Journal of Oral Pathology & Medicine最新文献

{"title":"Pemphigus Vulgaris Scoring Systems: A Scoping Review.","authors":"Sue-Ching Yeoh, Stephen Adelstein, Omar Kujan","doi":"10.1111/jop.70071","DOIUrl":"https://doi.org/10.1111/jop.70071","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus vulgaris is a rare autoimmune blistering condition characterised by mucocutaneous lesions secondary to acantholysis. Assessment of disease activity, severity, and treatment response is crucial for guiding management and research. Multiple clinical scoring systems have been developed for pemphigus vulgaris; however, consensus on their optimal use is lacking. This scoping review aims to identify, evaluate, and summarise the clinical scoring systems used in pemphigus vulgaris, focusing on validity, reliability, and application in clinical practice and research.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using electronic databases (PubMed (Medline), Embase, Web of Science, Scopus, and Cochrane Library) as well as grey literature to identify studies describing clinical scoring systems for pemphigus vulgaris. Data on scoring system components, validity, clinical applicability, and limitations were extracted and synthesised.</p><p><strong>Results: </strong>The review identified several scoring systems, including the Pemphigus Disease Area Index, Autoimmune Bullous Skin Disorder Intensity Score, and other less commonly used tools. Scoring systems varied in design, with key differences noted in assessment domains, including mucosal versus cutaneous involvement, patient-reported outcomes, and usability.</p><p><strong>Conclusion: </strong>Current clinical scoring systems for pemphigus vulgaris provide frameworks for disease assessment but exhibit variability in scope, validation, and practical implementation. Further development to incorporate emerging biomarkers and quality of life, as well as encompass all clinical subsites, will enhance their utility in guiding patient care and advancing research. This review highlights the need for consensus on a universal scoring system tailored to the multifaceted nature of pemphigus vulgaris.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Profile of Intraosseous Adenoid Cystic Carcinoma of the Jaws: A Systematic Review.","authors":"Luccas Lavareze, João Figueira Scarini, Reydson Alcides de Lima-Souza, Talita de Carvalho Kimura, Rogério de Oliveira Gondak, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano","doi":"10.1111/jop.70063","DOIUrl":"https://doi.org/10.1111/jop.70063","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to evaluate the clinicopathological features, survival rate, and potential prognostic markers of the jaws' primary intraosseous adenoid cystic carcinoma (PIACC).</p><p><strong>Materials and methods: </strong>MEDLINE/PubMed, Scopus, and Embase searches were performed with the keywords \"adenoid cystic carcinoma,\" and \"jaw,\" or \"maxilla,\" or \"mandible.\" We included articles that evaluated cases diagnosed as PIACC in jaws. Studies with insufficient demographic data, inconclusive histopathologic diagnosis, and appropriate follow-up were excluded. The Joanna Briggs Institute tool was used to assess the risk of bias.</p><p><strong>Results: </strong>Fifty-five PIACC comprising 27 studies met the inclusion criteria. The mean age of the patients was 56.4 ± 19.6 years with no sex predilection. PIACC showed a strong predilection for the mandible (69.1%), mainly in the posterior segment (40%). The patients presented symptoms in 87.3% of cases. Radiographically, PIACC presented as an ill-defined radiolucent lesion (40%). Most cases showed a cribriform pattern (32.7%). PIACC with a solid growth pattern presented a lower disease-free survival (DFS) (p = 0.040). The 2- and 5-year overall survival rates were 57.9% and 53.8%, respectively. Distant metastases were seen in 3.6% of the patients and were related to a lower DFS (p = 0.043).</p><p><strong>Conclusion: </strong>PIACC is a rare neoplasm of the jaws with an incidence in the fifth and sixth decades of life and no sex predilection. The posterior mandible was affected in most cases. Solid growth patterns and distant metastases are prognostic factors for a lower DFS.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated N6-Methyladenosine (m6A)-RNA-Methylation During Oral Carcinogenesis.","authors":"Zhiming Qin, Yanting Chi, Xinpei Wang, Jing Yan, Xinning Zhang, Binbin Li","doi":"10.1111/jop.70066","DOIUrl":"https://doi.org/10.1111/jop.70066","url":null,"abstract":"<p><strong>Background/purpose: </strong>Oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) encompass a series of molecular events in the malignant transformation process, ranging from simple epithelial hyperplasia to mild, moderate, and severe dysplasia. N6-methyladenosine (m6A)-RNA methylation participates in the regulation of the tumorigenesis of various malignant tumors, yet the roles played by m6A-RNA methylation in OED and OSCC remain unclear. Therefore, this study focused on investigating OED and OSCC from an epigenetic perspective, aiming to elucidate the underlying molecular mechanisms of malignant transformation.