Journal of Oral Pathology & Medicine最新文献

{"title":"Impact of Information Provided in Remote Case Discussions on Oral Medicine Teleconsultants' Diagnostic Impression.","authors":"Liliana Wolf Braun, Eduarda Soares, Alan Roger Santos-Silva, Liliane Janete Grando, Luiz Alcino Monteiro Gueiros, Maria Inês Meurer, Márcio Ajudarte Lopes, Cassius Carvalho Torres-Pereira, Janete Dias Almeida, Ricardo Alves Mesquita, Vinicius Coelho Carrard","doi":"10.1111/jop.70001","DOIUrl":"https://doi.org/10.1111/jop.70001","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the impact of case descriptions, alongside clinical photographs, on telediagnosis accuracy in Oral Medicine.</p><p><strong>Methods: </strong>An analytical cross-sectional observational study used 100 cases from Oral Medicine services at three universities. Three specialists in Oral Diagnosis remotely analyzed these cases. Simulated teleconsultations were presented via Google Forms, requesting: (a) diagnostic hypotheses based solely on clinical photographs; (b) identification of essential information for diagnosis; and (c) revised hypotheses after reviewing case descriptions. The specialists' opinions, with and without case descriptions, were compared to in-person diagnoses and categorized as: negative impact, maintenance of incorrect opinion, maintenance of correct opinion, and refinement of the response.</p><p><strong>Results: </strong>Diagnostic accuracy based on images alone were 84%, 83%, and 75%. There was no statistically significant difference in accuracy before and after accessing case descriptions. Although these descriptions were not essential for a correct diagnosis, they contributed to refining diagnostic hypotheses in some cases. The most frequently requested information was the \"duration of the condition\" (84% of cases).</p><p><strong>Conclusion: </strong>Experienced Oral Diagnosis specialists demonstrate satisfactory diagnostic accuracy when analyzing cases of oral lesions from a distance using photos, even when no clinical information is provided about the cases.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Role of Artificial Intelligence in Oral Pathology: Diagnostic and Prognostic Implications.","authors":"Ibrahim S Alsanie, Ahmed Qannam, Ibrahim O Bello, Syed Ali Khurram","doi":"10.1111/jop.70002","DOIUrl":"https://doi.org/10.1111/jop.70002","url":null,"abstract":"<p><strong>Objectives: </strong>This narrative review aims to briefly discuss the concepts of artificial intelligence (AI), explore its role in oral pathology and oncology, and shed light on AI's potential in addressing diagnostic and prognostic challenges in the field. Additionally, future perspectives of AI are postulated.</p><p><strong>Methods: </strong>A literature search using PubMed, EMBASE, Web of Science, and Scopus for studies published before February 2025 related to AI usage in the assessment of oral diseases such as oral potentially malignant disorders and transformation to oral cancer, oral squamous cell carcinoma, salivary gland tumors, and odontogenic tumors.</p><p><strong>Results: </strong>Numerous investigative efforts have been directed at AI applications for diagnostic, risk assessment, and prognostication of oral diseases, although these are still relatively in their infancy, and more still needs to be done to refine these tools to make them overcome all the challenges that are being encountered.</p><p><strong>Conclusions: </strong>While AI does not seek to replace oral pathologists but supplement their efforts, it has an immense potential to revolutionize oral pathology practice in the years to come. AI applications would greatly improve diagnostic accuracy, enhance epidemiological surveillance of diseases, drive the profession toward more personalized patient care and ultimately improve patient outcomes beyond the current level.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes Simplex Treated With Antimicrobial Photodynamic Therapy: Randomized Controlled Trial.","authors":"Andreia La Selva, Daniella Teixeira Bezerra, Rodrigo Melim Zerbinati, Marcela Leticia Leal Gonçalves, Ricardo Scarparo Navarro, Marina Stella Bello-Silva, Ellen Sayuri Ando-Suguimoto, Ana Cecília Corrêa Aranha, Paulo Henrique Braz-Silva, Karen Muller Ramalho, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Céline Frochot, Anna Carolina Ratto Tempestini Horliana","doi":"10.1111/jop.13647","DOIUrl":"https://doi.org/10.1111/jop.13647","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy of antimicrobial photodynamic therapy (aPDT) with topical acyclovir in terms of healing time for herpes simplex lesions, recurrence rates, HSV-1 quantification in secretion and saliva, pain levels, temperature changes, and outcomes measured by the Oral Health Impact Profile Questionnaire (OHIP-14).