Journal of Oral Pathology & Medicine最新文献

Risk Assessment of Oral Leukoplakia by Individual Dysplasia Features. 个体发育不良特征对口腔白斑的风险评估。

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-27 DOI: 10.1111/jop.13633

Andresa Borges Soares, Saman Warnakulasuriya, Letícia da Silveira Terra Junqueira, André Luis Santana de Freitas, Amanda Schneider, Alan Roger Santos Silva, Marcelo Sperandio

{"title":"Risk Assessment of Oral Leukoplakia by Individual Dysplasia Features.","authors":"Andresa Borges Soares, Saman Warnakulasuriya, Letícia da Silveira Terra Junqueira, André Luis Santana de Freitas, Amanda Schneider, Alan Roger Santos Silva, Marcelo Sperandio","doi":"10.1111/jop.13633","DOIUrl":"https://doi.org/10.1111/jop.13633","url":null,"abstract":"Objectives: Malignant transformation (MT) risk assessment in oral leukoplakia (OL) relies on tissue sample and oral epithelial dysplasia (OED) grading. The aim of this study was to evaluate the role of each OED feature in predicting MT in OL.Subjects and methods: Ninety-nine OL patients were selected (81 non-transforming and 18 with MT). All OED features were individually scored for each case. Follow-up data were obtained from both local and regional cancer registries. Spearman correlation, logistic regression, and Kaplan-Meier were tested with MT as outcome. Thresholds for number of features indicating risk and predictive values (PV) were calculated. A random forest (RF) model was built to assess the relevance of each feature.Results: Loss of epithelial cohesion, increased nucleoli, and inflammation were the associated with MT (p ≤ 0.016). Combining these three features yielded high specificity (95%) and PV (50% positive and 85% negative). Using a six-feature threshold to establish risk reached 54%, 26% and 90%, and 72%, respectively. Specifying and counting OED features proved crucial to establishing risk.Conclusion: Loss of epithelial cohesion, increased size and number of nucleoli, and inflammation are key risk features and sum of OED features is the most useful predictor of MT.","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological Significance and Prognostic Value of the Caveolae Constitutive Proteins Dynamin-2 and Caveolin-1 in Oral Squamous Cell Carcinoma. 口腔鳞状细胞癌中小窝组成蛋白Dynamin-2和Caveolin-1的临床病理意义及预后价值。

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-26 DOI: 10.1111/jop.13646

Yoshiaki Kishikawa, Koroku Kato, Kyosuke Hakoda, Hayato Funaki, Hisano Kobayashi, Yutaka Kobayashi, Hiroki Miyazawa, Natsuyo Noguchi, Shuichi Kawashiri

{"title":"Clinicopathological Significance and Prognostic Value of the Caveolae Constitutive Proteins Dynamin-2 and Caveolin-1 in Oral Squamous Cell Carcinoma.","authors":"Yoshiaki Kishikawa, Koroku Kato, Kyosuke Hakoda, Hayato Funaki, Hisano Kobayashi, Yutaka Kobayashi, Hiroki Miyazawa, Natsuyo Noguchi, Shuichi Kawashiri","doi":"10.1111/jop.13646","DOIUrl":"https://doi.org/10.1111/jop.13646","url":null,"abstract":"Background: We investigated the clinicopathological significance of the expression of two caveolae component proteins, dynamin-2 (DNM2) and caveolin-1 (CAV1), in primary tumors of patients with oral squamous cell carcinoma (OSCC).Methods: Immunohistochemical staining for DNM2 and CAV1 was performed on resected primary tumor specimens from 80 OSCC patients, and the individual expressions and combined expression status of these proteins were analyzed in relation to clinicopathological factors and prognosis.Results: We observed that the DNM2 expression was significantly correlated with the OSCC T-classification and the stage, while CAV1 expression was significantly correlated with the mode of invasion and recurrence. Moreover, the combined DNM2/CAV1 expression status was significantly correlated with the T-classification, stage, cell differentiation, and recurrence. In terms of overall survival, the CAV1-positive patients had a significantly poorer prognosis compared to the CAV1-negative patients, and the patients who expressed neither DNM2 nor CAV1 had a significantly better prognosis than those expressing either or both proteins.Conclusion: These results suggest that in OSCC, the expression of DNM2 is involved in tumor growth and the expression of CAV1 is involved in tumor invasion, and DNM2 and/or CAV1 expression affects the progression and prognosis of OSCC. The expressions of DNM2 and CAV1 may therefore be useful markers for OSCC progression and prognosis.","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Synergistic Effect of Honokiol and 5-Fluorouracil on Apoptosis of Oral Squamous Cell Carcinoma Cells". 更正“厚木酚和5-氟尿嘧啶对口腔鳞癌细胞凋亡的协同作用”。