</p><p><strong>Materials and methods: </strong>Laser microdissection was performed on OED and OSCC samples. Methylated RNA immunoprecipitation sequencing (MeRIP-Seq) and RNA sequencing (RNA-seq) were applied to establish comprehensive profiles of m6A methylation modifications and gene expression patterns and to identify differentially modified/expressed genes in OED and OSCC.</p><p><strong>Results: </strong>We presented the overall modification/expression profiles of m6A-RNA-methylation in OED and OSCC. Four hypermethylated genes and 11 hypomethylated genes were found in both OED and OSCC, together with the expression of 107 upregulated and 37 downregulated genes. The most common motifs GRAGRA (R = A/G) of the OED and OSCC methylation sites were mainly located in coding and stop codon regions. In the stable group, C4B, DNAH9, and NCALD all exhibited hypermethylated and upregulated, and the overall survival rate of patients with high expression of these genes was higher than that of patients with low-level expression.</p><p><strong>Conclusion: </strong>Our study revealed that the level of m6A-RNA methylation in the epithelial tissues of OED and OSCC was higher than that in oral normal epithelium, suggesting that the methylation modification might be involved in the occurrence of OED and its progression to OSCC. Furthermore, hypermethylation and upregulated expression of C4B, DNAH9, and NCALD were associated with a favorable prognosis in these diseases.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Oral Health Deserves a Seat at the Global Health Table.","authors":"Chukwuemeka L Anyikwa, Peter A Brennan, Chukwuebuka E Ogwo","doi":"10.1111/jop.70065","DOIUrl":"https://doi.org/10.1111/jop.70065","url":null,"abstract":"<p><p>Oral diseases affect billions worldwide yet remain sidelined in both national and global health policies. This oversight has perpetuated disparities in care access, particularly in low- and middle-income countries. The separation of oral health from broader healthcare systems is illogical and dangerous, given oral health's deep connections to systemic health. This commentary calls for the integration of oral health into primary care and its recognition as a fundamental health right. Essential dental services must be incorporated into universal health coverage (UHC), financial barriers dismantled, and policy frameworks updated. A paradigm shift is essential to position oral health at the heart of global health policy and noncommunicable disease (NCD) prevention strategies.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Pulp Mesenchymal Stem Cell-Secretome Gel Reverse Areca Nut Induced Oral Submucous Fibrosis in Mice: A Pilot Study.","authors":"Nishant Mante, Supriya Kheur, Avinash Sanap, Avinash Kharat, Pranjali Potdar, Poonam Suryawanshi, Ravindra Badhe, Vaishali Undale, Nitika Monga, Ramesh Bhonde","doi":"10.1111/jop.70064","DOIUrl":"https://doi.org/10.1111/jop.70064","url":null,"abstract":"<p><strong>Objectives: </strong>Oral submucous fibrosis is a pre-malignant disorder caused by habitual areca nut consumption. This pilot study investigated the therapeutic potential of dental pulp mesenchymal stem cell-secretome chitosan gel in a mice model of areca nut extract-induced oral submucous fibrosis.</p><p><strong>Materials and methods: </strong>Angiogenic potential of dental pulp mesenchymal stem cell-secretome was validated using a chick yolk sac membrane assay. Oral submucous fibrosis was induced in male Swiss albino mice (n = 40) via intraoral areca nut extract administration for 3 months. Post-induction, animals were divided into disease control, DPMSCs-S, and DPMSCs-S gel groups. Treatments were administered intraorally twice weekly for 1 month. Therapeutic efficacy was assessed through measurements of mouth opening, histopathology, oxidative stress markers (LDH, MDA, SOD), and fibrotic gene expression (COL1, COL3, α-SMA).</p><p><strong>Results: </strong>Dental pulp mesenchymal stem cells' secretome contains pro-angiogenic growth factors. Dental pulp mesenchymal stem cells' secretome gel significantly improved mouth opening, restored epithelial architecture, and reduced collagen deposition. Histological staining and gene expression analyses confirmed the reversal of fibrosis and downregulation of COL1, COL3, and α-SMA. Additionally, the gel reduced LDH and MDA levels and enhanced SOD activity, indicating antioxidant effects. The gel showed superior efficacy over the secretome alone.</p><p><strong>Conclusion: </strong>DPMSCs-S gel demonstrates significant anti-fibrotic, antioxidant, and regenerative potential in reversing ANE-induced OSMF in mice. These findings warrant further investigation into larger, long-term preclinical studies.