</p><p><strong>Subjects and methods: </strong>Patients with vesicle or ulcer phase lesions were randomly divided into two groups: the control group (topical acyclovir four times daily for 7 days + aPDT simulation, n = 12) and the experimental group (placebo acyclovir ointment + aPDT applied once, n = 12). The primary outcome was lesion resolution time, with secondary assessments for recurrence, pain, local temperature, virus quantification via quantitative polymerase chain reaction (qPCR), and impact on quality of life.</p><p><strong>Results: </strong>After 1 year, the remission and recurrence rates were similar between groups (p = 0.718 and p = 0.317, respectively), as were pain levels and temperature (p = 0.039 and 0.217). There was an increase in HSV-1 viral load in saliva, measured by qPCR, on Day 3 in the ACV group (p = 0.043). The OHIP-14 scores were similar between groups after 1 year.</p><p><strong>Conclusion: </strong>This study found no differences between aPDT and topical acyclovir regarding lesion resolution time, recurrence rates, pain levels, local temperature changes, and OHIP-14 scores. Both treatments showed similar efficacy in managing herpes simplex lesions over 1 year. While there was an increase in HSV-1 viral load in saliva in the acyclovir group on Day 3, this did not translate into differences in clinical outcomes between the groups.</p><p><strong>Trial registration: </strong>NCT04037475.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Assessment of Oral Leukoplakia by Individual Dysplasia Features.","authors":"Andresa Borges Soares, Saman Warnakulasuriya, Letícia da Silveira Terra Junqueira, André Luis Santana de Freitas, Amanda Schneider, Alan Roger Santos Silva, Marcelo Sperandio","doi":"10.1111/jop.13633","DOIUrl":"https://doi.org/10.1111/jop.13633","url":null,"abstract":"<p><strong>Objectives: </strong>Malignant transformation (MT) risk assessment in oral leukoplakia (OL) relies on tissue sample and oral epithelial dysplasia (OED) grading. The aim of this study was to evaluate the role of each OED feature in predicting MT in OL.</p><p><strong>Subjects and methods: </strong>Ninety-nine OL patients were selected (81 non-transforming and 18 with MT). All OED features were individually scored for each case. Follow-up data were obtained from both local and regional cancer registries. Spearman correlation, logistic regression, and Kaplan-Meier were tested with MT as outcome. Thresholds for number of features indicating risk and predictive values (PV) were calculated. A random forest (RF) model was built to assess the relevance of each feature.</p><p><strong>Results: </strong>Loss of epithelial cohesion, increased nucleoli, and inflammation were the associated with MT (p ≤ 0.016). Combining these three features yielded high specificity (95%) and PV (50% positive and 85% negative). Using a six-feature threshold to establish risk reached 54%, 26% and 90%, and 72%, respectively. Specifying and counting OED features proved crucial to establishing risk.</p><p><strong>Conclusion: </strong>Loss of epithelial cohesion, increased size and number of nucleoli, and inflammation are key risk features and sum of OED features is the most useful predictor of MT.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Significance and Prognostic Value of the Caveolae Constitutive Proteins Dynamin-2 and Caveolin-1 in Oral Squamous Cell Carcinoma.","authors":"Yoshiaki Kishikawa, Koroku Kato, Kyosuke Hakoda, Hayato Funaki, Hisano Kobayashi, Yutaka Kobayashi, Hiroki Miyazawa, Natsuyo Noguchi, Shuichi Kawashiri","doi":"10.1111/jop.13646","DOIUrl":"https://doi.org/10.1111/jop.13646","url":null,"abstract":"<p><strong>Background: </strong>We investigated the clinicopathological significance of the expression of two caveolae component proteins, dynamin-2 (DNM2) and caveolin-1 (CAV1), in primary tumors of patients with oral squamous cell carcinoma (OSCC).</p><p><strong>Methods: </strong>Immunohistochemical staining for DNM2 and CAV1 was performed on resected primary tumor specimens from 80 OSCC patients, and the individual expressions and combined expression status of these proteins were analyzed in relation to clinicopathological factors and prognosis.</p><p><strong>Results: </strong>We observed that the DNM2 expression was significantly correlated with the OSCC T-classification and the stage, while CAV1 expression was significantly correlated with the mode of invasion and recurrence. Moreover, the combined DNM2/CAV1 expression status was significantly correlated with the T-classification, stage, cell differentiation, and recurrence. In terms of overall survival, the CAV1-positive patients had a significantly poorer prognosis compared to the CAV1-negative patients, and the patients who expressed neither DNM2 nor CAV1 had a significantly better prognosis than those expressing either or both proteins.</p><p><strong>Conclusion: </strong>These results suggest that in OSCC, the expression of DNM2 is involved in tumor growth and the expression of CAV1 is involved in tumor invasion, and DNM2 and/or CAV1 expression affects the progression and prognosis of OSCC. The expressions of DNM2 and CAV1 may therefore be useful markers for OSCC progression and prognosis.