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-25 DOI: 10.1111/jop.13648

引用次数: 0

Corrigendum to "RNAi-Mediated Downregulation of Oral Cancer Overexpressed 1 (ORAOV1) Inhibits Vascular Endothelial Cell Proliferation, Migration, Invasion, and Tube Formation". “rnai介导的口腔癌过表达1 （orav1）下调抑制血管内皮细胞增殖、迁移、侵袭和管形成”的更正。

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-25 DOI: 10.1111/jop.13649

引用次数: 0

Correction to "Expression of HHLA2, TMIGD2, and GITR in Salivary Gland Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma". 对“HHLA2、TMIGD2和GITR在唾液腺腺样囊性癌和黏液表皮样癌中的表达”的更正。

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-21 DOI: 10.1111/jop.13645

引用次数: 0

Biological Consequences and Assessment Methods Analysis of Fixed Orthodontic Appliances on Oral Epithelial Cells: A Systematic Review. 固定正畸矫治器对口腔上皮细胞的生物学影响及评估方法分析：系统综述。

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-19 DOI: 10.1111/jop.13643

Francesco Paolo Modugno, Elisabetta Kuhn, Chiara Luisa Bianchi, Letterio Runza, Matteo Pellegrini, Federica Pulicari, Francesco Spadari

{"title":"Biological Consequences and Assessment Methods Analysis of Fixed Orthodontic Appliances on Oral Epithelial Cells: A Systematic Review.","authors":"Francesco Paolo Modugno, Elisabetta Kuhn, Chiara Luisa Bianchi, Letterio Runza, Matteo Pellegrini, Federica Pulicari, Francesco Spadari","doi":"10.1111/jop.13643","DOIUrl":"https://doi.org/10.1111/jop.13643","url":null,"abstract":"Introduction: Fixed orthodontic appliances (OAs) expose the oral mucosa to mechanical traumas and metal ions throughout the whole orthodontic therapy. This review aims to understand the cytological and genetic changes consequent to fixed orthodontic therapy, their clinical implications, and how they can be assessed.Materials and methods: A comprehensive search was conducted in PubMed (MEDLINE), Scopus, and Web of Science using MeSH terms related to cytology, DNA damage, mutagenicity, and orthodontic appliances. The PICO model and PRISMA guidelines were followed. The risk of bias was assessed using the ROBINS-I tool, and study quality was evaluated with the NHLBI Quality Assessment Tools. Two independent evaluators assessed the methodological quality of the included studies using the Joanna Briggs Institute (JBI) levels of evidence; inter-reviewer agreement was measured using Cohen's kappa coefficient (κ = 0.80).Results: Nineteen prospective and cross-sectional studies were included in the analysis. The findings suggest the presence of higher metal cellular content, as well as cytological changes, nuclear alterations, and cytotoxic and genotoxic effects. Different appliance compositions and treatment durations may influence the biological consequences. The analysis shows a tendency toward regression, especially for nuclear alterations. No dysplastic changes have been observed in any of the studies included.Conclusion: OAs cause cellular alterations, which tend to be reversible and do not seem to evolve into dysplastic changes. Future research should focus on longitudinal studies with standardized methodologies to better understand the persistence and reversibility of the changes associated with OAs, as well as exploring alternative materials that pose less risk during orthodontic treatment.","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-Dimensional Stereophotogrammetry Facial Morphologic Signatures of Temporomandibular Disorders. 颞下颌疾病的三维立体摄影测量面部形态学特征。

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-14 DOI: 10.1111/jop.13644

Li Mei, Carmen Au, Stacy Foo, Cui Gao, Sichao Zhu, Guangzhao Guan

{"title":"Three-Dimensional Stereophotogrammetry Facial Morphologic Signatures of Temporomandibular Disorders.","authors":"Li Mei, Carmen Au, Stacy Foo, Cui Gao, Sichao Zhu, Guangzhao Guan","doi":"10.1111/jop.13644","DOIUrl":"https://doi.org/10.1111/jop.13644","url":null,"abstract":"Aim: To utilize stereophotogrammetry to investigate changes in three-dimensional (3D) facial morphology in both TMD-free individuals and TMD patients, both before and after treatment, and to classify subjects as either TMD-free or TMD patients.Methods: 40 participants (TMD and TMD-free, mean age of 38.9 ± 15.3 years) were recruited from the Oral Medicine Clinic at the Faculty of Dentistry, University of Otago. Participants were given a questionnaire, and 3D images of their faces at maximum mouth opening and in occlusion were recorded using the 3dMDtrio craniofacial scanner. Participants were followed up after 3 months and 6 months. The 3D images captured were analysed using the 3dMD Vultus software.Results: Significant changes were observed between baseline and 3-month follow-up measurements in TRAR-GoR(C), GoR-GN(C) and LS-PG(O) (p < 0.05). At the 6-month follow-up, additional significant differences were found in G-PG(R), TRAL-SN(C), TRAR-GoR(C), GoR-GN(C), LS-PG(O), and maximum mouth opening (MMO) (p < 0.05). TRAR-GoR(C), LS-PG(O), TRAL-GoL(C), MMO, and TRAR-SN(C) exhibited significant correlations. LS-PG(R) was the most reliable predictor. Discriminant analysis revealed an 85% sensitivity and 90% specificity in classifying individuals with and without TMD.Conclusion: Significant 3D morphological changes were detected in TMD patients' post-treatment, with notable mouth opening and masseter muscle volume reduction.","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient Education and Levels of Disease-Specific Information Needs Among Individuals With Oral Epithelial Dysplasia. 口腔上皮发育不良患者的患者教育和疾病特异性信息需求水平