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Oral Alterations and Correlation Between Oral and Cutaneous Neurofibromas in Neurofibromatosis Type 1: A Retrospective Case-Control Study.","authors":"Pâmella de Pinho Montovani, Gabriela Pizão Werneck Moreira da Costa, Rafaela Elvira Rozza-de-Menezes, Karin Soares Cunha","doi":"10.1111/jop.70056","DOIUrl":"https://doi.org/10.1111/jop.70056","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the prevalence of oral alterations detectable through physical examination in NF1 individuals. Additionally, we assessed the correlation between the number of oral and cutaneous neurofibromas.</p><p><strong>Design: </strong>This retrospective study evaluated oral alterations in individuals with and without NF1. In the NF1 group, associations between oral and cutaneous neurofibromas, age, sex, pregnancy, and family history of NF1 were assessed.</p><p><strong>Results: </strong>A total of 327 participants were evaluated (81 with NF1 and 246 controls). Oral mucosal alterations (92.6% vs. 79.3%) and exostoses (12.3% vs. 4.5%) were significantly more prevalent in the NF1 group. The most frequent oral alterations were enlarged fungiform papillae (46.9% vs. 8.1%), coated tongue (45.7% vs. 29.3%), neurofibromas (38.3% versus none), physiological melanin pigmentation (30.9% vs. 10.6%), and exostoses (12.3% vs. 4.5%). Oral neurofibromas were more prevalent in older individuals, without a family history of NF1, and those with multiple cutaneous neurofibromas.</p><p><strong>Conclusions: </strong>Enlarged fungiform papillae and oral neurofibromas are the most common oral alterations detectable through physical examination in NF1. Coated tongue, physiological melanin pigmentation, and exostoses were also more frequent in NF1. The number of oral and cutaneous neurofibromas is correlated. These findings underscore the necessity of regular oral assessments in NF1 individuals.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways.","authors":"Leong-Perng Chan, Ya-Ping Tseng, Hui-Ching Wang, Chen-Yu Chien, Che-Wei Wu, Ling-Feng Wang, Tung-Wen Yen, Po-Chun Wang, Chih-Chuang Liaw, Chia-Hua Liang","doi":"10.1111/jop.70060","DOIUrl":"https://doi.org/10.1111/jop.70060","url":null,"abstract":"<p><strong>Background: </strong>16-hydroxycleroda-3,13-dien-15,16-olide (HCD), a compound isolated from Polyalthia longifolia var. pendula, has been identified as a PI3K inhibitor. P. longifolia var. pendula is recognized for its diverse pharmacological properties, including antimicrobial, hypotensive, anti-inflammatory, and cytotoxic activities. Considering the pivotal role of PI3K in the regulation of apoptosis in cancer cells, this study aims to investigate the apoptotic effects induced by HCD in head and neck cancer cell models.</p><p><strong>Methods: </strong>The study focused on investigating the mechanism through which HCD induces apoptosis in oral squamous cell carcinoma (OSCC) using SCC25 and SCC180 cells. These cells were treated with HCD at IC₂₀, IC₅₀, and IC₈₀ concentrations over periods of 24, 48, and 72 h. Assessments included cell viability, oxidative stress levels using MitoSOX and CellROX, and the analysis of gene and protein expressions related to apoptosis via immunofluorescence staining, flow cytometry, RT-PCR, and western blotting.</p><p><strong>Results: </strong>The results demonstrated that HCD significantly increased the sub-G₁ phase cell population, suppressed clonogenic activity, and promoted mitochondrial ROS production, accompanied by a reduction in glutathione levels. HCD also activated cytochrome c (cyto. c) release and Bax expression while downregulating Bcl-2 expression. Notably, in SCC25 cells, HCD induced apoptosis through the TNF-α/TNF-R and FasL/Fas death domains, leading to caspase cascade activation. Moreover, HCD showed dose-dependent growth inhibition of SCC25 cells, both alone and combined with cisplatin, by enhancing caspase-3 expression.</p><p><strong>Conclusion: </strong>This investigation into HCD's molecular mechanisms in OSCC cells offers insight into developing effective anticancer therapies, highlighting its role in apoptosis induction through oxidative stress, mitochondrial pathways, and death receptor signaling.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Analysis of Clinical Aspects of Conventional Polymorphous Adenocarcinoma and Cribriform Adenocarcinoma of Salivary Glands: A Systematic Review.","authors":"Bruno Romano de Oliveira, Warley Oliveira Silva, Carolina Cavaliéri Gomes, Jean Nunes Dos Santos, Fabrício Tinôco Alvim de Souza","doi":"10.1111/jop.70067","DOIUrl":"https://doi.org/10.1111/jop.70067","url":null,"abstract":"<p><strong>Background: </strong>Polymorphous adenocarcinoma (PmA) is the second most common malignant neoplasm in minor salivary glands; a subtype of this lesion was described in 2005 with more aggressive behavior, Cribriform Adenocarcinoma of Salivary Glands (CASG).</p><p><strong>Objective: </strong>To compare the clinical aspects of conventional PmA and CASG originating in minor salivary glands of the oral cavity through the analysis of observational studies reported in the literature between 2005 and 2025.</p><p><strong>Method: </strong>This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The review included searches of Pubmed, Lilacs, Scopus, and Web of Science databases. A total of 988 records were identified, and after the selection process, 47 articles were chosen for inclusion.