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Synergistic Effect of Honokiol and 5-Fluorouracil on Apoptosis of Oral Squamous Cell Carcinoma Cells\".","authors":"","doi":"10.1111/jop.13648","DOIUrl":"https://doi.org/10.1111/jop.13648","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"RNAi-Mediated Downregulation of Oral Cancer Overexpressed 1 (ORAOV1) Inhibits Vascular Endothelial Cell Proliferation, Migration, Invasion, and Tube Formation\".","authors":"","doi":"10.1111/jop.13649","DOIUrl":"https://doi.org/10.1111/jop.13649","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Expression of HHLA2, TMIGD2, and GITR in Salivary Gland Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma\".","authors":"","doi":"10.1111/jop.13645","DOIUrl":"https://doi.org/10.1111/jop.13645","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Consequences and Assessment Methods Analysis of Fixed Orthodontic Appliances on Oral Epithelial Cells: A Systematic Review.","authors":"Francesco Paolo Modugno, Elisabetta Kuhn, Chiara Luisa Bianchi, Letterio Runza, Matteo Pellegrini, Federica Pulicari, Francesco Spadari","doi":"10.1111/jop.13643","DOIUrl":"https://doi.org/10.1111/jop.13643","url":null,"abstract":"<p><strong>Introduction: </strong>Fixed orthodontic appliances (OAs) expose the oral mucosa to mechanical traumas and metal ions throughout the whole orthodontic therapy. This review aims to understand the cytological and genetic changes consequent to fixed orthodontic therapy, their clinical implications, and how they can be assessed.</p><p><strong>Materials and methods: </strong>A comprehensive search was conducted in PubMed (MEDLINE), Scopus, and Web of Science using MeSH terms related to cytology, DNA damage, mutagenicity, and orthodontic appliances. The PICO model and PRISMA guidelines were followed. The risk of bias was assessed using the ROBINS-I tool, and study quality was evaluated with the NHLBI Quality Assessment Tools. Two independent evaluators assessed the methodological quality of the included studies using the Joanna Briggs Institute (JBI) levels of evidence; inter-reviewer agreement was measured using Cohen's kappa coefficient (κ = 0.80).</p><p><strong>Results: </strong>Nineteen prospective and cross-sectional studies were included in the analysis. The findings suggest the presence of higher metal cellular content, as well as cytological changes, nuclear alterations, and cytotoxic and genotoxic effects. Different appliance compositions and treatment durations may influence the biological consequences. The analysis shows a tendency toward regression, especially for nuclear alterations. No dysplastic changes have been observed in any of the studies included.</p><p><strong>Conclusion: </strong>OAs cause cellular alterations, which tend to be reversible and do not seem to evolve into dysplastic changes. Future research should focus on longitudinal studies with standardized methodologies to better understand the persistence and reversibility of the changes associated with OAs, as well as exploring alternative materials that pose less risk during orthodontic treatment.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Stereophotogrammetry Facial Morphologic Signatures of Temporomandibular Disorders.","authors":"Li Mei, Carmen Au, Stacy Foo, Cui Gao, Sichao Zhu, Guangzhao Guan","doi":"10.1111/jop.13644","DOIUrl":"https://doi.org/10.1111/jop.13644","url":null,"abstract":"<p><strong>Aim: </strong>To utilize stereophotogrammetry to investigate changes in three-dimensional (3D) facial morphology in both TMD-free individuals and TMD patients, both before and after treatment, and to classify subjects as either TMD-free or TMD patients.</p><p><strong>Methods: </strong>40 participants (TMD and TMD-free, mean age of 38.9 ± 15.3 years) were recruited from the Oral Medicine Clinic at the Faculty of Dentistry, University of Otago. Participants were given a questionnaire, and 3D images of their faces at maximum mouth opening and in occlusion were recorded using the 3dMDtrio craniofacial scanner. Participants were followed up after 3 months and 6 months. The 3D images captured were analysed using the 3dMD Vultus software.</p><p><strong>Results: </strong>Significant changes were observed between baseline and 3-month follow-up measurements in TRAR-GoR(C), GoR-GN(C) and LS-PG(O) (p < 0.05). At the 6-month follow-up, additional significant differences were found in G-PG(R), TRAL-SN(C), TRAR-GoR(C), GoR-GN(C), LS-PG(O), and maximum mouth opening (MMO) (p < 0.05). TRAR-GoR(C), LS-PG(O), TRAL-GoL(C), MMO, and TRAR-SN(C) exhibited significant correlations. LS-PG(R) was the most reliable predictor. Discriminant analysis revealed an 85% sensitivity and 90% specificity in classifying individuals with and without TMD.</p><p><strong>Conclusion: </strong>Significant 3D morphological changes were detected in TMD patients' post-treatment, with notable mouth opening and masseter muscle volume reduction.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}