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-13 DOI: 10.1111/jop.13642

Waleed Alamoudi, Abdullah Alsoghair, Richeal Ni Riordain, Stefano Fedele, Stephen Porter

{"title":"Patient Education and Levels of Disease-Specific Information Needs Among Individuals With Oral Epithelial Dysplasia.","authors":"Waleed Alamoudi, Abdullah Alsoghair, Richeal Ni Riordain, Stefano Fedele, Stephen Porter","doi":"10.1111/jop.13642","DOIUrl":"https://doi.org/10.1111/jop.13642","url":null,"abstract":"Background: Oral epithelial dysplasia (OED) is a histological diagnosis that carries an increased risk of the individual developing oral squamous cell carcinoma. We assessed the information needs (IN) and explored the sources of education used by individuals with OED using a validated OED-specific measurement.Methods: A total of 102 adults with OED from the oral medicine clinic of a dental hospital in Central London were selected using convenience sampling. A cross-sectional survey was conducted in which participants completed the 33-item Oral Epithelial Dysplasia Informational Needs Questionnaire (ODIN-Q), which assessed IN and gathered perspectives on patient education.Results: Approximately two-thirds of the participants (n = 66, 64%) reported meeting the IN, whereas the remaining participants (n = 36, 35%) did not. The mean and median total scores from the questionnaire were 2.43 (± 0.38) and 2.6, respectively, indicating a low sufficient level of IN. Most participants (n = 80, 78%) preferred one-on-one meetings as the primary mode of obtaining information, followed by written materials (n = 64, 62%), audiovisual resources (n = 24, 23%), and group discussions (n = 8, 0.7%).Conclusions: Some topics were insufficiently met, necessitating additional educational efforts, such as risk factors and lifestyle modifications, physical and psychological impacts, awareness of potential complications, and seeking medical and psychological support. Sex and degree of dysplasia were associated with the levels of IN. These findings may guide future longitudinal research on OED IN assessment, support the creation of tailored educational tools, and facilitate further evaluation of the psychometric properties of the ODIN-Q.","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Health in Individuals with Severe Mental Illness on Second-Generation Antipsychotics-A Scoping Review. 第二代抗精神病药物对重度精神疾病患者口腔健康的影响

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-06 DOI: 10.1111/jop.13639

Dileep Sharma, Oliver Higgins, Aleksander Sawicki, Poornima Ramamurthy, Belinda Field, Paul Hussein, Kiran Singh, Sarbin Ranjitkar

{"title":"Oral Health in Individuals with Severe Mental Illness on Second-Generation Antipsychotics-A Scoping Review.","authors":"Dileep Sharma, Oliver Higgins, Aleksander Sawicki, Poornima Ramamurthy, Belinda Field, Paul Hussein, Kiran Singh, Sarbin Ranjitkar","doi":"10.1111/jop.13639","DOIUrl":"https://doi.org/10.1111/jop.13639","url":null,"abstract":"Introduction: There has been a significant increase in antipsychotic usage, particularly belonging to second-generation antipsychotics (SGAs), in the management of severe mental illnesses (SMIs) over the past few decades, but their impact on oral health is unclear. This review evaluated the oral side effects of the SGAs used in managing SMIs.Methods: A PRISMA-guided scoping review was conducted, using predefined criteria and relevant word combination in Medline (PubMed), Embase, Scopus and Cochrane databases. Eligible studies were assessed for study type, population demographics, antipsychotic medication usage, oral diseases and conditions, and their outcomes. Primary outcomes were explicitly studied oral conditions or diseases, and secondary outcomes were broader oral or general \"treatment-emergent adverse effects.\"Results: Twelve studies met the inclusion criteria for the primary outcomes and 13 for the secondary outcomes. The most reported primary outcomes were salivary gland dysfunction (hypofunction, three studies; hypersalivation, two studies), dental caries (positive association, three studies; no association, one study), and periodontal disease (five studies). Secondary outcomes included dysgeusia and oral hypoesthesia (six studies).Discussion: SGAs significantly compromise oral health, particularly through salivary gland and sensory dysfunction, highlighting the need for up-to-date guidelines on routine oral screening and preventive care.","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burning Mouth Syndrome: Unlocking the Future of Pharmacological Treatment 灼口综合征：打开药理学治疗的未来

IF 2.7 3区医学

Journal of Oral Pathology & Medicine Pub Date : 2025-05-04 DOI: 10.1111/jop.13641

Daniela Adamo

引用次数: 0