</p><p><strong>Results: </strong>Females were the most affected (61% in PmA and 73.3% in CASG). The average age variation was 60 in PmA and 57.3 in CASG. The most frequent anatomical location was the palate (42.4%) in PmA and the tongue (46.7%) in CASG. Lymph node metastasis was found in 15.2% in PmA and in 60% in CASG. The most commonly used treatment was surgical excision (72.72%) in PmA and surgical excision and neck dissection (46.67%) in CASG. Recurrence rates were 9.09% in PmA and 33.33% in CASG. The average follow-up period was 21.7 months in PmA and 43.9 in CASG.</p><p><strong>Conclusion: </strong>Female predilection and average age of 60 years are common between the two tumors. The clinical variables with quantitative differences are anatomical location, lymph node metastasis, treatment modality, and recurrence.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Nucleotide Polymorphisms as Markers of Genetic Susceptibility for Oral Submucous Fibrosis Risk: A Systematic Review and Meta-Analysis.","authors":"Divya Gopinath, Cheng Yung On, Chathathayil Mohammedali Shafeeque, Sajesh K Veettil, Wanninayake M Tilakaratne","doi":"10.1111/jop.70054","DOIUrl":"https://doi.org/10.1111/jop.70054","url":null,"abstract":"<p><strong>Background: </strong>Varied susceptibility to Oral submucous fibrosis (OSF) among individuals exposed to the same environmental variables indicates that genetic variation may contribute as a risk factor in its development. The objective was to comprehensively analyze the association between single gene polymorphisms (SNPs) and the risk of OSF.</p><p><strong>Methods: </strong>This comprehensive systematic review encompassed all relevant published studies up until June 2024 that examined the influence of gene polymorphisms on the likelihood of OSF. The search was conducted across multiple databases, including Medline, Scopus, and EBSCOhost. Data were pooled in a random-effect meta-analysis where at least two studies on the same SNP tested the same genotyping model. The assessment of heterogeneity was conducted using the I² statistic. The Q-Genie tool was used to evaluate the quality of the included studies.</p><p><strong>Results: </strong>Out of the 4573 papers initially searched, only 37 articles met the criteria to be included in this review. A total of 63 SNPs from 27 genes were tested, and 38 SNPs had significant associations. The meta-analysis revealed that five SNPs, including GSTM1 null (OR = 1.90; 1.41-2.56), GSTT1 null (OR = 2.41; 1.64-3.53), MMP3 (-1171; promoter region) (OR = 3.33; 1.45-7.61), XXCR3 (T vs. C) (OR = 1.70 (1.23-2.36)) and CYP1A1 m2 at Ncol site (-) (OR = 4.32; 1.22-15.29), are associated with an increased risk of OSF.</p><p><strong>Conclusion: </strong>The limited SNPs identified in this review could be used as markers to identify patients at a higher risk of OSF. Further studies are warranted to validate the SNPs, which demonstrate contradictory results among the currently available studies.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Cannabis and Odds Ratio for Oropharyngeal and Oral Cancer-A Cohort Study.","authors":"J Katz, H Gao, S Spritzer, I A Garcia","doi":"10.1111/jop.70055","DOIUrl":"https://doi.org/10.1111/jop.70055","url":null,"abstract":"<p><strong>Background: </strong>Widespread legalizations of cannabis in many states also cause increased interest in the adverse effects of its use, including increased risk for head and neck cancer.</p><p><strong>Methods and results: </strong>To test the hypothesis that cannabis increases the risk for head and neck cancers, we have used the i2b2 platform and ICD 10 codes to access a large Hospital database and identify patients with head and neck cancer and patients who were cannabis users. Binary Logistic regression of factors such as demographics, smoking, alcohol consumption, and HPV vaccine history was used. The odds ratio for oropharyngeal cancer among cannabis users was 3.12. After logistic regressions, it remained significant after adjusting for gender, age, and race but became insignificant after adjusting for alcohol, cigarette smoking, and HPV vaccine (1.07, 0.87, 1.02), respectively. The odds ratio for oral cancer among cannabis users was 2.38 before adjustments. It remained significant after adjustment for gender, age, race, and HPV vaccine but became insignificant after adjustment for alcohol and cigarette smoking (0.7, 0.62). After adjusting for cannabis use, the odds ratio for oropharyngeal cancer in the alcohol users was 7.95 and 7.39 for smokers. The odds ratio for oral cancer after adjusting for cannabis in the alcohol users was 9.67 and 7.52 in the cigarette smokers. HPV vaccination had an inhibitory effect on both cancers.</p><p><strong>Conclusions: </strong>Alcohol and cigarette smoking rather than the use of cannabis may play a major role in establishing an association between cannabis use and both types of head and neck cancers.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}