new qualitative and quantitative features of bone lesions affecting the maxillomandibular complex.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Information Provided in Remote Case Discussions on Oral Medicine Teleconsultants' Diagnostic Impression.","authors":"Liliana Wolf Braun, Eduarda Soares, Alan Roger Santos-Silva, Liliane Janete Grando, Luiz Alcino Monteiro Gueiros, Maria Inês Meurer, Márcio Ajudarte Lopes, Cassius Carvalho Torres-Pereira, Janete Dias Almeida, Ricardo Alves Mesquita, Vinicius Coelho Carrard","doi":"10.1111/jop.70001","DOIUrl":"https://doi.org/10.1111/jop.70001","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the impact of case descriptions, alongside clinical photographs, on telediagnosis accuracy in Oral Medicine.</p><p><strong>Methods: </strong>An analytical cross-sectional observational study used 100 cases from Oral Medicine services at three universities. Three specialists in Oral Diagnosis remotely analyzed these cases. Simulated teleconsultations were presented via Google Forms, requesting: (a) diagnostic hypotheses based solely on clinical photographs; (b) identification of essential information for diagnosis; and (c) revised hypotheses after reviewing case descriptions. The specialists' opinions, with and without case descriptions, were compared to in-person diagnoses and categorized as: negative impact, maintenance of incorrect opinion, maintenance of correct opinion, and refinement of the response.</p><p><strong>Results: </strong>Diagnostic accuracy based on images alone were 84%, 83%, and 75%. There was no statistically significant difference in accuracy before and after accessing case descriptions. Although these descriptions were not essential for a correct diagnosis, they contributed to refining diagnostic hypotheses in some cases. The most frequently requested information was the \"duration of the condition\" (84% of cases).</p><p><strong>Conclusion: </strong>Experienced Oral Diagnosis specialists demonstrate satisfactory diagnostic accuracy when analyzing cases of oral lesions from a distance using photos, even when no clinical information is provided about the cases.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}